• Clinical and Experimental Pediatrics
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• v.64 no.10
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• pp.497-503
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• 2021

Reading disability (dyslexia) refers to an unexpected difficulty with reading for an individual who has the intelligence to be a much better reader. Dyslexia is most commonly caused by a difficulty in phonological processing (the appreciation of the individual sounds of spoken language), which affects the ability of an individual to speak, read, and spell. In this paper, I describe reading disabilities by focusing on their underlying neurobiological mechanisms. Neurobiological studies using functional brain imaging have uncovered the reading pathways, brain regions involved in reading, and neurobiological abnormalities of dyslexia. The reading pathway is in the order of visual analysis, letter recognition, word recognition, meaning (semantics), phonological processing, and speech production. According to functional neuroimaging studies, the important areas of the brain related to reading include the inferior frontal cortex (Broca's area), the midtemporal lobe region, the inferior parieto-temporal area, and the left occipitotemporal region (visual word form area). Interventions for dyslexia can affect reading ability by causing changes in brain function and structure. An accurate diagnosis and timely specialized intervention are important in children with dyslexia. In cases in which national infant development screening tests have been conducted, as in Korea, if language developmental delay and early predictors of dyslexia are detected, careful observation of the progression to dyslexia and early intervention should be made.

• Perspectives in Nursing Science
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• v.18 no.1
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• pp.16-27
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• 2021

Purpose: Sexuality is a fundamental element of human life and is closely related to mental health. This study was conducted to understand domestic research trends on gender, mental health, and psychological well-being through an integrated review. Methods: Through four domestic databases, 15 papers were finally selected using the search terms 'sex', 'mental health', and 'psychological well-being'. Results: Fifteen papers have been published since 2000 and 10 documents have been published since 2010. A majority of the studies were basic research and reviews, and these included four qualitative studies. Depending on the subject, we classified five articles into three themes by the developmental stages (youth, married women, and the elderly), eight sexual minority studies, and two other studies (right to sexual self-determination, and dating for people with disabilities). Conclusion: A more open social concern and approach to sex, the most basic human need, is warranted. The field of nursing practice requires more attention.

• Journal of Genetic Medicine
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• v.17 no.2
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• pp.92-96
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• 2020

Hypotonia, Ataxia, and Delayed Development Syndrome (HADDS) is an autosomal-dominant, extremely rare neurodevelopmental disorder caused by the heterozygous EBF3 gene mutation. EBF3 is located on chromosome 10q26.3 and acts as a transcription factor that regulates neurogenesis and differentiation. This syndrome is characterized by dysmorphism, cerebellar hypoplasia, urogenital anomaly, hypotonia, ataxia, intellectual deficit, and speech delay. The current report describes a 3-year-old Korean male carrying a de novo EBF3 mutation, c.589A>G (p.Asn197Asp), which was identified by whole exome sequencing. He manifested facial dysmorphism, hypotonia, strabismus, vermis hypoplasia, and urogenital anomalies, including vesicoureteral reflux, cryptorchidism, and areflexic bladder. This is the first report of a case of HADDS cause by an EBF3 mutation in the Korean population.

• Proceedings of the Korean Society of Broadcast Engineers Conference
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• 2020.07a
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• pp.607-610
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• 2020

21세기 핵심 키워드 중 하나로 두뇌 산업이 떠오르고 있다. 미국, 일본 등 선진 국가에서는 이미 뇌 연구에 활발한 투자가 진행되고 있다. 이에 따라 본 논문에서는 출생과 성장기 뇌 발달에 문제가 발생하는 발달 장애 아동을 위한 음악 치료 프로그램을 개발하고자 한다. 효과적인 발달 장애 치료를 위해, 조기 발견 후 인지 학습 치료가 필요하다. 그 중 인지 기능과 자가 관리 기능을 기르는 것이 중요한데, 리듬 타이밍 훈련이 발달 장애 아동의 기억 능력 개선에 도움이 된다는 여러 입증된 연구 결과가 있다. 그러나 아직까지 발달 장애 아동을 위한 적절한 치료 방법이 없기에 본 논문에서는 인지 학습 치료가 필요한 아동에게 도움을 주기 위해 동요의 정확한 리듬, 음정을 학습하는 프로그램을 제안한다. 아동의 지속적인 흥미를 끌 수 있는 게임과 인지능력 훈련을 결합하였기에, 보다 좋은 학습 효과를 유도할 수 있을 것이다.

