• Title/Summary/Keyword: Dihydroindole

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Anticoccidial Effect of 3-(4-Methoxybenzylaminomethylene)-1,3-dihydroindole-2-one(5-108) (3-(4-Methoxybenzylaminomethylene)-1,3-dihydroindole-2-one(5-108) 화합물의 항콕시디움 효과)

  • Yeo, Seon-Ju;Kim, Hak Sung;Kim, Suk;Lee, Kee-In;Park, Hyun
    • YAKHAK HOEJI
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    • v.59 no.6
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    • pp.266-269
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    • 2015
  • Coccidiosis is induced by Toxoplasma gondii and Eimeria tenella and novel anticoccidial drugs have been requested. In this study, the anticoccidial effect of 3-(4-methoxybenzylaminomethylene)-1,3-dihydroindole-2-one (5-108) on T. gondii and E. tenella was evaluated. Novel synthetic derivative 5-108 showed 1.44 fold higher relative selectivity compared to pyrimethamine against T. gondii in vitro assay. In chicken study, compound 5-108 significantly decreased the number of oocytes of E. tenella in feces, obtained from E. tenella-infected chickens, by $33{\pm}2.64%$ and $23{\pm}3.60%$ (P<0.001) at $7^{th}$ day and $9^{th}$ day p.i.. Conclusively, compound 5-108 was effective against T. gondii and E. tenella.

Correlation of Chemical Shifts with Substituent Parameters in N-Benzyl Derivatives of Pyrrole,3a,7a-Dihydroindole,and Indole Esters

  • Jeon, Kyu-Ok;Yu, Sook-Yu;Lee, Chang-Kiu
    • Bulletin of the Korean Chemical Society
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    • v.23 no.9
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    • pp.1241-1255
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    • 2002
  • Series of m- and p-substituted benzyl derivatives of pyrrole, tetramethyl 1-benzyl-3a,7a-dihydroindole-2,3,3a,4-tetracarboxylate, and trimethyl 1-benzylindole-2,3,4-tricarboxylate were prepared and their 13C NMR spectra were obtained in 0.1 M solutions of chloroform-d. Both single substituent parameter and dual substituent parameter analyses were carried out to correlate the substituent chemical shifts. The ${\beta}$ carbon of the indole series showed the most profound substituent effect dependence as well as the best correlation. The results are explained by the hyperconjugation of the benzyl methylene group.