• 제목/요약/키워드: Diet control

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Suppressed Fat Accumulation in Rats Fed a Histidine-Enriched Diet

  • Endo, Michiko;Kasaoka, Seiichi;Takizawa, Miki;Goto, Kiyoko;Nakajima, Shigeru;Moon, Soo-Kyung;Kim, In-Soo;Jeong, Bo-Young;Nakamura, Soichiro
    • Preventive Nutrition and Food Science
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    • 제15권1호
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    • pp.1-6
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    • 2010
  • The effect on body fat accumulation on male Wistar rats undergoing continuous feeding with a histidine-enriched diet was investigated. Five-week-age rats were assigned to two groups and were fed either the control diet (purified diet AIN-$76^{TM}$) or the histidine-enriched diet containing 3% histidine for 28 days. It was observed that both adipose tissue masses in retroperitoneal and epididymal areas of rats fed histidine-enriched diet significantly decreased (p<0.05) compared to those of control rats, while there was no significant difference in the food efficiency ratio between them. The blood levels of histidine derivatives of 3-methylhistidine and carnosine were significantly (p<0.05) increased in the rats fed a histidine-enriched diet, whereas there were no significant different between the histidine-enriched diet and control groups in the general amino acid distribution. Our results demonstrate that a histidine-enriched diet suppresses body fat accumulation in rats.

Anti-obesity Effect of Monascus pilosus Mycelial Extract in High Fat Diet-induced Obese Rats

  • Lee, Sang-Il;Kim, Jae-Won;Lee, Ye-Kyung;Yang, Seung-Hwan;Lee, In-Ae;Suh, Joo-Won;Kim, Soon-Dong
    • Journal of Applied Biological Chemistry
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    • 제54권3호
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    • pp.197-205
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    • 2011
  • This study was carried out to investigate the dietary effects of Monascus pilosus mycelial extract on obesity in high-fat with cholesterol-induced obese rat models. It was observed that M. pilosus mycelial extract contains $25.85{\pm}1.98mg%$ of total monacolin K without citrinin by highperformance liquid chromatography (HPLC). The rats were randomly divided into 2 groups; normal control and a high-fat with cholesterol diet group. The high-fat with cholesterol diet group was fed a 5L79 diet with an added 15% lard and 1% cholesterol supplemented diet for 3 weeks for induction of obesity. After induction, obesity was confirmed by checking obesity indexes, the animals were divided into 4 groups (n=5); first, the normal control (NC), and then taken from the obese model of rats, a high-fat with cholesterol diet obesity control group (HF), 0.5% M. pilosus mycelial extract supplemented high-fat with cholesterol diet group (MPMs), 2% conjugated linoleic acid supplemented high-fat with cholesterol diet group (CLA) for 7 weeks. Body weight gains, obesity indexes, and body fat contents in the experimental groups (MPMs and CLA) were decreased compared with HF group. Feed Efficiency Ratio (FER) in MPMs was significantly lower than that of HF without change of feed intake. These results suggested that the anti-obesity effects of the M. pilosus mycelial extracts (MPMs) could prevent obesity induced by high-fat with cholesterol diet possibly via inhibition of lipid absorption.

Effects of dietary taurine supplementation on plasma and liver lipids in OVX rats fed calcium-deficient diet

  • Choi, Mi-Ja
    • Nutrition Research and Practice
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    • 제2권1호
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    • pp.13-16
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    • 2008
  • Taurine supplementation has been shown to have an effect on lowering blood lipids in ovariectomized (OVX) rats. It therefore seemed desirable to find out whether the beneficial effect of taurine on OVX rats fed calcium-deficient diet could also be reproduced. Forty female Sprague-Dawley rats were divided into two groups. One group was OVX and the other group received a sham operation (Sham). Each rat group was further divided into the control diet and the taurine supplemented (2.0g/100g diet) diet group. All rats were fed on calcium-deficient diet and deionized water ad libitum for 6 weeks. Plasma and liver lipids were determined by using commercial kits. LDL-cholesterol concentrations were estimated with the equation of Friedewald et al. (1972). There were no significant differences in body weight gain and food intake between the control and taurine group within Sham and OVX groups, but body weight gain, food intake, and food efficiency ratio was higher in the OVX group. Concentrations of plasma total cholesterol, triglyceride, LDL-cholesterol were significantly lower in the taurine fed group of OVX rats fed Ca deficient diet, while HDL-cholesterol concentration was increased in the taurine fed group. Therefore, in this study, we examined whether taurine also prevented hypercholesterolemia induced by ovarian hormone deficiency in ovariectomized rats when they were fed a calcium-deficient diet. These results indicate that taurine may have some beneficial effects on hypercholesterolemia and hypertriglyceridemia in OVX rats fed calcium-deficient diet.

