• 한국임상수의학회지
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• 제17권1호
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• pp.194-204
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• 2000

Echocardiography was performed to obtain the optimal planes for diagnosis of canine heartworm disease in 11 dogs. Imaging planes were taken the left ventricular outflow tract long-axis view, 4-chamber long-axis view, chordae tendineae level short-axis view and modified pulmonary arteries level short-axis view in the right parasternal window, and aptical 4-chamber long-axis view in hte left parasternal window. After echocaridography, the pulmonary artery valve pat was ligated with double 1-0 silk under the general anesthesia to prevent heartworm moving from pulmonary artery to right ventricle. The dogs were euthanized and examained for heartworms in heart and great vessels. Many adult heartworms were identified ultrasonographically within main pulmonary artery, bifurcation of pulmonary artery and right pulmonary artery, but not identified within right ventricle and atrium. At necropsy, adult heartworms were mainly found in pulmonary artery in 11 days, and also found in right ventricular outflow tract and right ventricle in 2 of 11 dogs. The modified pulmonary arteries level short-axis view was the best imaging plane for identifiying heartworms because the main pulmonary artery, branches of pulmonary artery and right pulmonary artery could be showed. The aortic root internal dimension (AOID) and right pulmonary atery internal dimension (RPAID) were measured from the modified pulmonary ateries level short-axis view and left ventricular outflow tract long-axis view. The RPAID and RPAID/AOID was higher in heartworm infected dogs than normal Korea Jin-do dogs in modified pulmonary arteries level short-axis view, and the AOID, RPAID and RPIAID/AOID was higher than in left ventricular outflow tract long-axis view, respectively. These results indicate that the pulmonary arteries were the major habitat of adult heartworm in canine heartworm disease and the modified pulmonary arteries level short-axis view was the best imaging planes for identifying heartworms because the main pulmonary arteries could be showed. Therefore the modified pulmonary arteries level short-axis view can be used for diagnosing heartworm disease and for monitoring dilation of pulmonary artery.

• 한국임상수의학회지
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• 제28권6호
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• pp.595-597
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• 2011

5년령의 수컷 비글견이 복통을 주증으로 내원하였다. 환자는 ELISA를 통한 심장사상충 항원 검사 및 자충검사에 양성결과를 보여, 심장사상충 감염증이 확인되었다. 흉부 방사선 검사에서 심비대 및 폐동맥 확장증 소견이 관찰 되었으며, 심초음파를 통하여 주 폐동맥 내의 심장사상충이 확인 되었다. 심초음파상 사상충 감염 이외의 다른 이상은 발견되지 않았다. 복통에 대한 정확한 원인 규명을 위하여 탐색적 복강경 시술이 시행되었으며, 환축에서 복강으로 이소기생한 심장사상충이 관찰되었다. 복강내 심장사상충의 제거 이후 환축의 임상증상은 사라졌다. 본 증례는 탐색적 복강경을 통하여 복강내 이소기생한 심장사상충을 제거한 증례 보고이다.

• 한국임상수의학회지
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• 제27권6호
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• pp.735-739
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• 2010

8개월령 말티스가 호흡곤란, 운동불내성의 증상으로 내원하였다. 흉부방사선상 환자는 심한심종대와 주폐동맥의 확장 소견을 보였고, 심초음파상 대동맥근이 우심실을 향하고 좌-우 단락을 가지고 있는 대동맥하 심실중격결손증이 확인되었다. 또한 중격결손에 의한 좌-우 단락성 혈류에 의해 폐혈관계에 과순환 소견과 폐성 고혈압에 의한 심한 폐동맥 역류가 (최고속도 4.7 m/s, 압력구배 ~88 mmHg) 확인되었다. 상기의 소견을 토대로 환자는 양대혈관 우심실기시로 진단되었다. 환자는 우심실의 혈량과부하를 줄이기 위한 이뇨제 처치(furosemide 1 mg/kg), 심장재구성을 늦추어주기 위해 spironolatcone (1 mg/kg) 및 enalapril (0.5 mg/kg) 처치와 폐의 과순환과 폐성 고혈압을 완화시켜주기 위해 sildenafil (1 mg/kg)를 처방하였다. 일주일뒤 재검에서 환자의 임상 증상은 크게 개선되었다. 현재 환자는 생존해 있고 정기적으로 모니터하고 있다.

