• Title/Summary/Keyword: Dermatomycoses

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Studies on Fungi Isolated from Dermatomycoses Patients in Egypt

  • El-Said, A.H.M.
    • Mycobiology
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    • v.30 no.3
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    • pp.154-159
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    • 2002
  • Fifty cases of dermatomycoses were recorded from adult male and female at Qena Gvernorates. These included tinea capitis(62% of total cases), tinea corporis(20%), tinea versicolor(12%) and tinea unguium(6%). Males are more susceptible to all cases of tinea than females. Thirty-one species and 2 varieties belonging to 16 genera were recovered from several infection sites. These were identified as Aphanoascus fulvescens, A. terreus, Arthroderma fulva, A. obtusa, Trichophyton rubrum and T. soudanense. Several saprophytes were also found. These were : Aspergillus flavus, A. fumigatus, A. niger, A. terreus, Cochliobolus lunatus, Mycosphaerella tassiana, Penicillium chrysogenum and P. citrinum. Twenty-one isolates were able to hydrolyze gelatin with variable capabilities. T. rubrum was the most active protease producer. The maximum production of protease was obtained at 8 days of incubation at $30^{\circ}C$ in Sabouraud's basal medium with maltose as a carbon source and pepton as a nitrogen source. The optinal pH for the maximum production of protease was pH 6.

Synthesis and biological activity of 6'-phenylgriseofulvin as analogs of antibiotic griseofulvin (항진균성항생물질 griseofulvin 유도체인 6'-phenylgriseofulvin의 합성과 항균활성)

  • Ko, Byoung-Seob;Oritani, Takayuki;Yamashita, Kyohei
    • Applied Biological Chemistry
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    • v.35 no.5
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    • pp.395-398
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    • 1992
  • In order to study the influence of a 6'-methyl group in ring C of griseofulvin ${\underline{(1)}}$ on the fungicidal activity, 6'-methyl group was replaced with a larger phenyl group as $({\pm})-6'-phenylgriseofulvin$ ${\underline{(3)}}$, $({\pm})-6'-epiphenylgriseofulvin$ ${\underline{(4)}}$, synthesized by a Diels-Alder cycloaddition. Their biological activities were examined against Botrytis allii (IFO 9430) and B. cinerea (AHU 9573). $({\pm})-6'-Phenylgriseofulvin $ ${\underline{(3)}}$ showed high activity in $25\;{\mu}g/disc$.

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Kerion Celsi Caused by Trichophyton verrucosum Mimicking a Hypervascular Tumor in a Pediatric Patient: A Case Report (고혈관성 종양으로 오인된 Trichophyton verrucosum에 의한 두피 백선종창 1례)

  • Kim, Kyung-Ran;Park, Hwanhee;Kim, Doo Ri;Yoon, Yoonsun;Jeon, Chiman;Lee, Sanghoon;Lim, So Young;Kim, Ji Hye;Kim, Yae-Jean
    • Pediatric Infection and Vaccine
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    • v.29 no.2
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    • pp.118-123
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    • 2022
  • A dermatophyte is a zoonotic infection that causes infection on the skin, hair, and nails and is transmitted through contact. The species of Microsporum, Trichophyton, and Epidermophyton are the major dermatophytes that infect humans. Tinea capitis is a dermatophyte infection in the scalp, and it may progress to kerion celsi, including severe redness, swelling, and pus formation. Kerion celsi is sometimes misdiagnosed as a bacterial infection or a tumor. Trichophyton verrucosum is a zoophilic dermatophyte that mainly causes infection in cattle. It can be spread to dairy farmers or ranchers who have frequent contact with infected cattle. We report a pediatric case who received scalp tumor excision and a split-thickness skin graft for extensive and severe inflammatory scalp tumors that occurred after contact with cattle with ringworm. Finally, the patient was diagnosed with kerion celsi caused by T. verrucosum infection. This was based on the patient's medical history, clinical manifestations, and histopathologic findings.