• Proceedings of the Korean Society for Bioinformatics Conference
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• 2006.02a
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• pp.83-89
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• 2006

Cellular functions are carried out by a concerted action of biochemical pathways whose components have genetic interactions. Abnormalities in the activity of the genes that constitute or modulate these pathways frequently have oncogenic implications. Therefore, identifying the upstream regulatory genes for major biochemical pathways and defining their roles in carcinogenesis can have important consequences in establishing an effective target-oriented antitumor strategy We have analyzed the gene expression profiles of human liver cancer samples using cDNA microarray chips enriched in liver and/or stomach-expressed cDNA elements, and identified groups of genes that can tell tumors from non-tumors or normal liver, or classify tumors according to clinical parameters such as tumor grade, age, and inflammation grade. We also set up a high-throughput cell-based assay system (cell chip) that can monitor the activity of major biochemical pathways through a reporter assay. Then, we applied the cell chip platform for the analysis of the HCC-associated genes discovered from transcriptome profiling, and found a number of cancer marker genes having a potential of modulating the activity of cancer-related biochemical pathways such as E2F, TCF, p53, Stat, Smad, AP-1, c-Myc, HIF and NF-kB. Some of these marker genes were previously blown to modulate these pathways, while most of the others not. Upon a fast-track phenotype analysis, a subset of the genes showed increased colony forming abilities in soft agar and altered cell morphology or adherence characteristics in the presence of purified matrix proteins. We are currently analyzing these selected marker genes in more detail for their effects on various biological Processes and for Possible clinical roles in liver cancer development.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.48 no.1
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• pp.71-79
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• 2011

The objective of the imaging pipeline is to transform the original scene into a display image that appear similar, Generally, gamma adjustment or histogram-based method is modified to improve the contrast and detail. However, this is insufficient as the intensity and the chromaticity of illumination vary with geometric position. Thus, MSR (Multi-Scale Retinex) has been proposed. the MSR is based on a channel-independent logarithm, and it is dependent on the scale of the Gaussian filter, which varies according to input image. Therefore, after correcting the color, image quality degradations, such as halo, graying-out, and dominated color, may occur. Accordingly, this paper presents a novel color correction method using a modified image formation model in which the image is divided into three components such as global illumination, local illumination, and reflectance. The global illumination is obtained through Gaussian filtering of the original image, and the local illumination is estimated by using JND-based adaptive filter. Thereafter, the reflectance is estimated by dividing the original image by the estimated global and the local illumination to remove the influence of the illumination effects. The output image is obtained based on sRGB color representation. The experiment results show that the proposed method yields better performance of color correction over the conventional methods.

• Korean Journal of Remote Sensing
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• v.15 no.2
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• pp.131-146
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• 1999

The satellite visible data have been successfully applied to study the ocean color. Another ocean color sensor, the Ocean Scanning Multi-spectral Imager (OSMI) on the Korea Multi-Purpose Satellite (KOMPSAT) will be launched in 1999. In order to understand the characteristics of future OSMI images, we have first discussed the simulation models and procedures in detail, and produced typical patterns of radiances at visible bands by using radiative transfer models. The various simulated images of full satellite passes and Korean local areas for different seasons, water types, and the satellite crossing equator time (CET) are presented to illustrate the distribution of each component of radiance (i.e., aerosol scattering, Rayleigh scattering, sun glitter, water-leaving radiance, and total radiance). A method to evaluate the image quality and availability is then developed by using the characteristics of image defined as the Complex Signal Noise Ratio (CSNR). Meanwhile, a series of CSNR images are generated from the simulated radiance components for different cases, which can be used to evaluate the quality and availability of OSMI images before the KOMPSAT will be placed in orbit. Finally, the quality and availability of OSMI images are quantitatively analyzed by the simulated CSNR image. It is hoped that the results would be useful to all scientists who are in charge of OSMI mission and to those who plan to use the data from OSMI.

• Journal of Korea Water Resources Association
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• v.54 no.spc1
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• pp.1155-1166
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• 2021

In this study, statistical analysis was performed to suggest the optimal analysis techniques for the main measuring instruments of the fill dam, such as seepage, crest settlement, and porewater pressure gauge. In addition, correlation analysis with water level and rainfall data was performed. Based on the results of descriptive statistical analysis for each instrument, porewater pressure gauges could be classified into 3 groups or 2 groups through principal component analysis, In the case of the group having a high correlation with the water level instrument, the correlation between the gauges was also large. In the case of seepage instrument, the distribution showed an extremely asymmetric distribution, so for quantitative analysis, the average seepage during non-precipitation and precipitation could be estimated through decision tree analysis. In the case of the crest settlement instrument, the correlation analysis showed that the correlation between the gauges was large, but the relationship with the water level instrument did not show a significant linear relationship, so EMD analysis was performed to analyze it in more detail. It is judged that principal component analysis, decision tree analysis, and data filtering method can be applied to analyze the behavior of pore water pressure meters, seepage, and crest settlement instrument as major measurement items of fill dam.

• Korean Journal of Construction Engineering and Management
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• v.20 no.2
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• pp.113-118
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• 2019

Recently, the maintenance concept of infrastructure has been changed from the stability management of the structure determined by the safety inspection of the existing facilities to the asset management related to evaluating and managing the performance of the facilities. For management of the property of the facilities, it is necessary to efficiently classify their information for the maintenance and service level of the facilities and to manage them. In the case of power plant facility, especially, it is a complex structure, which is constructed in a various component and detail. In this study, therefore, the components of power plant facility were classified into facilities, spaces, parts, and elements considering the type of integrated construction classification system in Korea. To reflect the deterioration rate of the facility in accordance with environmental conditions such as airborne salt and humidity etc., it was classified by adding direction, interior, and exterior condition of each component not to be considered in the existing classification system for its effective and systematic maintenance, since it is generally located in the coastal area due to the operation of the power generation structure. The classification system developed in this study can be used as fundamental data for development of the computer system for asset management of power plant facility.

