• 한국한의학연구원논문집
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• 제13권3호
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• pp.111-117
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• 2007

The study aims to measure and analyze the thickness and depth of blood vessel on the pulse diagnosis locations and the blood velocity through the use of ultrasonic waves (LOGIQ5PRO, GE Medical, U.S.) in order to understand the structural difference of pulse diagnosis locations. The subjects included 44 healthy men and women(22.28${\pm}$2.62 age) considered normal in terms of Body Mass Index(BMI). The thickness and depth of the blood vessel and the blood velocity were measured three times on CHON, KWAN and CHUCK to obtain the average value. Results showed there is a statistically significant difference among the variables measured on CHON, KWAN and CHUCK. A difference according to gender was also observed. This explains why an oriental medical doctor can tell the difference in pulses depending on the location of CHON, KWAN and CHUCK. In addition, the difference in pressure between CHON and KWAN was higher than that in pressure between KWAN and CHUCK. The findings explain why oriental medical doctors take pulses by dividing CHON, KWAN and CHUCK in the short length of the three fingers. It can be used to develop a pulse diagnosis device enabling accurate measurement according to the characteristics of blood vessel structure based on where the pulse is taken. Furthermore, the results can be used as basic data for the development of a pulse diagnosis simulator.

• 한국산학기술학회논문지
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• 제14권11호
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• pp.5847-5855
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• 2013

본 연구의 목적은 생체센서와 자체진단 프로그램의 연동을 통하여 치매를 조기에 진단할 수 있는 스마트폰용 어플리케이션을 개발하는 것이다. 생체센서로부터 산소포화도와 혈압 데이터를 블루투스를 통해 수신 받고 스마트폰에 내장된 치매진단 설문지와 기억력 테스트 게임 등의 점수를 합산하여 스마트폰은 최종 치매지수를 도출해낸다. 간단한 임상실험 통해 치매 판단용 임계값을 결정하고 치매지수와 비교하여 치매를 진단하였다. 60세 이상의 노인에게 제안 어플리케이션을 적용한 결과, 초기 치매를 쉽고 빠르게 진단 가능함을 알 수 있었다. 추가적으로 산소챔버와 제안하는 치매진단용 어플리케이션을 융합함으로써 초기 치매를 치료하는 의료기기로서의 가능성을 제시하였다.

• 대한후두음성언어의학회지
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• 제28권1호
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• pp.43-47
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• 2017

Laryngopharyngeal reflux disease (LPRD) is common in laryngologic practice. In Korea, up to 1 out of every 5 patients who visit otorhinolaryngology clinic is supposed to have LPRD with symptoms and physical findings. Major symptoms of LPRD include hoarseness, cough, reflux symptom and mild dysphagia. Even though LPRD is common, its diagnosis may be difficult, because its symptoms are nonspecific and the laryngeal findings are not always associated with symptom severity. In Recent study, 66.4% of Patient who has LPRD also associated with esophageal motility disorders. Esophageal achalasia is a disease of unknown etiology characterized by an absence of peristalsis in the body of esophagus and nonrelaxing hypertension of the lower esophageal sphincter. Common cause is loss of ganglion cells in Auerbachs plexus. The classic triad of symptoms in achalasia includes dysphagia, regurgitation and weight loss. LPRD and esophageal achalasia have similar symptoms but have different treatment of choice. The Differentiation diagnosis of theses disease is important and should be established by history, radiologic examination and endoscopic examination. We recently assessed a 59-year-old female patient who complained of an epigastric pain, dysphagia and chronic cough. LPRD was initially diagnosed on Laryngoscopic examination and Reflux Symptom Index, but patient was not relieved of any symptoms after treatment of Proton Pump Inhibitor for 3 months. After high resolution manometry, esophageal achalasia was finally diagnosed. We report this case regarding the diagnosis and treatment with review of literatures because we have to think about esophageal motility disorders as a differential diagnosis in laryngology.

• Journal of Veterinary Science
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• 제23권5호
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• pp.78.1-78.13
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• 2022

