• Title/Summary/Keyword: Discrete system

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The estimation of Draize score by in vitro cytotoxicity using continuous cell lines (In Vitro cytotoxicity에 의한 Draize score 측정 체계 수립)

  • 정민석;최종완
    • Proceedings of the SCSK Conference
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    • 1996.07a
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    • pp.33-51
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    • 1996
  • 화장품의 변질요인은 크게 물리적 또는 화학적 변화에 의한 요인과 미생물오염으로 인한 각종 문제점으로 대별될 수 있다. 이 중에서 미생물 오염문제는 제품의 상품가치에 미치는 영향 뿐만 아니라 지속적인 사용에 의한 피부의 위생적 측면때문에 그 중요성에 대한 인식이 높아지고 있다. 따라서, 제품개발시는 화장품 처방중의 영양성분의 배합, pH, 유화형태, 방부제의 혼합, 분배계수 및 그 안정성을 고려하여야 함은 물론이고 처방중의 모든 원료의 각각에 대한 항균능 및 피부자극여부를 사전에 미리 조사하여 각 제품별로 적당한 방부체계를 선택하는 것은 매우 중요한일이다. 독성실험방법에 있어서 in vivo 실험에 대체할 수 있는 새로운 in vitro 실험방법 수립 즉, 동물실험을 하지 않고 in vitro 실험결과로부터 in vivo 결과를 예측할 수 있도록 새로운 in vitro 실험체계의 가능성을 실험하였다. 4종의 cell line중 transformed mouse fibroblast L929가 본 실험에서 사용하기에 배양상의 용이성과 안정성, 재현성의 관점에서 가장 알맞은 cell line이었다. transformed mouse fibroblast L929를 사용한 NR$_{50}$ assay와 Draize score간의 regression coefficient ${\gamma}$값은 0.91이었다. 혈청은 시험물질의 세포에 대한 민감성에 영향을 주었다. 따라서, modified serum-free method를 이용함으로써 regression coefficient가 증가된 즉, 상관성 및 재현성이 높은 결과를 얻을 수 있었다. 이러한 기술은 독성실험에 실험동물을 사용하지 않고 in vivo test에 대체 할 수 있고, 또한 화학물질에 대한 prescreening으로 이용할 수 있을 것으로 판단된다.원과 섭식장소, 수중생물의 경우는 특히 수온, 수량 영양원등이다.(중략). 본 연구의 접근방법으로는 ASRS의 개념적인 Reference Model을 수립하고 이 Reference Model에 대한 Formal Model로 DEVS(Discrete Event System Specification)을 이용하여 시스템을 Modeling하였다. 이의 Computer Simulation을 위하여 DEVS형식론 환경에서의 Simulation Language인 DEVSim ++ⓒ를 이용하여 시스템을 구현하였다.. 실형 결과로는 먼저 선형 상미분방정식의 예로 mass-damper-spring system, 비선형 상미분방정식의 예로는 van der Pol 방정식, 연립 상미분방정식의 예로는 mixing tank problem 등을 보였으며, 그의 공학에서 일어나는 여러 가지 문제들도 다루었다.화물에 대한 방어력이 증가되어 나타난 결과로 여겨지며, 또한 혈청중의 ALT, ALP 및 LDH활성을 유의성있게 감소시키므로서 감잎 phenolic compounds가 에탄올에 의한 간세포 손상에 대한 해독 및 보호작용이 있는 것으로 사료된다.반적으로 홍삼 제조시 내공의 발생은 제조공정에서 나타나는 경우가 많으며, 내백의 경우는 홍삼으로 가공되면서 발생하는 경우가 있고, 인삼이 성장될 때 부분적인 영양상태의 불충분이나 기후 등에 따른 영향을 받을 수 있기 때문에 앞으로 이에 대한 많은 연구가 이루어져야할 것으로 판단된다.태에도 불구하고 [-wh]의미의 겹의문사는 병렬적 관계의 합성어가 아니라 내부구조를 지니지 않은 단순한 단어(minimal $X^{0}$ elements)로 가정한다. 즉, [+wh] 의미의 겹의문사는 동일한 구성요 소를 지닌 병렬적 합성어([$[W1]_{XO-}$ $[W1]_{XO}$ ]