• Korean Journal of Remote Sensing
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• v.34 no.6_1
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• pp.857-868
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• 2018

The microphysics and spatio-temporal distribution of atmospheric aerosols are responsible for estimating the optical properties at a given location. Its accurate estimation is essential to plan efficient simulation for radiative transfer. For this sake, synergetic use of reanalysis data with optics database was used as a potential tool to precisely derive the aerosol model on the basis of the major representative particulates exist within a model grid. In detail, mixing of aerosol types weighted by aerosol optical depth (AOD) components has been developed. This synergetic aerosol model (SAM) is spectrally extended up to $40{\mu}m$. For the major aerosol event cases, SAM showed that the mixed aerosol particles were totally different from the typical standard aerosol models provided by the radiative transfer model. The correlation among the derived aerosol optical properties along with ground-based observation data has also been compared. The current results will help to improve the radiative transfer model simulation under the real atmospheric environment.

• Journal of the Korean Institute of Traditional Landscape Architecture
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• v.37 no.1
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• pp.76-84
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• 2019

This study was conducted for the purpose of examining the Outstanding Universal Value, World Heritage Values, in Suzhou classical gardens and the operational method of the protection management of historic gardens, and the results of the study are as follows; The first, as a world heritage, Suzhou gardens proved OUV by showing the taste and lifestyle of the literati, the unique class of Chinese history, to the natural environment of the East Yangtze Delta region. In addition, it showed the exchange of international culture with unique Chinese garden techniques. Second, a authentic reconstruction of garden have original value because it exist records of the near past. The 20th-century archives described by the contemporary language and describing the heritage through images using such media as photography and drawing played a decisive role in restoring gardens. Third, the protection management of Suzhou gardens, which began in the 1950s, was carried out in detail, including the reconstruction of components such as buildings, the restoration of plant materials and horticulture technique, the creation of a list through the records of trees, the maintenance of props such as plaque, furniture, and the project to improve water quality and restore waterscape. The last, after the World Heritage inscribing, Garden's protection management was proceeded in two directions. One is that through the reorganization of the administrative management system and the enactment of laws related to Suzhou classical Gardens, the listing heritage is strictly protected and managed, and the other is that the historical gardens are used to establish urban masterplan and urban identity in Suzhou. The range of garden properties greatly expanded by distinguishing the principle of conservation from protection to rational use and the grade of protection, such as whole protection, maintenance protection and protection of historical sites.

• Journal of the Korean Society for Library and Information Science
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• v.55 no.3
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• pp.17-56
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• 2021

The purpose of this study was to focus on the discussion on the introduction of the librarian qualification certification system, which is being discussed as a way to raise the qualification level of experts as a system for expert certification and to raise social awareness as experts. First, the introduction of the library and information science curriculum certification system was discussed. Second, the issues to be considered when introducing the certification system were discussed. In other words, we analyzed in depth what matters we should consider when discussing the certification system. Third, the components of domestic and overseas certification systems were investigated and analyzed, and measures applicable to the librarian qualification certification system were discussed. Fourth, it was proposed to introduce a certification system for the Department of Library and Information Science. Also, based on the results of the analysis, it was suggested what could be a problem when introducing the certification system to the Department of Library and Information Science in Korea and what contents should be reviewed. In this study, in order to propose the introduction of the librarian qualification certification system, the purpose of the librarian qualification certification system, the certification criteria, the certification institution, and the contrast between the university and the Department of Library and Information Science were also dealt with in detail.

• Korean small business review
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• v.43 no.4
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• pp.95-115
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• 2021

Quality is an important factor influencing organizational performance, so it should be possible to accurately and effectively measure the quality perceived by members. The Consumer Cooperative can be seen as a retail industry by industry classification, and there are various studies based on the dimension of retail quality, but compared to the general retail industry, few studies have been conducted based on the quality level perceived by members. The purpose of this study is to develop quality dimensions and sub-attributes by analyzing in detail and elaborately how the quality of cooperative is viewed from the perspective of members who are both consumers and owners. To this end, the quality dimension of cooperative quality is needed to be newly developed and quality components are demonstrated based on previous studies on the quality dimension. The quality dimension of the cooperative was developed through prior research to suit the value of the cooperative in product, service, and social responsibility, and a survey was conducted to demonstrate the four major cooperative members in Korea. Through this, sub-dimensions were constructed and the quality dimension of the high-order model was demonstrated through exploratory factor analysis and confirmatory factor analysis. It aims to discover key management elements in terms of quality management and provide practical implications to management.

• The Mathematical Education
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• v.62 no.2
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• pp.175-194
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• 2023

Despite the importance of pattern learning for elementary school students, few studies have investigated in detail the understanding of patterns of lower-grade students. This study aimed to analyze the understanding of patterns of second-grade elementary school students. Since the patterns in the second grade are taught through the unit called Finding Rules, students' understanding of patterns was compared and contrasted before and after they learned the unit. To this end, a written instrument to measure students' understanding of patterns was developed on the basis of previous studies on pattern learning for lower-grade students. A total of 189 students were analyzed. As a result of the study, the overall correct answer rates in the post-test were higher in most items than those in the pre-test, illustrating the positive effect of the specific unit. However, students found it difficult to find rules in which two components would change simultaneously either in geometric or numeric patterns, find patterns that would be similar in structure, represent geometric patterns into numeric patterns, find empty terms in increasing patterns, and reason the specific terms in patterns that can be differently interpreted. Based on these research results, this study sheds light on students' understanding of patterns and suggests implications to improve their understanding.