• 제목/요약/키워드: Dependence of a patient

검색결과 63건 처리시간 0.027초

Homozygous Missense Epithelial Cell Adhesion Molecule Variant in a Patient with Congenital Tufting Enteropathy and Literature Review

  • Guvenoglu, Merve;Simsek-Kiper, Pelin Ozlem;Kosukcu, Can;Taskiran, Ekim Z.;Saltik-Temizel, Inci Nur;Gucer, Safak;Utine, Eda;Boduroglu, Koray
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • 제25권6호
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    • pp.441-452
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    • 2022
  • Congenital diarrheal disorders (CDDs) with genetic etiology are uncommon hereditary intestinal diseases characterized by chronic, life-threatening, intractable watery diarrhea that starts in infancy. CDDs can be mechanistically divided into osmotic and secretory diarrhea. Congenital tufting enteropathy (CTE), also known as intestinal epithelial dysplasia, is a type of secretory CDD. CTE is a rare autosomal recessive enteropathy that presents with intractable neonatal-onset diarrhea, intestinal failure, severe malnutrition, and parenteral nutrition dependence. Villous atrophy of the intestinal epithelium, crypt hyperplasia, and irregularity of surface enterocytes are the specific pathological findings of CTE. The small intestine and occasionally the colonic mucosa include focal epithelial tufts. In 2008, Sivagnanam et al. discovered that mutations in the epithelial cell adhesion molecule (EpCAM, MIM# 185535) were the genetic cause of CTE (MIM# 613217). More than a hundred mutations have been reported to date. Furthermore, mutations in the serine peptidase inhibitor Kunitz type 2 (SPINT2, MIM# 605124) have been linked to syndromic CTE. In this study, we report the case of a 17-month-old male infant with congenital diarrhea. Despite extensive etiological workup, no etiology could be established before admission to our center. The patient died 15 hours after being admitted to our center in a metabolically decompensated state, probably due to a delay in admission and diagnosis. Molecular autopsy with exome sequencing revealed a previously reported homozygous missense variant, c.757G>A, in EpCAM, which was confirmed by histopathological examination.

뼈전이의 방사성동위원소 통증치료 (Radiopharmaceuticals for the Therapy of Metastatic Bone Pain)

  • 안병철
    • Nuclear Medicine and Molecular Imaging
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    • 제40권2호
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    • pp.82-89
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    • 2006
  • Bone metastasis is a common sequelae of solid malignant tumors such as prostate, breast, lung, and renal cancers, which can lead to various complications, including fractures, hypercalcemia, and bone pain, as well as reduced performance status and quality of life it occurs as a result of a complex pathophysiologic process between host and tumor cells leading to cellular invasion, migration adhesion, and stimulation of osteoclastic and osteoblastic activity. Several sequelae occur as a result of osseous metastases and resulting bone pain can lead to significant debilitation. A multidisciplinary approach is usually required not only to address the etiology of the pain and its complicating factors but also to treat the patient appropriately. Pharmaceutical therapy of bone pain, includes non-steroidal analgesics, opiates, steroids, hormones, bisphosphonates, and chemotherapy. While external beam radiation therapy remains the mainstay of pain palliation of a solitary lesions, bone seeking radiopharmaceuticals have entered the therapeutic armamentarium for the treatment of multiple painful osseous lesions. $^{32}P,\;^{89}SrCl,\;^{153}Sm-EDTMP,\;^{188}Re/^{186}Re-HEDP,\;and\;^{177}Lu-EDTMP$ can be used to treat painful osseous metastases. These various radiopharmaceuticals have shown good efficacy in relieving bone pain secondary to bone metastasis. This systemic form of metabolic radiotherapy is simple to administer and complements other treatment options. This has been associated with improved mobility in many patients, reduced dependence on narcotic and non-narcotic analgesics, improved performance status and quality of life, and, in some studios, improved survival. All of these agents, although comprising different physical and chemical characteristics, offer certain advantages in that they are simple to administer, are well tolerated by the patient if used appropriately, and can be used alone or in combination with the other forms of treatment. This article illustrates the salient features of these radiopharmaceuticals, including the usual therapuetic dose, method of administration, and indications for use and also describe about the pre-management checklists, and jndication/contraindication and follow-up protocol.

