• Korean Journal of Agricultural Science
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• v.43 no.1
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• pp.40-51
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• 2016

This study analyzed settlement condition changes of Chungcheong region's mountain area during 10 years, from 2001 to 2012. We performed factor analysis and cluster analysis of data from the 'Census for Mountain Area' carried out by the Korea Forest Service in 2001 and 2012. Factors 1, 2, 3, and 4 represent 'the superiority of non-agricultural income', 'the industrialized mountainous area', 'residential conveniences and benefits', and 'the use of forest resources', respectively. Clusters 1, 2, 3, 4, and 5 are categorized as 'non-agricultural income', 'various mass social functions', 'production of forest products', 'industrialized mountainous region', and 'ordinary mountain region', respectively. We suggest that cluster 1 has potential for development and should be promoted as a possible tourist attraction by digging up geographically unique themes. Cluster 2 has great potential for development and needs planned management through the maintenance or expansion of existing infrastructure. Cluster 3 has potential for development with various high value added industries uncovered. Cluster 4 shows vitality as it holds plenty of more job opportunities than other regions. Cluster 5 is deteriorating as a mountainous region because of an aging population, and it urgently demands development. For a decade, 45 of the 60 regions belonged to a single category, which are now differentiated broadly into two types: Firstly, deterioration changes to potential development and Secondly, vitality is differentiated into potential development and deterioration.

• Journal of Digital Convergence
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• v.11 no.12
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• pp.21-28
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• 2013

This study conducted a survey 361 immigrants by Cheongju Yullyang II Land Development Projects of Chungbuk, Multifunctional Administrative City Construction Projects and analyzes the factor which affects their residential satisfaction. The result of study is as follows. The level of subjects' residential satisfaction is 5.35(SD=1.33) which is average. By looking the level of related factors which affect residential satisfaction, the levels of facilities region and residential environment region are normal. The levels of housing environment and trust of development are lower than the normal. To figure out the factor which affects residential satisfaction, a regression analysis is conducted. The result showed that age of research subject, family type, residence period, physical status, owner or renter, housing environment region, facilities region, residential environment region, and trust of development among factors related to residential satisfaction affect the residential satisfaction. Based on these results, several ways are suggested to improve residential satisfaction of the immigrants.

• The Korean Journal of Rehabilitation Nursing
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• v.2 no.2
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• pp.234-242
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• 1999

The meaning of the study is in the following points. The first is to find the linguistic development of children through IQ test. The second is to find the family fostering factor for the linguistic development. For these meaning this study will have the following aims. 1) To judge the similarly agreement between the children lexical ability with the teachers evaluation to the children. 2) To compare the gender differences of lexical abilities between the urban with the rural. 3) To find the family fostering factors for the children linguistic development. The collection data has been from April 13, 1999 to April 27. The subjects for this study were two grade of elementary school, which is located in "K" city and "O"rural a chosen students(273), teachers(5), parents(176). The instruments used for this study were IQ test by Korea Behavioral Science institute and family fostering environment 25 items. Teachers linguistic evaluation. The data analysis was done using Pearson's Correlation Coefficient, t-test, ANOVA using SPSS/pc program. This study found following results. 1) The similarly agreement degree between children lexical abilities with teachers comprehending evaluation maler r= .745, female r=0.809 The similarly agreement degree between children lexical abilities with teachers expressing evaluation, male r= .657, female r= .797(P<.01) 2) In comparing of the gender difference of urban, the femail is a little high than male(t= .5065), but the especial point is more large difference in male than in female. In comparing of the gender difference of rural, the female is especial high than the male(t=-4.411). (P<.01) 3) The higher factor of influencing the linguistic development is the breast-feeding(r=-.3279) in all the gender(P<.01), So that the brast-feeding better than cow's milk, mother better than the other family members in feeding, 6~8months better than one or two years in feeding term.

