• 대한한방내과학회지
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• 제29권1호
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• pp.177-188
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• 2008

Objectives : This study was performed to investigate the anti-fibrogenic effect of Artemisiae Capillaris Herba on cultured rat hepatic stellate cells. Materials and Methods : Hepatic stellate cells(HSC-T6) were treated with various concentrations of Artemisiae Capillaris Herba extract for 24 hours. The extraction was done either with distilled water or 50% EtOH. After the treatment, cell viability, proliferation, procollagen levels and the mRNA of the collagen type 1a2 and ASMA were measured by using MTT assay, BrdU assay, RT-PCR, and Procollagen Type I C-peptide EIA Kit. Results : The viability and proliferation of the hepatic stellate cells were decreased as the concentration increased. The mRNA expression decreased consistently with the volume of the secreted procollagen with the extraction made with distilled water, which indicates the herb has inhibitory effect on fibrogenesis of the liver by regulating one of the fibrosis associated genes in transcription. However, it increased in 50% EtOH extraction, which shows that a more stable reaction is expected of the extraction made with distilled water than the extraction made with 50% EtOH. The production of procollagen was decreased by a low-concentration treatment with Artemisiae Capillaris Herba, but increased by a high concentration. It seemed that the cells were responding to Artemisiae Capillaris Herba in low- concentrations, thus producing small amounts of collagen. When the drug was administered at high enough concentration to give direct toxicity to cells, the ability of cells to produce collagen was activated, and the overproduction of collagen was observed as an undesirable results. Conclusion : These results suggest that Artemisiae Capillaris Herba is beneficial in the treatment of cirrhotic patients as well as for the patients with chronic hepatitis when extracted with water in the proper concentrations.

• Mass Spectrometry Letters
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• 제10권2호
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• pp.66-70
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• 2019

Rivaroxaban (RRN) is the first available active direct factor Xa inhibitor (anticoagulant) with oral administration. Due to its success in market, there have been efforts to develop various RRN formulations, and the development of good analytical methods for its in vivo evaluation is an essential prerequisite. Thus, here, a simple and efficient method to determine RRN in rat plasma using liquid-liquid extraction (LLE) and liquid chromatography and multiple reaction monitoring (LC-MRM) was presented. The use of ethyl acetate as the LLE solvent results appropriate extraction and purification of RRN and it also helps the significant reduction of rat plasma volume required for RRN quantitation. The developed method showed good analytical performance including specificity, linearity ($r^2{\geq}0.999$ within 0.5 - 500 ng/mL), sensitivity (the lower limit of quantitation at 0.5 ng/mL), accuracy (89.3 - 107.0%), precision (${\geq}12.7%$), and recovery (89.2 - 105.7%). Additionally, RRN in sample extracts showed good stability. Finally, the applicability of the validated method to the PK evaluation of RRN was confirmed after its oral administration to normal rats. The present method is the first analytical method employing LLE for the simple and efficient extraction and purification of RRN in rat plasma. Therefore, the present method can contribute to the development of new RRN formulations as well as to the monitoring of RRN in special clinical situations through its efficient determination in various samples with or without minor modification.

• 전기전자학회논문지
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• 제24권1호
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• pp.140-146
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• 2020

We investigated light extraction film based on polymer dispersed liquid crystal (PDLC) for application in organic light emitting diodes (OLEDs). At least 30 seconds of direct UV irradiation process for curing PDLC film on a bottom-emitting OLEDs was successfully achieved without damage on the intrinsic properties of the OLED. We demonstrated that high haze and transmittance can be tuned simultaneously by controlling the UV curing time. By adding PDLC as an external layer without any additional treatment, the light scattering and extraction is increased. Consequently, a PDLC scattering film with 89.8% and 59.9 of total transmittance and haze respectively, achieved about 16% of light intensity enhancement from integrating sphere measurement.

