• Applied Microscopy
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• v.31 no.2
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• pp.199-206
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• 2001

In 1980s, the fragmentation or subdivision of protein deposits at the periphery of protein storage vacuole was suggested as the only route of PB development in pea cotyledon cells. Since then, other independant processes such as terminal dilation , transformation and de novo development have been discussed as alternative routes for PB development, and today, these multiple mechanisms of PB development are accepted as a result of active investigations. For analysis of the protein accumulations in the ER cisternae during seed development, immunocytochemical gold labellings were applyed on the single cells separated by enzymatic digestion from cotyledon tissue. Anti-legumin labellings at the early stage, and anti-vicilin labellings at the intermediate stage were observed on the protein-filled ER. The $\alpha-Tip$, which is the ER retention protein, was labelled somewhat at late stage, and PPase, a sort of tonoplast membrane protein, was labelled at early stage.

• The Journal of Internal Korean Medicine
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• v.15 no.1
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• pp.80-98
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• 1994

According to the original documents, Sagungsan is considered as an effective drug for controlling the hypertensive epistaxis induced by tension of autonomic nerve and it's hyperfunction. The present experiment was designed to understand the effect of Sagungsan extract on the hemostatic action, intracranial pressure, blood pressure and cardiovascular system in experimental animals. And thus the bleeding time, prothrombin time, capillary dilation, blood pressure, Intracranial pressure, and enzymatic analysis of the ATPase activities were studied. The result obtained here were as followings: 1. Sagungsan water extract reduced the bleeding time in mouse, and prolonged the prothrombin time in rabbits. 2. The drug extract increased the tail volume by capillary dilation in rats. 3. The drug extract inhibited the increase of intracranial pressure and arterial blood pressure in rabbits. 4. At the early time, the increase of arterial blood pressure by the drug extract significantly inhibited by pretreated atropin and regitine in rabbits. 5. The drug extract relaxed the smooth muscle by stimulating the Mg2+-Ca2+-ATPase activities of gastric sarcoplasmic reticulum isolated from rabbit stomach. 6. The drug extract stimulated the heart contraction by inhibiting the $Mg^{2+}-Ca^{2+}-ATPase$ activities of cardiac sarcoplasmic reticulum isolated from rabbit heart. The inhibitory mechanism was reversible and noncompatitive. 7. The drug extract increased the hepatic blood volume by stimulating the hepatic total ATPase activities and hepatic metabolism. 8. The drug extract acted as a tranquilizer by inhibiting the neural Na+-K+-ATPase activity. According to the results, Sagungsan water extract dilated the capillaries, stimulated the heart beat, and thus increased the blood flow with decreasing the intracranial pressure and blood pressure. These effects stanches the epistaxis collectively.

• Applied Microscopy
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• v.29 no.4
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• pp.499-509
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• 1999

Accumulations of the storage proteins in protein storage vacuole and the differentiation of protein bodies from protein-filled ER in developing pea cotyledons have been investigated using conventional and immunoelectron microscopy. To improve the fixation quality, single cells separated enzymatically from sliced cotyledons were used. At early stages of seed development osmiophilic protein accumulates in rER lumen were observed quite often. This protein-filled ER cisternae were differentiated into cytoplasmic protein bodies at late stage by the process called terminal dilations which have been considered a principal route of the formation of cytoplasmic protein bodies somewhat later in seed maturation. Immunocytochemical labellings of the vicilin and legumin show that presence of vicilin on both of the cytoplasmic PB and PD, but limited presence of legumin only on the cytoplasmic PB at intermediate stage of seed development. Immunogold labellings of Bip, ER retention protein, were observed on the inner periphery of protein deposits in protein storage vacuole. This result was regarded that Bip can recognize and retrieve misfolded protein during active accumulation of storage protein to the PD in PSV.

• Journal of the Korean Geotechnical Society
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• v.21 no.8
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• pp.27-35
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• 2005

Several damages due to large displacement caused by liquefaction have been reported increasingly. Numerical procedures based on effective stress analysis are therefore necessary to predict liquefaction-induced deformation. In this paper, the fully coupled effective stress model called UBCSAND is proposed to simulate pore pressure rise due to earthquake or repeated loadings. The proposed model is a modification of the simple perfect elasto-plactic Mohr-Coulomb model, and can simulate a continuous yielding by mobilizing friction and dilation angles below failure state. Yield function is defined as the ratio of shear stress to mean normal stress. It is radial lines on stress space and has the same shape of Mohr-Columob failure envelope. Plastic hardening is based on an isotropic and kinematic hardening rule. The proposed model always causes plastic deformation during loading and reloading but it predicts elastic unloading. It is verified by capturing direct simple shear tests on loose Fraser River sand.

