• Journal of Chest Surgery
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• 제54권6호
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• pp.480-486
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• 2021

Background: Although various methods are already used to calculate predicted postoperative forced expiratory volume in 1 second (FEV₁) based on preoperative FEV₁ in lung surgery, the predicted postoperative FEV₁ is not always the same as the actual postoperative FEV₁. Observed postoperative FEV₁ values are usually the same or higher than the predicted postoperative FEV₁. To overcome this issue, we investigated the relationship between the number of resected lung segments and the discordance of preoperative and postoperative FEV₁ values. Methods: From September 2014 to May 2020, the data of all patients who underwent anatomical lung resection by video-assisted thoracoscopic surgery (VATS) were gathered and analyzed retrospectively. We investigated the association between the number of resected segments and the differential FEV₁ (a measure of the discrepancy between the predicted and observed postoperative FEV₁) using the t-test and linear regression. Results: Information on 238 patients who underwent VATS anatomical lung resection at Kyung Hee University Hospital at Gangdong and by DH. Kim for benign and malignant disease was collected. After applying the exclusion criteria, 114 patients were included in the final analysis. In the multiple linear regression model, the number of resected segments showed a positive correlation with the differential FEV₁ (Pearson r=0.384, p<0.001). After adjusting for multiple covariates, the differential FEV₁ increased by 0.048 (95% confidence interval, 0.023-0.073) with an increasing number of resected lung segments (R²=0.271, p<0.001). Conclusion: In this study, after pulmonary resection, the number of resected segments showed a positive correlation with the differential FEV₁.

• Asian Pacific Journal of Cancer Prevention
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• 제14권1호
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• pp.351-354
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• 2013

Objective: To assess the practical utility of pleural fluid carbonic anhydrase XII (CAXII) quantification for differential diagnosis of effusions. Materials and Methods: Fluid was collected prospectively from fifty patients presenting with lymphocytic pleural effusions for investigation and CAXII was quantified by ELISA. Results: Pleural fluid CAXII concentrations were significantly higher in lung cancer patients (n=30) than in tuberculous controls (n=20). The sensitivity and specificity of this biomarker were 60%and 75%, respectively. CAXII measurement was not inferior to cytological examination in the diagnosis and exclusion of pleural effusions from lung cancer patitents (sensitivity 60% vs. 57%; specificity 75% vs. 100%; positive predictive value 77%; negative predictive value 54%). In patients with negative cytology, it offered a sensitivity of 54%. Conclusions: Pleural fluid CAXII is elevated in pleural effusions from lung cancer patients. Measurement of CAXII may be used in the future as a valuable adjunct to cytology in the diagnostic assessment of patients with pleural effusions related to lung cancer, especially when cytological examination is inconclusive.

• 대한의생명과학회지
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• 제12권3호
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• pp.177-183
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• 2006

To demonstrate the effect of formulation conditions and evaluations of structural integrity from ovalbumin containing poly lactide glycolide copolymer (PLGA) microspheres for Vaccine delivery, OVA microspheres were prepared by a W/O/W multiple emulsion solvent extraction technique. Dichloromethan (DCM) and Ethyl acetate (EA) were applied as an organic phase and poly vinyl alcohol (PVA) as a secondary emulsion stabilizer. Microspheres were characterized for particle size, morphology (optical microscopy and Scanning Electron Microscope (SEM)). Protein denaturation was evaluated by size exclusion chromatography (SEC), SDS-PAGE and isoelectric focusing (IEF). Residual organic solvent was estimated by gas chromatography (GC) and differential scanning calorimetry (DSC). Optical photomicrograph and SEM revealed that micro spheres were typically spherical but various morphologies were observed. Mean particle size $(d_{vs})$ of microspheres were in the range of $3{\sim}50{\mu}m$. Also, The protein stability was not affected by the fonnulation process and residual organic solvent was beyond the detection below 0.1ppm. These results demonstrated that micro spheres might be a good candidate for the parenteral vaccine delivery system.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제8권2호
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• pp.233-237
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• 2005

저자들은 분유 수유를 하던 1개월 된 영아가 토혈을 주소로 내원하여 시행한 내시경 검사에서 출혈성 위염으로 진단되어 고식적인 치료를 하였으나 토혈이 멎지 않고 발열이 동반되는 등 증상의 호전이 없었고 오히려 증상이 악화되어 우유 알레르기를 의심하였다. 금식시킨 후 증상이 호전되었고 우유를 가수분해 분유로 바꾼 후 출혈이 소실된 우유 알레르기로 인한 출혈성 위염 1예를 경험하였기에 보고하는 바이다.