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An approach to capture travelers' choice behaviour in response to unexperienced transportation modes: A case study of Personal Rapid Transit (미경험 교통수단에 대한 이용자 선택행태 분석: Personal Rapid Transit 사례를 중심으로)

  • Yu, Jeong-Whon;Shin, Seung-Kwon;Choi, Jung-Yoon
    • Proceedings of the KSR Conference
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    • 2011.10a
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    • pp.1730-1738
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    • 2011
  • Personal Rapid Transit (PRT) has emerged as a promising alternative transportation mode for transit-oriented sustainable communities by creating compact and walkable environments with competitive construction and operational costs. This study seeks to capture the changes in travel mode choice behavior in response to the introduction of PRT to travelers who have no previous experience of using it. A critical issue in modeling the PRT mode choice is how to capture travelers' perception and evaluation of the unexperienced travel mode. The data used come from questionnaire surveys, in which RP (Revealed Preference) and SP (Stated Preference) data were collected in relation to travel mode choices with and without PRT systems. The questionnaire was designed especially for mitigating the potential bias in favor of or against choosing PRT. In addition, an efficient approach was proposed to reduce the number of SP questions by avoiding the complex fractional factorial design which tends to make it difficult for respondents to keep their attention throughout the survey. The analysis results show that the proposed approach is able to realistically capture the effects of explanatory variables on the travel mode choice. Discrete choice models are developed to predict travelers' mode choices under different choice scenarios by varying PRT system specifications and operational characteristics. PRT patronages are projected for two different test sites using the developed PRT mode choice models.

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Chemical/Biological/Radiological Protective Facility Entering Time Estimation Simulation with Procedure Analysis (화생방 방호시설의 행동 절차 분석을 통한 진입 소요시간 예측 시뮬레이션)

  • Park, Sun Ho;Lee, Hyun-Soo;Park, Moonseo;Kim, Sooyoung
    • Korean Journal of Construction Engineering and Management
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    • v.15 no.5
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    • pp.40-48
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    • 2014
  • As CBR(Chemical, Biological, and Radiological) attack increases, the importance of CBR protective facilities is being emphasized. When CBR warfare emerges, a task force team, who exist outside of CBR protective facility, should enter the CBR protective facility through neutralizing process in CCA(Contamination Control Area) and TFA(Toxic Free Area). If a bottleneck occurs in the process or zones, the task force team cannot enter the CBR protective facility efficiently and may cause inefficiency in its operation performance or result in casualties. The current design criteria of the CBR protective facility is only limited to ventilation system and it does not consider how much time it takes to enter the facility. Therefore, this research aims to propose the entering time estimation model with discrete event simulation. To make the simulation model, the procedure performed through CCA and TFA is defined and segmented. The actual time of the procedure are measured and adapted for the simulation model. After running the simulation model, variables effecting the entering time are selected for alternatives with adjustments. This entering time estimation model for CBR protective facility is expected to help take time into consideration during the designing phase of CBR protective facility and help CBR protective facility managers to plan facility operation in a more realistic approach.

Validation Technique of Simulation Model using Weighted F-measure with Hierarchical X-means (WF-HX) Method (계층적 X-means와 가중 F-measure를 통한 시뮬레이션 모델 검증 기법)

  • Yang, Dae-Gil;HwangBo, Hun;Cheon, Hyun-Jae;Lee, Hong-Chul
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.13 no.2
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    • pp.562-574
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    • 2012
  • Simulation validation techniques which have been employed in most studies are statistical analysis, which validate a model with mean or variance of throughput and resource utilization as an evaluation object. However, these methods have not been able to ensure the reliability of individual elements of the model well. To overcome the problem, the weighted F-measure method was proposed, but this technique also had some limitations. First, it is difficult to apply the technique to complex system environment with numerous values of interarrival time because it assigns a class to an individual value of interarrival time. In addition, due to unbounded weights, the value of weighted F-measure has no lower bound, so it is difficult to determine its threshold. Therefore, this paper propose weighted F-measure technique with cluster analysis to solve these problems. The classes for the technique are defined by each cluster, which reduces considerable number of classes and enables to apply the technique to various systems. Moreover, we improved the validation technique in the way of assigning minimum bounded weights without any lack of objectivity.

