• Research in Community and Public Health Nursing
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• v.24 no.3
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• pp.255-263
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• 2013

Purpose: This study examined the fitness of a path model for the relationship among daily life stress, problem of life, social support, depression, and suicidal ideation in adolescents. Methods: The subjects consisted of 247 adolescents. Data were collected through self-report questionnaires. The data were analyzed by the SPSS and AMOS programs. Results: Daily life stress, problem of life, social support, and depression showed direct effects on suicidal ideation in adolescents, while daily life stress and problem of life showed indirect effects on suicidal ideation in adolescents. Daily life stress and problem of life showed direct effects on social support and depression in adolescents. The hypothetical path model of adolescents' suicidal ideation was proven correct. Conclusion: Based on the outcomes of this study, it is necessary to design an intervention program that emphasizes the reduction of daily life stress, problem of life, depression and enhancement social support in order to prevention adolescents' suicidal ideation.

• International Journal of Oral Biology
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• v.34 no.4
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• pp.191-197
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• 2009

Somatostatin (SST) is a known neuromodulator of the central nervous system. The substantia gelatinosa (SG) of the trigeminal subnucleus caudalis (Vc) receives many thinmyelinated $A{\delta}$-fiber and unmyelinated C primary afferent fibers and is involved in nociceptive processing. Many studies have demonstrated that SST plays a pivotal role in pain modulation in the spinal cord. However, little is yet known about the direct effects of SST on the SG neurons of the Vc in adult mice. In our present study, we investigated the direct membrane effects of SST and a type 2 SST receptor agonist, seglitide (SEG), on the SG neurons of the Vc using a gramicidin-perforated current clamp in adult mice. The majority (53%, n = 27/51) of the adult SG neurons were hyperpolarized by SST (300 nM) but no differences were found in the hyperpolarization response rate between males and females. When SST was applied successively, the second response was smaller ($76{\pm}9.5%$, n=19), suggesting that SST receptors are desensitized by repeated application. SST-induced hyperpolarization was also maintained under conditions where presynaptic events were blocked ($75{\pm}1.0%$, n=5), suggesting that this neuromodulator exerts direct effects upon postsynaptic SG neurons. SEG was further found to induce membrane hyperpolarization of the SG neurons of the Vc. These results collectively demonstrate that SST inhibits the SG neuronal activities of the Vc in adult mice with no gender bias, and that these effects are mediated via a type 2 SST receptor, suggesting that this is a potential target for orofacial pain modulation.

• The Korean Journal of Food And Nutrition
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• v.25 no.4
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• pp.888-896
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• 2012

Considering the dearth of information regarding the medicinal properties of Luffa cylindrica, we assessed the antioxidative, antimutagenic and hyperplasia inhibitory activity of cancer cells from Luffa cylindrica extracts by employing biological and biochemical assays. Ethanol extracts of Luffa cylindrica inhibited MDA-BSA (malondialdehyde-bovine serum albumin) conjugation reaction ($66.38{\pm}2.65$), DPPH (1,1-diphenyl-2-picryl-hydrazyl) radical production ($60.13{\pm}0.42$) and lipid peroxidation ($56.04{\pm}3.24$). In this study, Luffa cylindrica is believed to exert possible antioxidative effects. The direct and indirect antimutagenic effects of the ethanol extracts of Luffa cylindrica were examined by the Ames test using Salmonella typimurium TA98 and TA100. The inhibitory effects on indirect and direct mutagenicity shows an weak tendency, particularly in direct mutagenicity mediated by 2-nitrofluorene in Salmonella typimurium TA98 ($5.82{\pm}5.74$) and in indirect mutagenicity mediated by 2-anthramine in Salmonella typimurium TA100 ($5.76{\pm}2.15$). The ethanol extracts of Luffa cylindrica on cancer cell hyperplasia inhibitory activity via MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay exerted cytotoxic effects on Hela cells ($55.83{\pm}3.83$) and MCF-7 cells ($33.03{\pm}2.09$), which were used in this study. Based on these results, it believed that the ethanol extracts of Luffa cylindrica have antioxidative capacities as well as hyperplasia inhibitory activity of cancer cells. Furthemore, Luffa cylindrica is a candidate for the prevention and dietetic treatment of chronic diseases and for the development of functional food.

• Journal of Convergence for Information Technology
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• v.10 no.10
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• pp.88-99
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• 2020

This study aimed to explore the effects of perceived family stress, supportive resources, intentional rumination, and coping behaviors on posttraumatic growth of cancer survivors based on the Double ABCX Family Stress Model. Data were collected from 200 cancer survivors currently living with their spouses and analyzed by path analysis using AMOS program. The results of this study were as follows. First, perceived family stress of cancer survivors had direct effects on supportive resources, intentional rumination, and coping behaviors, and had indirect effects on posttraumatic growth mediated by supportive resources, intentional rumination, and coping behaviors. Second, supportive resources, intentional rumination, and coping behaviors had direct effects on posttraumatic growth. Third, supportive resources and intentional rumination had direct effects on coping behaviors and had an indirect effect on posttraumatic growth mediated by coping behaviors. The current study supported the applicability of the Double ABCX Family Stress Model to the posttraumatic growth process of cancer survivors.

