• Journal of Communications and Networks
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• v.14 no.5
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• pp.566-577
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• 2012

In randomly deployed networks, such as sensor networks, an important problem for each node is to discover its neighbor nodes so that the connectivity amongst nodes can be established. In this paper, we consider this problem by incorporating the physical layer parameters in contrast to the most of the previous work which assumed a collision channel. Specifically, the pilot signals that nodes transmit are successfully decoded if the strength of the received signal relative to the interference is sufficiently high. Thus, each node must extract signal parameter information from the superposition of an unknown number of received signals. This problem falls naturally in the purview of random set theory (RST) which generalizes standard probability theory by assigning sets, rather than values, to random outcomes. The contributions in the paper are twofold: First, we introduce the realistic effect of physical layer considerations in the evaluation of the performance of logical discovery algorithms; such an introduction is necessary for the accurate assessment of how an algorithm performs. Secondly, given the double uncertainty of the environment (that is, the lack of knowledge of the number of neighbors along with the lack of knowledge of the individual signal parameters), we adopt the viewpoint of RST and demonstrate its advantage relative to classical matched filter detection method.

• Journal of Elementary Mathematics Education in Korea
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• v.15 no.3
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• pp.641-654
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• 2011

In order to grow students' rational and creative problem-solving ability which is one of the primary goals in mathematics education. students' proper understanding of mathematical concepts, principles, and rules must be backed up as its foundational basis. For the relevant teaching strategies. National Mathematics Curriculum advises that students should be allowed to discover and justify the concepts, principles, and rules by themselves not only through the concrete hands-on activities but also through inquiry-based activities based on the learning topics experienced from the diverse phenomena in their surroundings. Hereby, this paper, firstly, looks into both the meaning and the inductive reasoning process of mathematical principles and rules, secondly, suggest "learning through discovery teaching method" for the proper teaching of the mathematical principles and rules recommended by the National Curriculum, and, thirdly, examines the possible discovery-led teaching strategies using inductive methods with the related matters to be attended to.

• Journal of Pharmaceutical Investigation
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• v.38 no.2
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• pp.105-110
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• 2008

Indapamide (4-chloro-N-(2-methyl-1-indolinyl)-3-sulfamoyl-benz-amide) is an oral antihypertensive diuretic agent indicated for the treatment of hypertensive. The diuretic and natriuretic effects are mainly due to the structure of o-chlorobenzenesulfonamide. The objective of this study was to formulate sustained release indapamide granules and assess their formulation variables. Granules were prepared by fluid bed coating method and consist of drug layer and membrane layer. The granules were coated with HPC and ethyl cellulose along with plasticizer dibuthyl sebacate. The release of indapamide depended on the type of Eudragit such as RS and NE 30 D used in the formulation controlled release layer. These results obtained clearly suggest that the sustained release oral delivery system for indapamide could be designed with satisfying drug release profile approved.

• Journal of Pharmaceutical Investigation
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• v.38 no.1
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• pp.15-21
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• 2008

Liposomes as one of the efficient drug carriers have some shortcomings such as their short circulation time, fast clearance from human body by reticuloendothelial system (RES) and limited intracellular uptake to target cell. In this study, polyethylenglycol (PEG)-incorporated cationic liposomes were prepared by ionic complexation of positively charged liposomes with carboxylated polyethyleneglycol (mPEG-COOH). The cationic liposomes had approximately $98.6{\pm}1.0nm$ of mean particle diameter and $42.8{\pm}0.8mV$ of zeta potential value. The PEG-incorporated cationic liposomes had $110.1{\pm}1.2nm$ of mean particle diameter with an increase of about 10 nm compared to the cationic liposomes. Zeta potential value of them was $12.9{\pm}0.6mV$ indicating 30mV decrease of cationic charge compared to the cationic liposomes. The amount of PEG which was incorporated onto the cationic liposomes was assayed by using picrate assay method and the incorporation efficiency was $58.4{\pm}1.1%$. Loading efficiency of model drug, doxorubicin, into cationic liposomes or PEG-incorporated cationic liposomes was about $96.0{\pm}0.7%$. Results of intracellular uptake which were evaluated by flow cytometry analysis of doxorubicin loaded liposomes showed that intracellular uptake of PEG-incorporated cationic liposomes was higher than the cationic liposomes or DSPE-mPEG liposomes. In addition, cytotoxicity of PEG-incorporated cationic liposomes was comparable to cationic liposomes. Consequently, the PEG-incorporated cationic liposomes of which surface was incorporated with PEG by ionic complex may be applicable as anticancer drug carriers that can increase therapeutic efficacy.

