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Association between Angiotensin I-Converting Enzyme Gene Polymorphism and Hypertension in Selected Individuals of the Bangladeshi Population

  • Morshed, Mahboob;Khan, Haseena;Akhteruzzaman, Sharif
    • BMB Reports
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    • v.35 no.3
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    • pp.251-254
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    • 2002
  • The genetic factors that contribute to the development of coronary artery disease (CAD) are poorly understood. It is likely that multiple genes that act independently or synergistically contribute to the development of CAD and the outcome. Recently, an insertion/deletion (I/D) polymorphism of the human angiotensin I-converting enzyme (ACE) gene, a major component of the renin-angiotensin system (RAS), was identified. The association of the ACE gene D allele with essential hypertension and CAD has been reported in the African-American, Chinese, and Japanese populations. However, other studies have failed to detect such an association. It has been suggested that these inconsistencies may be due to the difference in backgrounds of the population characteristics. In the present study, we investigated the I/D polymorphism of the ACE gene in 103 subjects of both sexes, consisting of 59 normal controls and 44 patients with hypertension. The allele and genotype frequency were significantly different between the hypertensive and control groups (p < 0.01). Among the three ACE I/D variants, the DD genotype was associated with the highest value of the mean systolic blood pressure [SBP] and mean diastolic blood pressure [DBP] (p = < 0.05) in men, but not in women. In the overall population, the mean SBP and DBP was highest in DD subjects, intermediate in I/D subjects, and the least in II subjects.

An Innovative Approach of Bangla Text Summarization by Introducing Pronoun Replacement and Improved Sentence Ranking

  • Haque, Md. Majharul;Pervin, Suraiya;Begum, Zerina
    • Journal of Information Processing Systems
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    • v.13 no.4
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    • pp.752-777
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    • 2017
  • This paper proposes an automatic method to summarize Bangla news document. In the proposed approach, pronoun replacement is accomplished for the first time to minimize the dangling pronoun from summary. After replacing pronoun, sentences are ranked using term frequency, sentence frequency, numerical figures and title words. If two sentences have at least 60% cosine similarity, the frequency of the larger sentence is increased, and the smaller sentence is removed to eliminate redundancy. Moreover, the first sentence is included in summary always if it contains any title word. In Bangla text, numerical figures can be presented both in words and digits with a variety of forms. All these forms are identified to assess the importance of sentences. We have used the rule-based system in this approach with hidden Markov model and Markov chain model. To explore the rules, we have analyzed 3,000 Bangla news documents and studied some Bangla grammar books. A series of experiments are performed on 200 Bangla news documents and 600 summaries (3 summaries are for each document). The evaluation results demonstrate the effectiveness of the proposed technique over the four latest methods.

TP53 Codon 72 Polymorphisms and Lung Cancer Risk in the Bangladeshi Population

  • Chowdhury, Miraj Kobad;Moniruzzaman, Md;Al Emran, Abdullah;Mostafa, Mohammad Golam;Kuddus, Ruhul H;Uddin, M Aftab
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.8
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    • pp.3493-3498
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    • 2015
  • Objective: To assess associations between codon 72 polymorphisms (Pro or B and Arg or b alleles) of the TP53 gene and lung cancer risk among Bangladeshis. Materials and Methods: The distribution of the BB, Bb, and bb genotypes and the frequencies of the B and b alleles were determined by PCR-RFLP method using DNA extracted from leucocytes of 50 confirmed lung cancer patients and 50 age-matched controls and the data were analysed. Results: The ratio of BB, Bb, and bb genotypes were in Hardy-Weinberg equilibrium except for the male patients (${\chi}2=4.6$). The B allele is overrepresented among all patients (OR=2.0, p=0.02) and the female patients (OR=4.1, $p{\leq}0.01$) compared to the controls. The BB/bb ratio was also higher among the patients (OR=3.0, p=0.03). The relative risk of cancer for having BB over bb genotype was 1.8 (p=0.04) but no effect was observed for the Bb genotype. The B allele was overrepresented among patients with adenocarcinomas (OR=2.4, $p{\leq}0.01$) and squamous cell carcinomas (OR=2.7, $p{\leq}0.01$) over the controls but the difference was not significant for those with small cell lung carcinomas (OR=1.1, p=0.66). The B allele was overrepresented among patients age 50 or younger (OR=2.7, $p{\leq}0.01$), but not for older patients (OR=1.7, p=0.07), and among smokers compared to the controls (OR=1.8-10.0, $p{\leq}0.01-0.03$). However, no correlation between increasing pack-years and lung cancer was observed. Conclusions: The Pro/Pro (BB) genotype and the B allele are risk factors for lung cancer among Bangladeshis, particularly for people under age 50, women and smokers.

Determinants of Quality of Financial Information: Empirical Evidence from Cement Sector of Bangladesh

  • Rahman, Md. Musfiqur;Hasan, Md. Mehedi
    • Asian Journal of Business Environment
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    • v.9 no.1
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    • pp.13-20
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    • 2019
  • Purpose - The purpose of this paper is to find out the determinants of the quality of financial information in the financial environment of the cement companies of Bangladesh. Research design, data and methodology - This study considers a total of fifty-eight firm years as the sample from the seven listed cement companies of Bangladesh during the period of 2007 to 2015. This study applies the multivariate regression analysis including the pooled OLS, panel and controlling time. Results - This study finds that profitability and external financing are the two major explanatory variables in determining the quality of financial information. This study also finds that firm size and accrual quality don't have any significant influence on quality of financial information. Conclusion - This study observed that profitability of this sector which is much volatile and prone to be manipulated. Thus, this paper suggests that higher profitability needs more scrutiny while assessing quality of financial information. Finally, this study provides some indications for future research such as considering the listed firms of other sectors of Bangladesh or cross country comparison in different country setting.