Agent-based SAF Modeling Tool for DEVS M&S (DEVS M&S 환경을 위한 에이전트 기반의 SAF 모델링 도구)

  • Shin, Suk-Hoon;Park, Kang-Moon;Lee, Eun-Bog;Chi, Sung-Do;Han, Seung-Jin
    • Journal of the Korea Society for Simulation
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    • v.22 no.4
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    • pp.49-55
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    • 2013
  • Recently the CGF/SAF (Computer Generated Force / Semi-Automated Force) technology has been getting attention to deal with the increasing complexity in a DM&S(Defence Modeling and Simulation) environment. OneSAF is one of well-known CGF/SAF systems, however, it is not able to support the DEVS framework which is an advanced discrete event based modeling and simulation environment. Especially, most DM&S systems in Korea has been developed on the basis of the DEVS framework. In this paper, we have proposed the agent-based SAF design methodology and tool for supporting DEVS M&S environment. The proposed SAF modeling tool is divided into two parts; the agent modeling part and SAF modeling part. In the agent modeling environment, the modeler can simply create the agent model by writing down the necessary rules. It also provides the agent testing environment so that the modeler maybe conveniently verify the prescribed agent model. The SAF model is finally created by combing the individual agents based on the pre-defined structure. DM&S engineers will be able to employ our tools and modeling methodology to design the DEVS-based DM&S system to be developed.

Comparison Study on Projection and Backprojection Methods for CT Simulation (투사 및 역투사 방법에 따른 컴퓨터단층촬영 영상 비교)

  • Oh, Ohsung;Lee, Seung Wook
    • Journal of radiological science and technology
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    • v.37 no.4
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    • pp.323-330
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    • 2014
  • Image reconstruction is one of the most important processes in CT (Computed tomography) technology. For fast scanning and low dose to the objects, iterative reconstruction is becoming more and more important. In the implementation of iterative reconstruction, projection and backprojection processes are considered to be indispensable parts. However, many approaches for projection and backprojection may result severe image artifacts due to their discrete characteristics and affects the reconstructed image quality. Thus, new approaches for projection and backprojection are highly demanded these days. In this paper, distance-driven approach was evaluated and compared with other conventional methods. The numerical simulator was developed to make the phantoms, and projection and backprojection images were compared using these approaches. As a result, it turned out that there are less artifacts during projection and backprojection in parallel and fan beam geometry.

Wave Control by Bottom-Mounted and Fluid-Filled Flexible Membrane Structure (유체가 채워진 착저신 유연막 구조물에 의한 파랑제어)

  • 조일형;강창익
    • Journal of Korean Society of Coastal and Ocean Engineers
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    • v.12 no.3
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    • pp.139-148
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    • 2000
  • In this paper, the interaction of oblique incident waves with a bottom-mounted and fluid-filled flexible membrane structure is investigated in the frame of linear hydro-elastic theory. The static shape of a membrane structure containing the fluid of a specific density is initially unknown and must be calculated before the hydrodynamic analysis. To solve hydrodynamic problem, the fluid domain is divided into the inner and outer region. The inner solution based on discrete membrane dynamic model and simple-source distribution over the entire fluid boundaries is matched to the outer solution ba~ed on an eigenfunction expansion method. The numerical results were compared to a series of Ohyama's experimental results. The measured reflection and tran¬smission coefficients reasonably follow the trend of predicted values. Using the computer program developed, the performance of a bottom-mounted and fluid-filled flexible membrane strocture is tested with various system parameters (membrane shape, internal pressure, density ratio) and wave characteristics (wave frequencies, incident wave angle). It is found that a bottom-mounted and fluid-filled flexible membrane structure can be an effel;tive wave barrier if properly designed.

