• Title/Summary/Keyword: Design Safety

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COMPARISON OF TRAMADOL/ACETAMINOPHEN AND CODEINE/ACETAMINOPHEN/IBUPROFEN IN ONSET OF ANALGESIA AND ANALGESIC EFFICACY FOR POSTOPERATIVE ACUTE PAIN (수술후 급성 동통에 대한 Tramadol/Acetaminophen과 Codeine/Acetaminophen/Ibuprofen의 효과 발현시점과 진통효과의 비교)

  • Jung, Young-Soo;Kim, Dong-Kee;Kim, Moon-Key;Kim, Hyung-Jun;Cha, In-Ho;Han, Moo-Young;Lee, Eui-Wung
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.30 no.2
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    • pp.143-149
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    • 2004
  • Background: Some clinical trials have reported that a new analgesic combination of tramadol and acetaminophen provides good efficacy in various pain models. For the more clinical uses of this agent, comparisons about the onset of analgesia and analgesic efficacy in the acute state of pain with the other drugs known as strong analgesics were needed. Purpose: The goal of this study was to compare the times to onset of analgesia and the other analgesic efficacy of 75 mg tramadol/650 mg acetaminophen and 20 mg codeine/500 mg acetaminophen/400 mg ibuprofen in the treatment of acute pain after oral surgery. Patients and Methods: Using a randomized, single-dose, parallel-group, single-center, and active-controlled test design, this clinical study compared the times to onset of analgesia using a two-stopwatch technique and the other analgesic efficacy of the single-dose tramadol/acetaminophen and codeine/acetaminophen/ibuprofen. These were assessed in 128 healthy subjects with pain from oral surgical procedures involving extraction of one or more impacted third molars requiring bone removal. From the time of pain development, the times to onset of perceptible and meaningful pain relief, pain intensity, pain relief, an overall assessment, and adverse events of the study medications were recorded for 6 hours. Results: The demographic distribution and baseline pain data in the two groups were statistically similar. The median times to onset of perceptible pain relief were 21.0 and 24.4 minutes in the tramadol/acetaminophen and codeine/acetaminophen/ibuprofen groups respectively and those to onset of meaningful pain relief were 56.4 and 57.3 minutes, which were statistically similar. The other efficacy variables such as mean total pain relief (TOTPAR) and the sum of pain intensity differences (SPID) were also similar in the early period after pain development and drug dosing. The safety of tramadol/acetaminophen was well tolerated and very comparable to that of codeine/acetaminophen/ibuprofen. Conclusions: In this acute dental pain model, the onset of analgesia and analgesic efficacy of tramadol/acetaminophen was comparable to that of codeine/acetaminophen/ibuprofen. These results showed that tramadol/acetaminophen was recommendable for fast and effective treatment in the management of postoperative acute pain.

Research Trends of Randomized Controlled Trials on Herbal Medicine Treatment for Atopic Dermatitis-Focusing on CNKI (아토피 피부염의 한약 치료에 대한 무작위대조군연구 중심의 연구 동향 - CNKI를 중심으로)

  • Yang, Geum-Jin;Jo, Eun-hee;Kang, Su-Jin;Hong, Jieun;Shim, Yu-Hwa;Lee, Ju-Hyun;Park, Min-cheol
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.34 no.2
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    • pp.102-116
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    • 2020
  • The purpose of this study was to analyze the research trends of randomized controlled trials on herbal medicine treatment for atopic dermatitis in China for the last 5 years. We searched for randomized controlled trials with the intervention of herbal medicine for the treatment of atopic dermatitis in the CNKI (China National Knowledge Infrastructure) from January 2014 to December 2018. For the screening of the paper, we used '特应性皮炎' and '异位性皮炎' which mean atopic dermatitis and search was limited to three areas within Medicine & Public Health: Traditional Chinese Medicine, Traditional Chinese Medicinal Herbs, Combination of Traditional Chinese Medicine with Western Medicine. Among the 136 searched studies, we selected a total of 34 studies and analyzed a year of publication, subject characteristics, study design and intervention, prescribed herbal medicine and herbs, pattern identification, evaluation criteria, and outcomes. Longmu decoction (龍牡湯) and Polia Sclerotium (茯笭) was the most frequently prescribed medicine and herb. The most commonly used pattern identification was Blood deficiency and Wind-dryness (血虛風燥), and among them, the most frequently prescribed herb is Rehmanniae Radix (生地黃). In most studies using the total effectiveness and SCORAD index as an outcome measure, the herbal medicine treatment group showed statistically better results than the control group. As a result of the safety assessment, the herbal medicine treatment group was reported having significantly fewer side effects compared to the control group. Hence, it was confirmed that the intervention including herbal medicine had a significant effect on atopic dermatitis. This study would be able to provide the basis of clinical research on atopic dermatitis and applied to the treatment of atopic dermatitis.