• Journal of The Korean Astronomical Society
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• v.45 no.6
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• pp.167-173
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• 2012

Inter-granular Bright Points (igBPs) are small-scale objects in the Solar photosphere which can be seen within dark inter-granular lanes. We present a new algorithm to automatically detect and extract igBPs. Laplacian and Morphological Dilation (LMD) technique is employed by the algorithm. It involves three basic processing steps: (1) obtaining candidate "seed" regions by Laplacian; (2) determining the boundary and size of igBPs by morphological dilation; (3) discarding brighter granules by a probability criterion. For validating our algorithm, we used the observed samples of the Dutch Open Telescope (DOT), collected on April 12, 2007. They contain 180 high-resolution images, and each has a $85{\times}68\;arcsec^2$ field of view (FOV). Two important results are obtained: first, the identified rate of igBPs reaches 95% and is higher than previous results; second, the diameter distribution is $220{\pm}25km$, which is fully consistent with previously published data. We conclude that the presented algorithm can detect and extract igBPs automatically and effectively.

• Journal of the Korean Geotechnical Society
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• v.20 no.1
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• pp.5-12
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• 2004

The purpose of this paper is to make an understanding of fundamental mechanism of shear behaviour between rock and concrete interfaces in the pile socketed into granite. The interface of pile socketed in rock can be modeled in laboratory tests by resolving the axi-symmetric pile situation into the two dimensional situation under CNS(constant normal stiffness) direct shear condition. In this paper, the granite core samples were used to simulate the interface condition of piles socketed in granite in our country. The samples were prepared in the laboratory to simulate field condition, roughness(angle and height), stress boundary condition, and then tested by CNS direct shear tests. This paper describes shearing behaviour of socket piles into domestic granite through the analysis of CNS test results. It was found out that the peak shear strength increases with the angle of asperity and CNS value, and also the dilation increases with the angle of asperity but decreases with the CNS value.

• Applied Microscopy
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• v.28 no.2
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• pp.225-236
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• 1998

Adriamycin is a one of anthracyclin antibiotics isolated from the culture media of Streptomyces peucetius var casius. The formation of reactive oxygen metabolite by redox cycling during the metabolism and the inhibition of DNA synthesis results in antineoplastic effects of adriamycin. The authors have demonstrated the effects of SOD(superoxide dismutase) or DMTU (dimethyl thiourea), which are used as an antioxidant, on the ultrastructural changes of the gastric chief cells after the administration of adriamycin in the rat. Adriamycin (30 mg/kg) was administered intraperitoneally to the Sprague-Dawley rats weighing about 220 gm and SOD (15000 unit/kg) or DMTU (500 mg/kg) were administered intraperitoneally to the rats 30 minutes after the administration of adriamycin. The gastric chief cells 24, 48 and 72 hours after the administration of adriamycin were observed with Hitachi-600 electron microscope. The results were as follows. 1. SOD or DMTU alone did not affect the ultra structures of the gastric chief cells in the rat. 2. Dilation, sacculation and segmentation of the cisternae of rough endoplasmic reticulum, dilation of the saccules of Golgi complex and dilated mitochondria with electron lucent matrix were seen in the adriamycin treated rats. In the course of time, the ultrastructures of the chief cell changed markedly. 72 hours after drug administration, severely dilated cisternae of rough endoplasmic reticulum, with clumping of chromatin around the nuclear envelope and mitochondria with electron lucent matrix and dilated cristae were seen in the chief cell. 3. The treatment of SOD is more effective than DMTU to attenuated the ultrastructural changes of the chief cells in the adriamycin administered rat. Consequently it is suggested that adriamycin would induce the degenerative changes of the organelles of the chief cell. The treatment of SOD is more effective than DMTU to attenuate the adriamycin induced damage.

