• 한국통신학회논문지
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• 제21권7호
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• pp.1803-1813
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• 1996

This paper describes an automatic threshold decision using a maximum mismatched correlation value in the direct sequence spread spectrum (DS-SS) system. For received PN codes with different single-to-noise ratio (SNR), this scheme is able to detect a desired threshold value in the search mode, i.e. a maximum mismstched correlation value, so that value is utilized as a threshold for the verification mode. Performance of the proposed scheme in both the additive white gaussian noise (AWGN) and frequency-selective Rayleigh fading channels is analyzed through the Monte Carlo simulation. And hardware implementation of this scheme using a DSP processor is demonstrated. The proposed acquisition shceme is compared to the conventional constant threshold (CT) scheme, and significant improvement of performance is shown. Analysis of system performance in the verification mode is presented, and key quantities such as the false alarm probability and the detection probability are derived in a AWGN channel.

• KSBB Journal
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• 제17권1호
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• pp.1-13
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• 2002

Label-free optical methods for the monitoring of interactions between biological molecules have become increasingly popular within the last decade. A rising number of publications have demonstrated the benefits of direct biomolecular interaction analysis(BIA) for biology and biochemistry, such as antigen-antibody Interactions, receptor-ligand interactions, protein-DNA, DNA- intercalator, and DNA-DNA interactions. This article gives an overview of the historical development, principle and application of label-free optical biosensor to examine the functional characteristics of biospecific interaction, such as kinetics, affinity, and binding position of biomolecular between an immobilized species at the transducer surface and its dissolved binding partner.

• Bulletin of the Korean Chemical Society
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• 제33권6호
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• pp.1983-1988
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• 2012

Stem cell transplantation is emerging as a possible new treatment for liver cirrhosis, and recent animal studies have documented the benefits of stem cell therapy in a hepatic fibrosis model. However, the underlying mechanism of stem cell therapy is still unclear. Among the proposed mechanisms, the cell replacement mechanism is the oldest and most important, in which permanently damaged tissue can be replaced by normal tissue to restore function. In the present study, Cy5.5-labeled superparamagnetic iron oxide (SPIO) was used to label human mesenchymal stem cells. The uptake of fluorescently labeled nanoparticles enabled the detection and monitoring of the transplanted stem cells; therefore, we confirmed the direct incorporation and differentiation of SPIO into the hepatocyte-like transplanted stem cells by detecting human tyrosine aminotransferase (TAT), well-known enzymatic marker for hepatocyte-specific differentiation.

• 전기화학회지
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• 제14권1호
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• pp.44-49
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• 2011

This paper describes an electrochemical immunosensor for simple, fast and quantitative detection of a urinary hippuric acid which is one of major biological indicator in toluene-exposed humans. The feature of this electrochemical system for immunoassay of hippuric acid is based on the direct conjugation of ferrocene to a hippuric acid. With the competition between the ferrocene-hippuric acid complex and hippuric acid for binding to the anti-hippuric acid monoclonal antibody coated onto gold nanoparticles, the electrical signals are turned out to be proportional to urinary hippuric acid in the range of 0.01-10 mg/mL, which is enough to be used for the point-of-care. The proposed electrochemical method could extend its applications to detect a wide range of different small molecules of antigens in the health care area.

• 대한전기학회논문지:전기물성ㆍ응용부문C
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• 제52권1호
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• pp.25-34
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• 2003

Gas insulated switchgear(GIS) is an important equipment in a substation. It is highly desirable to measure a partial discharge(PD) in GIS which is a symptom before insulation breakdown occurs. The issue is that the PD signal is weak and sensitive to external noise. In this paper, the algorithm for detection of PD in GIS using wavelet transform is proposed. The wavelet transform provides a direct quantitative measure of spectral content, "dynamic spectrum", in the time-frequency domain. The recommended mother wavelet is 'Daubechies' wavelet. 'db4', the most commonly applied mother wavelet in the power quality analysis, can be used most properly in disturbance phenomena which occurs rapidly for a short time. Through the procedure of wavelet transform, noise extraction and reconstruction, the signal is Analyzed to determine the magnitude of PD in GIS. In experimental results, we can know that partial discharge is exactly detected in combination of Dl and D2 using wavelet transform.transform.

