• Journal of Korean society of Dental Hygiene
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• v.15 no.3
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• pp.523-529
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• 2015

Objectives: Oropharynx tumors(oral cancer), are caused by tobacco, alcohol consumption, and high-risk human papillomavirus(HPV) infection. Oral squamous cell carcinoma(OSCC) is the most common type of oral cancer and frequently arises from the mucosa of the oropharynx and oral cavity. Despite advances in the diagnosis and treatment(chemotherapy, radiotherapy, and surgery) of oral cancer, over the past two decades, the overall survival rates remains at about 60%. Methods: We pretreated HSC-2 cells with various doses of exposed the cells to eugenol and then we measured cell viability by MTT assay. Results: Cell proliferation was markedly inhibited after eugenol treatment compared to the control. The majority of HSC-2 cells in the control groups showed normal morphology with round regular nuclei. In contrast, apoptotic bodies were seen in the 0.5 mM, 1 mM, 2 mM group. However, the pretreatment with eugenol increased HSC-2 cells apoptosis according to dose-dependency. PI staining quantitatively confirmed the anti-apoptotic effects of propofol. The expression levels of cleaved caspase 3, and Bak significantly increased in HSC-2 cells. Conclusions: These findings indicate that eugenol could be a potential anti-cancer agent for human OSCC and provide valuable data for the development of a novel anticancer strategy.

• The Journal of Internal Korean Medicine
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• v.22 no.2
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• pp.239-243
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• 2001

Alcoholism is a chronic behavior disorder that disturbs the health, social, and economical functions by intaking alcohol repeatedly. Alcoholism includes some habituation, dependency, and addiction. It may be clinically silent or severe enough to lead to the rapid development of hepatic, renal and gastrointestinal failure. Alcoholism can also cause death. In this case, we administrated saenggangunbitang and sungjoocheonggantang to a patient suffering from alcohoism and its withdrawal symptoms. After administration of saenggangunbitang-sungjoocheonggantang medication, clinical symptoms, including liver function with diabetes mellitus and splenomegaly improved. saenggangunbitang-sungjoocheonggantang showed desirable effect on alcoholism symptoms.

• Applied Chemistry for Engineering
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• v.16 no.4
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• pp.581-587
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• 2005

In order to obtain a highly purified p-dioxanone (PDX) as monomer of biodegradable polymer, suitable solvent must be selected. The selection was based on the solubility of impurities, and partial layer melt crystallization were carried out under the presence of solvent. The solubility of PDX in various solvents such as ethyl acetate, tetrahydrofuran, acetone, alcohols (methanol, ethanol, 1-propanol, 1-butanol and 1-pentanol) were measured over the temperature range of $-10{\sim}15^{\circ}C$. As solubility parameters, the mixing and dissolution enthalpy between the PDX and the solvents was studied based on empirical equations and the regular solution theory. The solubility and the temperature dependency of the solubility with the solvents of acetone, ethylacetate, and tetrahydrofuran of PDX were shown to have relatively high values compared to the alcohol type solvents. Also, in same alcohols, the smaller molecules and higher polarity gave higher solvency. In partial layer melt crystallization, small amount of ethylacetate selectively dissolved impurities and gave highly purified p-dioxanone, over 99.9% purity.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.8
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• pp.5287-5295
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• 2015

This study was conducted to identify the related factors of cancer preventive behaviors for adolescent smokers. Data were collected from September 1st 2012 to March 31st 2013 of 200 adolescent smokers who were participating in smoking cessation school at W hospital in B city. As a results, there were significant differences in cancer preventive behaviors by grade, religion, benefit, barrier, perceived health status, daily living, alcohol, exercise, nicotine dependency, first smoking age, smoking duration and non-smoking intention. Cancer preventive behaviors were weakly negative related to knowledge about cancer, And there is weakly positive correlation between cancer preventive behaviors and attitude about cancer. Meaningful variables which explain cancer preventive behaviors were daily living, barrier, grade, exercise, benefit, knowledge about cancer, smoking cessation intention in order. Total explanation power was 30.6% and daily living has most explanation power. In conclusion, It is necessary to encourage sound hobbies and exercise instead of smoking for adolescent smokers in their daily living. And health education programmes, based on the grade and smoking cessation intention of adolescent smokers, need to be developed to emphasize the benefit of cancer preventive behaviors, and to decrease barriers against those behaviors.