400 MeV/nucleon 12C Ions Shielding Benchmark Calculations using MCNPX with Different Nuclear Data Libraries (400 MeV/nucleon 12C 이온의 MCNPX 와 핵자료를 이용한 차폐 벤치마킹 계산)

  • Shin, Yun Sung;Kim, yong min;Kim, dong hyun;Jung, nam suk;Lee, hee seock
    • Journal of the Korean Society of Radiology
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    • v.9 no.5
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    • pp.295-300
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    • 2015
  • There are various type of particle accelerators such as Kyoungju 100-MeV proton beam accelerator in Korea. And Korea plans to build large particle accelerator such as heavy ion accelerator and 4th generation light source facility. The accelerated high energy particles of these facility produce 2nd neutron after nuclear reaction with target materials. And then these 2nd neutron activate structural materials and surrounding environment. Accordingly, it is important to consider the activation and shielding calculation on design of facility for safety operation. In this study, we tried to calculate and compare the neutron flux from the interaction $^{la}150$ beam with target material(Cu) according to thickness of iron and concrete shielding material by MCNPX 2.7 with nuclear library JENDL/HE 07and la150. To verify the properties of nuclear library, we compared computational results with experimental value. These results can be used for dose evaluation technology in planning of the shielding of large particle accelerator.

Late season commercial mosquito trap and host seeking activity evaluation against mosquitoes in a malarious area of the Republic of Korea

  • Buekett, Douglas-A.;Lee, Won-Ja;Lee, Kwan-Woo;Kim, Heung-Chul;Lee, Hee-Il;Lee, Jong-Soo;Shin, E-Hyun;Wirtz, Robert-A.;Cho, Hae-Wol;Ckaborn, David-M.;Coleman, Russel-E.;Kim, Wan-Y;Klein, Terry-A.
    • Parasites, Hosts and Diseases
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    • v.40 no.1
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    • pp.45-54
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    • 2002
  • Field trials evaluating selected commercially available mosquito traps variously baited with light, carbon dioxide, and/or octenol were conducted from 18-27 September 2000 in a malarious area near Paekyeon-ri (Tongil-Chon) and Camp Greaves in Paju County, Kyonggi Province, Republic of Korea. The host-seeking activity for common mosquito species, including the primary vector of Japanese encephalitis, Culex tritaeniorhynchus Giles. was determined using hourly aspirator collections from a human and propane lantern-baited Shannon trap doting hours when temperatures exceeded $15^{\circ}C$. The total number of mosquitoes and number of each species captured during the test was compared using a block design. Significant differences were observed for the total number of mosquitoes collected, such that, the Mosquito MagnetTM with octenol > Shannon trap > ABC light trap with light and dry ice > Miniature Black Light trap (manufactured by John W. Hock) $\geq$ New Jersey Trap > ABC light trap with light only. Significant differences in numbers collected among trapes were noted for several species including: Aedes vexans (Meigen), Anopheles lesteri Baisas and Hu. An. sinensis Weidemann, An. sineroides Yamada, An. yatsushiroensis Miyazaki. Culex pipiens pallets Coquillett L., Cx. orientalis Edwards and Cx. tritaeniorhynchus. Host-seeking activity for most common species showed a similar bimodal pattern. Results from these field trap evaluations can significantly enhance current vector and disease surveillance efforts especially for the primary vector of Japanese encephalitis, Cx. tritaeniorhunchus.

