• Biomolecules & Therapeutics
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• 제31권2호
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• pp.161-167
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• 2023

Despite the various medications used in clinics, the efforts to develop more effective treatments for depression continue to increase in the past decades mainly because of the treatment-resistant population, and the testing of several hypotheses- and target-based treatments. Undesirable side effects and unresponsiveness to current medications fuel the drive to solve this top global health problem. In this study, we focused on neuroinflammatory response-mediated depression which represents a cluster of depression etiology both in animal models and humans. Several meta-analyses reported that proinflammatory cytokines such as interleukin 6 (IL-6) and tumor necrosis factor-α (TNF-α) were increased in major depressive disorder patients. Inflammatory mediators implicated in depression include type-I interferon and inflammasome pathways. To elucidate the molecular mechanisms of neuroinflammatory cascades underlying the pathophysiology of depression, we introduced hycanthone, an antischistosomal drug, to check whether it can counteract depressive-like behaviors in vivo and normalize the inflammation-induced changes in vitro. Lipopolysaccharide (LPS) treatment increased proinflammatory cytokine expression in the murine microglial cells as well as the stimulation of type I interferon-related pathways that are directly or indirectly regulated by Janus kinase-signal transducer and activator of transcription (JAK-STAT) activation. Hycanthone treatment attenuated those changes possibly by inhibiting the JAK-STAT pathway and inflammasome activation. Hycanthone also ameliorated depressive-like behaviors by LPS. Taken together, we suggest that the inhibitory action of hycanthone against the interferon pathway leading to attenuation of depressive-like behaviors can be a novel therapeutic mechanism for treating depression.

• 정신신체의학
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• 제22권1호
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• pp.40-45
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• 2014

연구목적 경도인지장애와 치매는 인지기능의 퇴행과 우울 등과 같은 신경정신증상을 나타낸다. 이들의 진단에 도움을 줄 수 있는 다양한 진단 도구 중 혈중 호모시스테인 농도를 측정하는 방법이 있으며, 연구에 따르면 혈중 호모시스테인 농도의 증가는 알쯔하이머병, 우울증 그리고 다른 신경정신질환의 발생위험을 증가시킨다. 본 연구는 혈중 호모시스테인이 인지기능장애와 연관된다는 사실을 기초로 경도인지장애와 알쯔하이머형 치매에서 우울증상 유무에 따른 혈중 호모시스테인 농도를 분석해보았다. 방법 경도인지장애, 알쯔하이머형 치매로 진단된 환자 86명이 참여하였고 혈액검사를 통해 혈중 호모시스테인 농도를 측정하였다. 환자들의 전반적인 인지기능 및 심각도의 단계 평가는 한국판 간이정신상태검사(MMSE-KC)와 전반적 퇴화척도(Global Deterioration Scale, GDS), 치매임상평가척도(Clinical dementia rating, CDR)를 이용하여 측정하였고, 우울증상 유무에 대한 평가는 한국판 노인우울척도(Korean version of Geriatric Depression Scale, K-GDS)를 통해 측정하였다. 결과 혈중 호모시스테인 농도는 경도인지장애군 중 우울증상이 있는 군에서 우울증상이 없는 군보다 통계적으로 유의한 높은 수치를 보였다. 치매환자군에서는 우울증상이 있는 군과 우울증상이 없는 군사이에 통계적으로 유의한 차이는 없었다. 상관분석에서 혈중 호모시스테인 농도와 MMSE-KC는 유의한 음의 상관 관계를 보였고, CDR, GDS는 유의한 양의 상관 관계를 보였다. 결론 이러한 결과는 혈중 호모시스테인 농도의 증가가 인지기능저하와 우울증의 위험인자라는 사실을 나타낸다. 특히 본 연구에서는 경도인지장애 환자군에서 혈중 호모시스테인 농도와 우울증상 간의 의미있는 연관성을 제시하였다. 본 연구 중의 몇 가지 제한점을 보완한 좀 더 대규모의 연구가 필요하다.

• 한국직업건강간호학회지
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• 제7권2호
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• pp.155-163
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• 1998

In order to investigate the effects of rotating shift work on the subjective characteristics of sleep and mental depression questionnaire survey was carried out on 405 shift workers and 153 nonshift workers who were nurses employed. in three university hospital. The questionnaire forms used in this study were the self rating depression scale(SDS) and circadian type questionnaire(CTQ) factor R(rigidity/flexbility of sleeping habit) and factor V(inability/ability to overcome drowsiness). The results were as follows ; 1. Mean score of CTQ R in shift workers was significantly lower than that in nonshift workers, however, no significant difference in CTQ V was observed between two groups. 2. Mean score of SDS was significantly higher in shift workers(44.1) than in nonshift workers(39.8). 3. Mean self rating depression scale scores of pervasive affect, physiologic equivalents and psychological equivalents were significantly higher in shift workers than in nonshift workers. 4. In shift worker, mean SDS score was the highest in confusion and followed by diurnal variation, retardation, and indeciveness in the descending order. In nonshift worker, that score was the highest in decreased libido and followed by confusion, and indeciveness in the descending order. 5. Circadian type questionnaire scores was significantly and negatively correlated with significantly and negatively correlating with Self-rating depression scale scores(r=-0.473).