• Proceedings of the Korea Information Processing Society Conference
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• 2023.11a
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• pp.988-989
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• 2023

본 논문에서는 발달장애 아동의 교육 및 치료에 있어서 감각, 인지훈련을 효과적으로 할 수 있는 웨어러블 기기 및 연동앱을 제시한다. 이를 위해 임베디드 하드웨어를 개발하고 이와 연동할 수 있는 앱, 앱 내 게이미피케이컨텐츠, 학습 내용 및 결과 리포트를 개발했다. 발달장애 아동의 특성을 고려한 하드웨어는 유아 친화적 디자인으로 설계해 아동이 쉽게 착용 가능하며, 주의집중을 위한 감각 훈련을 집중적으로 할 수 있도록 시각, 촉각 등의 자극 촉구 행동을 유도하며, 반복적 교육으로 인한 개선 효과를 제공한다. 개발한 기기 및 연동앱을 직접 교육현장에 적용해봄으로써 주의집중과 저작능력 향상을 위한 센터에서의 지속적인 실사용 가능성을 제고했다.

• Clinical and Experimental Pediatrics
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• v.57 no.3
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• pp.140-148
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• 2014

Purpose: Lowe syndrome is a rare, X-linked recessive disorder caused by mutations in the OCRL gene. It involves multiple anatomic systems, particularly the eyes, central nervous system, and kidneys, and leads to profound growth failure and global developmental delay. This study evaluated the clinical and genetic characteristics of Korean patients with Lowe syndrome. Methods: The clinical findings and results of genetic studies were reviewed for 12 male patients diagnosed with Lowe syndrome at a single medical institution. Results: The mean age of the patients at presentation was 2.2 months (range, 0-4 months), although the diagnosis was delayed by a mean of 2.8 years (range, 0-9.7 years). The mean follow-up period was 9.0 years (range, 0.6-16.7 years). Nine mutations in OCRL were identified in 11 patients (92%), with three novel mutations. The main presentation was congenital cataract in both eyes necessitating early cataract removal in the 11 patients with impaired visual acuity. Profound short stature and developmental delay were observed in all patients, and seizures occurred in 50% of the patients. All patients suffered from proximal renal tubular dysfunction, and one patient developed chronic renal failure. Other manifestations included pathologic fracture (50%), cutaneous cysts (42%), and cryptorchidism (42%). However, there was no bleeding tendency, and none of the patients died during the study period. Conclusion: This study describes the clinical and genetic characteristics of Korean patients with Lowe syndrome. The observations are helpful for understanding the natural courses of Lowe syndrome and for appropriate genetic counseling.

• The Journal of Korean Academy of Sensory Integration
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• v.16 no.3
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• pp.34-49
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• 2018

Objective : This study aimed to examine the psychometric properties of Korean version of Pediatric Volitional Questionnaire (PVQ-K) using classical test theory. Methods : For the translation of Pediatric Volitional Questionnaire (PVQ), as recommended in the literature, four-stage translation method was used. For the psychometric properties of Korean version of the Pediatric Volitional Questionnaire (PVQ-K), internal consistency reliability, content validity, and construct validity of the test using the known groups method and convergent and divergent methods were examined. For the recruitment of participants, a convenience sampling method is used. Participants of this study were 10 children with neuro-developmental disabilities hospitalized two different rehabilitations center and 10 children with typical development living in Daejeon, South Korea. All 20 participants were in aged from two to five years. Results : In terms of the content validity index, it was over 0.78, confirmed by nine experts of children development. PVQ-K successfully discriminated the scores of children with typical development from those with neurodevelopmental disabilities (p < .05). It is found that there is significant correlations between achievement stage of PVQ-K and the Korean Developmental Screening Test for Infants & Children (K-DTS)(.652 ~ .799 for subcategory, .706 for total scale). The internal consistency was .944 (Cronbach's ${\alpha}$). In qualitative content analysis, it was examined that how Korean children behave and respond in the environment, and how children's volition was strengthened or weakened by the environment. Conclusion : The results propose that PVQ-K can be a useful occupation-focused measure. This study recommend further study on PVQ-K with larger samples combined with the item-response theory approach.

