• 한국인공지능학회지
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• 제8권2호
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• pp.7-10
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• 2020

In this paper, a study was conducted to find main factorsto Pima Indians Diabetes based on machine learning. Diabetes is a type of metabolic disease such as insufficient secretion of insulin or inability to function normally and is characterized by a high blood glucose concentration. According to a situation report from WHO(World Health Organization), Diabetes is a chronic, metabolic disease characterized by elevated levels of blood glucose (or blood sugar), which leads over time to serious damage to the heart, blood vessels, eyes, kidneys and nerves. And also about 422 million people worldwide have diabetes, the majority living in low-and middle-income countries, and 1.6 million deaths are directly attributed to diabetes each year. Both the number of cases and the prevalence of diabetes have been steadily increasing over the past few decades. Therefore, in this study, we used Support Vector Machine (SVM), Decision Tree, and correlation analysisto discover three important factorsthat predict Pima Indians diabetes with 70% accuracy. Applying the results suggested in this paper, doctors can quickly diagnose potential Pima Indians diabetics and prevent Pima Indians diabetes.

• Archives of Pharmacal Research
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• 제26권7호
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• pp.559-563
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• 2003

Cytokines produced by immune cells infiltrating pancreatic islets have been incriminated as important mediators of $\beta$-cell destruction in insulin-dependent diabetes mellitus. In non insulin-dependent diabetes, cytokines are also associated with impaired $\beta$-cell function in high glucose condition. By the screening of various natural products blocking $\beta$-cell destruction, we have recently found that epigallocatechin gallate (EGCG) can prevent the in vitro destruction of RINm5F cell, an insulinoma cell line, that is induced by cytokines. In that study we suggested that EGCG could prevent cytokine-induced $\beta$-cell destruction by down-regulation of nitric oxide synthase (NOS) through inhibition of NF-kB activation. Here, to verify the in vivo antidiabetogenic effect of EGCG, we examined the possibility that EGCG could also prevent the experimental autoimmune diabetes induced by the treatment of multiple low doses of streptozotocin (MLD-STZ), which is recognized as an inducer of type I autoimmune diabetes. Administration of EGCG (100 mg/day/kg for 10 days) during the MLD-STZ induction of diabetes reduced the increase of blood glucose levels caused by MLD-STZ. Ex vivo analysis of $\beta$-islets showed that EGCG downregulates the MLD-STZ-induced expression of inducible NOS (iNOS). In addition, morphological examination showed that EGCG treatment ameliorated the decrease of islet mass induced by MLD-STZ. In combination these results suggest that EGCG could prevent the onset of MLD-STZ-induced diabetes by protecting pancreatic islets. Our results therefore revealed the possible therapeutic value of EGCG for the prevention of diabetes mellitus progression.

• 한국인공지능학회지
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• 제4권1호
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• pp.4-7
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• 2016

These days, citizens have made change of food life to take Western style food and to suffer from diabetes because of excessive nutrition taking, less exercise, stress and other environmental factors. They may suffer from diabetes because of genetic defect, surgery of pancreas, disinfection and medicine and others. One of ten Koreans may have symptom of diabetes to be popular. The diabetes that is a kind of metabolic disease has high blood sugar at disorder of hyper insulinism and/or defect of insulin action. Long time high blood sugar may produce chronic disease of kidney, eyes, nerve, heart and blood vessel and others. The purpose of health care of diabetes patient was to reach target blood sugar by diet, physical exercise and medicine and to prevent and delay complication. Diabetes patient shall control blood sugar to keep healthy. The blood sugar control requires time and effort, and all of the patients are difficult to make effort and to spend time. You can control blood sugar by the application. The application allows patients to control blood sugar and to save time and efforts and to make small sized input and automation of remaining area. The service was limited to blood sugar graph, and user carries smart phone to conduct test and to have difficulty. Further study needs to solve the problems and to investigate blood sugar testing not carrying smart phone and to make application of easy control of blood sugar.