• Journal of Digital Convergence
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• v.17 no.12
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• pp.575-582
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• 2019

The purpose of this study empirically verified the effects which family cohesion has on the emotional and behavioral problems(internal and external problems) in middle school students, sampling 375 of 1st, 2nd and 3rd grades middle school students. Also, this study aims to confirm the mediating effect of relationship with teachers and relationship with peers considering that the social relationship in middle school students of adolescence expands to teachers and peers and is a important developmental stage. The results of this study are as follows. Family cohesion is shown to have direct effects on internal and external problems in middle school students. Also, relationship with teachers is shown to have direct effects on internal and external problems. However, relationship with peers is shown to have direct effects on internal problems while it is shown to have insignificant results statistically on external problems.

• Journal of Korean Academy of Nursing
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• v.53 no.1
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• pp.129-143
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• 2023

Purpose: This study aimed to examine the mediating effects of clinical nurses' job crafting on organizational effectiveness based on the job demands-resources model proposed by Bakker and Demerouti (2017). Methods: The participants consisted of 393 nurses working in nursing units of a tertiary general hospital located in Cheongju region. The data, collected using questionnaire from August 9 to August 20, 2021, were analyzed using SPSS 23.0 and AMOS 27.0. Results: The goodness-of-fit (GoF) test results on the modified model (χ² = 2.7, GFI = .94, SRMR = .03, RMSEA = .06, NFI = .92, CFI = .94, TLI = .92, AGFI = .90), indicated that the GoF index satisfied the recommended level. Regarding the effects of each variable on organizational effectiveness, job crafting showed statistically significant direct (β = .48, p < .001), indirect (β = .23, p < .001), and total effects (β = .71, p < .001). Burnout showed statistically significant direct effect (β = - .17, p < .001). Work engagement showed statistically significant direct (β = .41, p < .001) and total effects (β = .41, p < .001). The factors explaining organizational effectiveness were job crafting, burnout, and work engagement, which had an explanatory power of 76.7%. Conclusion: Nurses' job crafting is an important mediating factor for enhancing the organizational effectiveness of nursing organizations. Hospitals should develop job-crafting success cases and related education and training programs as a strategy for enhancing the job crafting of nurses and, consequently organizational effectiveness.

• Journal of Korean Academy of Nursing
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• v.22 no.4
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• pp.476-490
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• 1992

This study was designed to develop and test a structural model for maternal adaptation and family stress in families with mentally handicapped children. A hypothetical model was constructed on the basis of the family stress theory developed by McCubbin etc. The model included 6 theoretical concepts and 11 paths. For the purpose of the model testing, empirical data were collected from May to August, 1992. The subjects of the study constituted 190 mothers of children in five special schools and one private institute in Seoul and Choong Nam. An SPSS PC＋ and PC－LISREL 7.13 computer programs were used for descriptive and covariance structure analysis. The results of the study were as follows. (1) The hypothetical model showed itself a good fit to the empirical data ［Chi - square＝18.35(df＝7, P＝0.005), Goodness of Fit Index＝0.991, Adjusted Goodness of Fit Index＝0.959, Root Mean Square Residual＝0.042), Non Normed Fit Index＝0.90, Normed Fit Index＝0.96］. (2) The results of Hypothesis testing indicated : 1) Social support(${\gamma}$$_{11}$＝.238, T＝2.352), Family functioning(${\gamma}$$_{12}$＝.729, T＝5.957) and Family life event stress(${\gamma}$$_{13}$＝.125) had direct effects on situational definition. 2) Life event stress(${\gamma}$$_{23}$＝.319, T＝3.872) had direct effects on the effect of the handicapped child on the family. Family functioning(${\gamma}$$_{22}$＝-.245) and situational definition($\beta$$_{21}$＝-.335, T＝3.227) had direct effects on the effect of the handicapped child on the family. 3) Situational definition($\beta$$_{31}$＝-.273, T＝3.493), family life event stress (${\gamma}$$_{33}$＝.124, T＝2.169) and the effect of the handicapped child on the family($\beta$$_{32}$＝.264, T＝-3.227) showed the direct effect on the maternal adaptation. The model was supported by the empirical data. Thus it was suggested that the model could be applied to family nursing care with the families with the mentally handicapped. The construction and testing of the comprehensive model seem to be the first trial in Korea.a.a.a.