• 여성건강간호학회지
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• 제10권2호
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• pp.91-98
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• 2004

Purpose: The purpose of this study was to examine the relationship between spiritual well-being, depression, and health status of elderly women in a community for providing the basic data necessary to improve the practice of nursing. Method: The participants were 295 elderly women, over 65 years old in Gwangju and Kyongbuk province, Korea. The data were collected between April 15th and June 15, 2003 using a structured questionnaire and were analyzed using SPSS Win 8.0. Result: Factors such as religious belief (p<.001), type of religion (p<.001), participation of worship (p<.001), significance of religion (p<.001), education(p=.001), spouse(p=.015), financial supporter(p=.001), and living satisfaction(p<.001) showed a statistically significant relation with spiritual well-being. There was a negative correlation between spiritual well-being and depression(r=-0.32, p<.001),and between health status and depression(r=-0.50, p<.001). However, there was a positive correlation between spiritual well-being and health status(r=0.32, p<.001). Conclusion: In order to promote spiritual well-being in elderly women, it is necessary to develop a nursing intervention program classified by the type of religions, followed by studies on the results of proven intervention programs.

• 대한가정학회지
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• 제41권3호
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• pp.165-180
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• 2003

The number of the functionally disabled elderly has been increasing in Korea and their families should have been in charge of supporting and taking care of them. This study was designed to grope for devices which were helpful to improve the psychological welfare of the functionally disabled elderly in the present situation. The results of this study were as follows: First, considering the level of psychological welfare of the functionally disabled elderly, the depression degree of the subjects was 52.9 which was higher than the middle point, 50. And the degree of family support the functionally disabled elderly were aware of, it also was high ; the score was 34.6 compared to the middle point, 33. On the other hand, the degree of public support that the functionally disabled elderly received was 2.01 which was lower than the middle point, 4.5. Second, the level of the depression of the functionally disabled elderly followed by background variables, the degree of agreement with family support, and public support represented significant differences among group according to religion, the type of previous occupation, the ownership of house, the type of residence, the presence of spouse, education level, and the source of income. Third, the relative influence toward the depression of the functionally disabled elderly was shown in the order of importance as follows: family support, the degree of functional disability, the ownership of house, public support, the presence of spouse, the source of income, the number of daughters, the degree of functional disablity.

• 한국가족관계학회지
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• 제23권3호
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• pp.201-228
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• 2018

Objectives: The objectives of this study were to classify never-married types of adult men and women and explore factors related to these types. Never-married types were categorized into 4 types according to continuity and voluntariness: continuous voluntary type; changed voluntary type; continuous non-voluntary type; and changed non-voluntary type. Factors related to types of being single were examined in terms of socio-demographic factors, individual and psychological factors (self-esteem, depression), dating relationship factors (current relationship status), original family factors (parental conflict, relationship with parents, parents' demand for marriage), marriage related factors (division of roles after marriage), and occupation related factors (work values, employment instability). Method: As for research method, a survey was conducted with never-married adult men and women between the ages of 35 and 49 living in Seoul, Gyeonggi or Incheon areas. Of 300 copies of questionnaire distributed, data from 295 copies were processed using SPSS 24.0 program for multinomial logit analysis. Results: The study results showed that, of never-married men respondents, continuous voluntary type accounted for 20.5%; changed voluntary type 18.9%; continuous non-voluntary type 49.6%; and changed non-voluntary type 11.0%. It was found that the factors related to continuous non-voluntary type among never-married men are age, religion, average monthly income, while the factors related to changed voluntary type are religion, self-esteem, depression, and frequency and strength of parental conflict, while the factor related to changed non-voluntary type men was living with parents. Examining never-married women respondents, it was found that, continuous voluntary type accounted for 33.9%; changed non-voluntary type 19.6%; continuous non-voluntary type 22.6%; and changed voluntary type 23.8%. The factor related to continuous non-voluntary type among never-married women was parents' demand for marriage, while the factors related changed voluntary type were age, depression and strength of parental conflict. Also, the factors related to changed non-voluntary type of never-married women were age, religion, living with parents, depression and parents' demand for marriage. Conclusion: In conclusion, it was found that continuous non-voluntary type formed the largest group among never-married men, whereas continuous voluntary type was the majority in never-married women. Both never-married men and women chose to remain single when they are living with their parents and their parental conflict is intense. Parents' demand for marriage was related to women, but not to men.