• Child Health Nursing Research
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• 제25권4호
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• pp.449-457
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• 2019

Purpose: The purpose of this study was to identify predictors of eating disorders in adolescents with type 1 diabetes, with the goal of providing data in support of nursing interventions to improve their health. Methods: A total of 136 adolescents aged 13-18 years with type 1 diabetes completed the Diabetes Eating Problem Survey-Revised, Rosenberg Self-Esteem Scale, and the Beck Depression Inventory-II, using structured self-reported questionnaires. The collected data were analyzed using the t-test, $x^2$ test, and binominal logistic regression with SPSS version 23.0 for Windows. Results: The prevalence of eating disorders in adolescents with type 1 diabetes was 39%. Four significant predictors of eating disorders were identified; absence of body satisfaction (odds ratio [OR]=3.87, 95% confidence interval [CI]=1.55~9.65), depression (OR=2.87, 95% CI=1.13~7.28), female gender (OR=2.67, 95% CI=1.09~6.54), and glycosylated hemoglobin type A1c levels (OR=1.47, 95% CI=1.10~1.97). Conclusion: In order to prevent eating disorders among adolescents with type 1 diabetes, programs for managing adolescents' depression and improving their body satisfaction should be developed. Futhermore, more attention should be directed towards programs aiming to prevent eating disorders in female adolescents.

• 한국치위생학회지
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• 제15권5호
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• pp.925-932
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• 2015

Objectives: The aim of this study is to investigate the relationship between diabetes mellitus and oral disease in the Korea adults by using the representative data of Korea National Health and Nutrition Examination Survey (KNHANES) V. Methods: Using data from a cross-sectional survey of Korea National Health and Nutrition Examination Survey V. The subjects were 5,602 adults over 19 years old. The survey data and the examination data are used for the independent variables. KNHANES included health status, nutrition survey, and oral examination. The health status was obtained by a self-reported questionnaire of the study subjects and direct interview was carried out on economic status, prevalence rate, and use of medical services. Results: The regular dental checkup of diabetes patients was significantly lower than the general population. Regular dental visits allow adults to receive early diagnosis and obtain restorative care at the first visit. The regular annual oral examination is very important to prevent and manage the chronic diseases including diabetes mellitus. Conclusions: Diabetes mellitus can be fully prevented and managed by the regular annual dental checkup. The establishment of the regular dental checkup system can prevent and manage the complication due to diabetes mellitus and other chronic diseases.

• 대한한의학회지
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• 제19권2호
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• pp.137-152
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• 1998

Acute complications of diabetes mellitus were diminished after Banting and Best discovered insulin. But chronic complications of diabetes mellitus have been increased. The main complications of diabetes mellitus are diabetic retinopathy, diabetic nephropathy, diabetic neuropathy, diabetic foot lesion and macrovascular complication. These complications can result in renal failure, loss of sight, cerebral infarction and myocardial infarction. So it is very difficult to treat the complications of diabetes mellitus. In oriental medicine, the transformations(傳變症) of Sogal(消渴) are edema, carbuncle, loss of sight and so on. The comparative study between the trcmsformations(傳變症) of SogaI(消渴) and the complications of diabetes mellitus has come to the following conclusions. 1. In oriental medicine, diabetic retinopathy was expessed as loss of sight and the treament of diabetic retinopathy should be started at an early stage, to prevent vitreous hemorrhage and traction retinal detachment. 2. In oriental medicine. diabetic nephropathy was expressed as edema and the treatment should be started at an early stage of renal injury when the protein comes from urine.3. Symmetrical distal polyneuropathy is the main part of diabetic neuropathy and it was expressed as weakness of the lower limbs and pain of joints in the symptoms of Haso(下消). In Oriental medicine, acupuncture and herb medicine which effect is SopungHwalHyul can treat polyneuropathy. 4. Chief macrovascular complications are coronary artery disease and cerebrovascular disease, The cause of macrovascular complication is atherosclerosis. So the method of treating atherosclerosis should be studied in oriental medicine. 5. Diabetic foot were expressed as carbuncle and its main causes are decreasing perfusion of fool, diabetic neuropathy and infection. So these causes should be studied in oriental medicine. 6. The complications of diabetes mellitus afe very similar to the transfonnatiuns of Sogal(消渴).The control of blood glucose is indispensable to prevent and delay the complication of diabetes mellitus.