• Journal of the Korean Applied Science and Technology
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• v.36 no.4
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• pp.1385-1398
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• 2019

This study was a survey study to provide the base data necessary to prepare efficient management plans for the mothers with disabled children by type, comparing degrees of disability acceptance, stress, coping method and wellness between mothers with physical functional disordered children and developmental disordered children. The study subjects were a mother who raises disordered children. Data collection was conducted from October 2018 to April 2019, and differences between the two groups were analyzed as t-test, ANOVA, and Pearson correlation. In results, Studies have shown that there are differences between the two groups as mothers with physical functional disordered children and mothers with developmental disordered children as degrees of disability acceptance, stress, treatment and wellness. Disability acceptance and coping method of mothers with physical functional disordered children (r=0.23, p=.033), disability acceptance and Wellness (r=0.51, p<.001) have shown positive correlations and disability acceptance and stress (r=-0.72, p<.001) have shown negative correlations. Disability acceptance and wellness (r=0.40, p<.001) of the mother with a developmental disordered child have shown a significant positive correlation, and disability acceptance and stress (r=-0.71, p<.001) have shown a significant negative correlations. The higher the degree of disability acceptance, the lower the stress level and the higher the coping method and wellness mothers with physical functional disordered children had. The higher disability acceptance, the lower stress degrees and the higher wellness degrees mothers with developmental disordered children had. In order to improve disability acceptance by mothers with physical functional disordered children, it was necessary to improve both coping methods and wellness with stress reducing strategy, while the mother with developmental disordered children were needed strategies to reduce stress and improve wellness.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.12 no.1
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• pp.51-70
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• 2001

Characteristics of handwriting were investigated and compared between the patients with writing disabilities and normal elementary school pupils. Generally, the heights of the letters of the patients were significantly larger than those of normal children, and letters of the patients were more sparsely distributed than those of controls. The distance between the words were significantly reduced in the patients’ writings, which indicated that patients had much more problems of space-leaving than normal pupils. Letter heights differences were significant across all grades in the patients and normal controls. The heights of the letters decreased as they grew older, and the slope of the decrements were more steeper in normal girls(r=-0.45) than girls with writing disabilities(r=-0.16). Sex differences were found in the letter spacings in low grades(grades 1, 2), that is, the distances between the letters were significantly narrower in the male patients than normal boys in these grades, and the differences were almost indiscriminating in grades 3 through 5, and finally, in sixth grade, letter spacings were signifycantly broader in normal boys than male dysgraphics. In girls, letter spacings were significantly broader in the patients across all grades. These findings supports the hypothesis that male and female writings were qualitatively different and that distinct mechanisms served in boys and girls dysgraphics. Across all grades and sexes, spaces between the words of the patients were significantly broader than normal pupils, which suggested that space-leaving between the words was important in Korean writings. There was trend that letter spacings and word spacings decreased across grades, but in girls, no correlations between the letter spacings and grades were found. Correlation analyses revealed that letter heights and letter spacings had mild correlation(r=0.11-0.15), and that letter spacings and word spacings had robust correlation(r=0.99). Phonological errors were mostly found in last phoneme(Jong-seong), especially double-phoneme(ㄳ, ㄵ, ㄶ, ㄺ, ㄻ, ㄼ, ㄾ, ㄿ, ㅀ, ㅄ), and in the case the sound values changed due to assimilations of phonemes. Semantic errors were rare in both groups. Space-leaving errors were correlated with phonological errors, and more frequent in boys than girls. In conclusion, significant differences existed in the letter heights, letter spacings, word spacings, and frequencies of phonological errors and spaceleaving errors between the patients with writing disabilities and normal pupils. The characteristics of writings changed across grades and the developmental profiles were somewhat quantitatively different between the groups. The differences became obvious from the second-third grades.

• The Journal of Korean Academy of Sensory Integration
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• v.7 no.2
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• pp.1-12
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• 2009

Objective : The purpose of this study is to find out whether group approach of sensory integration (SI) enhances sensory processing, fine motor function, and social skill for the children with sensory integration disorders. Method : Three children with problems related in sensory integration had got received 21 intervention sessions. We evaluated children with sensory profile(SP), social maturity test, Korean-developmental test of visual perception(K-DTVP), Bruininks-Oseretsky Test of Motor Proficiency(BOTMP) before-and after intervention. The statistical significance of data is tested by the Wilcoxon matched-pair signed rank test. Results : All data of post-intervention did not show any statistically significant differences; SP, social maturity test, K-DTVP, BOTMP. Conclusions : This study is to verify the effect of group SI intervention on sensory processing, fine motor function, and social skill for children with sensory integration disabilities. The results were not statistically significant. However, the average score after SI intervention has been improved in the section of fine motor and social skill comparing to that of pre-intervention period. It would have positive impact for children with sensory integration disabilities. It is needed to study with the larger number of target children and more often treatment session are suggested. The confounding variables also should be controlled in the further study.