• Title/Summary/Keyword: Destruction

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Can herbal drug(s) meet the challenges of genomewide screen results on rheumatoid arthritis

  • Paul, Bholanath
    • Advances in Traditional Medicine
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    • v.5 no.4
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    • pp.251-261
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    • 2005
  • Rheumatoid arthritis (RA) is an autoimmune/inflammatory disorder with a complex genetic component. RA is characterized by chronic inflammation of the synovial membrane in the joint, which leads to the progressive destruction of articular cartilage, ligament and bone. Several cytokines such as tumor necrosis $factor-{\alpha}\;TNF-{\alpha}\;and\;interleukin-1{\beta}\;(IL-1{\beta})$ and interleukin-6 (IL-6) have been implicated in the pathological mechanisms of synovial tissue proliferation, joint destruction and programmed cell death in rheumatoid joint. Genome wide screening of subjects suffering from autoimmune diseases especially arthritis revealed linkage to inflammatory molecules like $TNF-{\alpha},\;IL-1{\beta}$ and IL-6, inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), nuclear factor-kappaB $(NF-{\kappa}B)$ and human leucocyte antigen/major histocompatibility complex (HLA/MHC) locus. The status of the pharmacological mechanism of herbal drugs in the light of genome wide screening results has been discussed to reinforce the therapeutic potential and the pharmacological basis of the herbal drugs.

Vestibular Schwannoma Atypically Invading Temporal Bone

  • Park, Soo Jeong;Yang, Na-Rae;Seo, Eui Kyo
    • Journal of Korean Neurosurgical Society
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    • v.57 no.4
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    • pp.292-294
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    • 2015
  • Vestibular schwannoma (VS) usually present the widening of internal auditory canal (IAC), and these bony changes are typically limited to IAC, not extend to temporal bone. Temporal bone invasion by VS is extremely rare. We report 51-year-old man who revealed temporal bone destruction beyond IAC by unilateral VS. The bony destruction extended anteriorly to the carotid canal and inferiorly to the jugular foramen. On histopathologic examination, the tumor showed typical benign schwannoma and did not show any unusual vascularity or malignant feature. Facial nerve was severely compressed and distorted by tumor, which unevenly eroded temporal bone in surgical field. Vestibular schwannoma with atypical invasion of temporal bone can be successfully treated with combined translabyrinthine and lateral suboccipiral approach without facial nerve dysfunction. Early detection and careful dissection of facial nerve with intraoperative monitoring should be considered during operation due to severe adhesion and distortion of facial nerve by tumor and eroded temporal bone.

Neuropathic Arthropathy of the Shoulder Associated with Cervical Syringomyelia: A Case Report

  • Park, Jaehyun;Im, Taekang;Moon, Jinsun;Lee, Yongbeom
    • Clinics in Shoulder and Elbow
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    • v.18 no.4
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    • pp.261-265
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    • 2015
  • Neuropathic shoulder arthropathy or Charcot's shoulder is an extremely rare disease, and sometimes it is associated with cervical syringomyelia. Clinical symptoms of the disease include edema of the shoulder and restriction in range of motion. Radiological diagnosis can be made through plain radiography through a characteristic, atrophic destruction of the joint. We experienced a Charcot's joint of the shoulder wherein destruction of the joint progressed extremely quickly and reviewed the literature concerning this condition.

The Effect of Ginseng Petroleum Ether Fraction on Immunosuppressed Mice by Lead acetate (II) II. Cellular Immune Response and Histological Studies (납의 면역독성에 미치는 인삼의 영향(II) II. 세포성면역 및 조직학적 검사)

  • 김휘배;안영근;김주영;문재규
    • Environmental Analysis Health and Toxicology
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    • v.1 no.1
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    • pp.37-46
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    • 1986
  • Experiments were performed to investigate the effect of Panax ginseng petroleum ether fraction on delayed type hypersensitivity, rosette formation, phagocytic activity and histophathological influence in lead acetate treated mice. Lead acetate was administered in the drinking water and ginseng pet. ether fraction was injected i.p.. Mice were sensitized and challenged with sheep red blood cells. Erythrocyte(I) rosette formation and DTH reaction were significantly depressed in lead acetate treated mice, and those were restored administration of ginseng fraction. Ginseng pet. ether fraction administration did not have any effect on decreased phagocytic activity. Follicular and parafollicular areal destruction of spleen, and destruction of thymus were finded in lead acetate exposed-mice. Small dose of ginseng pet. ether fraction (5 mg/kg, 10 mg/kg), administraction inhibited those histopathological changes, but large dose (20 mg/kg) didn't.

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Clean-up of Contaminated Groundwater by Permeable Reactive Barrier (투수성 반응벽에 의한 오염지하수 복원효과 분석)

  • 정하익;김상근
    • Proceedings of the Korean Geotechical Society Conference
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    • 2000.03b
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    • pp.542-547
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    • 2000
  • It has become interested in the concept of permeable barriers for the containment and/or destruction of contaminated groundwater. The purpose of these trench-like barriers is to provide in situ capture and possibly destruction of the contaminant while preserving groundwater flow to uncontaminated zones. For instance, a trichloreethylene(TCE) plume may be contained by a permeable in which reactive iron reduces TCE to ethylene and ethane, compounds which can be easily biodegraded. The objective of this research is to examine the feasibility of using zero-valent iron as a clean-up media in permeable reactive barrier system. A series of laboratory column tests are performed. The concentration of influent and effluent water and the rate of clean up are analysed from these test results. The experimental result shows that the majority of the contamination in groundwater is removed in the reactor. And it shows the corresponding increase in the concentration of chloride ions through the reactor. Results from this study indicate that permeable reactive barrier containing admixtures of zero-valent iron and other materials can effectively clean up groundwater contaminated with organic compounds.

