• Title/Summary/Keyword: Depletion effect

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A Study on the Releasing Characteristics of Organic Matter and Heavy Metals and Changes of Dissolved Oxygen Concentration during Sediment Resuspension (퇴적물 재부유에 따른 유기물과 중금속 용출 및 용존산소량 변화 특성에 대한 연구)

  • Kang, Seon Gyeong;Lee, Han Saem;Lim, Byung Ran;Rhee, Dong Seok;Shin, Hyun Sang
    • Journal of Korean Society on Water Environment
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    • v.37 no.1
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    • pp.1-9
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    • 2021
  • The depletion of dissolved oxygen (DO) in urban streams has a profound effect on the aquatic ecosystem; however, the change in DO by resuspension of sediments and the cause have not been sufficiently investigated. In this study, the physicochemical properties (particle size, and the content of organic and heavy metals) of the sediments of an urban stream (Anyang Stream) and the characteristics of water quality changes (DO, dissolved organic carbon (DOC), dissolved nitrogen (DN), sediment oxygen demand (SOD), and adenosine triphosphate (ATP)) by sediment resuspension were investigated. The sediment content of fine particles (< 0.2 mm) increased from 36.7% to 52.7% from the upstream to the downstream, and the contents of heavy metals and organic matter of the sediment were also higher towards the downstream. The depletion of DO by resuspension was observed in the sediment at the downstream sites (P8, P9), where the fine particle content was high, and biological SOD (BSOD) was more than 88% compared to the total SOD. The increase in BSOD coincided with the increase in ATP. It was also confirmed that the depletion of DO could increase the amount of heavy metals (such as Fe, Mn, and Pb) released from the sediment. Based on the above results, it can be concluded that resuspension of sediments induces rapid water quality changes and may cause accidents, such as fish mortality, during rainfall, and such a water quality effect can be more pronounced in sediments with a high content of fine particles and organic matter and high biological activity.

Effects of Phosphate, Precursor and Exogenous Berberine on the Production of Alkaloid in Plant Cell Cultures

  • Kim, Dong-Il
    • Journal of Microbiology and Biotechnology
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    • v.1 no.1
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    • pp.79-83
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    • 1991
  • The effects of phosphate concentration in the medium, feeding of biosynthetic precursor, and the addition of exogenous berberine on cell growth and berberine production were studied in cell suspension cultures of Thalictrum rugosum. The depletion of phosphate in the medium enhanced the specific productivity up to twofold with significant release of berberine into the medium. Extracellular berberine was 19% of the total in the culture without phosphate while it was 2-5% of total berberine in the culture with even low amounts of phosphate. Precursor feeding was not effective in enhancing alkaloid formation. Initial presence of exogenous berberine did not have much effect on cell growth and alkaloid production. It was found that the cells have the capacity to take up large quantities of berberine. When $500{\;}mg{\cdot}l^{-1}$ of berberine was added exogenously at the beginning, 81% of total berberine was found in the cells.

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A case report of breast cancer (유암(乳巖)환자 치험1례(例)에 대한 임상보고)

  • Kim, Sung-Ran;Yoo, Dong-Youl
    • Journal of Haehwa Medicine
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    • v.14 no.2
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    • pp.189-195
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    • 2005
  • Purpose: The purpose of this case study is to report the effect of just oriental treatments to the breast cancer. Methods: A 37-year-old woman had breast cancer of stage II according AJCC staging system, but she dosen't want be operated for a tumor. So, she was treated with herbal medicine, acuputure, moxa, patch made from herb medicine and depletion for four weeks. In herbal theraphy sihosogansan and saengmaksan. The patch made from herb medicine is put on the skin of the cancer. Depletion is done on the breast cancer, too. In acuputure theraphy, Sojangjeonggyeok(小腸正格) was used. In Moxa theraphy Chungwan, Kwanwon were used. Results: After oriental medicine for 27 days, she was on the mend about the size, complexion, solidity and pain of the breast cancer. Conclusion: This study shows that breast cancer is improved if only oriental treatments. But after this, further approach and studys on the breast cancer.

