• The Journal of Pediatrics of Korean Medicine
• /
• v.36 no.3
• /
• pp.1-18
• /
• 2022

Objectives The purpose of this study was to investigate the current status of interventional clinical trial registration for children with precocious puberty and to secure basic data for the design of clinical trials for traditional Korean medicine treatment of precocious puberty. Methods The following resources were used to search for data: Clinicaltrial.gov, World Health Organization International Clinical Trials Registry Platform (WHO ICTRP), and Clinical Research Information Service (CRIS), using the search terms, 'Precocious puberty', 'child'. All clinical trials which were registered as of June 2022 were used. Results For the intervention and clinical trial design, gonadotropin releasing hormone (GnRH) analog was reported in 41.7% of trials, and single group assignment was performed in 66.7% of the studies. Prior consent had not been reported in 50% of the studies. Tanner stage and GnRH stimulation tests were reported by multiple trials as inclusion criteria, and prior treatment experiences for trial drugs were reported as exclusion criteria. The peak serum concentration of luteinizing hormone following GnRH stimulation test was used as a primary outcome in 45.8% of clinical trials, and other growth-related indicators such as growth rate, height, and predicted adult height were also reported. Conclusions In consideration of the design, eligibility criteria, and outcome measurement of the existing clinical trials identified in this study, it should be referred to in the design of clinical trials for traditional Korean medicine treatment of precocious puberty.

• The Journal of the Convergence on Culture Technology
• /
• v.9 no.6
• /
• pp.833-841
• /
• 2023

The study is to suggest the example of convergence capstone design operation in department of early childhood education at a college and intellectual property rights application and registration. Based on key experiences such as practical training, students derived ideas for solving problems across the field related to young child, and overlaps with existing intellectual property rights ideas were verified. Linkage with industry and engineering experts was established for mentoring, after going through a refinement process, it contains the process by which five teams among the winning works of the school competition achieved the result of patent application and registration. Through this, we revitalize convergence capstone design education that goes beyond a creative and practical competency-centered curriculum and is linked to the performance of securing intellectual property rights.

• Journal of Distribution Science
• /
• v.11 no.4
• /
• pp.23-35
• /
• 2013

Purpose - This paper attempts to identify the problems and limitations of a market maintenance project conducted according to the 「Special Act for the Development of Traditional Markets and Shopping Street」 and to present a revised direction for the special law and lay the groundwork for market maintenance projects to be promoted smoothly. Research design, data, and methodology - The revised direction for the legislation and the proposal were written based on an investigation of the problems and the legal system, and proposed measures for market maintenance operation and system improvements to derive the improvements needed for market maintenance projects. Results - A market maintenance project has been conducted as a means to reinvigorate traditional markets that are economically depressed, and to revive the local economy. It was largely conducted in the form of reconstruction and redevelopment and represents the interests of landowners and merchants. Thus, it is most likely to contribute to the gradual disappearance of traditional markets. First, as part of a market maintenance project, many companies are building multipurpose buildings or high-rise residential buildings to increase profits. In these high-rise buildings, they can raise rents, which may not be affordable for some existing small businesses. To solve such problems, the large-scale store registration requirement needs to be relaxed or abolished once the market maintenance project is completed. If the large-scale store registration requirement is to be abolished, the term 'large retail store' should be changed in the 「Special Act for the Development of Traditional Markets and Shopping Street」. After registration, the Small and Medium Business Administration should train merchants, offer consultations, and support events, to the extent that the existing traditional market management modernization project permits, and further continue to manage and support its ongoing activities. However, unless large-scale store registration is abolished, adding an exception clause in the special law to relax large-scale store registration criteria, and permitting changes to building use is another option. At the end of a market maintenance project, empty stores should be purchased by the Small and Medium Business Administration, and local government, etc., at the actual construction cost, to utilize them as public rental shopping areas, which in turn may be re-utilized as a temporary market for another market maintenance project. The second problem in market maintenance projects is merchant-protection. Currently, the special law prescribes that a temporary market be created for merchants to conduct business during the rental period of a market maintenance project. Conclusions - In reality, a market maintenance project is conducted usually in big metropolitan cities with 500,000 residents or more. The main building type created under these projects is a multipurpose building. For this reason, it is very difficult to secure a location for a temporary market in the surrounding area of such a project. To solve this problem, this study suggests 'public rental shopping areas' as mentioned above.

• Journal of Biomedical Engineering Research
• /
• v.32 no.3
• /
• pp.237-244
• /
• 2011

In this paper, a feature-based registration technique is proposed for pre-contrast and post-contrast lung CT images. It utilizes three dimensional(3-D) features with their descriptors and estimates feature correspondences by nearest neighborhood matching in the feature space. We design a transformation model between the input image pairs using a free form deformation(FFD) which is based on B-splines. Registration is achieved by minimizing an energy function incorporating the smoothness of FFD and the correspondence information through a non-linear gradient conjugate method. To deal with outliers in feature matching, our energy model integrates a robust estimator which discards outliers effectively by iteratively reducing a radius of confidence in the minimization process. Performance evaluation was carried out in terms of accuracy and efficiency using seven pairs of lung CT images of clinical practice. For a quantitative assessment, a radiologist specialized in thorax manually placed landmarks on each CT image pair. In comparative evaluation to a conventional feature-based registration method, our algorithm showed improved performances in both accuracy and efficiency.

