• Proceedings of the KSAR Conference
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• 2001.03a
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• pp.15-15
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• 2001

We recently demonstrated that satellite regions exhibit an aberrant DNA methylation in cloned bovine embryos. Here, we examined, using bisulfite -sequencing technology, whether the inefficient demethylation of cloned donor genomes could be rescued by the presence of oocytic nuclei. Both AciI digestion and sequencing analyses showed that satellite sequence was demethylated more efficiently in cloned tetraploid blastocysts than in diploid clones. When methyl -CpG density (the number of methyl-CpG sites per string) was scored, a significant decrease was observed In tetraploids (P<0.001). These results suggest that unknown mechanisms provided by oocytic nuclei could assist the demethylation of satellite sequences in tetraploid clones.

• The Journal of the Korea Contents Association
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• v.20 no.8
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• pp.466-479
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• 2020

The purpose of this study was to explore the possibility of jobs for people with developmental disabilities in social farming and to derive job-creation plans. To this end, we analyzed the cases of social farms targeted for people with developmental disabilities among overseas social farming activities. And we visited and observed 5 social farms in Korea and interviewed the person in charge. The content of the study was to grasp the meaning and possibility of social farming as a job for people with developmental disabilities, and to explore ways to create a sustainable job for people with developmental disabilities in social farming. As a result of the study, social farming in Korea is in its infancy, and most of the activities are centered on agricultural experiences focused on healing and care for people with developmental disabilities. In the future, it was concluded that continuous agricultural education and activities are sufficient as suitable agricultural jobs for people with developmental disabilities. Based on these results, this study proposed a job model for people with developmental disabilities in social farming. The job model presented in this study is largely divided into a healing-oriented experience model, a care-oriented protective work model, and a social job model. In addition, a smart farm model and a plant factory model were added to the social job model.

• The Journal of the Korea Contents Association
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• v.10 no.11
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• pp.275-284
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• 2010

The purpose of this study is to investigate the relationship between family environment and developmental delay in a sample of normal 3-5 years old children. Developmental evaluation is performed using K-DDST II and K-ASQ. Family environment is researched by survey. The survey questions include children's order, family numbers, religion, patient's age, patient's education history. Subject is selected between the age of 3-5 years old children. The test has been conducted to find an interrelationship between a developmental delayed result and family environment. Study has found that there is a strong relationship between developmental delay and children's family environment. Family environment factor includes children's gender, birth order, parent's age, education history. Therefore, developmental evaluation must have consideration on the element of children's family environment for developmental delay test because of a strong relationship between family environment and developmental delay result.

• Journal of the Korea Society of Computer and Information
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• v.25 no.11
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• pp.255-262
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• 2020

The purpose of this study is to find out an effective way for students with developmental disabilities to use smartphone applications as a social real life tools in a society. For the purpose of this study, the researcher reviewed relevant previous literature on topics such as "students with developmental disabilities, information society, use of smartphone, and application use". The results of this study are as follows. First, the researcher describes strategies to support students with developmental disabilities living in an information society to improve their social integration ability by using smartphone. Second, it describes the types of smartphone applications that could support the social real life of students with developmental disabilities. Third, it describes the needs of smartphone applications to improve social adaptability of students with developmental disabilities. The results of this study will lead students with developmental disabilities to learn and use various functions of smartphone in the information society to interact with people around them and improve their communication skills. In addition, the results can be used as basic data to develop and support appropriate applications that can help vocational rehabilitation and social integration of students with developmental disabilities.

• Proceedings of the Botanical Society of Korea Conference
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• 1996.06a
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• pp.68-78
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• 1996

Two types of immunoloigcal probes, anti-ABBP Abs, have been developed. The purified ABBP from ABA-C1-BSA-sepharose 4B column was identified by PAGE and appeared in one band of about 56KD, as well as showed a specific binding ability and a high affinity for ABA (Kd2.0$\times$10-9 mol/L). Unexpectedly, the existence of rRNA with a length of around 300 nucleotides could be found, when the ABBP was digested with proteinase K and identified by eletrophorsis on an agarose gel (1%). As a result, about 120 cDNA clones coding maize 17s RNA and only one cDNA clone coding ABBP (24cDNA) were obtained from 200,000 seperated phage plaques by the anti-ABBP pAbs. 24cDNA had 1075bp and contained an open reading frame coding 254 amino acids. The anti-idiotypic Ab raised against an ABA MAb showed the ability of either mimicking ABA or competing with ABA. The localization of ABBPs in plant cell was investigated.