A Numerical Study for the Atrium Smoke Control by Fire Shutter and Evacuation (방화셔터를 이용한 아트리움 제연과 피난안전에 관한 수치해석 연구)

  • Jeon, Heung-Kyun;Choi, Young-Sang;Choo, Hong-Lok
    • Fire Science and Engineering
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    • v.24 no.5
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    • pp.50-59
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    • 2010
  • Four fire scenarios, as the cases of fire sizes of 2 MW and 5 MW, and no installation and activation of atrium fire shutter for dormitory building of Daegu 'D college', were developed and fire simulations were run using FDS (ver. 5.5.0) and Pathfinder 2009 programs. By assessing fire and evacuation, the effects of atrium fire shutter and vents on the smoke control of atrium were evaluated and this study also analyzed fire hazard and egress safety for occupants in the dormitory. Fire shutter's preventing smoke transport around atrium was much effective, but smoke layer descended down the design limit of smoke height and kept about 2 m height from the atrium floor in all cases because flow rate through vents was not enough. For the case of 5 MW fire and no fire shutter, fire hazard was higher due to visibility than temperature and allowable egress time to stairwell was short less than 5 seconds for the occupants on the floors of 4F to 7F. For total occupants, egress time out of main doorway was calculated about 136 seconds. It is sure that additional systems improving the performance of smoke control need to be installed for more safe evacuation.

Applicability of the Hydrocyclone for Efficiency Improvements to Sea-water Cooling Systems (해수 냉각시스템 효율 향상을 위한 하이드로사이클론의 적용가능성)

  • Kim Bu-Gi;Han Won-Hui;Cho Dae-Hwan;Choi Min-Sun
    • Proceedings of KOSOMES biannual meeting
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    • 2004.11a
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    • pp.109-115
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    • 2004
  • Hydrocyclone has been widely used for the solid-liquid separation in many industrial sites because of its comparatively preferable applications that can be applied to wide-range particle sizes. If seawater with impurities flows through pumps or heat exchanger, it might cause an decrease in efficiency of cooling system. In this paper, we have suggested some methods of separating impurities from seawater in the cooling system by using a Hydrocyclone. The effects of design factors as solid concentration, cyclone inlet pressure, flow rate and diameter of underflow on the separating performance of the Hydrocyclone were investigated The results from this study are summarized as follows: 1) In proportion to the decrease of solid concentration, the efficiency of solid-liquid separation is improved 2) According as the cyclone inlet pressure increases the efficiency of separation is improved Conclusively, this research suggested that the Hydrocyclone will be used as a pre-treatment system of cooling water in machines, and eventually prevent unexpected accidents in engine systems.

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Studies of application of artificial ground freezing for a subsea tunnel under high water pressure - focused on case histories - (고수압 해저터널 건설을 위한 동결공법 적용성에 관한 연구 - 사례를 중심으로 -)

  • Son, Young-Jin;Lee, Kyu-Won;Ko, Tae Young
    • Journal of Korean Tunnelling and Underground Space Association
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    • v.16 no.5
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    • pp.431-443
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    • 2014
  • In this paper case studies of artificial ground freezing, which have not been applied in Korea, have been investigated for the water cut-off in a subsea tunnel under high water pressure and the most commonly used cooling mediums of brine and liquid nitrogen are examined. Since sea water with pressure has the lower freezing point than pure water, the lower temperature cooling medium is required in the application of subsea tunnel. Also, the cooling medium must have refrigeration safety and is able to reduce executing time. Brine freezing system can reuse cooling medium and is safer than liquid nitrogen freezing. But it takes more time to freeze ground and needs complex circulation plants. On the other hand, liquid nitrogen freezing system can't recycle cooling medium and may cause breathing problems or asphyxiation through oxygen deficiency. But, freezing with liquid nitrogen is fast and requires simple refrigeration equipment. Principal elements of design for ground freezing in subsea tunnel have been extracted and these elements are needed further research.

