• Journal of Microbiology and Biotechnology
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• 제25권10호
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• pp.1734-1741
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• 2015

Few research had investigated the secretion of phospholipase and aspartyl proteinase from Candida spp. causing infection in females with type 2 diabetes mellitus. This research aimed to investigate the prevalence of vulvovaginal candidiasis (VVC) in diabetic versus non-diabetic women and compare the ability of identified Candida isolates to secrete phospholipases and aspartyl proteinases with characterization of their genetic profile. The study included 80 females with type 2 diabetes mellitus and 100 non-diabetic females within the child-bearing period. Candida strains were isolated and identified by conventional microbiological methods and by API Candida. The isolates were screened for their extracellular phospholipase and proteinase activities by culturing them on egg yolk and bovine serum albumin media, respectively. Detection of aspartyl proteinase genes (SAP1 to SAP8) and phospholipase genes (PLB1, PLB2) were performed by multiplex polymerase chain reaction. Our results indicated that vaginal candidiasis was significantly higher among the diabetic group versus nondiabetic group (50% versus 20%, respectively) (p = 0.004). C. albicans was the most prevalent species followed by C. glabrata in both groups. No significant association between diabetes mellitus and phospholipase activities was detected (p = 0.262), whereas high significant proteinase activities exhibited by Candida isolated from diabetic females were found (82.5%) (p = 0.000). Non-significant associations between any of the tested proteinase or phospholipase genes and diabetes mellitus were detected (p > 0.05). In conclusion, it is noticed that the incidence of C. glabrata causing VVC is increased. The higher prevalence of vaginal candidiasis among diabetics could be related to the increased aspartyl proteinase production in this group of patients.

• Diabetes and Metabolism Journal
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• 제42권6호
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• pp.544-545
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• 2018

• Diabetes and Metabolism Journal
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• 제42권6호
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• pp.546-547
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• 2018

• 대한근전도전기진단의학회지
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• 제20권2호
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• pp.91-97
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• 2018

Objective: The aim of this study was to compare the electrodiagnostic outcomes of carpal tunnel release in patients with and without diabetes with carpal tunnel syndrome (CTS), and to evaluate the effect of diabetes mellitus (DM) on electrodiagnostic outcomes. Method: We conducted a retrospective analysis of 67 patients with electro-diagnostic evidence of CTS. Patients were classified into two groups according to the presence of DM. Both groups were evaluated using nerve conduction studies preoperatively and 3 weeks and 3 months postoperatively. Results: There were no statistical differences in any of the electrodiagnostic parameters between groups 3 weeks postoperatively. However, there were statistical differences in the amplitude and the latency of compound muscle action potential, and sensory nerve conduction velocity 3 months postoperatively. Conclusion: Patients with DM did not show a significantly different outcome 3 weeks after surgery but showed a worse electrodiagnostic outcome 3 months after surgery than those without DM.

• 대한족부족관절학회지
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• 제8권2호
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• pp.153-156
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• 2004

Purpose: To investigate the status of foot, preventive foot care and appropriateness of shoe size in patients with diabetes. Materials and Methods: One hundred and sixty-five patients who visited endocrinology clinic due to clinically proven diabetes mellitus were studied. Average age was 59.3 years (range, 36-90 years) and average duration of diabetes was $9.6{\pm}8.2$ years. Patients were questioned about their basic educational level and their foot and ankle problems. Physical examination of the foot was done including sensation testing of four areas of plantar surface with the 5.07 monofilament. Both feet and shoes were measured for width, length and the height of toes and toebox. Shoes were defined as properly fitting the foot if it is 5mm wider than the foot, and $20{\pm}30\;mm$ longer than the foot, and the height of toebox is more than 5mm higher than the height of the toes. Results: 48.5 percent of the patients were educated about how to select an appropriate shoewear. 47.3 percent of the patients had symptoms of neuropathy and 42.4 percent of patients were unable to feel the monofilament in at least one area. 25.5 percent of the patients had appropriate shoes in length, 63.6 percent of the patients in width, and 72.7 percent of the patients in the height of toebox. Conclusion: This study suggets that more patients needs to be educated about foot care and appropriate shoes which have adequate height of toebox as well as the length and width.