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Chatbot Design Method Using Hybrid Word Vector Expression Model Based on Real Telemarketing Data

  • Zhang, Jie;Zhang, Jianing;Ma, Shuhao;Yang, Jie;Gui, Guan
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.14 no.4
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    • pp.1400-1418
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    • 2020
  • In the development of commercial promotion, chatbot is known as one of significant skill by application of natural language processing (NLP). Conventional design methods are using bag-of-words model (BOW) alone based on Google database and other online corpus. For one thing, in the bag-of-words model, the vectors are Irrelevant to one another. Even though this method is friendly to discrete features, it is not conducive to the machine to understand continuous statements due to the loss of the connection between words in the encoded word vector. For other thing, existing methods are used to test in state-of-the-art online corpus but it is hard to apply in real applications such as telemarketing data. In this paper, we propose an improved chatbot design way using hybrid bag-of-words model and skip-gram model based on the real telemarketing data. Specifically, we first collect the real data in the telemarketing field and perform data cleaning and data classification on the constructed corpus. Second, the word representation is adopted hybrid bag-of-words model and skip-gram model. The skip-gram model maps synonyms in the vicinity of vector space. The correlation between words is expressed, so the amount of information contained in the word vector is increased, making up for the shortcomings caused by using bag-of-words model alone. Third, we use the term frequency-inverse document frequency (TF-IDF) weighting method to improve the weight of key words, then output the final word expression. At last, the answer is produced using hybrid retrieval model and generate model. The retrieval model can accurately answer questions in the field. The generate model can supplement the question of answering the open domain, in which the answer to the final reply is completed by long-short term memory (LSTM) training and prediction. Experimental results show which the hybrid word vector expression model can improve the accuracy of the response and the whole system can communicate with humans.

Numerical Analysis of Horizontal Collector Well in Riverbank Filtration (수평 방사형 집수정 활용 강변여과 취수 수치 분석)

  • Kim, Hyoung-Soo;Jeong, Jae-Hoon
    • Journal of Soil and Groundwater Environment
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    • v.14 no.1
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    • pp.1-10
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    • 2009
  • Groundwater flow due to intake of horizontal collector well in riverbank filtration site was analyzed by use of numerical groundwater modeling program (FEFLOW 5.1). Drawdowns of groundwater table nearby collector well were evaluated according to variations of several conditions; pumping rate, thickness of aquifer, offset distance from well to shore line of stream, conductance of streambed. It is observed that the drawdowns of groundwater table are clearly changed according to the variations of these conditions. The results of sensitive analysis shows that the thickness of alluvial aquifer and the offset distance are more sensitive than the conductance of streambed in evaluation of drawdown. This result implies that hydrogeological conditions, as like thickness of aquifer and its distribution in the site are important factors in site selection and evaluating the availability of riverbank filtration intake using horizontal collector well system. It is also revealed that numerical modeling using FEFLOW with 1-D discrete element feature can give efficient quantitative evaluation of horizontal collector well and estimation of availability of riverbank filtration site.

DCT-domain MPEG-2/H.264 Video Transcoder System Architecture for DMB Services (DMB 서비스를 위한 DCT 기반 MPEG-2/H.264 비디오 트랜스코더 시스템 구조)

  • Lee Joo-Kyong;Kwon Soon-Young;Park Seong-Ho;Kim Young-Ju;Chung Ki-Dong
    • The KIPS Transactions:PartB
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    • v.12B no.6 s.102
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    • pp.637-646
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    • 2005
  • Most of the multimedia contents for DBM services art provided as MPEG-2 bit streams. However, they have to be transcoded to H.264 bit streams for practical services because the standard video codec for DMB is H.264. The existing transcoder architecture is Cascaded Pixel-Domain Transcoding Architecture, which consists of the MPEG-2 dacoding phase and the H.264 encoding phase. This architecture can be easily implemented using MPEG-2 decoder and H.264 encoder without source modifying. However. It has disadvantages in transcoding time and DCT-mismatch problem. In this paper, we propose two kinds of transcoder architecture, DCT-OPEN and DCT-CLOSED, to complement the CPDT architecture. Although DCT-OPEN has lower PSNR than CPDT due to drift problem, it is efficient for real-time transcoding. On the contrary, the DCT-CLOSED architecture has the advantage of PSNR over CPDT at the cost of transcoding time.