• Health Policy and Management
• /
• v.33 no.1
• /
• pp.3-18
• /
• 2023

Background: A chronic disease management program including patient education, recall and remind service, and reduction of out-of-pocket payment was implemented in Korea through a chronic care model. This study aimed to assess the effect of a community-based intervention program for improving medication adherence of patients with diabetes mellitus in rural areas of Korea. Methods: We applied a non-equivalent control group design using Korean National Health Insurance Big Data. Hongcheon County has been continuously adopting this program since 2012 as an intervention region. Hoengseong County did not adopt such program. It was used as a control region. Subjects were a cohort of patients with diabetes mellitus aged more than 65 years but less than 85 years among residents for 11 years from 2010 to 2020. After 1:1 matching, there were 368 subjects in the intervention region and 368 in the control region. Indirect indicators were analyzed using the difference-in-difference regression according to Andersen's medical use model. Results: The increasing percent point of diabetic patients who continuously received insurance benefits for more than 240 days from 2010 to 2014 and from 2010 to 2020 were 2.6%p and 2.7%p in the intervention region and 3.0%p and 3.9%p in the control region, respectively. The number of dispensations per prescription of diabetic patient in the intervention region increased by approximately 4.61% by month compared to that in the control region. Conclusion: The intervention program encouraged older people with diabetes mellitus to receive continuous care for overcoming the rule of halves in the community. More research is needed to determine whether further improvement in the continuity of comprehensive care can prevent the progression of cardiovascular diseases.

• Journal of Korea Society of Digital Industry and Information Management
• /
• v.6 no.1
• /
• pp.131-142
• /
• 2010

In this paper, we propose a web GPS based logistics vehicle control management system using MVC design patterns. The proposed system is designed by applying design patterns of object oriented modeling called mini-architecture to enhance reliability of software as well as promote stability of overall system design. In addition, we can get a position information by means of the GPS embedded in PDA and communicate between client and monitoring server using CDMA network so that the position of client can be identified directly by the map service. The system provides an moving object indexing technique which extends the existing TB-tree to manage and retrieve a transporting trajectory of logistics efficiently. Finally, with development of the logistics vehicle control service called WG-LOGICS system, we can verify the usefulness of our system which is able for monitoring a vehicle preparation, allocating registration, loading a burden, transfer path, and destination arrival in real world.

• Transactions of the Society of Information Storage Systems
• /
• v.1 no.2
• /
• pp.137-142
• /
• 2005

In this paper, we propose a new servo system design strategy to reduce the position error signal(PES) and track mis-registration(TMR) in magnetic disk drive systems. The proposed method provides a systematic design procedure based on the plant model and an optimal solution via an optimization with a 'Robust Random Neighborhood Search(RRNS)' algorithm. In addition, it guarantees the minimum PES level as well as stability to parametric uncertainties. Furthermore, the proposed method can be used to estimate the performance at the design stage and thus can reduce the cost and time for the design of the next generation product. The reduction of PES as well as robust stability is demonstrated by simulation and experiments.

• Korean Journal of Remote Sensing
• /
• v.27 no.2
• /
• pp.141-150
• /
• 2011

Precise image-to-image registration is required to process multi-sensor data together. The purpose of this paper is to develop an algorithm that register between high-resolution optical and SAR images using linear features. As a pre-processing step, initial alignment was fulfilled using manually selected tie points to remove any dislocations caused by scale difference, rotation, and translation of images. Canny edge operator was applied to both images to extract linear features. These features were used to design a cost function that finds matching points based on their similarity. Outliers having larger geometric differences than general matching points were eliminated. The remaining points were used to construct a new transformation model, which was combined the piecewise linear function with the global affine transformation, and applied to increase the accuracy of geometric correction.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
• /
• v.29 no.6
• /
• pp.667-675
• /
• 2011

In this paper, we propose an automatic image-to-image registration between high resolution multi-sensor images. To do this, TerraSAR-X image was shifted according to the initial translation differences of the x and y directions between images estimated using Mutual Information method. After that, the Canny edge operator was applied to both images to extract linear features. These features were used to design a cost function that finds matching points based on the similarities of their locations and gradient orientations. For extracting large number of evenly distributed matching points, only one point within each regular grid constructed throughout the image was extracted to the final matching point pair. The model, which combined the piecewise linear function with the global affine transformation, was applied to increase the accuracy of the geometric correction, and the proposed method showed RMSE lower than 5m in all study sites.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.14 no.11
• /
• pp.5385-5391
• /
• 2013

As on-line purchases is activated, customers' demand increases for the realistic and accurate digital information of a product design. In this paper, we propose a practical method that can generate a realistic 3D model of a real product using a 3D geometry obtained by a 3D scanner and its photographic images. In order to register images to the 3D geometry, the camera focal length, the CCD scanning aspect ratio and the transformation matrix between the camera coordinate and the 3D object coordinate must be determined. To perform this 2D-3D registration with consideration of computational complexity, a three-step method is applied, which consists of camera calibration, determination of a temporary optimum translation vector (TOTV) and nonlinear optimization for three rotational angles. A case study for a metallic coated industrial part, of which the colour appearance is hardly obtained by a 3D colour scanner has performed to demonstrate the effectiveness of the proposed method.