• International Journal of Vascular Biomedical Engineering
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• 제3권2호
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• pp.1-9
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• 2005

Flow-induced dilation of blood vessel is the result of a series of bioreaction in vascular endothelial cells(VEC). Shear stress change by blood flow in human artery or vein is sensed by the mechanoreceptor and responsible for such a chain reaction. The inositol(1,4,5)-triphophate($IP_3$) is produced in the first stage to elevate permeability of the intercellular membrane to calcium ions by which the cytosolic calcium concentration is consequently increased. This intracellular calcium transient triggers synthesis of EDRF and prostacyclin. The mathematical model of this VEC calcium dynamics is reproduced from the literature. We then use the Computational Fluid Dynamics(CFD) technique to investigate the blood stream dictating the VEC calcium dynamics. The pulsatile blood flow in a stenosed blood vessel is considered here as a part of study on thrombogenesis. We calculate the pulsating shear stress (thus its temporal change) distributed over the stenosed artery that is implemented to the VEC calcium dynamics model. It has been found that the pulsatile shear stress induces larger intracellular $Ca^{2+}$ transient plus much higher amount of EDRF and prostacyclin release in comparison with the steady shear stress case. It is concluded that pulsatility of the physiological shear stress is important to keep the vasodilation function in the stenosed part of the blood vessel.

• 대한한방내과학회지
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• 제18권1호
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• pp.97-113
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• 1997

The present experiment was designed to investigate the effects of Sambutang water extracts on the serum cholesterol levels and the cardiovascular system in the experimental animals. Thus, the changes of blood pressure and heart rate were measured after oral administration. Measurment of Mortality rate was observed for measuring the effect of Sambutang water extract. Sambutang water extract against pulmonary thromboembolism induced by collagen the mixture(0.1 ml/10 g, 2 mg/kg) plus serotonin(5 mg/kg) in mouse. The effect of Sambutang water extract was examined by observing the change of collagen-induced platelet aggregation, coagulation activity, ex vivo and in vitro fibrinolytic activity of euglobulin fraction in rats. The results were summarized as follows. 1. Sambutang decreased the serum cholesterol levels in rats. 2. Sambutang dropped the blood pressure in spontaneous hypertensive rat. 3. The drug increased the auricular blood flow in rabbit. 4. The drug relaxed the artery contraction by pretreated norepinephrine in rat. 5. The drug inhibited the death rate of mouse which was led to thromboembolism by serotonin and collagen. 6. The drug inhibited the platelet aggregation in rat. 7. The drug prolonged the prothrombin time and activated partial thromboplastin time on the test of plasma coagulation factor activity in rat, but was not valuable. 8. The drug increased the antithrombin activity in rat and the fibrinogen lysis time was reduced and lysis area was increased. 9. Sambutang reduced fibrinogen lysis time of rat in vitro assay. According to the above mentioned results. Sambutang increased the blood flow and dropped the blood pressure by the dilation of blood vessel. And the drug presented the antithrombin activity, inhibited the platelet aggregation.

• 한국전자통신학회논문지
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• 제11권9호
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• pp.901-908
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• 2016

에지는 영상의 가장 기본적인 특징을 나타내며, 에지 검출은 영상처리 분야 및 컴퓨터 비전 영역에서 매우 중요한 역할을 한다. 이러한 에지를 검출하기 위한 연구들이 국내 외적으로 많이 수행되고 있다. 기존의 에지 검출 방법에는 로버츠, 소벨, 프리윗, 라플라시안 등 고정된 값의 마스크를 사용하는 방법들이 있으며 모폴로지 처리 기술 가운데 팽창과 침식을 이용하는 모폴로지 그라디언트 방법 등이 있다. 그러나 이러한 방법들은 대각선 방향이나 완만한 영상의 변화가 있는 경우 에지 검출이 잘 되지 않는 문제가 있다 따라서 본 논문에서는 이러한 경우에도 에지 검출이 잘 되는 변형된 top-hat 및 bottom-hat 변환 방식의 에지 검출 알고리듬을 제안하였다. 제안된 알고리듬을 기존의 방법들과 비교하여 에지 검출 영상을 제시하였으며 코사인 기반의 유사도를 사용하여 성능 및 유사성을 평가하였다.

• 한국항행학회논문지
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• 제14권4호
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• pp.553-561
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• 2010

본 논문에서는 로봇의 시각시스템에 효과적으로 적용할 수 있는 얼굴 추적 방법을 제안하였다. 제안한 알고리즘은 동영상의 움직임 영역을 검출한 후 얼굴 영역을 추적한다. 동영상의 움직임 검출은 연속되는 2개의 프레임을 사용하여 차영상을 구한 후, 잡음을 제거하기 위한 방법으로 메디안 필터와 침식 및 팽창연산을 사용하여 움직임 영역을 검출한다. 움직임 영역에서 피부색을 추출하기 위하여 표본영상의 칼라 정보를 이용하였다. 칼라정보의 MIN-MAX값을 퍼지화 데이터로 멤버십 함수를 생성한 후, 유사도를 평가하여 피부색 영역과 배경영역을 분리하였다. 얼굴 후보영역에 대하여 CMY 칼라 공간 C 채널에서 눈을 검출하고, YIQ 칼라 공간 Q 채널에서 입을 검출하였다. 지식기반으로 검출된 눈과 입의 특징을 찾아가며 얼굴영역을 추적하였다. 실험영상으로는 10명 각각에 대하여 150프레임의 동영상 총 1,500프레임을 입력받아 실험한 결과, 1,435프레임의 영상에 대하여 움직임 영역이 검출되어 95.7%의 프레임 검출율을 보였으며, 1,401개에 대한 얼굴을 추적 97.6%의 우수한 얼굴 추적결과를 나타내었다.

