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Study on the Selection of Solvent for Purificatino of p-Dioxanone by Crystallization Method  

kim, Sung-Il (Chemical Process and Engineering Center, Korea Research Institute of Chemical Technology)
Koh, Joo-young (Chemical Process and Engineering Center, Korea Research Institute of Chemical Technology)
Kim, Chul-Ung (Chemical Process and Engineering Center, Korea Research Institute of Chemical Technology)
Koh, Jae-Cheon (Chemical Process and Engineering Center, Korea Research Institute of Chemical Technology)
Park, So-Jin (Department of Chemical Engineering, Chungnam National University)
Seo, Young-Jong (3rd Research Laboratory, Daedeok Research Institute, Honam Petrochemical Corporation)
Choi, Byung-Ryul (3rd Research Laboratory, Daedeok Research Institute, Honam Petrochemical Corporation)
Publication Information
Applied Chemistry for Engineering / v.16, no.4, 2005 , pp. 581-587 More about this Journal
Abstract
In order to obtain a highly purified p-dioxanone (PDX) as monomer of biodegradable polymer, suitable solvent must be selected. The selection was based on the solubility of impurities, and partial layer melt crystallization were carried out under the presence of solvent. The solubility of PDX in various solvents such as ethyl acetate, tetrahydrofuran, acetone, alcohols (methanol, ethanol, 1-propanol, 1-butanol and 1-pentanol) were measured over the temperature range of $-10{\sim}15^{\circ}C$. As solubility parameters, the mixing and dissolution enthalpy between the PDX and the solvents was studied based on empirical equations and the regular solution theory. The solubility and the temperature dependency of the solubility with the solvents of acetone, ethylacetate, and tetrahydrofuran of PDX were shown to have relatively high values compared to the alcohol type solvents. Also, in same alcohols, the smaller molecules and higher polarity gave higher solvency. In partial layer melt crystallization, small amount of ethylacetate selectively dissolved impurities and gave highly purified p-dioxanone, over 99.9% purity.
Keywords
solubility parameter; crystallization; selection of solvent; p-dioxanone;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
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