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The application levee material in the bed sediment of Nakdong River (낙동강 하상토의 제방재료 활용방안)

  • Choi, Gye-Woon;Lee, Seung-Woo;Lee, Ho-Sun;Lee, Byung-Joo
    • Proceedings of the Korea Water Resources Association Conference
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    • 2006.05a
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    • pp.1576-1580
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    • 2006
  • The destruction of river and damage caused by flood are suddenly increasing due to the abnormal climate. In the investigation result about the damage, approximate 52% of the destruction of embankment are caused by earth work. Moreover, to recover conveyance of relief channel, bed sediment is dredged about 198 millions $m^3$ with 'the project of bed dredging'. So, the concern for bed sediment is the more increasing, the requiring high quality material for banking and the way for application of bed sediment are also the more increasing. In this paper, properties of bed sediment were analyzed through sedimentary mechanism analysis. Moreover, possibility to build embankment with bed sediment in 6 points which is in catchment of the Nak-dong river was also analyzed. At 6 points, which were selected to survey easily, sediment discharge was analyzed with formula. Moreover, size and permeability were analyzed and the feasibility for material of embankment was proposed. If bed sediment wasn't proper, complementary measures were proposed.

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Chemical Agent Disposal Technology by a 2-step Process(II) (Agent Hydrolysis followed by Supercritical Water Oxidation) (화학작용제의 2단계 폐기기술(II) (작용제 가수분해 후 초임계수 산화처리))

  • Lee, Jong-Chol;Bambang, Veriansyah;Song, Eun-Suk;Kim, Jae-Duck
    • Journal of the Korea Institute of Military Science and Technology
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    • v.10 no.1
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    • pp.123-129
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    • 2007
  • A 2-step process for the safe destruction of chemical wafare agents(agent hydrolysis followed by supercritical water oxidation) was studied to obtain kinetic data for the pilot plant design. This process is simple to operate by using commercial equipments and could be applied as an alternative technology to incineration. Sarin(GB) and sulfur mustard(HD) were hydrolysed in sodium hydroxide and water respectively and their hydrolysates and OPA, which is binary agent for GB were oxidized in a continuous flow supercritical water oxidation system. Destruction efficiencies of the materials were above 99.99% in supercritical water.

Studies on the Natural Dyes (V) - Depression of Silk Yellowing and Destruction by the Treatment with Color of Camellia Leaf- (천연염료에 관한 연구 (V) - 동백잎색소처리에 의한 견직물의 광취화 억제효과에 관하여 -)

  • 조경래;장정대;박종범
    • Textile Coloration and Finishing
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    • v.5 no.2
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    • pp.91-98
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    • 1993
  • The silk fabrics were treated with color solution extracted from leaf of Camellia. The depression effect of destruction and yellowing of silk treated with color solution, shift of UV-VIS spectra of color solution, color difference of silk fabrics by dyeing with acid dyes and drycleaning fastness of silk treated with color solution were studied. UV-VIS spectra appeared to hypsochromic shift by irradiation. The decrease of tensile strength and the elongation of the silk treated with color solution showed depressed but those of untreated silk increased by irradiation. The yellowness index of silk treated with color solution showed a little change by irradiation. The color difference after dyeing with several acid dyes on treated and untreated silk showed not remarkable changes. Dsrycleaning fastness of silk treated by color solution was excellent.

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Non-destruction Properties of Hwangtoh Mortar (황토모르터르의 비파괴 특성)

  • Youn, Joon-No;Sung, Chan-Yong
    • Proceedings of the Korean Society of Agricultural Engineers Conference
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    • 2002.10a
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    • pp.197-200
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    • 2002
  • This study is performed to examine the non-destruction properties of the Hwangtoh mortar. The absorption ratio is in the range of $8.25%{\sim}18.16%$, it tend to increase with increase using the stone dust and Hwangtoh. The pulse velocity and dynamic modulus at the curing age 7 and 28days are in the range of $2,290m/s{\sim}4,140m/s,\;2,976m/s{\sim}4,219m/s\;and\;105{\times}10^3kgf/cm^2{\sim}293{\times}10^3kgf/cm^2,\;137{\times}10^3kgf/cm^2{\sim}318{\times}10^3kgf/cm^2$, respectively. They tend to decrease with increase using the stone dust and Hwangtoh.

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A Study on Table Design for Disassembly (분해 가능한 테이블 디자인 연구)

  • Han, Jung-Yeob
    • Proceedings of the Korean Institute of Interior Design Conference
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    • 2007.05a
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    • pp.110-113
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    • 2007
  • Modernity which is superficial phenomenon set off the mass scale for mass consumption and provide uniformly artificial environment. But natural destruction, environment pollution, resources exhaustion and so on has been caused by this and now ecology is threatened by destruction and damage beyond the limitation and human beings survival is even threatened. Accordingly furniture development for environment preservation considered environment problem is the urgent real situation. Recent paradigm is the concept of Eco-design which is the green design possible to live together in symbiosis, and new types of alternative furniture are needed in Korea as well. 'Furniture for disassembly' is presented as new method for alternative furniture.

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