• Research in Community and Public Health Nursing
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• v.12 no.1
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• pp.49-59
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• 2001

Purpose: This study was intended to develop the framework of public health center based 'Child growth and developmental clinic' and analyze the efficiency of services. This was the part of Mother-Child Health Guidance Project by the Public Health Center in Seoul. The purposes of this project were to improve children's health and development with early detection of developmental delay by screening test, and to assist and guide the parent for child care and rearing, so that children can reach their maximum potential. Method: Framework and standards for operation of 'Child growth and development clinic' were developed. We selected screening tool. developed parent education materials, and educated the personnel of public health center. Result: 243 children were enrolled for developmental screening, and we detect the children with developmental delay and referred them for further evaluation. The proportion of developmental delayed children was approximately 2% of the enrolled children. Also, we analyzed the characteristics of enrolled children, and their parental needs and attitude on child rearing. Some problems in operation of developmental clinic were discussed. Conclusion: Though we can found some limitations, we are confident that pubic health center can be charge of important role for improving child development for the majority. This study will be the basis of children's developmental clinic running by public health center.

• The Journal of the Korea Contents Association
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• v.21 no.11
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• pp.711-722
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• 2021

The purpose of this study is to explore the effects of employment for people with developmental disabilities on their social activities. As a research method, cross-analysis, correlation analysis, and logistic regression analysis were performed using questionnaire data on employment status and social activity for 391 persons with developmental disabilities. As a result of the analysis, first, employment for people with developmental disabilities was found to be significant in social activities. In other words, 79.7% of those with developmental disabilities who were employed participated in social activities, and 39.3% of those who were not employed. Second, employment for people with developmental disabilities, whose personal characteristics were carefully verified as a control variable, had a significant effect on social activities and increased by 5.2 times. According to the results of the study, it can be seen that active employment support for people with developmental disabilities and policy efforts for employment are required for participation in social activities of people with developmental disabilities. Finally it was suggested to supported employment, expand standard workplaces for the disabled, introduce a job coach system, and establish a network with related organizations.

• Child Health Nursing Research
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• v.13 no.2
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• pp.222-229
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• 2007

Purpose: This study was done to evaluate the validity of the Korean - Child Development Review in screening children with developmental risks. Method: The participants in the study were 172 children aged 6-75 months old and their parents. Data were collected by questionnaire or interview. Korean Denver II and Bayley test were administered with K-CDR for validation of children who were referred for developmental assessment at D University Hospital or public health center. The data were analyzed using correlation, $X^2$ test, and cross tab analysis. Results: There was a significant relationship between the K-CDR and Korean Denver II. The correlation coefficients were .42 to .61 by developmental sector. The sensitivity and specificity of K- CDR were .84 and .66 respectively when "abnormal" with MDI of Bayley test defined as lower than 85 the score which was used as a diagnosis of developmental delay. The responses to 6 questions for parents showed significant differences according to 3 groups by developmental state. Parents of children in the developmental disability group more frequently checked problems from the 26 problem checklist about their children's development and behavior. Conclusion: The results show that K-CDR is valid and has good sensitivity and moderate specificity in screening developmental delay.

• Journal of Korean Clinical Health Science
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• v.2 no.1
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• pp.47-57
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• 2014

Purpose. The purpose of this study is to investigate effects of group play therapy program on improvement of social skills of children with developmental disabilities. Methods. With 4-year children with developmental disabilities with developmental problems, group play therapy program with 16 sections, 40minutes for each section for 16 weeks was conducted, and by using Korean infant social skills test (K-SSRSP), social skills index (SSQ) between before and after applying group play therapy program on children with developmental disabilities were compared. Results. When group play therapy are applied on children with developmental disabilities, it was found that there was improvement of social skills including problem solving, emotional expression, sense of order and self-confidence. Conclusions. According to the result of this study, if more specific studies regarding group play therapy program are conducted and they can reflect on other integrated programs, then it is expected that there will be greater synergy effects on improving not only children with developmental disabilities but also social skills of them.

• Toxicological Research
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• v.29 no.4
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• pp.221-227
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• 2013

Embryonic stem (ES) cells have potential for use in evaluation of developmental toxicity because they are generated in large numbers and differentiate into three germ layers following formation of embryoid bodies (EBs). In earlier study, embryonic stem cell test (EST) was established for assessment of the embryotoxic potential of compounds. Using EBs indicating the onset of differentiation of mouse ES cells, many toxicologists have refined the developmental toxicity of a variety of compounds. However, due to some limitation of the EST method resulting from species-specific differences between humans and mouse, it is an incomplete approach. In this regard, we examined the effects of several developmental toxic chemicals on formation of EBs using human ES cells. Although human ES cells are fastidious in culture and differentiation, we concluded that the relevancy of our experimental method is more accurate than that of EST using mouse ES cells. These types of studies could extend our understanding of how human ES cells could be used for monitoring developmental toxicity and its relevance in relation to its differentiation progress. In addition, this concept will be used as a model system for screening for developmental toxicity of various chemicals. This article might update new information about the usage of embryonic stem cells in the context of their possible ability in the toxicological fields.