• 생물정신의학
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• 제27권2호
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• pp.84-93
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• 2020

Objectives The purpose of the present study was to examine the relationship between the chronotype and the burnout, so we investigated the mediating effects of the mediators such as perceived stress, stress response, and depression. Methods Employees working at Incheon Customs conducted a mental health self-examination through the internet. Among them, 174 people who agreed to the mental health survey participated in the study. Participants completed questionnaires including Composite Scale of Morningness (CSM), Center for Epidemiological Studies-Depression Scale (CES-D), Perceived Stress Scale (PSS), Stress Response Inventory (SRI), Maslach Burnout Inventory-General Survey (MBI-GS). Results Our results showed a higher degree of CES-D, SRI, exhaustion, and cynicism in evening and intermediate type compared to morning type, and a higher degree of professional efficacy in morning type compared to intermediate type. CSM was shown to have a direct effect on exhaustion and indirect effect through CES-D and SRI. CSM also had a direct effect on professional efficacy and had an indirect effect through the CES-D. However, CSM was found to have only indirect effects through the SRI for Cynicism. Conclusions In this study, individuals with evening type tend to experience a high degree of burnout (exhaustion, cynicism and professional efficacy) through the mediation effect of depression and stress response. Further study is necessary to reveal the effect of management of the depression and stress response in the employee with evening type.

• 성인간호학회지
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• 제25권5호
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• pp.549-558
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• 2013

Purpose: The purpose of this study was to identify impact of stress on depression among university students and the moderating effect of social support in the relationship between stress and depression in university students. Methods: A total of 445 subjects were participated from May to July 2011. Data were collected by self-reported questionnaires and t-test, ANOVA, and stepwise multiple regression with SPSS/WIN 20.0 were used to analyze the data. Results: The results indicate that depression was increased by stress and decreased with social support. Social support included four type of social support behavior; emotional support, informational support, material support, and appraisal support. Multiple regression analysis showed that moderating effect of emotional support was significant when provided by friends but not by parents. Conclusion: These finding indicate the importance of emotional support of friends on depression in university students.

• 동서간호학연구지
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• 제23권2호
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• pp.180-189
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• 2017

Purpose: This study was conducted to identify the perception of and attitude toward dementia and depression among residents in a community. Methods: Data were collected using the questionnaire from 226 residents in Incheon city from February to May, 2017. The data were analyzed using t-test, ANOVA and Scheffe's test to identify differences in perception of and attitude toward dementia and depression. Pearson correlation coefficients were used to identify the correlation between the study variables, and multiple regression was used to identify factors affecting depression. Results: There were significant differences in perception of dementia according to age, education, marital status, and exercise. Also, significant differences in attitude toward dementia were found in occupation, family history of dementia and education about dementia. Depression was significantly different depending on the type of health insurance coverage and alcohol drinking. The scores of perception of dementia and depression were 11.09, 2.37, respectively on a 2-point scale and for attitude toward dementia was 85.94 on a 7-point Likert scale. The perception of dementia was positively correlated with the attitude toward dementia and there were negative correlations between perception of dementia and age and between depression and attitude toward dementia. Conclusion: The results of this study suggest that we should improve perception of and attitude toward dementia and reduce depression to prevent and manage dementia effectively.

• 가정간호학회지
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• 제19권2호
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• pp.150-161
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• 2012

Purpose: This study was performed to investigate the influencing factors of cognitive function and depression in elderly. Method: From 3 provinces, 282 elders who resided in community and facilities completed structured questionnaires, including cognitive functions, depression, self-esteem, ADL, and IADL. Data were analyzed by applying ${\chi}^2$-test, ANOVA, partial correlation coefficient, and stepwise multiple regression analysis with SAS 8.12. Results: Community dwelling aged people showed higher scores in MMSE-K, self-esteem, ADL and IADL, and showed lower scores in depression than facility elders. MMSE-K was positively correlated in self-esteem, ADL, and personal cognition of health, except depression. Major factors that affect cognitive function of elderly were residual type, age, and IADL. In addition, major factors that affect depression of elderly were self-esteem, personal cognition of health, and marital status. Conclusions: Based on the results above, it is necessary to identify the status of cognition and depression in the elderly, and to develop nursing intervention programs, which improve cognitive function and reduce depression for aged, especially for the facility admitted aged.