• The Korean Journal of Physiology and Pharmacology
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• 제22권5호
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• pp.555-566
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• 2018

Human umbilical cord blood mesenchymal stem cells (hUCB-MSCs) are used in tissue repair and regeneration; however, the mechanisms involved are not well understood. We investigated the hair growth-promoting effects of hUCB-MSCs treatment to determine whether hUCB-MSCs enhance the promotion of hair growth. Furthermore, we attempted to identify the factors responsible for hair growth. The effects of hUCB-MSCs on hair growth were investigated in vivo, and hUCB-MSCs advanced anagen onset and hair follicle neogeneration. We found that hUCB-MSCs co-culture increased the viability and up-regulated hair induction-related proteins of human dermal papilla cells (hDPCs) in vitro. A growth factor antibody array revealed that secretory factors from hUCB-MSCs are related to hair growth. Insulin-like growth factor binding protein-1 (IGFBP-1) and vascular endothelial growth factor (VEGF) were increased in co-culture medium. Finally, we found that IGFBP-1, through the co-localization of an IGF-1 and IGFBP-1, had positive effects on cell viability; VEGF secretion; expression of alkaline phosphatase (ALP), CD133, and ${\beta}-catenin$; and formation of hDPCs 3D spheroids. Taken together, these data suggest that hUCB-MSCs promote hair growth via a paracrine mechanism.

• 대한한방부인과학회지
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• 제18권3호
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• pp.152-164
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• 2005

Purpose : A survey was conducted to investigate the intake pattern of health food by using questionnaire. Methods : This study was carried out to patients visiting OB&GY clinic in Jaseng and Dongseo hospital of oriental medicine during 2005.3.4-2005.5.13. Results : 1. Among the 114 respondents, most respondents(66.6%) were located between 3rd and 4th decade. 2. Among the respondents, 107(93.9%) persons had the experience of intake of health foods and 7(6.1%) persons not. 3. Among the health foods, the natural foods(48.0%) were most frequently taken. 4. Two major reasons for the intake of the health food were 'for relieving easy fatigability'(24.8%) and 'for the prevention of disease'(23.0%). 5. Most respondents felt that the effects of health foods were 'intermideate'(65.8%). Positive responses to the effect were 24.6%, and negative ones were 3.5%. 6. The discussion with medical personnel about taking health foods was present in fractionary population (13.2% ). 7. Among 107 respondents who had taken health food, 7 respondents(6.1%) experienced side effect of health food. Side effects were gastrointestinal disturbance in 4 cases, dermatologic problems in 2 cases. Conclusion : A study on analysis of health food in Oriental Medicine is necessary to make a guide for efficient use of that.

• 농촌의학ㆍ지역보건
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• 제24권1호
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• pp.103-113
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• 1999

이 연구는 1997년 3월부터 1999년 2월까지 경상북도 소재 일개 군지역에서 피부질환으로 피부과 전문의의 검진을 받은 환자 847명 중 설문조사가 가능하였던 760명의 환자를 대상으로 이들 환자별 성별연령별 분포를 조사하고 치료 경험 여부와, 처음 치료를 시작한 곳과 민간 요법이나 개인적인 치료법 사용여부 및 치료 경험이 있을 경우 그 효과에 대한 만족도를 조사하여 환자들이 피부 질환의 진료 및 치료에 있어 어떤 경로를 밟고 그 일반적인 치료 행태의 경향은 어떠한지를 분석하고자 시행하였으며 다음과 같은 결과를 얻었다. 1. 총 760명의 조사대상자는 남자가 283명으로 37.2%였고 여자가 477명으로 67.3%였다. 총 대상환자 중 20대 환자가 3.3%로 가장 적었고 60대 환자가 21.3%로 가장 많았다. 2. 대상 환자들에게 빈도가 높은 15개 질환은 족부 백선이 34.9%로 가장 많았고 노인성 소양증, 접촉성 피부염, 주부습진, 지루성 피부염, 화폐상 습진, 아토피성 피부염, 체부 백선, 조갑 백선, 심상성 여드름, 전염성 농가진, 박탈성 각질용해층, 만성 두드러기 및 전염성 연속중의 순이었다. 3. 환자들이 피부질환을 위해 최초로 치료받은 곳은 약국이 39.6%로 가장 많았으며, 피부과 전문의가 아닌 개인의원, 피부과 의원 및 종합병원 피부과의 순이었다. 4. 대상환자 760명 중 121명(15.9%)이 민간 요법을 사용한 경험이 있었으며 이 중 가장 많이 사용하는 방법으로서는 환부를 식초에 담그거나 도포하는 방법이었다. 이러한 민간 요법을 시행한 후 환자 본인이 느끼는 자각증상은 변화가 없었다는 경우가 가장 많았고 호전되었다, 악화되었다의 순으로 빈도가 높았다. 결론적으로 농촌지역의 경우 다수의 피부과 환자들이 약국에서 일차진료를 받고 있는 현실이며 피부질환에 대한 인식이 낮음으로 인해 의학적 근거가 없는 다양한 민간요업을 시행하고 있었다. 그러므로 환자들이 잘못된 치료 행태로 인해 경제적, 시간적 손실을 입지 않게 올바른 보건교육이 이루어져야 될것으로 생각된다.