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Variations of the Polar Temperature in the Lower Stratosphere during 1955-2004

  • Choi, Wookap;Kim, Dongjoon
    • Atmosphere
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    • v.18 no.4
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    • pp.429-439
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    • 2008
  • The lower-stratospheric polar temperature in winter and spring for both hemispheres is investigated based on the NCEP/NCAR 50-year reanalysis data with respect to the strength of the stratospheric eddy heat flux. Both the polar temperature and the eddy heat flux show significant variation on the decadal and year-to-year time scales except during the Southern Hemisphere winter. The year-to-year variation in the polar temperature is mainly determined by the eddy heat flux convergence. The eddy heat flux convergence is compared with the diabatic heating rate obtained from a two-dimensional model. Radiative heating caused by absorption of solar radiation is comparable to the heating caused by the eddy heat flux convergence in the Southern Hemisphere. The effect of ozone depletion on diabatic heating has been found to be secondary in the Northern Hemisphere, even in March 1997 when the record depletion of ozone took place.

Charge Depletion Effect on Collection Efficiency of an Electret Cabin Air Filter for Submicron Particles (승용차용 정전 필터 내의 정전 섬유의 보유 하전 감쇄에 의한 미세 입자 포집효율 변화)

  • Ji, Jun-Ho;Kang, Suk-Hoon;Hwang, Jung-Ho;Bae, Gwi-Nam
    • Proceedings of the KSME Conference
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    • 2001.11b
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    • pp.71-76
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    • 2001
  • An electret filter is composed of permanently charged electet fibers and is widely used in applications requiring high collection efficiency and low-pressure drop. In this work, the collection efficiency of the filter media used in manufacturing cabin air filters was investigated by using poly-disperse particles when submicron particles are loaded. Long-term experiments were conducted by applying different charging states, which are spray electrification and charge equilibrium by bipolar ionization. In order to investigate on the effect of particle loading in filter media, NaCl particles were generated from 0.1% and 1% solutions by an atomizer. In NaCl 0.1%, the collection efficiency of electret filter decreased and then did not change in equilibrium state. In the case of relative larger particles of NaCl 1%, collection efficiency for the equilibrium charged particles increases due to the particle loading on the filter fibers. Particles charged by spray electrification are small in collection efficiency after equilibrium state and increase of filter media's pressure drop was very low in comparison of the equilibrium charged particles.

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Comparative LCA(life cycle assessment) between two different model of Electric Motor Unit(EMU) (서로다른모델의 전동차에 대한 비교 전과정평가)

  • Kim, Jin-Yong;Choi, Yo-Han;Kim, Young-Ki;Lee, Kun-Mo
    • Proceedings of the KSR Conference
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    • 2007.11a
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    • pp.6-14
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    • 2007
  • The objective of this research is to comparative LCA(life cycle assessment) between two different model of Electric Motor Unit(EMU).the environmental impact of Aluminum body Electric Motor Unit(EMU) and Stainless Steel(STS) body Electric Motor Unit(EMU). LCA process consists of four steps which are goal, scope definition, life cycle impact analysis(LCIA) and life cycle interpretation. ISO 14044 provides the LCA standard method which can be conducted by using comparative LCA. From the research it is foung that the Aluminium Body Electric Motor Unit (EMU) is 3.6ton heaver than Stainless Steel(STS) body Electric Motor Unit(EMU). The system boundary of both Electric Motor Unit (EMU) are same life span and travel same distance. These both Electric Motor Unit (EMU) has same kind of environmental impact which is maximum Ozone Depletion(OD). During using period of these two models, the Aluminium Body Electric Motor Unit(EMU) has more global warming(GW) effect but Stainless Steel(STS) body Electric Motor Unit(EMU) has more Ozone Depletion(OD) effect. The above result is obtained by using LCA software PASS verson 3.1.3.

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Protein phosphatase 4 dephosphorylates phosphofructokinase-1 to regulate its enzymatic activity

  • Jaehong Park;Dong-Hyun Lee
    • BMB Reports
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    • v.56 no.11
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    • pp.618-623
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    • 2023
  • Most cancer cells utilize glucose at a high rate to produce energy and precursors for the biosynthesis of macromolecules such as lipids, proteins, and nucleic acids. This phenomenon is called the Warburg effect or aerobic glycolysis- this distinct characteristic is an attractive target for developing anticancer drugs. Here, we found that Phosphofructokinase-1 (PFK-1) is a substrate of the Protein Phosphatase 4 catalytic subunit (PP4C)/PP4 regulatory subunit 1 (PP4R1) complex by using immunoprecipitation and in vitro assay. While manipulation of PP4C/PP4R1 does not have a critical impact on PFK-1 expression, the absence of the PP4C/PP4R1 complex increases PFK-1 activity. Although PP4C depletion or overexpression does not cause a dramatic change in the overall glycolytic rate, PP4R1 depletion induces a considerable increase in both basal and compensatory glycolytic rates, as well as the oxygen consumption rate, indicating oxidative phosphorylation. Collectively, the PP4C/PP4R1 complex regulates PFK-1 activity by reversing its phosphorylation and is a promising candidate for treating glycolytic disorders and cancers. Targeting PP4R1 could be a more efficient and safer strategy to avoid pleiotropic effects than targeting PP4C directly.