• Journal of the Korean Chemical Society
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• v.52 no.1
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• pp.57-65
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• 2008

are nanometer or micrometer scale vesicles that can be used as drug delivery carriers. However, plain liposomes are plagued by rapid opsonization, making their circulation time in bloodstream be shortened. In this study, model protein, bovine serum albumin (BSA)-coated liposomes were prepared by coating cationic liposomes with BSA molecules at higher pH than isoelectric point of BSA. The BSA molecules coated on the liposomal surface were denatured by thermal treatment at above 60oC. While both plain and cationic liposomes had about mean particle diameter of 1041 nm, BSA-coated cationic liposomes (BCL) had mean particle diameter of 1091 nm. Encapsulation of model drug, doxorubicin (DOX), in liposomes were carried out by using remote loading method and the loading efficiency of DOX to liposomes was about 90%. The mean particle diameter of BCL did not increase in blood plasma and adsorption of plasma protein was much less than plain or cationic liposomes. These results suggest that BCL can be used as a long-circulating liposomes in bloodstream.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.21 no.9
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• pp.1777-1787
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• 2017

Federated authentication (FA) is a multi-domain authentication and authorization infrastructure that enables users to access nationwide R&D resources with their home-organizational accounts. An FA-enabled user is redirected to his/her home organization, after selecting the home from an identity-provider (IdP) discovery service, to log in. The discovery service allows a user to search his/her home from all FA-enabled organizations. Users get troubles to find their home as federation size increases. Therefore, a discovery service has to provide an intuitive way to make a fast IdP selection. In this paper, we propose a discovery system which leverages geographical information. The proposed system calculates geographical proximity and text similarity between a user and organizations, which determines the order of organizations shown on the system. We also introduce a server redundancy and a status monitoring method for non-stop service provision and improved federation management. Finally, we deployed the proposed system in a real service environment and verified the feasibility of the system.

• Journal of Pharmaceutical Investigation
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• v.38 no.2
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• pp.127-134
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• 2008

Peroral administration is the most convenient one for the administration of pharmaceutically active compounds. Most of poorly water-soluble drugs administered via the oral route, however, remain poorly available due to their precipitation in the gastrointestinal (GI) tract and low permeability through intestinal mucosa. In this study, one of drug delivery carriers, lipid nanoparticles (LNPs) were designed in order to reduce side effects and improve solubility and stability in GI tract of the poorly water soluble drugs. However, plain LNPs are generally unstable in the GI tract and susceptible to the action of acids, bile salts and enzymes. Accordingly, the surface of LNPs was modified with polyethylene glycol (PEG) for the purpose of improving solubility and GI stability of paclitaxel (PTX) in vitro. PEG-modified LNPs containing PTX was prepared by spontaneous emulsification and solvent evaporation (SESE) method and characterized for mean particle diameter, entrapping efficiency, zeta potential value and in vitro GI stability. Mean particle diameter and zeta potential value of PEG-modified LNP containing PTX showed approximately 86.9 nm and -22.9 mV, respectively. PTX entrapping efficiency was about 70.5% determined by UV/VIS spectrophotometer. Futhermore, change of particle diameter of PTX-loaded PEG-LNPs in simulated GI fluids and bile fluid was evaluated as a criteria of GI stability. Particle diameter of PTX-loaded PEG-LNPs were preserved under 200 nm for 6 hrs in simulated GI fluids and bile fluid at $37^{\circ}C$ when DSPE-mPEG2000 was added to formulation of LNPs above 4 mole ratio. As a result, PEG-modified LNPs improved stability of plain LNPs that would aggregate in simulated GI fluids and bile solution. These results indicate that LNPs modified with biocompatible and nontoxic polymer such as PEG might be useful for enhancement of GI stability of poorly water-soluble drugs and they might affect PTX absorption affirmatively in gastrointestinal mucosa.