• Journal of Korean Neurosurgical Society
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• 제53권2호
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• pp.72-76
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• 2013

Objective : Cerebral aneurysm (CA) is an important acquired cerebrovascular disease that can cause catastrophic results. MicroRNAs (miRNAs) are small non-coding RNAs, playing essential roles in modulating basic physiologic and pathological processes. Currently, evidences have been established about biologic relationship between miRNAs and abdominal aortic aneurysms. However, biologic roles of miRNAs in CA formation have not been explained yet. We employed microarray analysis to detect and compare miRNA expression profiles in late stage of CA in rat model. Methods : Twenty-six, 7-week-old male Sprague-Dawley rats underwent a CA induction procedure. The control animals (n=11) were fed a normal diet, and the experimental animals (n=26) were fed a normal diet with 1% normal saline for 3 months. Then, the rats were sacrificed, their cerebral arteries were dissected, and the five regions of aneurysmal dilation on the left posterior communicating artery were cut for miRNA microarrays analysis. Six miRNAs (miRNA-1, miRNA-223, miRNA-24-1-5p, miRNA-551b, miRNA-433, and miRNA-489) were randomly chosen for validation using real-time quantitative PCR. Results : Among a set of differentially expressed miRNAs, 14 miRNAs were over-expressed more than 200% and 6 miRNAs were down-expressed lower than 50% in the CA tissues. Conclusion : The results show that miRNAs might take part in CA formation probably by affecting multiple target genes and signaling pathways. Further investigations to identify the exact roles of these miRNAs in CA formation are required.

• 한국한의학연구원논문집
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• 제16권2호
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• pp.143-157
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• 2010

Objectives : The objective of this study was to access the effect of Artemisiae capillaris herba Extracts on the organogenetic reproductive toxicity of New Zealand White rabbits when administered by oral gavage. Methods : Gestational New Zealand White rabbits were dosed from 6 days of gestation to 18 days of gestation. It was conducted in accordance with the recommendations of the KFDA Guideline for Detection of Toxicity to Reproduction for Medicinal Products. In addition, serum AST, ALT, LDH and ALP levels were detected with their necropsy and histopathological observation Results: No significant changes of body weights, gains and food consumption were demonstrated in all dosed groups compared to those of vehicle control group except for 2,000mg/kg-dosing group, which showed significantly increase of body weight compared to that of vehicle control group. Normal gross findings were demonstrated in all tested groups. No significant changes of number of corpora lutea, implantation, implantation rate, number of fetal death, loss rate of post-implantation, number of live youngs at C-section, survival rate of post-implantation, number of male live youngs at C-section, number of female live youngs, sex ratio of live young, external anomalies of live youngs and body weight of live youngs were demonstrated in all dosed groups compared to those of vehicle control group. Although some visceral variations such as thymic reminant in the neck, dilation of renal pelvis, dilated ureter and malpositioned left common carotid artery, no significant changes were demonstrated in all dosed groups compared to that of vehicle control group. Some malformations and variation were demonstrated with retardations. However, no significant changes were demonstrated in all dosed groups compared to that of vehicle control group. In addition, similar ossification numbers were detected in sternebrae, metacarpals, metatarsals, phalanges, cervical vertebrae, and sacral and caudal vertebrae. No Artemisiae capillaris herba Extracts treatment-related changes of serum AST, ALT, LDH and ALP levels were demonstrated in all dosed levels in this study. Conclusions : We could conclude that oral administration of Artemisiae capillaris herba Extracts hasn't an influence on the organogenetic reproductive toxicity.

• 터널과지하공간
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• 제13권1호
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• pp.44-51
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• 2003

응력 재분포에 의해 발생하는 수리전도도의 변화를 평가하기 위하여 변형률 의존 수리전도도 변화방정식을 사용하였다. 주요 입력 변수는 탄성계수 감소비와 응력 재분포에 의해 발생한 변형률이다. 무결암에서부터 완전히 파쇄된 암반조건을 나타내기 위하여 탄성계수 감소비 대신에 탄성계수 감소비와 RMR간의 상관관계를 이용하였다. 전단 변형에 따른 팽창이 수리전도도의 증가에 영향을 미치지만 그 영향 정도는RMR에 따라 달라졌으며, 인장변형률이 절리에 작용하는 경우 암반의 RMR이 감소함에 따라 수리전도도는 증가하는 것으로 나타났다. 암반에 작용하는 응력 상태에 따라 수리전도도의 변화도 다른 것으로 나타났는데, 수평응력 대 수직응력의 비가 다른 이방성 응력 상태가 수리전도도의 변화에 가장 큰 영향을 미치는 것으로 나타났다.