• 성인간호학회지
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• 제29권1호
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• pp.1-11
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• 2017

Purpose: The purpose of this study was to identify the factors and the relative risk associated with admission of patients with diabetes mellitus (DM). Methods: The sample included one hundred twenty-eight patients with type II DM. Seventy-seven patients who were admitted within six months of a hospitalization to one hospital from the first of February to the 31st of August 2014, were compared with fifty-one patients who regularly attended an outpatient clinic and had no hospitalizations. Results: Hospitalization probabilities among patients who had only diet and exercise or took oral diabetic medication were 0.03 (p=.004) and 0.21 (p=.007) times independently lower than the ones with insulin injection. The risks for hospitalization increases 6.33 times if there is absence of a spouse (p=.027) whereas the presence of a spouse seems to make hospitalization less likely. The risk among the ones having diabetic complications was 5.15 times higher than ones having no recognition of the complications (p=.040). For every one point increase in self-efficacy and every 1 mg/dL increase in high density lipoprotein (HDL) cholesterol, there was a 0.84 (p=.005) and a 0.96 (p=.036) decrease in hospitalization risk, respectively. Conclusion: Nurses should be sensitive to the risk groups of hospital admission among patients with DM including no spouse, insulin injection, diabetic complications, low self-efficacy, and low HDL cholesterol.

• Journal of Obesity & Metabolic Syndrome
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• 제27권4호
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• pp.213-222
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• 2018

Bariatric surgery has evolved from a surgical measure for treating morbid obesity to an epochal remedy for treating metabolic syndrome as a whole, which is represented by type 2 diabetes mellitus. Numerous clinical trials have advocated bariatric or metabolic surgery over nonsurgical interventions because of markedly superior metabolic outcomes in morbidly obese patients who satisfy traditional criteria for bariatric surgery (body mass index [BMI] >$35kg/m^2$) and in less obese or simply overweight patients. Nevertheless, not all diabetes patients achieve the most desirable outcomes; i.e., diabetes remission after metabolic surgery. Thus, candidates for metabolic surgery should be carefully selected based on comprehensive preoperative assessments of the risk-benefit ratio. Predictors for diabetes remission after metabolic surgery may be classified into two groups based on mechanism of action. The first is indices for preserved pancreatic beta-cell function, including younger age, shorter duration of diabetes, and higher C-peptide level. The second is the potential for an insulin resistance reduction, including higher baseline BMI and visceral fat area. Several prediction models for diabetes remission have been suggested by merging these two to guide the joint decision-making process between clinicians and patients. Three such models, DiaRem, ABCD, and individualized metabolic surgery scores, provide an intuitive scoring system and have been validated in an independent external cohort and can be utilized in routine clinical practice. These prediction models need further validation in various ethnicities to ensure universal applicability.

• 대한간호
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• 제5권1호통권21호
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• pp.38-59
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• 1966

This study was designed to identify and find out the scope and content of clinical teaching of patients with diabetes mellitus by graduate and student nurses. A questionnaire was constructed and data was obtained from 55 graduate nurses who work on medica

• 정신신체의학
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• 제7권2호
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• pp.203-212
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• 1999