Evaluation test of applicability of Compressed Air Foam fire extinguishing system for train fire at rescue station in Subsea tunnel (해저터널 구난역 열차화재시 압축공기포(Compressed Air Foam) 소화설비의 적용성 평가 실험)

  • Park, Byoung-Jik;Shin, Hyun-Jun;Yoo, Yong-Ho;Park, Jin-Ouk;Kim, Hwi-Seong
    • Journal of Korean Tunnelling and Underground Space Association
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    • v.18 no.5
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    • pp.413-418
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    • 2016
  • Recently, a mega project such as Korea-China or Korea-Japan undersea tunnel project has been emerged for detail discussion and the interest in undersea tunnel is on the rise. More severe damage by train fire is expected in undersea tunnel comparing to ground tunnel and thus the study on more efficient fire extinguishing system, besides existing disaster prevention design is underway. To that end, a full-scale fire tests using CAF fire extinguishing system which has been developed by modifying traditional foam fire extinguishing system for fire suppression at rescue station in timely manner were conducted over 7 times. The test was conducted after setting the rescue station in virtual tunnel with a car of KTX. As a result of using compressed air foam directly to the fire source, 30 liter of Heptane combustibles was extinguished within 1 minutes. Applicability of compressed air foam to train fire at rescue station in undersea tunnel was has been proven and further study is considered required while changing the nozzle angle and location so as to achieve quick and easy extinguishing goal, making use of the advantage of CAF, as well as to reduce the fire water and chemicals required.

Design and Performance Analysis of a new MAC Protocol for Providing Real-time Traffic Information using USN (USN 기반 실시간 주행 상황 정보 제공을 위한 MAC 설계 및 성능 분석)

  • Park, Man-Kyu;So, Sang-Ho;Lee, Jae-Yong;Lim, Jae-Han;Son, Myung-Hee;Kim, Byung-Chul
    • Journal of the Institute of Electronics Engineers of Korea CI
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    • v.44 no.5
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    • pp.38-48
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    • 2007
  • In ubiquitous environment, sensor networks that sense and transmit surrounding data without human intervention will become more important. If sensors are installed for detecting vehicles and measuring their speed in the road and that real-time information is given to drivers, it will be very effective for enhancing safety and controlling traffic in the road. In this paper, we proposed a new reliable and real-time sensor MAC protocol between AP and sensor nodes in order to provide real-time traffic flow information based on ubiquitous sensor networks. The proposed MAC allocates one TDMA slot for each sensor node on the IEEE 802.15.4 based channel structure, introduces relayed communication for distant sensors, and adopts a frame structure that supports retransmission for the case of errors. In addition, the proposed MAC synchronizes with AP by using beacon and adopts a hybrid tracking mode that supports economic power consumption according to various traffic situations, We implemented a simulator for the proposed MAC by using sim++ and evaluated various performances. The simulation results show that the proposed MAC reduces the power consumption and reveals excellent performance in real-time application systems.

ICT-based Living in the Contact Type Service Model for Self-life Support of the Elderly Living Alone (독거노인 자가생활지원을 위한 ICT기반의 생활밀착형 서비스 모델 개발)

  • Kim, Mi-Yun;Seo, Dong-Jo;Byun, Jong-Bong;Kang, Jong-Kwan
    • Journal of Digital Convergence
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    • v.13 no.4
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    • pp.25-38
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    • 2015
  • In case of current South Korea, the rapid graying is in the progress. Because of it, the increase of elders who live alone causes variety of social, economic and national problems. Especially in the modern city, the health care, safety and maintenance of pleasant and joyful life of elders who live alone are being a big social issue. Even though practical services have been tried at the whole of government approach, the detailed alternatives are insufficient to improve the daily life support and service to approach the information. This research suggests the "ELA Service Model" which actively improves the easy access to information and corresponds to condition and circumstance of elders for providing the ICT-base Elderly Living alone care service. It is a step self-life support service based on fundamental desire of elders which resolves the problem and contributes to establish the active and balanced policy to the elderly.