• 대한한방소아과학회지
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• 제24권2호
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• pp.40-48
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• 2010

Objectives The purpose of this study is to get the basic information about the actual amount of consumption of the Health supplements and Herbal Medicines. Also, we investigated the consumption differences according to the regions. Methods 500 questionnaires were handed out to parents of elementary students in O O, Gyeonggi-do province, and 331 questionnaires were collected and evaluated for this study. Results Among the 331 students, 58.4% were female, and 41.6% were male. The percentages of the subjects consuming health supplements and herbal medicines were 67.4% and 59.2% respectively. The maximum period of taking the health supplements were from 1 month to 6 month (49.5%), and the maximum period of taking the herbal medicine was within one month (55.6%). The total cost of the health supplements was less than 100,000won (43.7%), which was the most common while herbal medicine cost was between 100,000won and 200,000won (40.6%). The most common age of consuming the health supplements and herbal medicine for the first time was six to ten years old (47.3%); the case of herbal medicine was one to six years old (64.0%). Most of people purchased health supplements from pharmacy (48.0%), and purchased the herbal medicine from the oriental medical clinic (61.8%). Among those people who purchased health supplements, they bought nutritional supplements (82.8%), red ginseng or ginseng products (43.4%), plum extract products (10.9%), and chlorella products (6.8%). The reason for consuming health supplements was to be healthier even though there is no ongoing illness (47.1%), which was the most common reason. The reason for consuming herbal medicine was to cure weakness (39.3%). For the responses about effectiveness after taking medications, people thought herbal medicine seemed to be more effective compare to health supplements (72.3%, 63% respectively). Only 1.4% of the subjects consuming the health supplements showed adverse effects while herbal medicine showed 4.6%. The most common adverse effects were 'general reaction' caused by the health supplements and dermatologic problems caused by the herbal medications. Conclusions Among 331 subjects, the percentage of consuming the health supplements (67.4%) was higher than the Herbal Medicine (59.2%). The total consuming cost of the herbal medications was higher than general health supplements. Also, the maximum period of consuming the health supplements was longer than herbal medications. Therefore, it is shown that herbal medications have no price competitiveness compare to health supplements. The age of using the herbal medicine for the first time was younger than the health supplements. Even though many people can purchase both health supplements and herbal medication from pharmacies and local oriental medical clinic, it is also shown that some people thought that the health supplements should be purchased from oriental medical hospital (13.9%). The most commonly taken forms of the health supplement was nutrition-supplying products, and the second common health supplements were ginseng and red ginseng. The health supplements were commonly consumed for preventing illness and for maintaining healthy life rather than for cure diseases. On the other hand, the herbal medicine was more commonly consumed to be taller or to treat diseases. More than half of the entire people replied as 'satisfied' for their purchase. Some adverse effects and general reaction were common with the subjects consuming health supplements while dermatological adverse reaction was common with the subjects consuming herbal medications.