• Parasites, Hosts and Diseases
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• v.58 no.3
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• pp.249-255
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• 2020

Toxoplasma gondii, a ubiquitous, intracellular parasite of the phylum Apicomplexa, infects an estimated one-third of the human population as well as a broad range of warm-blooded animals. We have observed that some tyrosine kinase inhibitors suppressed the growth of T. gondii within host ARPE-10 cells. Among them, afatinib, human epithermal growth factor receptor 2 and 4 (HER2/4) inhibitor, may be used as a therapeutic agent for inhibiting parasite growth with minimal adverse effects on host. In this report, we conducted a proteomic analysis to observe changes in host proteins that were altered via infection with T. gondii and the treatment of HER2/4 inhibitors. Secreting proteins were subjected to a procedure of micor basic reverse phase liquid chromatography, nano-liquid chromatography-mass spectrometry, and ingenuity pathway analysis serially. As a result, the expression level of heterogeneous nuclear ribonucleoprotein K, semaphorin 7A, a GPI membrane anchor, serine/threonine-protein phosphatase 2A, and calpain small subunit 1 proteins were significantly changed, and which were confirmed further by western blot analysis. Changes in various proteins, including these 4 proteins, can be used as a basis for explaining the effects of T. gondii infections and HER2/4 inhibitors.

• Journal of Animal Science and Technology
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• v.54 no.6
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• pp.383-394
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• 2012

Microarray analyses provide information that can be used to enhance the efficiency of livestock production. For example, microarray profiling can potentially identify the biological processes responsible for the phenotypic characteristics of porcine liver. We performed transcriptome profiling to identify differentially expressed genes (DEGs) in liver of pigs from two breeds, the Korean native pigs (KNP) and Yorkshire pigs. We correctly identified expected DEGs using factor analysis for robust microarray summarization (FARMS) and robust multi-array average (RMA) strategies. We identified 366 DEGs in liver (p<0.05, fold-change>2). We also performed functional analyses, including gene ontology and molecular network analyses. In addition, we identified the regulatory relationship between DEGs and their transcription factors using in silico and qRT-PCR analysis. Our findings suggest that DEGs and their transcription factors may have a potential role in adipogenesis and/or lipid deposition in liver tissues of two pig breeds.

• BMB Reports
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• v.42 no.6
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• pp.338-343
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• 2009

The Wnt/$\beta$-catenin signaling pathway alters adipocyte differentiation by inhibiting adipogenic gene expression. $\beta$-catenin plays a central role in the Wnt/$\beta$-catenin signaling pathway. In this study, we revealed that tumour necrosis factor-$\alpha$ (TNF-$\alpha$), a potential negative regulator of adipocyte differentiation, inhibits porcine adipogenesis through activation of the Wnt/$\beta$-catenin signaling pathway. Under the optimal concentration of TNF-$\alpha$, the intracellular $\beta$-catenin protein was stabilized. Thus, the intracellular lipid accumulation of porcine preadipocyte was suppressed and the expression of important adipocyte marker genes, including peroxisome proliferator-activated receptor-$\gamma$ (PPAR$\gamma$) and CCAAT/enhancer binding protein-$\alpha$ (C/EBP$\alpha$), were inhibited. However, a loss of $\beta$-catenin in porcine preadipocytes enhanced the adipogenic differentiation and attenuated TNF-$\alpha$ induced anti-adipogenesis. Taken together, this study indicated that TNF-$\alpha$ inhibits adipogenesis through stabilization of $\beta$-catenin protein in porcine preadipocytes.

• Journal of Biosystems Engineering
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• v.39 no.3
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• pp.151-157
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• 2014

Purpose: In order to develop strategies to prevent farm-work accidents relating to agricultural machinery, influential factors were examined in this paper. The effects of these factors were quantified using logistic regression. Methods: Based on the results of a survey on farm-work accidents conducted by the National Academy of Agricultural Science, 21 tentative independent variables were selected. To apply these variables to regression, the presence of multicollinearity was examined by comparing correlation coefficients, checking the statistical significance of the coefficients in a simple linear regression model, and calculating the variance inflation factor. A logistic regression model and determination method of its goodness of fit was defined. Results: Among 21 independent variables, 13 variables were not collinear each other. The results of a logistic regression analysis using these variables showed that the model was significant and acceptable, with deviance of 714.053. Parameter estimation results showed that four variables (age, power tiller ownership, cognizance of the government's safety policy, and consciousness of safety) were significant. The logistic regression model predicted that the former two increased accident odds by 1.027 and 8.506 times, respectively, while the latter two decreased the odds by 0.243 and 0.545 times, respectively. Conclusions: Prevention strategies against factors causing an accident, such as the age of farmers and the use of a power tiller, are necessary. In addition, more efficient trainings to elevate the farmer's consciousness about safety must be provided.