연구목적 : Alexithymia(감정표현불능증)는 내면적 감정을 올바로 인식하거나 언어적으로 표현하기 어려운 상태를 뜻하는 용어이다. 최근에는 말로 표현하는데 장애가 있는 것만이 아니라 인지과정에서의 결함도 강조하고 있다. 그리고 감정은 신체증상과 전반적인 건강상태에 영향을 준다는 점에서 정신신체연구에 매우 중심적인 역할을 하고 있다. 이에 본 연구는 신체형 장애 환자와 정신신체장애의 하나로 알려져 있는 당뇨병 환자를 대상으로 alexithymia의 척도를 비교하고 이 환자들에서의 정신병리와 성격특성을 알아 보고자하였다. 방법 : 본 연구는 만 18세 이상의 신체형장애 환자 20명, 당뇨병 환자 20명 그리고 정상 대조군 20명을 대상으로 세 군의 alexithymia의 정도, 정신병리 및 성격특성을 알아보기 위하여 각각 Toronto Alexithymia Scale(TAS), 한국판 Symptoms Check List 9G-R(SCL-90-R) 및 Sixteen Personality Factor Questionnaire(16-PF)를 이용하여 세 군간의 차이를 분석하고 TAS와 SCL-90-R 및 TAS와 16-PF와의 상관관계를 분석하였다. 결과 : 1) TAS에 따른 세 군간의 비교에서는 신체형장애 환자군이 당뇨병 환자군과 정상 대조군보다 유의하게 높은 수치를 나타냈다. 2) SCV90-R에 의한 비교에서는 신체화증상과 불안증상 척도에서 신체형장애 환자군이 당뇨병 환자군과 정상 대조군보다 유의하게 높게 나타났다. 강박증상, 우울증상, 공포증상 및 정신증상 척도에서는 선체형장애 환자군이 정상 대조군보다 유의하게 높게 나타났다. 전체지표 중 전체심도지수는 신체형장애 환자군과 당뇨병 환자군이 정상 대조군보다 높았고, 표출증상심도지수는 신체형장애 환자군과 당뇨병 환자군이 정상 대조군보다 높았으며 표출증상합계에서는 신체형장애 환자군이 정상 대조군보다 유의하게 높은 결과를 보였다. 3) 16-PF에 의한 비교에서는 지능요인에서만 정상 대조군이 신체형장애 환자군보다 높게 나타났고 다른 요인에서는 차이가 없었다. 4) TAS와 SCL-90-R과의 상관관계분석에서는 신체형장애 환자군에서 표출증상심도지수를 제외한 모든 척도에서 정적 상관관계를 보였다. 그러나 다른 두 군에서는 유의한 상관관계를 보이지 않았다. 5) TAS와 16-PF와의 상관관계분석에서는 모든 대상군에서 유의한 상관관계를 보이지 않았다. 결론 : 신체형장애 환자군이 당뇨병 환자군이나 정상 대조군에 비하여 높은 alexithymia 척도와 많은 정신병리를 보였다. 그리고 신체형 환자군에서의 높은 alexithymia 척도는 정신병리와 유의한 정적 상관관계를 보이고 있었다. 당뇨병환자들은 정상 대조군과 유의한 차이를 보이지 않았다. 그러므로 신체형장애 환자들에게는 감정을 표현하고 그들의 정신병리를 완화하거나 해소할 수 있는 치료적 접근이 도움이 되겠고, 당뇨병환자들에게는 우선적으로 신체질환의 상태를 호전시킬 수 있는 치료가 더욱 필요로 하겠다.

• 생물정신의학
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• 제10권2호
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• pp.107-115
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• 2003

Objective:The purpose of this study was to know about the mechanism of pathogenesis of type 2 diabetes mellitus by using of blood glucose, glucoregulatory factor, insulin resistance in schizophrenic patients receiving antipsychotics. Method:Modified oral glucose tolerance tests were performed in 20 schizophrenic patients receiving haloperidol, risperidone and olanzapine. Insulin, glucagon, C-peptide and cortisol were measured in 0, 15, 45, 75 minutes after glucose loading, and insulin resistance was calculated by HOMA(homeostasis model assessment) method. Result:Olanzapine-treated patients had significant glucose elevation 45 minutes after glucose challenge. Also modest increases in HOMA IR values were detected in patients treated with olanzapine. Conclusion:Olanzapine treatment of non-diabetic patients with schizophrenia can be associated with type 2 diabetes mellitus through the elevation of glucose and insulin resistance. Elevated insulin resistance may be a causative mechanism of type 2 diabetes mellitus in patients receiving olanzapine.