• Asian-Australasian Journal of Animal Sciences
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• v.25 no.6
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• pp.764-771
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• 2012

Direct and maternal genetic heritabilities and their correlations with body weight at 5 stages in the life span of purebred Berkshire pigs, from birth to harvest, were estimated to scrutinize body weight development with the records for 5,088 purebred Berkshire pigs in a Korean farm, using the REML based on an animal model. Body weights were measured at birth (Birth), at weaning (Weaning: mean 22.9 d), at the beginning of a performance test (On: mean 72.7 d), at the end of a performance test (Off: mean 152.4 d), and at harvest (Finish: mean 174.3 d). Ordinary polynomials and Legendre with order 1, 2, and 3 were adopted to adjust body weight with age in the multivariate animal models. Legendre with order 3 fitted best concerning prediction error deviation (PED) and yielded the lowest AIC for multivariate analysis of longitudinal body weights. Direct genetic correlations between body weight at Birth and body weight at Weaning, On, Off, and Finish were 0.48, 0.36, 0.10, and 0.10, respectively. The estimated maternal genetic correlations of body weight at Finish with body weight at Birth, Weaning, On, and Off were 0.39, 0.49, 0.65, and 0.90, respectively. Direct genetic heritabilities progressively increased from birth to harvest and were 0.09, 0.11, 0.20, 0.31, and 0.43 for body weight at Birth, Weaning, On, Off, and Finish, respectively. Maternal genetic heritabilities generally decreased and were 0.26, 0.34, 0.15, 0.10, and 0.10 for body weight at Birth, Weaning, On, Off, and Finish, respectively. As pigs age, maternal genetic effects on growth are reduced and pigs begin to rely more on the expression of their own genes. Although maternal genetic effects on body weight may not be large, they are sustained through life.

• Korean Management Science Review
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• v.22 no.2
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• pp.109-133
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• 2005

The exponential growth of the on-line shopping mall has been the advent of buying and selling products and services over the internet. In these circumstances, this paper presents the importance of understanding and managing the purchasing behavior of on-line shopping mall customers. The main purpose of this research is to find out the antecedents of customer trust and to conceptualize and investigate the relationship between endogenous mediating variables(such as customer trust, attitude, loyalty, relationship involvement) and purchasing and/or repurchasing intention in internet shopping mall. The empirical findings are as follows : First, the three antecedents of customer trust( EC system characteristics, psychological propensity, and trustworthiness) had the positive effects on the formation of site trust. Second, we found out that there were direct or indirect relationships between the mediating variables and on-line purchasing and/or repurchasing intention. In Particular, the direct effects of customer attitude on customer loyalty and buying intention were rejected, but the indirect effects through relationship involvement were accepted. This means that the relationship marketing is probably more important for the success of internet shopping mall Third, there were no direct relationship between the mediating variables and the repurchasing intention, but most researches in the brick and mortar, the proposition are supported. This implies that repurchasing intention was intensified by the indirect path, such as site trust $\longrightarroe$ attitude $\longrightarroe$ involvement $\longrightarroe$ loyalty $\longrightarroe$ purchasing intention $\longrightarroe$ repurchasing intention. So, the internet marketers must make an effort not only to strengthen the direct casual linkage between them but also to consolidate the indirect connections leading to boost purchasing and repurchasing intention.

• Journal of the Korean Society of Food Science and Nutrition
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• v.28 no.3
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• pp.599-606
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• 1999

Water extracts of persimmon leaf tea(PLTE), green tea(GTE) and oolong tea(OTE), at the con centration used for human consumption, were examined for inhibitory effects on the mutagenicity of major classes of dietary and environmental mutagens including indirect acting mutagens, B[ ]P (benzo[ ]pyrene), IQ(2 amino 3 methylimidazo[4,5 f]quinoline), 2 AA(2 aminoanthracene) in the presence of S9 mix and direct acting mutagen, 4 NQO(4 nitroquinoline 1 oxide) without S9 mix, using the modified Ames Salmonella/microsome assay. PLTE, GTE and OTE showed very potent and concentration dependent antimutagenic effects against indirect acting mutagens B[ ]P and IQ. At the maximum concentration(16,200 g/plate) of each tea extract, number of colonies decreased in a dose dependent manner up to 82~100%. Similar inhibition of PLTE, GTE and OTE were seen at higher concentration in the mutagenicity of the 2 AA following an initial increase in the activity at lower concentration. However, the mutagenicity of the direct acting mutagen 4 NQO were not suppressed at lower concentration of the three tea extracts, and higher concentration of the tea extracts enhanced mutagenic activity of the mutagen. There were no differences in the mode of antimutagenesis between PLTE, GTE, and OTE, in both Salmonella typhimurium TA98 and TA100 strains against the same mutagen. In conclusion, the water extracts of persimmon leaf tea, green tea and oolong tea possess marked antimutagenic potential against a variety of important dietary and environmental indirect acting mutagens, but the activity was not observed against the direct acting mutagens. These results suggest that the mode of inhibitory action may not have resulted from direct interaction between tea extracts and the mutagens, but rather from indirect metabolic inactivation of mutagens by tea extracts.