• Proceedings of the KSRS Conference
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• v.2
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• pp.627-630
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• 2006

Sequential Pattern Mining is the mining approach which addresses the problem of discovering the existent maximal frequent sequences in a given databases. In the daily and scientific life, sequential data are available and used everywhere based on their representative forms as text, weather data, satellite data streams, business transactions, telecommunications records, experimental runs, DNA sequences, histories of medical records, etc. Discovering sequential patterns can assist user or scientist on predicting coming activities, interpreting recurring phenomena or extracting similarities. For the sake of that purpose, the core of sequential pattern mining is finding the frequent sequence which is contained frequently in all data sequences. Beside the discovery of frequent itemsets, sequential pattern mining requires the arrangement of those itemsets in sequences and the discovery of which of those are frequent. So before mining sequences, the main task is checking if one sequence is a subsequence of another sequence in the database. In this paper, we implement the subsequence matching method as the preprocessing step for sequential pattern mining. Matched sequences in our implementation are the normalized sequences as the form of number chain. The result which is given by this method is the review of matching information between input mapped sequences.

• Korean Journal of Remote Sensing
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• v.22 no.5
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• pp.457-462
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• 2006

Sequential Pattern Mining is the mining approach which addresses the problem of discovering the existent maximal frequent sequences in a given databases. In the daily and scientific life, sequential data are available and used everywhere based on their representative forms as text, weather data, satellite data streams, business transactions, telecommunications records, experimental runs, DNA sequences, histories of medical records, etc. Discovering sequential patterns can assist user or scientist on predicting coming activities, interpreting recurring phenomena or extracting similarities. For the sake of that purpose, the core of sequential pattern mining is finding the frequent sequence which is contained frequently in all data sequences. Beside the discovery of frequent itemsets, sequential pattern mining requires the arrangement of those itemsets in sequences and the discovery of which of those are frequent. So before mining sequences, the main task is checking if one sequence is a subsequence of another sequence in the database. In this paper, we implement the subsequence matching method as the preprocessing step for sequential pattern mining. Matched sequences in our implementation are the normalized sequences as the form of number chain. The result which is given by this method is the review of matching information between input mapped sequences.

• Journal of the Korean School Mathematics Society
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• v.3 no.1
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• pp.177-188
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• 2000

Mathematics is extreme the differences of the scholarly attainments in comparison with other subjects at a middle school. Specially, the students at islands and places leave much to be desired the scholarly attainments standards of mathematics. Therefore, every school takes movement class according to level these days. And the small schools put in effect the cooperation of group work through the small groups. These classes are effective at the scholarly attainments extension to some degree, but each student is extreme the differences of scholarly attainments. On this, the small school was the subject of study at the present research and put in effect the cooperation of group work through the small groups. The students were divided in three groups; the top class, average, the low class, And they were offered the fitting textbooks matching the cooperation of group work and the opportunities of discovery learning fitting an individual ability and standard. Consequently, some educational materials were made, for example, question papers, commonness learning materials, choice learning materials. These materials were put in effect to the students to be able to succeed discovery learning. With this, the students were investigated an interest of mathematics and the influence giving at the studies attainment. And the students were put in effect the cooperation of group work through the small groups to improve uniformity and sturdiness of the mathematical education. The conclusion at the present research is as follows. 1) When the students put in effect the cooperation of group work through the small groups, the scholarly attainments of mathematics totally didn't display useful changes as improvement. However, the students of average and the low class gradually seemed to improve the scholarly attainments of mathematics as the help of the top class positively. 2) An individual and cooperation learning in the method of the cooperation of group work through the small groups displayed many changes at the learning attitude of the students by means of discovery learning thanks to the learning heads. 3) When the investigator put in effect the cooperation of group work through rather the small groups than the large groups, the numbers of the students experiencing interest about mathematics increased in 26% and this learning method should continue to progress.