Background: Florfenicol might be ineffective for treating Staphylococcus aureus small colony variants (SCVs) mastitis. Objectives: In this study, florfenicol-loaded chitosan (CS)-sodium tripolyphosphate (TPP) composite nanogels were prepared to allow targeted delivery to SCV infected sites. Methods: The formulation screening, the characteristics, in vitro release, antibacterial activity, therapeutic efficacy, and biosafety of the florfenicol composite nanogels were studied. Results: The optimized formulation was obtained when the CS and TPP were 10 and 5 mg/mL, respectively. The encapsulation efficiency, loading capacity, size, polydispersity index, and zeta potential of the optimized florfenicol composite nanogels were 87.3% ± 2.7%, 5.8% ± 1.4%, 280.3 ± 1.5 nm, 0.15 ± 0.03, and 36.3 ± 1.4 mv, respectively. Optical and scanning electron microscopy showed that spherical particles with a relatively uniform distribution and drugs might be incorporated in cross-linked polymeric networks. The in vitro release study showed that the florfenicol composite nanogels exhibited a biphasic pattern with the sustained release of 72.2% ± 1.8% at 48 h in pH 5.5 phosphate-buffered saline. The minimal inhibitory concentrations of commercial florfenicol solution and florfenicol composite nanogels against SCVs were 1 and 0.25 ㎍/mL, respectively. The time-killing curves and live-dead bacterial staining showed that the florfenicol composite nanogels were concentration-dependent. Furthermore, the florfenicol composite nanogels displayed good therapeutic efficacy against SCVs mastitis. Biological safety studies showed that the florfenicol composite nanogels might be a biocompatible preparation because of their non-toxic effects on the renal tissue and liver. Conclusions: Florfenicol composite nanogels might improve the treatment of SCV infections.

• Journal of Veterinary Science
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• 제23권1호
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• pp.1.1-1.11
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• 2022

Background: The poor bioadhesion capacity of tilmicosin resulting in treatment failure for Staphylococcus aureus small colony variants (SASCVs) mastitis. Objectives: This study aimed to increase the bioadhesion capacity of tilmicosin for the SASCVs strain and improve the antibacterial effect of tilmicosin against cow mastitis caused by the SASCVs strain. Methods: Tilmicosin-loaded chitosan oligosaccharide (COS)-sodium carboxymethyl cellulose (CMC) composite nanogels were formulated by an electrostatic interaction between COS (positive charge) and CMC (negative charge) using sodium tripolyphosphate (TPP) (ionic crosslinkers). The formation mechanism, structural characteristics, bioadhesion, and antibacterial activity of tilmicosin composite nanogels were studied systematically. Results: The optimized formulation was comprised of 50 mg/mL (COS), 32 mg/mL (CMC), and 0.25 mg/mL (TPP). The size, encapsulation efficiency, loading capacity, polydispersity index, and zeta potential of the optimized tilmicosin composite nanogels were 357.4 ± 2.6 nm, 65.4 ± 0.4%, 21.9 ± 0.4%, 0.11 ± 0.01, and -37.1 ± 0.4 mV, respectively; the sedimentation rate was one. Scanning electron microscopy showed that tilmicosin might be incorporated in nano-sized crosslinked polymeric networks. Moreover, adhesive studies suggested that tilmicosin composite nanogels could enhance the bioadhesion capacity of tilmicosin for the SASCVs strain. The inhibition zone of native tilmicosin, tilmicosin standard, and tilmicosin composite nanogels were 2.13 ± 0.07, 3.35 ± 0.11, and 1.46 ± 0.04 cm, respectively. The minimum inhibitory concentration of native tilmicosin, tilmicosin standard, and tilmicosin composite nanogels against the SASCVs strain were 2, 1, and 1 ㎍/mL, respectively. The in vitro time-killing curves showed that the tilmicosin composite nanogels increased the antibacterial activity against the SASCVs strain. Conclusions: This study provides a potential strategy for developing tilmicosin composite nanogels to treat cow mastitis caused by the SASCVs strain.

• 전력전자학회논문지
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• 제8권3호
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• pp.247-252
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• 2003

전동기 절연열화와 파괴는 전동기에 가해지는 스트레스에 영향을 받는다. 즉 절연물의 수명은 주어지는 스트레스의 심한 정도에 따라서 좌우된다. 전동차용 견인전동기에서도 과도서지에 의한 전기적인 열화를 검토하는 것은 매우 중요한 요소이다. 본 논문에서는 인버터에서 발생되는 과도서지에 의한 고정자 코일의 절연특성을 고찰해 보았다. 전동기의 절연상태, 열화진전도, 열화발생 범위 등을 측정하는 유용한 비파괴시험 방법에는 여러 가지가 이용되고 있다. 누설전류, 유전손실(tan$\delta$), 정전용량, 성극지수(PI), 부분방전 등의 방법들을 통하여 고정자 코일의 절연상태를 분석하였다. 이러한 진단 방법들은 전동차의 견인전동기에 대한 열화상태와 수명예측에 유용한 방법이 될 것으로 여겨진다.