• 대한한방내과학회지
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• 제42권2호
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• pp.175-183
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• 2021

Diabetes mellitus, commonly known as diabetes, comprises a group of metabolic disorders characterized by a high blood sugar level over a prolonged period of time. Diabetes is classified into type 1 diabetes and type 2 diabetes, and the incidence and prevalence of diabetes, mostly type 2, have increased remarkably in recent decades. A diagnosis of type 2 diabetes is greatly influenced by heredity, and it is important to prevent diabetes in people with a family history by improving lifestyle and environmental factors. Controlling overeating, obesity, lack of exercise, and stress is effective to prevent diabetes. The patient in this case report had impaired fasting glucose and mild hyperlipidemia. The patient experienced improvements in these sequelae after the administration of herbal medicine (Yangkyuksanwha-tang) for 12 weeks and the implementation of a plant-based diet. The complete blood count, XXXX, fasting blood sugar, HbA1c, insulin, and C-peptide levels were measured, and the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) and HOMA-β were calculated according to the FBS and fasting insulin levels. Total cholesterol, triglyceride, FBS, and HbA1c levels all decreased after 12 weeks compared with baseline measures. There was no change in the insulin secretory ability; the C-peptide level did not change as a result of β-cell function; and the HOMA-β level reflected an improved insulin secretory ability.

• Journal of Multimedia Information System
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• 제5권1호
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• pp.53-58
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• 2018

The Republic of Korea (ROK) has been putting much effort to deal with diabetes which is being increasingly found in all age groups due to inadequate diet. Diabetes is closely related to one's eating habits and lifestyle that often cause hyperglycemia so that it is essential for the diabetic patients to change them to improve or control the major symptoms of diabetes. This study introduces a software engineering solution to support these patients. The software designed for the solution lets the patients to easily recognize their sugar levels and current treatment schemes and then advises a more effective approach along with the essential information through the embedded push service. The major goal of this study is to support diabetes patients by providing a convenient but effective means to prevent or improve diabetic symptoms by patients themselves who will in turn change their lifestyles in a positive manner.

• 대한한방내과학회지
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• 제27권4호
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• pp.811-821
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• 2006

Objectives : Diabetes is a disease in which the body does not produce or properly use insulin. Etiological studies of diabetes and its complications showed that oxidative stress might play a major role. Therefore, many methods have been tried to regulate oxygen free radicals for treating diabetes and its complications. Because Mori foliumhas been known to be effective for the treatment of diabetes, the methanol extract of Mori folium was tested for its effectiveness in reducing the oxidative stress induced by streptozotocin. Methods : The crushed Mori folium was extracted 3 times, each time with 3 volumes of methyl alcohol at $60^{\circ}C$ or 24 h. The extract was filtered and evaporated under reduced pressure using a rotary evaporator to yield 11.7 g. Mori folium extract was oral-administered to diabetic rats induced by streptozotocin at 100 mg per 1 kg of body weight for 20 days. The efficacy of the Mori foliumextract was examined with regard to the enzymatic pathways involved in oxygen free radical production and glutathione balance. Results : The effects of the Mori foliumin streptozotocin-induced diabetic rats with regards to body weight, blood glucose and insulin level, hepatic lipid peroxide level, hepatic glutathione level, hepatic glutathione S-transferase and glutathione peroxidase level, hepatic aldose reductase activity, and hepatic sorbitol dehydrogenase activity were shown to be good enough to cure and prevent diabetes and its complications. Conclusions : These results indicated that Mori folium might reduce oxidative stress in tissues and organs by regulating the production of oxygen free radicals. Especially Mori folium might prevent and cure diabetes and its complications by reducing oxidative stress in the ${\beta}-cells$ of the pancreas.

• 한국컴퓨터정보학회논문지
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• 제19권11호
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• pp.149-157
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• 2014

당뇨병은 급성합병증을 예방하고 장기간의 합병증의 위험도를 감소하기 위하여 지속적인 치료와 환자 자가 관리 교육이 필요한 만성질환이다. 또한 전 세계적으로 당뇨병에 대한 유병률과 사망률이 대부분의 인구집단에서 역학적 비율에 도달하였다. 많은 연구에서 당뇨병에 대한 조기진단은 적절한 치료와 생활습관을 지키는 관리를 통하여 발병을 예방하는데 도움을 줄 수 있으며, 이를 통하여 당뇨병의 합병증을 감소시키고 생존률을 향상시킬 수 있다고 보고하고 있다. 본 연구는 PIMA Indians 당뇨 데이터에 대하여 mixture of expert 모형을 적용하여 당뇨유병환자의 여부를 분류하고, 이를 로지스틱 회귀분석, 신경망분석의 성능과 비교함으로서 그 유용성을 주장하고자 하였다. 연구결과 정확도 및 ROC 곡선, c-통계량에서 ME 모형이 다른 분류도구들에 비해서 높게 나타남을 확인할 수 있었다.