두충(杜沖) 전탕액(煎湯液)이 흰쥐의 혈청(血淸) 지질(脂質) 대사(代謝)에 미치는 영향(影響) (Effects of Cortex Eucommiae drink water from cholesterol-induced on lipid metabolism in rats)

  • 한상환
    • 대한한방내과학회지
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    • 제21권3호
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    • pp.461-465
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    • 2000
  • The effects of 3% Cortex Eucommiae extracts on serum lipid contents were evaluated in rats. Forty-two male Sprague-Dawley rats weighing $100{\pm}10g$ were divided into seven groups and fed different fat diets for four weeks. Each group was administered with following group: Control, basal fat diet, saturated fat diet and unsaturated fat diet respectively was fed 1% cholesterol, Cortex Eucommiae extracts 3%. The contents of serum lipid contents triglyceride in the basal fat diet group were higher than those of control group. The contents of total-cholesterol in serum of the saturated fat diet group was significantly higher than other group. The contents of HDL-cholesterol in serum of the 3% Cortex Eucommiae extract group were higher than those other fat diet group. The contents of LDL-cholesterol in serum of the 3% Cortex Eucommiae ex1ract group was lower than other fat diet groups. These results suggest that 3% Cortex Eucommiae extract group may reduced elevated levels of serum lipid contents in rats different fed fat diet.

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한국산 잣기름이 정상토끼의 혈중 지방질 및 지단백질의 대사에 미치는 영향 (Effect on Blood Lipids and Lipoproteins of A Supplement of Korean Pinenut Oil, rich in 5-Olefinic Acids, in Normocholesterolemic New Zealand White Rabbits)

  • 윤태헌
    • Journal of Nutrition and Health
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    • 제27권4호
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    • pp.323-335
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    • 1994
  • The present study was carried out in normocholesterolemic New Zealand white(NZW) rabbit, to evaluate the effect of dietary supplementation with Korean pinenut oil, on plasma lipids, plasma lipoproteins, liver lipids and platelet aggregation. NZW rabbits were fed for 80 days on a commercial chow diet supplemented with 5% of energy as fats(soybean oil or pinenut oil) or 10% of energy as fats(soybean oil or pinenut oil). A control group was fed a commercial stock diet. There were no significant effects of pinenut oil on plasma free cholesterol, HDL-cholesterol, triglycerides, glucose and lecithin-cholesterol acyltransferase, as compared with those obtained from rabbits fed the soybean oil diet. After 80 days, the concentration of plasma free fatty acid in only the pinenut oil group was significantly decreased by about 50% relative to the control diet. At the end of the dietary treatment, liver triglycerides and phospholipids were significantly decreased in the pinenut oil group, compared to the how diet, whereas the soybean oil-consuming rabbits had only significantly decreased phospholipid levels. Cholesterol contents of liver were unaffected by type of dietary fat. At the end of 80 days, a diet containing pinenut oil resulted in a decrease in apolipoprotein B and the apo B/apo AI ratio as compared with the stock diet or soybean oil diet. Platelet aggregation induced by collagen or arachidonic acid was depressed significantily in pinenut oil diet.

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시호(Bupleuri Radix)분말이 과산화지질을 급여한 흰쥐의 혈장 및 간장지질구성과 항산화능에 미치는 영향 (Effects of Powdered Siho(Bupleuri Radix) on Serum and Liver Lipid Composition and Antioxidative Capacity in Rat Fed High Oxidized Fat)

  • 이은주;최무영;오혜숙
    • Journal of Nutrition and Health
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    • 제33권5호
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    • pp.502-506
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    • 2000
  • Effects of powdered siho(bupleuri radix) on serum and liver lipid composition and antioxidative capacity were investigated in rat fed high oxidized fat. Sixty male Sprague-Dawley rats weighing 161.25$\pm$2.51g were blocked into four groups according to body weight and raised seven weeks with basal diet(normal group), basal diet and 10% oxidized fat(control group), basal diet, 10% oxidized fat and 2% powdered siho(2% powdered siho group) and basal diet, 10% oxidized fat and 3% powdered siho(3% powdered siho group). Feed intake, body weight gain and feed efficiency were not significantly different among oxidized fat diet groups. The values of total cholesterol and triglyceride in plasma and liver showed no significantly different(p>0.05) in the oxidized fat diet groups. Plasma HDL-cholesterol showed atendency to increase in powdered siho diet groups. The values of thiobarbituric acid in plasma and liver were lower in the powdered siho diet groups than control group. Plasma GOT and GPT activity showed a tendence to decrease in powdered siho groups. Liver glutathione peroxidase activity showed a tendence to increase in powdered siho diet groups. Thus, it seems that powdered siho had some antioxidative elements.

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Increase in dietary protein content exacerbates colonic inflammation and tumorigenesis in azoxymethane-induced mouse colon carcinogenesis