• 한국산업정보학회논문지
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• 제7권5호
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• pp.147-153
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• 2002

GHz에서 동작하는 초미세 MOSFET의 BSIM3 MOSFET 모델에 연결하여 사용할 수 있는 기판 회로망 모델과 그에 따른 물리적 의미를 가지는 직접 파라미터 추출법이 제안되었다. 제안된 기판 회로망에는 관례적인 저항과 링-형태의 기판콘택에 의해 생성된 단일의 인덕터가 포함되었다. 모델 파라미터는 최적화 과정 없이 단절된 게이트와 공통-벌크 구성을 갖는 MOS 트랜지스터에서 측정된 S-파라미터로부터 추출되었다. 제안된 모델링 기술은 다양한 크기의 MOS 트랜지스터에 적용되었고, 30GHz까지 그 타당성이 검증되었다.

• 생약학회지
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• 제41권1호
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• pp.62-66
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• 2010

In result of analysis for the content determination of ursolic acid(UA) and oleanolic acid(OA) in extract of Eriobotryae folium using HPLC with UV detector, UA in chloroform extract of Moo-mok variety was showed highest content(2.7843 mg/g). And OA in ethyl acetate extract of Dae-bang variety was showed highest content(0.5898 mg/g). These result suggest that direct extraction using organic solvent(chloroform or ethyl acetate) was useful method for rapid quantitative analysis of UA and OA without preprocessing such as drying or fractionation.

• 전자공학회논문지
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• 제49권12호
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• pp.173-178
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• 2012

RF 직접 추출 방법을 통해 얻은 정확한 MOSFET 기판 파라미터를 이용하여 기판저항만을 가진 BSIM4 모델은 스케일링 부정확성 때문에 넓은 영역의 게이트 길이에 적용하기에는 물리적으로 맞지 않다는 것이 증명됐다. BSIM4의 비물리적인 문제점을 제거하기 위해서 추가적인 유전체 기판 캐패시터를 가진 수정된 BSIM4 모델이 사용되었고, 이 모델의 물리적 타당성은 우수한 게이트 길이 scalability를 관찰함으로써 증명되었다.

• 한국전기전자재료학회논문지
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• 제17권4호
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• pp.367-372
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• 2004

Two new extraction methods for the thermal Resistance of HBT(Heterojunction Bipolar Transistors) are proposed. First, the analytical expression, based on the thermal characteristics that the base to emitter junction voltage drops with the increase of junction temperature, is derived. Second, the thermal resistance equation that can predict the measured DC(Direct Current) data optimally is derived. These optimal thermal resistance expression is applied to the 2 finger 2${\times}$20${\mu}{\textrm}{m}$-AlGaAs/GaAs HBT and shows the good agreement with the measured data.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1998년도 하계학술대회 논문집 G
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• pp.2427-2429
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• 1998

Digital watermarking is the techinque which embeds the invisible signal into multimedia data such as audio, video, images, for copyright protection, including owner identification and copy control information. This paper proposes a new watermark embedding and extraction technique by extending the direct sequence spread spectrum technique. The proposed technique approximates the frequency component of pixels in spatial domain by using Laplacian mask and adaptively embeds the watermark considering the HVS to reduce the degradation of Image. In watermark extraction process, the proposed technique strengthens the high frequency components of image and extracts the watermark by demodulation. All this processes are performed in spatial domain to reduce the processing time.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2000년도 하계학술대회 논문집 D
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• pp.3028-3030
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• 2000

In general. a speech coding is dedicated to the compression performance or the speech quality. But. the speech coding in this paper is focused on the performance of flexible transmission to the, network speed. For this. the subbanding coding is needed. which is used the wavelet packet concept in the signal analysis. The extraction of each frequency-band is difficult to general signal analysis methods, after coding each band, the reconstruction of these is also a difficult problem. But. with the wavelet packet concept(perfect reconstruction) and its fast computation algorithm. the extraction of each band and the reconstruction are more natural. Also, this paper describes a direct solution of the voice transmission on network and implement this algorithm at the TCP/IP network environment of PC.

• 한국항해항만학회지
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• 제29권4호
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• pp.341-347
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• 2005

A unique technique to extract the phase in time domain is proposed in order to measure the time parameters such as speed and depth by transmitting sound and electric waves. In the signal analysis processing, the phase of pulse signal can be transformed and digitalized with local data in real time without the effect of direct current bias and Nyquist limits. This method is sensitive to base frequency of pulse signal with high spacial resolution and is effective to compare two signals which have different forms. It is expected that the phase analysis technique will be applied to the measurement of the speed and depth accurately by ultrasonic pulse signal in water.