The Effects of Self-regulatory Resources and Construal Levels on the Choices of Zero-cost Products (자아조절자원 및 해석수준이 공짜대안 선택에 미치는 영향)

  • Lee, Jinyong;Im, Seoung Ah
    • Asia Marketing Journal
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    • v.13 no.4
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    • pp.55-76
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    • 2012
  • Most people prefer to choose zero-cost products they may get without paying any money. The 'zero-cost effect' can be explained with a 'zero-cost model' where consumers attach special values to zero-cost products in a different way from general economic models (Shampanier, Mazar and Ariely 2007). If 2 different products at the regular prices of ₩200 and ₩400 simultaneously offer ₩200 discounts, the prices will be changed to ₩0 and ₩200, respectively. In spite of the same price gap of the two products after the ₩200 discounts, people are much more likely to select the free alternative than the same product at the price of ₩200. Although prior studies have focused on the 'zero-cost effect' in isolation of other factors, this study investigates the moderating effects of a self-regulatory resource and a construal level on the selection of free products. Self-regulatory resources induce people to control or regulate their behavior. However, since self-regulatory resources are limited, they are to be easily depleted when exerted (Muraven, Tice, and Baumeister 1998). Without the resources, consumers tend to become less sensitive to price changes and to spend money more extravagantly (Vohs and Faber 2007). Under this condition, they are also likely to invest less effort on their information processing and to make more intuitive decisions (Pocheptsova, Amir, Dhar, and Baumeister 2009). Therefore, context effects such as price changes and zero cost effects are less likely in the circumstances of resource depletion. In addition, construal levels have profound effects on the ways of information processing (Trope and Liberman 2003, 2010). In a high construal level, people tend to attune their minds to core features and desirability aspects, whereas, in a low construal level, they are more likely to process information based on secondary features and feasibility aspects (Khan, Zhu, and Kalra 2010). A perceived value of a product is more related to desirability whereas a zero cost or a price level is more associated with feasibility. Thus, context effects or reliance on feasibility (for instance, the zero cost effect) will be diminished in a high level construal while those effects may remain in a low level construal. When people make decisions, these 2 factors can influence the magnitude of the 'zero-cost effect'. This study ran two experiments to investigate the effects of self-regulatory resources and construal levels on the selection of a free product. Kisses and Ferrero-Rocher, which were adopted in the prior study (Shampanier et al. 2007) were also used as alternatives in Experiments 1 and 2. We designed Experiment 1 in order to test whether self-regulatory resource depletion will moderate the zero-cost effect. The level of self-regulatory resources was manipulated with two different tasks, a Sudoku task in the depletion condition and a task of drawing diagrams in the non-depletion condition. Upon completion of the manipulation task, subjects were randomly assigned to one of a decision set with a zero-cost option (i.e., Kisses ₩0, and Ferrero-Rocher ₩200) or a set without a zero-cost option (i.e., Kisses ₩200, and Ferrero-Rocher ₩400). A pair of alternatives in the two decision sets have the same price gap of ₩200 between a low-priced Kisses and a high-priced Ferrero-Rocher. Subjects in the no-depletion condition selected Kisses more often (71.88%) over Ferrero-Rocher when Kisses was free than when it was priced at ₩200 (34.88%). However, the zero-cost effect disappeared when people do not have self-regulatory resources. Experiment 2 was conducted to investigate whether constual levels influence the magnitude of the 'zero-cost effect'. To manipulate construal levels, 4 different 'why (in the high construal level condition)' or 'how (in the low construal level condition)' questions about health management were asked. They were presented with 4 boxes connected with downward arrows. In a box at the top, there was one question, 'Why do I maintain good physical health?' or 'How do I maintain good physical health?' Subjects inserted a response to the question of why or how they would maintain good physical health. Similar tasks were repeated for the 2nd, 3rd, and 4th responses. After the manipulation task, subjects were randomly assigned either to a decision set with a zero-cost option, or to a set without it, as in Experiment 1. When a low construal level is primed with 'how', subjects chose free Kisses (60.66%) more often over Ferrero-Rocher than they chose ₩200 Kisses (42.19%) over ₩400 FerreroRocher. On contrast, the zero-cost effect could not be observed any longer when a high construal level is primed with 'why'.