Delignification Kinetics of Trema orientalis (Nalita) in Kraft Pulping

  • Jahan, M. Sarwar;Rubaiyat, A.;Sabina, R.
    • Journal of Korea Technical Association of The Pulp and Paper Industry
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    • v.39 no.5
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    • pp.7-11
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    • 2007
  • Kraft pulping of Trema orientalis (Nalita) was studied in order to find kinetic data for delignification. Pulping runs were carried out in the temperature range of $160-180\;^{\circ}C$ under constant and well-defined conditions. The delignification was found to be first order with respect to residual lignin and was chemically controlled. The rate of delignification reaction was increased 1.11-1.23 for $10\;^{\circ}C$ temperature increase in the range of $160-180\;^{\circ}C$ range. A mean value of 93% of lignin was removed at the transition between bulk and residual delignification. The influence of cooking temperature on the rate constant was expressed by an Arrhenius-type equation. The obtained activation energy of the delignification reaction was 6,164 cal/mol. The transition point between bulk and residual phase was shifted to lower lignin and carbohydrate yield with the increase of temperature.

Antimicrobial activity and cytotoxicity of Eclipta prostrata

  • Rahman, Mohammad S.;Rashid, Mohammad A.
    • Advances in Traditional Medicine
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    • v.8 no.1
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    • pp.47-52
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    • 2008
  • The plant Eclipta prostrata, a member of the Compositae family, has folkloric reputation of being used as a medicinal agent in Bangladesh. In the present investigation, attempt was taken to explore the antimicrobial potency and cytotoxicity of its extractives and purified compounds. The methanolic extract of the whole plant, its n-hexane, carbon tetrachloride, chloroform, aqueous soluble fractions and two purified compounds, eclalbasaponin I (1) and II (2), obtained from Eclipta prostrata were subjected to screening for inhibition of microbial growth by the disc diffusion method at 300 and 100 ${\mu}g$/disc for extracts and pure compounds, respectively. In this case, the carbon tetrachloride and chloroform soluble fractions of the methanolic extract appeared very potent in terms of both zone of inhibition and spectrum of activity. However, all the extractives were also subjected to brine shrimp lethality bioassay for preliminary cytotoxicity evaluation. Here, the carbon tetrachloride soluble fraction of methanolic extract revealed the strongest cytotoxicity having $LC_{50}$ of 1.318 ${\mu}g$/ml.

Synthesis, Characterization and Enhanced Selectivity in RP-HPLC of Polar Carbonyl Group Embedded Poly (Vinyl Octadecanoate) Grafted Stationary Phase by Simple Heterogeneous "Graft from" Technique

  • Rana, Ashequl A.;Karim, Mohammad Mainul;Takafuji, Makoto
    • Bulletin of the Korean Chemical Society
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    • v.32 no.1
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    • pp.77-82
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    • 2011
  • A new high performance liquid chromatograpgy (HPLC) stationary phase that possesses an internal carbonyl functional group is synthesized by heterogeneous "graft from" method. This new stationary phase, poly (vinyl octadecanoate) grafted silica (Sil-2) is then characterized by different physico-chemical methods such as diffuse reflectance infrared fourier transform, suspension state $^1H$ NMR, solid state $^{13}C$ CP/MAS NMR, $^{29}Si$ CP/MAS NMR, elemental analysis and thermogravimetric analysis. Chromatographic properties of Sil-2 were evaluated under reversed phase condition by separating polycyclic aromatic hydrocarbons (PAHs) and comparing the chromatographic results with those on polymeric as well as monomeric octadecylated silica stationary phases.

Preliminary antimicrobial and cytotoxic activities of Amoora cucullata extractives

  • Rahman, Mohammad S.;Rashid, Mohammad A.
    • Advances in Traditional Medicine
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    • v.9 no.2
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    • pp.182-185
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    • 2009
  • Amoora cucullata (Meliaceae), a mangrove plant, has folkloric reputation as a medicinal agent in Bangladesh. In this study, the n-hexane, ethyl acetate and methanolic extracts of the stem bark of this plant were subjected to microbiological investigation and brine shrimp lethality bioassay. In case of antimicrobial screening, the ethyl acetate and methanolic extracts appeared to be potent in terms of both zone of inhibition and spectrum of activity showing the average zones of inhibition 8 - 14 mm and 9 - 16 mm, respectively. In the brine shrimp lethality bioassay, the methanolic extract demonstrated highest cytotoxicity having $LC_{50}$ of $0.549{\mu}g/ml$, whereas the ethyl acetate and n-hexane extract showed $LC_{50}$ of 7.943 and $17.180{\mu}g/ml$, respectively.

Knowledge Management Initiative: A Case Study of the National Library of Bangladesh

  • Sultana, Nazmin;Mostofa, SK Mamun
    • Journal of Information Science Theory and Practice
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    • v.6 no.1
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    • pp.6-17
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    • 2018
  • This paper confers about the implementation of Knowledge Management (KM) in the National Library of Bangladesh (NLB). The main aim of this study was to investigate how the NLB goes about creating, implementing, disseminating, and applying knowledge within the organization. The other objectives of this paper were to identify the current status of KM in NLB and the understanding of different facets of KM by the staff of the National Library. The paper revealed that the situation of KM in NLB is not satisfactory. The paper also described the fact that the working environment supports the implementation but there needs to be some changes in the policies. Finally the research disclosed that NLB is a great place for implementing KM and has a large amount of possibilities for the adoption of KM. This qualitative research used the questionnaire as the main instrument for data collection. Finally, data has been processed and analyzed using SPSS and MS Excel.