• 한국식품과학회지
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• 제31권3호
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• pp.600-605
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• 1999

산소 존재하에 4가지 온도$(60,\;90,\;120,\;150^{\circ}C)$에서 methyl linoleate를 산화시켰다. 각 온도에서 시간에 따른 과산화물가를 조사한 후 4가지의 산화된 methyl linoleate 총 16종을 제조하여 이들의 과산화물가, 총 산화물함량, 중합체함량 및 그 결합특성, 점도, 굴절률, DSC에 의한 열분해 특성 등의 물리화학적 특성을 비교하여 보았다. High Performance Size Exclusion Chromatography (HPSEC)에 의하여 분석된 산화된 methyl linoleate의 결합특성은 $60^{\circ}C$와 $90^{\circ}C$에서 산화된 시료의 경우에는 C-O-O-C 결합형태를 갖는 중합체가 확인되었으나 $120^{\circ}C$와 $150^{\circ}C$에서는 단지 C-O-C/C-C 결합형태를 갖는 중합체만이 확인되었다. 한편 DSC에 의한 열분해 특성은 과산화물 함량이 증가함에 따라 엔탈피값은 비례적으로 증가하였으나 최대분해온도는 반대로 낮아지는 경향을 보여 주었다. 이상의 물리적 측정치와 화학적 측정치와의 상관관계를 조사한 결과 DSC에 의한 물리적 측정치들과 과산화 물가 및 C-O-O-C 결합을 갖는 중합체 함량 사이에 가장 높은 상관관계를 보여주었다.

• Macromolecular Research
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• 제8권1호
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• pp.44-52
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• 2000

Styrenic macromonomers with/without a silyloxy-functional group were synthesizedvia chain-end functionalization using 4-vinylbenzyl chloride as a terminating agent insec-butyllithium-initiated polymerization of styrene. The yields were 92 mol% for the silyloxy group and 88 mol% for the styrenic unit. Crystalline polystyrene-g-amorphous polystyrenes were synthesized by (η$^{5}$ -indenyl)-trichlorotitanium ((Ind)TiCl$_3$)-catalyzed copolymerizations of the macromonomers with styrene in the presence of methyl-aluminoxane (MAO) in toluene at 4$0^{\circ}C$. The macromonomer having $\alpha$, $\alpha$'-bis (4-[tert-butyldimethylsilyl-oxy]phenyl) group was also utilized for the preparation of a precursor of hydroxyl-functionalized syndio-tactic polystyrene. The obtained polymers were characterized by a combination of$^1$H, $^{13}$ C NMR spectroscopic, size exclusion chromatographic, and differential scanning calorimetric analysis. The (Ind)TiCl$_3$-catalyzed copolymerization of styrene with the macromonomer carrying the silyloxy functional group was found to be an efficient method to modify syndiotactic polystyrene without a great loss of physica] property by controlling the feud ratio of the macromonomer.

• Asian-Australasian Journal of Animal Sciences
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• 제18권11호
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• pp.1529-1534
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• 2005

Individual-breed assignments were implemented in six swine populations using twenty six microsatellites recommended by the Food and Agriculture Organization and the International Society for Animal Genetics (FAO-ISAG). Most microsatellites exhibited high polymorphisms as shown by the number of alleles and the polymorphism information content. The assignment accuracy per locus obtained by using the Bayesian method ranged from 33.33% (CGA) to 68.47% (S0068), and the accumulated assignment accuracy of the top ten loci combination added up to 96.40%. The assignment power of microsatellites based on the Bayesian method had positive correlations with the number of alleles and the gene differential coefficient ($G_{st}$) per locus, while it has no relationship to genetic heterozygosity, polymorphism information content per locus and the exclusion probabilities under case II and case III. The percentage of corrected assignment was highest for the Bayesian method, followed by the gene frequency and distancebased methods. The assignment efficiency of microsatellites rose with increase in the number of loci used, and it can reach 98% when using a ten-locus combination. This indicated that such a set of ten microsatellites is sufficient for breed verification purposes.