• Clinical and Experimental Pediatrics
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• 제54권5호
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• pp.183-191
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• 2011

Although antenatal diagnostic technique has considerably improved, precise detection and proper management of the neonate with congenital heart disease (CHD) is always a great concern to pediatricians. Congenital cardiac malformations vary from benign to serious conditions such as complete transposition of the great arteries (TGA), critical pulmonary and aortic valvular stenosis/atresia, hypoplastic left heart syndrome (HLHS), obstructed total anomalous pulmonary venous return (TAPVR), which the baby needs immediate diagnosis and management for survival. Unfortunately, these life threatening heart diseases may not have obvious evidence early after birth, most of the clinical and physical findings are nonspecific and vague, which makes the diagnosis difficult. High index of suspicion and astute acumen are essential to decision making. When patent ductus arteriosus (PDA) is opened Widely, many serious malformations may not be noticed easily in the early life, but would progress as severe acidosis/shock/cyanosis or even death as PDA constricts after few hours to days. Ductus dependent congenital cardiac lesions can be divided into the ductus dependent systemic or pulmonary disease, but physiologically quite different from each other and treatment strategy has to be tailored to the clinical status and cardiac malformations. Inevitably early presentation is often regarded as a medical emergency. Differential diagnosis with inborn error metabolic disorders, neonatal sepsis, persistent pulmonary hypertension of the newborn (PPHN) and other pulmonary conditions are necessary. Urgent identification of the newborn at such high risk requires timely referral to a pediatric cardiologist, and timely intervention is the key in reducing mortality and morbidity. This following review deals with the clinical presentations, investigative modalities and approach to management of congenital cardiac malformations presenting in the early life.

• Smart Structures and Systems
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• 제26권1호
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• pp.11-21
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• 2020

The hinge joint is the key to the overall cooperative working performance of the assembled beam bridge, and it is also the weakest part during the service period. This paper proposes a method for monitoring and evaluating the lateral cooperative working performance of fabricated beam bridges based on dynamic strain correlation coefficient indicator. This method is suitable for monitoring and evaluation of hinge joints status between prefabricated girders and overall cooperative working performance of bridge, without interruption of traffic and easy implementation. The remote cloud monitoring and diagnosis system was designed and implemented on a real assembled beam bridge. The algorithms of data preprocessing, online indicator extraction and status diagnosis were given, and the corresponding software platform and scientific computing environment for cloud operation were developed. Through the analysis of real bridge monitoring data, the effectiveness and accuracy of the method are proved and it can be used in the health monitoring system of such bridges.

• Journal of Chest Surgery
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• 제27권4호
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• pp.331-334
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• 1994

Pneumatic rupture is a rare cause of esophageal injury, as evidenced by only 19 cases reported in the literature. We experienced one case of esophageal rupture due to bursting of a truck inner tube. The patient, who was a 45-year old male, had severe chest pain, respiratory distress, flushing in the face and neck, and subcutaneous emphysema after tire explosion. Three days after the incident, a diagnosis of rupture of the thoracic esophagus was established by esophagogram using water soluble contrast media, and then emergency operation was done. The operation involved mediastinal and thoracic drainage and resection of the esophagus combined with cervical esophagostomy and feeding gastrostomy. On the 105th day after the operation, cervical esophagogastrostomy via substernal route was performed. The patient was successfully treated with the staged operations. As in the other reported cases, the injury was located in the lower one third of the esophagus. Four main characteristics of the clinical signs of pneumatic rupture are 1] wounds or burns to the face or mouth, 2] chest pain or epigastric pain, 3] subcutaneous emphysema, and 4] respiratory distress. We emphasize that the high index of suspicion of esophageal rupture is very important in diagnosis and that diagnosis should be based on the same findings common to other forms of esophageal injury.

• 한국경영과학회지
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• 제37권3호
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• pp.23-37
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• 2012

As Customer Relationship Management (CRM) strategy is becoming a core competence more recently, many companies want a reliable CRM assessment system which enables measuring and diagnosing corporate customer strategies for building an optimized CRM strategy. However, there has been short of researches on developing the CRM diagnosis methodology that is directly applicable to real practices. Drawing upon the theoretical framework of CRM scorecard, we developed and suggested a corporate CRM diagnosis methodology that can systematically understand and assess the corporate CRM capability and performance, guiding their future directions. Companies can search the important but weak areas among various CRM strategy subjects through the proposed diagnostic procedures. This framework has a hierarchical structure that has four evaluative domains each of which has several evaluative subjects consisting of many evaluative themes: the score of upper factor is the weighted average of its subordinate factor scores. And the score of each evaluative theme is the weighted average of quantitative and qualitative evaluative indexes. Quantitative indexes are calculated by analyzing customer and sales data and qualitative ones are derived from survey data. Each evaluative index has more than one measure and its score can be derived from its own formula consisting of the measures. To prove the concept, we applied this framework to a real company and concluded that it might be appropriate to understand the corporate CRM strategy situation, find the pain points, and resolve them for better CRM implementation.