• Bulletin of the Korean Chemical Society
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• 제20권6호
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• pp.696-700
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• 1999

A method has been developed for the determination of trace anion impurities in concentrated hydrogen peroxide. The method involves on-line decomposition of hydrogen peroxide, ion chromatographic separation and subsequent suppressed-type conductivity detection. H2O2 is decomposed in Pt-catalyst filled Gore-Tex membrane tubing and the resulting aqueous solution containing analytes is introduced to the injection valve of an ion chromatograph for periodic determinations. The oxygen gas evolving within the membrane tubing escapes freely through the membrane wall causing no problem in ion chromatographic analysis. Decomposition efficiency is above 99.99% at a flow rate of 0.4mL/min for a 30% hydrogen peroxide concentration. Analytes are quantitatively retained. The analysis results for several brands of commercial hydrogen peroxides are reported.

• Bulletin of the Korean Chemical Society
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• 제15권11호
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• pp.945-949
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• 1994

Mixtures of cyano complexes of palladium(II) and platinum(II) were separated by capillary electrophoresis using a fused silica capillary as a separation column and 30 mM phosphate buffer (pH 7) containing 15 wt. % acetonitrile as a running buffer. By virtue of the high ionic mobilities of the negatively charged cyano complexes of Pd(II) and Pt(II), they were separated using a cathodic injection and anodic detection scheme. The metal complexes eluted through the capillary were detected by direct UV absorption at 214 nm. A linear relationship between peak area and concentration was obtained for both ions and the detection limit was lower than $10^{-14}$ mole. The proposed method was applied to real sample, e.g., anode slime obtained from an electrolytic copper refinary, as a method for the simultaneous determination of palladium and platinum.

• Bulletin of the Korean Chemical Society
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• 제19권5호
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• pp.524-526
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• 1998

A sensitive and specific method is described for the determination of midazolam in human plasma. The drug was extracted from 1 mL of carbonate buffered plasma (pH 9.6) with 8 mL of diethyl ether. Famprofazone was used as internal standard. The organic phase was evaporated to dryness. The residue was dissolved in methanol for the direct analysis by gas chromatograph-nitrogen phosphorus detector system. In the concentration range of 1-5000 ng/mL, the calibration curve was linear. The coefficients of variation from the precision test were <6% at the range of the concentration of 0.10-2.00 μg/mL and the detection limit for midazolam in 1 mL of plasma was o.5 ng. This assay is more sensitive, selective, simple and rapid than earlier methods. Plasma midazolam concentrations were determined by this method after administration of midazolam.

• 천문학회보
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• 제46권1호
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• pp.27.4-28
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• 2021

Since the first direct detection of the gravitational waves in 2015, more than 50 events coming from the merging of compact binaries composed of black holes and neutron stars have been observed. The simultaneous detection of gravitational waves and electromagnetics waves from the merging of neutron stars opened up multi-messenger astronomy. The forthcoming observations with better sensitivity by the network of ground based detectors will enrich the gravitational wave source populations and provide valuable information regarding stellar evolution, dynamics of dense stellar systems, and star formation history across the cosmic time. The precision of the Hubble constant from the distance measurement of gravitational sources will improve with more binary neutron star events are observed together with the aftweglows. I will also briefly cover the expected scientiic outcomes from the future detectors that are sensitive to much lower frequenies than current detectors.

• Korean Journal of Radiology
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• 제21권9호
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• pp.1087-1094
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• 2020

Transrectal ultrasound (TRUS)-guided systematic biopsy, the current gold standard for the detection of prostate cancer, suffers from low sensitivity for clinically significant cancer. The use of diagnostic multiparametric MRI has increased the relevance of targeted biopsy techniques such as MRI-TRUS fusion biopsy and direct (in-bore) MRI-guided biopsy, which have higher detection rate for clinically significant cancer. Although primarily used in patients who remain at high clinical suspicion for prostate cancer despite a negative systematic biopsy, with the increasing use of upfront diagnostic MRI, these biopsies are expected to replace routine systematic biopsies. This pictorial essay aims to enhance our understanding of the concepts of these biopsy techniques so that they can be performed safely and provide maximum diagnostic yield.