• Tunnel and Underground Space
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• v.17 no.3 s.68
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• pp.186-196
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• 2007

In this study, direct shear tests were carried out on the 30 rock joint samples in order to investigate the influence of roughness and normal stress on the shear behaviour. Joint roughness profiles were measured by use of 3D laser profiler, and then the samples were equally classified into three individual groups according to the roughness index of rock joints. Peak shear strength, residual shear strength, shear stiffness, dilation angle of rock joints were investigated in condition of five different constant normal load. Peak shear strength was increased as roughness index was increased, and the influence of roughness on strength was found to be more considerable in case of lower normal stress condition. Residual shear strength and shear stiffness were increased as roughness index and normal stress were increased. Finally dilation angle was decreased as normal stress was increased, but it was increased as roughness index was increased in the same normal stress condition.

• Journal of KIISE:Software and Applications
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• v.26 no.11
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• pp.1342-1349
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• 1999

본 논문에서는 문서 내의 인접한 두 행 사이에는 일정한 두께의 공백 행이 존재하며 그 공백 행의 기울기는 실제 문서의 기울어진 정도를 반영한다는 사실에 기반하여, 선형적으로 기울어진 문서 영상의 기울기 추정을 위한 고속의 알고리즘을 제안한다. 먼저, 간단한 모폴로지 연산(dilation)을 이용하여 문자행 영역과 공백행 영역을 분리한 후, 이를 일정 간격으로 수직 샘플링하여 수직선 상에 있는 모든 공백행의 중심점(행간점)을 찾는다. 동일한 공백 행 상에 있는 인접한 두 행간점 간에 기울기를 계산하고, 전체 영상으로부터 이들의 분포를 조사하여 최대 빈도를 가지는 기울기를 입력 문서의 기울기로 추정한다. 실험에서는 제안한 알고리즘을 필기체 및 인쇄체를 포함하는 다양한 형태의 가로쓰기 문서에 적용한 결과를 보인다.Abstract In this paper, we propose a fast algorithm to estimate the skew angle of linearly skewed document images. This paper is based on the fact that there is a blank line with uniform thickness between two adjacent text lines and the slope of the line is the same as that of the document. Firstly, we apply a dilation operation to the image to separate blank lines from text lines, and we detect center points of blank lines along the vertically sampled lines. Then we calculate the slope between neighboring center points in the same blank line. Calculated slopes for the entire image are accumulated on the histogram to display the distribution of them. Finally, the peak in the histogram is detected and estimated as the slope of the document image. In the experiments, we adopted a lot of images of various format with hand-printed or machine-printed document to verify our algorithm.

• Clinical and Experimental Pediatrics
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• v.63 no.11
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• pp.447-450
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• 2020

Background: Esophageal stricture (ES) is an uncommon clinic entity in pediatrics that may be congenital or acquired in childhood. Acquired noncaustic ES is very rare, and clinical features of affected patients are unknown. Purpose: We aimed to evaluate the clinical findings, and outcomes of patients with acquired noncaustic ES to aid physicians in the early referral of patients to gastroenterologists. Methods: The medical data of patients with acquired noncaustic ES who were followed in our gastroenterology clinic between January 2009 and December 2019 were reviewed. Results: Acquired noncaustic ES was found in 12 of the 4,950 patients (0.24%) who underwent endoscopy during the study period. The main symptoms were dysphagia (58.3%), vomiting (33.3%), and chronic anemia (8.3%). Chronic malnutrition and underweight were found in 66.6% of the patients. The most common etiological factors were radiotherapy, peptic reflux, and achalasia (16.6%, each), while chemotherapy, squamous-cell carcinoma (SC) of the esophagus, eosinophilic esophagitis (EoE), esophageal web, epidermolysis bullosa, and esophageal diverticulum (8.2%, each) were the other etiological factors. Patients with EoE underwent endoscopic bougie dilation in addition to steroid use and elimination diet. Patients with epidermolysis bullosa and esophageal web underwent bougie dilation. Patients with peptic reflux-related ES were initially put on antireflux therapy, but during follow-up, one patient required esophageal replacement with colonic interposition. Patients with radiotherapy-related ES recovered with medical therapy. The patient with initially underwent surgical gastrostomy and tumoral mass excision. The patient then received chemotherapy and radiotherapy and underwent jejunal interposition. Patients with achalasia underwent surgical esophagomyotomy. Conclusion: The presence of solid dysphagia, malnutrition, and an associated disease may alert physicians to the presence of ES.