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Antitumor Effects of Camptothecin Combined with Conventional Anticancer Drugs on the Cervical and Uterine Squamous Cell Carcinoma Cell Line SiHa

  • Ha, Sang-Won;Kim, Yun-Jeong;Kim, Won-Yong;Lee, Chung-Soo
    • The Korean Journal of Physiology and Pharmacology
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    • v.13 no.2
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    • pp.115-121
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    • 2009
  • Functional defects in mitochondria are involved in the induction of cell death in cancer cells. We assessed the toxic effect of camptothecin against the human cervical and uterine tumor cell line SiHa with respect to the mitochondria-mediated cell death process, and examined the combined effect of camptothecin and anticancer drugs. Camptothecin caused apoptosis in SiHa cells by inducing mitochondrial membrane permeability changes that lead to the loss of mitochondrial membrane potential, decreased Bcl-2 levels, cytochrome c release, caspase-3 activation, formation of reactive oxygen species and depletion of GSH. Combination of camptothecin with other anticancer drugs (carboplatin, paclitaxel, doxorubicin and mitomycin c) or signaling inhibitors (farnesyltransferase inhibitor and ERK inhibitor) did not enhance the camptothecin-induced cell death and caspase-3 activation. These results suggest that camptothecin may cause cell death in SiHa cells by inducing changes in mitochondrial membrane permeability, which leads to cytochrome c release and activation of caspase-3. This effect is also associated with increased formation of reactive oxygen species and depletion of GSH. Combination with other anticancer drugs (or signaling inhibitors) does not appear to increase the anti-tumor effect of camptothecin against SiHa cells, but rather may reduce it. Combination of camptothecin with other anticancer drugs does not seem to provide a benefit in the treatment of cervical and uterine cancer compared with camptothecin monotherapy.

The Effect of Resource Depletion on Deciding on Product Assortments Size (소비자의 자원고갈이 제품구색간 의사결정에 미치는 효과)

  • Cho, Yeon-Jin;Park, Cheong-Kyu;Lim, Hyun-Woo
    • Journal of Distribution Science
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    • v.14 no.3
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    • pp.85-91
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    • 2016
  • Purpose - Prior research has suggested that consumers typically prefer to have a larger number of options. However, preference of assortment size may depend on how depleted resources in consumers' mind are. Reduced capacity for self-regulation by resource depletion makes people rely on more intuitive and less effortful decision processing. When they are mentally depleted, people are likely to focus on the choice difficulty from large assortment, which leads to preference for the small assortment when they make a decision. It could be an important question potentially how being in a depleted mode through effortful self-regulation will influence on the evaluation of assortment size. To answer this questioner, we hypothesized that being engaged in self-regulation, as compared with not being engaged in self-regulation, will influence on the evaluation of product assortment size such as attractiveness, difficulty of choice, and anticipated regret. Research design, data, and methodology - In this study, we first manipulated self-regulatory resource availability using a self-regulation task (i.e., instructing participants to solve Sudoku puzzle vs. to solve diagram cube by filling any diagrams that they prefer into cube instead of number) and asked to indicate the difficulty of the tasks available to them ("How much difficulty did you feel when you complete the task?") Next, participants were asked to imagine that they were planning to buy a laptop at one of the two stores (small assortment: 6 options vs. large assortment: 30 options), both offering good quality of products. After reading the product descriptions, participants were instructed to consider all the information and choose a store that they would like to shop. Finally we measured the choice difficulty, evaluation of product assortments, and anticipated regret on a 7-point scale. We conducted two-way ANOVA in testing the main hypothesis that depleted consumers will show poorer subsequent self-control than non-depleted consumers when they make a decision in large assortment. Results - Compared with non-depleted participants, depleted participants showed the bigger difference from the degree of choice difficulty and product attractiveness between large and small assortments, but the result revealed only a significant interaction effect of resource depletion and assortment size on choice difficulty. Also depleted participants showed the smaller difference from the degree of anticipated regret between large and small assortments than non-depleted participants. Conclusion - Depleted individuals by a prior task are relatively effortless and intuitive form of choosing products so that they try to avoid making effortful trade-offs among choice difficulty such as large assortment, compare with non-depleted individuals. However, for anticipated regret, non-depleted individuals in small assortment anticipate more regret by excluding or at least restricting the possibility of buying attractive items or another kind of potential items than depleted individuals, regardless less choice difficulty in small option. To sum up, it is important to note that individuals are influenced by self-regulatory resources and their self-regulatory conditions contribute to the overall positive or negative impact of product assortment on choice.