• YAKHAK HOEJI
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• v.40 no.1
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• pp.84-89
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• 1996

This study was done to investigate the effect of glycyrrhizin on the lethality induced by galactosamine and lipopolysaccharide coadministration in mice. Glycyrrhizin was injecte d intravenously as a multiple dose at 20, 15, 10, 5, and O hr before galactosamine and lipopolysaccharide coadministration. Lethality and tumor necrosis factor (TNF${\alpha}$) level in serum were surveyed as markers of glycyrrhizin effect. Glycyrrhizin had no effect on the lethality induced by galactosamine and lipopolysaccharide when glycyrrhizin was administered as a single dose. Glycyrrhizin reduced the lethality induced by galactosamine and LPS in dose-dependent manner when glycyrrhizin was administered as a multiple dose at 20, 15, 10, 5 and O hr before galactosamine and lipopolysaccharide coadministration. Glycyrrhizin reduced the serum TNF${\alpha$ level.

• Korean Journal of Agricultural Science
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• v.46 no.3
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• pp.653-660
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• 2019

Ganoderma lucidum, an oriental polypore fungus and medicinal mushroom, has a long history of use for promoting health and longevity in Korea, China, and other Asian countries. This study was aimed at determining the anti-inflammatory activity and mechanism of action of Ganoderma lucidum in murine macrophage RAW 264.7 cells. Ganoderma lucidum was extracted with ethanol and freeze-dried. The anti-inflammatory effect (nitrite production) of Ganoderma lucidum extracts was tested using a nitric oxide (NO) colorimetric assay. Semi-quantitative reverse transcription polymerase chain reaction (RT-PCR) was performed to quantify the mRNA expression of cytokines including tumor necrosis factor-${\alpha}$ ($TNF-{\alpha}$), interleukin $(IL)-1{\beta}$, and IL-6. Western blotting was performed to measure the expression levels of inflammation-related proteins, such as inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), nuclear factor kappa B ($NF-{\kappa}B$) p65, and phosphorylated $NF-{\kappa}B$ p65. The NO colorimetric assay showed that NO production increased with the treatment of lipopolysaccharide in (LPS)-activated RAW 264.7 macrophages and decreased with the cotreatment of Ganoderma lucidum extracts and LPS. Ganoderma lucidum extracts repressed the mRNA expressions of cytokines, which were increased after the LPS treatment. In addition, Ganoderma lucidum extracts inhibited the LPS-induced expression of iNOS and COX-2 and the LPS-induced phosphorylation of $NF-{\kappa}B$ p65. These results suggest that the Ganoderma lucidum extracts exert an anti-inflammatory activity by inhibiting $NF-{\kappa}B$ related proteins and cytokines.

• International Journal of Computer Science & Network Security
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• v.22 no.4
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• pp.209-216
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• 2022

The modern development of higher education in Ukraine is the result of two main factors. One of them - the factor of social progress - reflects the transformations inherent in modern Ukrainian society. These include, first of all, the processes of democratization and the development of civic responsibility. European the choice of Ukraine, the integration of our state into the European space determine accordingly, the second factor influencing the development of domestic higher education - the trends that guide the progress of the European Higher Education Area (European Higher Education Area (hereinafter - EHEA) and the European Research Area Research Area, hereinafter - ERA). The strategy of information support of the educational process (approved by the European Commission in 2010) recognizes the leading role of higher education as a driver of social progress, accordingly states the priority - the development of free economic education and identifies indicators of such progress - the achievement and international attractiveness of European free economic education. The information support of modernization challenges in higher education are aimed at the educational process, the leadership position of students, in particular through promotion and implementation of leading achievements and best practices in the context of globalization.