  • Tak, Ka-Hee;Ahn, Eunyeong;Kim, Eunjung
    • Nutrition Research and Practice
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    • 제11권4호
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    • pp.281-289
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    • 2017
  • BACKGROUND/OBJECTIVE: The incidence of colorectal cancer (CRC) has been attributed to higher intake of fat and protein. However, reports on the relationship between protein intake and CRC are inconsistent, possibly due to the complexity of diet composition. In this study, we addressed a question whether alteration of protein intake is independently associated with colonic inflammation and colon carcinogenesis. MATERIALS/METHODS: Balb/c mice were randomly divided into 4 experimental groups: 20% protein (control, 20P, 20% casein/kg diet), 10% protein (10P, 10% casein/kg diet), 30% protein (30P, 30% casein/kg diet), and 50% protein (50P, 50% casein/kg diet) diet groups and were subjected to azoxymethane-dextran sodium sulfate induced colon carcinogenesis. RESULTS: As the protein content of the diet increased, clinical signs of colitis including loss of body weight, rectal bleeding, change in stool consistency, and shortening of the colon were worsened. This was associated with a significant decrease in the survival rate of the mice, an increase in proinflammatory protein expression in the colon, and an increase in mucosal cell proliferation. Further, colon tumor multiplicity was dramatically increased in the 30P (318%) and 50P (438%) groups compared with the control (20P) group. CONCLUSIONS: These results suggest that a high protein diet stimulates colon tumor formation by increasing colonic inflammation and proliferation.

부로일러종계의 생산성에 미치는 L-트립토판 첨가사료의 영향 (Effect of Diet Supplemented with L-Tryptophan on the Performance of Broiler Breeder)

  • 고태송;최호연;조영석;유종희
    • 한국가금학회지
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    • 제17권4호
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    • pp.303-309
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    • 1990
  • L-트립토판이 충족된 사료에 0.015%의 L-트립토판이 더 첨가된 사료를 이용종계 PS(Hubbard) 1768수에 34주령부터 52주령까지 133일간 급여하여 산난율, 종난율, 수정률, 규격병아리수를 조사하여 대조사료를 급여한 1105수의 값들과 비교하였다. L-트립토판을 급여한 종계는 급여개시 후 7주간인 피크산란기에는 대조사료를 급여한 것과 비슷한 산난율을 보였으나, 피크기 이후 84일(41-52주령)간과 급여중지후 28일간(53-56주령)에는 대조사료를 급여한 것에 비해서 유의하게(P<0.05) 높은 산난율을 보였다. 종난율도 피크기 이후와 급여중지후의 조사기간에 L-트립토판을 급여한 것에서 대조사료를 급여한 것보다 유의하게 (P<0.01) 높았고, 실험사육 전기간의 평균종난율도 L-트립토판급여에 의해서 유의하게 (P<0.05) 높았다. 한편 산난율과 종난률의 변동률은 시험사료를 급여한것에서 대조구의 값들보다 일반적으로 낮았다. 수정률과 부화율은 L-트립토판급여의 영향이 관찰되지 않았으나, 규격병아리수는 L-트립토판을 급여하면 대조에 비해서 유의하게 (P<.05) 높았다. 그리고 수정률, 부화율 및 규격병아리수에 대한 변동률도 L-트립토판을 급여하면 일반적으로 낮아졌다. 이상과 같이 L-트립토판을 그 요구량 이상으로 첨가한 사료를 급여하면 종란율과 규격병아리수가 높아진다는 것을 나타내고 있다.

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맥문동 엑스가 고콜레스테롤 식이를 급여한 횐쥐의 지질대사에 미치는 영향 (Effects of Liriopis Tuber Extracts on Lipid Metabolism in Rats Fed High Cholesterol Diet)

  • 김은정;정성운;양준호;이인선;이인자
    • 생약학회지
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    • 제34권1호통권132호
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    • pp.65-69
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    • 2003
  • This study was performed to examine the effects of Liriopis Tuber extracts to high cholesterol diet on lipid metabolism in rats. Male Sprague-Dawley rats of $90{\pm}10\;g$ were divided into six groups; basal diet (normal group), 1% high cholesterol diet (control group), high cholesterol diet supplemented with 3%, 5% water extracts (C3W, C5W group) and high cholesterol diet supplemented with 3%, 5% MeOH extracts (C3M, C5M group). These experimental diets were fed for 4 weeks. The lipid contents on serum, liver, feces were lower Lriopis Tuber extracts groups than control group. Especially, the effects of water extract was better than MeOH extract.

Effect of the Dietary Protein Level on Plasma Glucose, Lipids and Hormones in Streptozotocin-Diabetic Rats

  • Han Yung Joo
    • Journal of Nutrition and Health
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    • 제26권7호
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    • pp.851-857
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    • 1993
  • Atherosclerotic vascular disease is a major cause of the increased morbidity and mortality assciated with diabetes mellitus. The prominent role of nutrition in hypercholesteolemia and atherosclerosis is generally accepted. Diet is a key element in the management of diabetes (type I-IDDM), yet the appropriate diet for patient with diabetes mellitus is not well known. Dietary protein has been shown to have a significant effect on plasma cholesterol levels in both experimental animals and humans. The present experiment was designed to determine the effect of the dietary protein level(20% vs 60%) on plasma glucose concentration, lipids profile, insulin and glucagon levels from non-diabetic and streptozotocin-induced diabetic rats. Results showed that a high protein diet decreased triglyceride concentration in diabetic rats. Also diabetic rats fed a high protein diet were hypocholesterolemic than rats fed a control diet. There were no effects by level of protein on fasting blood glucose concentration and insulin/glucagon ratio. Results from the present study suggest that a high protein diet may be beneficial to control pasma lipids in chemically-induced diabetic rats.

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