• Clinical and Experimental Pediatrics
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• 제59권sup1호
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• pp.99-102
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• 2016

Tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare disease, often underdiagnosed or misdiagnosed in children. We describe the case of a 12-year-old boy who presented to Severance Hospital with a 1-month history of bilateral conjunctival injection. He was first evaluated by an Ophthalmologist in another hospital and diagnosed with panuveitis. Laboratory tests indicated renal failure, and a renal biopsy confirmed the diagnosis of acute tubulointerstitial nephritis. An extensive exclusion of all possible causes allowed a diagnosis of TINU syndrome. The patient was treated with a systemic corticosteroid (initially prednisolone, 2 mg/kg and later deflazacort 1 mg/kg) and topical steroid drops for 1 month. Azathioprine was later added to the treatment regimen and the systemic steroid was slowly tapered. The final outcome of renal-ocular disease was favorable in the patient. However, long-term follow-up is necessary to properly manage frequent relapses and incomplete renal recovery. TINU should be considered as a differential diagnosis in children with uveitis or acute renal failure.

• 한국지역지리학회지
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• 제17권4호
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• pp.357-380
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• 2011

본 연구는 우리나라의 외국인 이주자 정책과 지원 활동이 어떤 성향을 가지고 있으며, 이러한 성향을 반영한 구체적인 정책 및 지원 프로그램들이 외국인 이주자들의 유형과 거주지역에 따라 어떻게 달리 인식되고 있는가를 고찰하고, 이들을 위해 필요한 정책의 개선 방안을 제시하고자 한다. 흔히 외국인 이주자 정책은 동화 모형, 차별적 배제 모형, 다문화 모형으로 구분되지만, 주변화의 성향이 함의된 것으로 이해된다. 또한 결혼이주자 정책은 동화 모형, 이주노동자 정책은 차별적 배제 모형, 전문직 이주자와 외국인 유학생 정책은 (거의 부재한 상태에서) 다문화주의적 성향을 가진 것으로 이해되지만, 설문조사에 의하면 외국인 이주자들은 관련 정잭에 대해 이러한 성향이 혼재된 것으로 인식하고 있다. 외국인 이주자를 위한 정책의 개선 방안으로, 첫째 동화주의, 차별적 배제주의, 그리고 주변화를 벗어날 수 있는 분배적 평등과 인정의 정의에 기초한 다문화주의, 둘째 지역사회에 기반을 두고 외국인 이주자 및 관련 기관과 단체들이 참여하는 외국인 이주자 네트워크 거버넌스의 구축, 셋째 지역 정체성 함양, 시민권의 보장, 종합적 복지 제공, 다문화교육 등 지속적이고 다문화주의적 내용들로 구성된 지원 프로그램의 개발 등이 제시된다.

• 접착 및 계면
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• 제18권3호
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• pp.109-117
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• 2017

본 연구에서는 poly(N-vinyl carbazole) (PVK), poly(4-vinylpyridine) (PVP), PVK-b-PVP 블록 공중합체를 RAFT 중합법으로 합성하였으며, 이를 이용하여 ethanol, N-methyl-2-pyrrolidone (NMP), dichloromethane (DCM), tetrahydrofuran (THF)와 같은 비 수계 용매에서 그래핀 분산액을 제조하였다. 합성된 고분자의 화학적 구조는 양성자 및 탄소 핵자기 공명 분광기($^1H-$, $^{13}C-NMR$), 크기 배제 크로마토그래피 (size exclusive chromatography, SEC), 시차 주사 열량계 (differential scanning calorimetry, DSC)를 이용하여 분석하였으며, 그래핀 분산액의 분산 안정성은 Turbiscan을 이용하여 시간에 따른 터비스캔 안정성 지수(Turbiscan stability index, TSI)를 측정, 정량적으로 평가하였다. 용매, 고분자, 그래핀의 표면장력(${\sigma}$), 용해도 상수(${\delta}$)를 이용하여 물질간의 상호작용에 대하여 설명하였으며, 이를 바탕으로 용매와 그래핀간의 용해도와 표면장력의 차이가 분산안정성에 큰 영향을 미침을 확인하였다. 그래핀의 분산 안정성이 좋지 못한 ethanol 및 THF 용매 하에서 PVK-b-PVP를 사용하여 그래핀을 분산시킬 경우 낮은 TSI값을 효과적으로 유지할 수 있었으며, 그래핀을 잘 분산시킨다고 알려진 NMP에 비하여 DCM이 더 좋은 그래핀 분산안정성을 보임을 확인하였다.