• Title/Summary/Keyword: Detoxification.

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Protection and Detoxification Effects of Oriental Herb Extract Mixture on TCDD-Induced Oxidative Stress (TCDD로 유발된 Oxidative Stress에 대한 생약재 추출물의 방어 및 해독효과)

  • Hwang, Jin-Kook;Lee, Kyung-Jin;Yang, Hee-Jin;Park, Ki-Moon
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.37 no.3
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    • pp.294-301
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    • 2008

  • This study was carried out to investigate the protective effects and detoxification of oriental herb extracts mixture (Saururus chinensis, Taraxacum platycarpum, Ulmus macrocarpa, Glycyrrhiza glabra, Rhynchosia nulubilis) on TCDD-induced oxidative stress. Thirty five male rats were divided into 5 groups: normal control group received saline; vehicle control group received DMSO and acetone; only TCDD-treated group received multiple intraperitoneal injection of TCDD ($100{\mu}g/kg$) and saline; post-treated group of OHEM (400 mg/kg/day) received oral administration for 5 weeks after TCDD treatment; and pre-treated group of OHEM (400 mg/kg/day) received oral administration for 6 weeks from 1 week before TCDD treatment. The elevated serum activities of alanine transaminase (AST), aspartate transaminase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and atherorganic index due to TCDD were significantly decreased by the treatment of OHEM (p<0.05); the pre-treatment of OHEM was especially effective. Hydropic lesions and cytoplasmic vacuolizations in the liver of TCDD-treated rats were inhibited by the treatment of OHEM. Also, OHEM treatment reduced edemas in small intestine villus of TCDD-treated rats. These results suggest that OHEM from various oriental herb extracts might be a useful protective and detoxification agent against TCDD.

  • https://doi.org/10.3746/jkfn.2008.37.3.294 인용 PDF KSCI

A Study on the Detoxification of Chrysotile and the use of High-density Extruded Cement Panel Reinforcement Fibers (백석면의 무해 섬유화 처리 방법과 고밀도 압출성형 패널 활용 연구)

  • Jang, Kyong-Pil;Kim, Tae-Hyoung;Song, Tae-Hyeob
    • Journal of the Korean Recycled Construction Resources Institute
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    • v.9 no.2
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    • pp.223-228
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    • 2021

  • The final disposal method for asbestos building materials is to be landfilled at a designated waste landfill in accordance with the Waste Management Act. However, it is difficult to secure a domestic designated waste landfill site to landfill the entire amount of asbestos waste, which is expected to emit more than 400,000 ton/year by 2044. In this study, a detoxification treatment was performed on a ceiling tex with a density of 1.0 to 1.2g/cm3 containing 3 to 7% of chrysotile, and it was used as a reinforcing fiber for extruded panels. It was confirmed that asbestos components were detoxified through the reaction process using 30% oxalic acid and carbon dioxide, and it was recognized that these detoxifying properties were maintained even after extrusion molding. However, it was found that milling to a fiber size of less than 1mm for complete detoxification of asbestos resulted in a decrease in reinforcing performance. Therefore, in the case of using detoxified asbestos fibers in the extrusion molding process, it is considered desirable to add fibers with a length of 5mm or more to improve the reinforcing performance.

  • https://doi.org/10.14190/JRCR.2021.9.2.223 인용 PDF KSCI

Degradation and Detoxification of Disperse Dye Scarlet RR by Galactomyces geotrichum MTCC 1360

  • Jadhav, S.U.;Ghodake, G.S.;Telke, A.A.;Tamboli, D.P.;Govindwar, S.P.
    • Journal of Microbiology and Biotechnology
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    • v.19 no.4
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    • pp.409-415
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    • 2009

  • Galactomyces geotrichum MTCC 1360 degraded the Scarlet RR(100 mg/l) dye within 18 h, under shaking conditions(150 rpm) in malt yeast medium. The optimum pH and the temperature for decolorization were pH 12 and $50^{\circ}C$, respectively. Enzymatic studies revealed an induction of the enzymes, including flavin reductase during the initial stage and lignin peroxidase after complete decolorization of the dye. Decolorization of the dye was induced by the addition of $CaCO_3$ to the medium. EDTA had an inhibitory effect on the dye decolorization along with the laccase activity. The metabolites formed after complete decolorization were analyzed by UV-VIS, HPLC, and FTIR. The GC/MS identification of 3 H quinazolin-4-one, 2-ethylamino-acetamide, 1-chloro-4-nitro-benzene, N-(4-chloro-phenyl)-hydroxylamine, and 4-chloro-pheny-lamine as the final metabolites corroborated with the degradation of Scarlet RR. The phytotoxicity study revealed the nontoxic nature of the final metabolites. A possible degradation pathway is suggested to understand the mechanism used by G. geotrichum and thereby aiding development of technologies for the application of this organism to the cleaning-up of aquatic and terrestrial environments.

  • https://doi.org/10.4014/jmb.0804.294 인용 PDF KSCI