골관절염 환자의 슬관절 전치환술 경험 (A Study on Experiences of Total Knee Replacement in Patients with Osteoarthritis)

  • 박현옥;박경숙
    • 근관절건강학회지
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    • 제3권2호
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    • pp.135-150
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    • 1996
  • This study was performed to analyze the patient's experience during the progress of disease in the patients with osteoarthritis, who are taken the replacement surgery of knee Joint. The examine was consisted of five patients with osteoarthritis, who are taken the replacement surgery of knee joint from Dec. 4. 1995 to May, 20, 1996 at C university hospital. After hospitalization, the physical and psycho-logical status of the patients during preoperation, postoperation and discharge was examined. The data were examined according to the ethnographic method. The results are as follows. The patients experienced the periods of embarrasment, conflict, before surgery suffering, acceptance period after surgery. In the embarrasment period, the patients take a multiple medication therapy including hospital treatment, oriental medication and folk medication to ameliorate joint pain after first diagnosis on arthritis. The embarrasment period includes compulsive drug medication, oriental medication, folk medication, trouble some, sadness and survey of hospitals. In the conflict period, the patients consider the operation of knee because of working difficulty and severe Joint Pain, while they feel anxiety about the surgery. They condemn their physical situations. They have the conflict and anxiety on surgical operation. they consider the quality of life. They hope the surgery makes patients to improve walking ability. This period includes self-condemned, sorry, tiresomeness, expectation, worrisomeness, anxiety and hesitance. In the suffering period, the patients experience post operation physical discomfort after the total knee replacement. They do physical exercise, including extension and straight leg raising to maintain walking ability, while they endure to wait approximately 6 months for normal walking movements and they are also unstable to environmental people's sight. This period includes postoperative pain, continuous discomfort, inability and communication difficulty to other's people. In the acceptance period, the patients consider longerity of artificial Joint and also endure mild remaining joint pain. Some of them have religions for their wellbeing of life. This period include a self-protesting policy, abandonment, self-consolation, dependence on religions. According to the result from this study I suggested these shown below. 1) After replacement surgery of knee joint, continuous investigation on outcome patient is necessary. 2) It is also necessary to analyze on patient's experiences, who are taken the replacement surgery of hip Joint. 3) Study on disease experiences of patients with rhematoid arthritis, who take drug medication and physical therapy alone without surgery, is necessary. 4) Investigation on patient's favorable folk medication may be helpful to analyze disease experience of patients with osteoarthritis.

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외래 환자의 임상특성이 예약 부도에 미치는 영향 분석 (Analysis of the Effect of Patients' Clinical Conditions on No-Shows)

  • 이상복;박기택;정광헌
    • 한국전자거래학회지
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    • 제22권4호
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    • pp.53-69
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    • 2017
  • 본 논문에서는 환자들의 임상특성이 예약 부도에 미치는 영향을 분석하고자 한다. 미국의 한 보훈병원에 있는 7,055명 환자들의 진단 상병명과 그들의 예약 부도 데이터를 이용하여 진단 상병에 따른 예약 부도의 차이, 진단 상병의 개수에 따른 차이에 대해서 분석 및 비교를 실시하였다. 약물 중독, 우울증과 같은 정신질환과, 고혈압과 같은 만성 질환에서 예약 부도가 유의하게 높게 나타났다. 진단 상병의 개수가 증가할수록 예약 부도가 감소하는 것을 확인할 수 있으나, 진단 상병의 개수가 4개를 넘어서면 예약 부도가 통계적으로 유의하게 감소하지 않는 것으로 나타났다. 이러한 통계적 분석 과정을 통해 의료 환경에서 수행하고 있는 진료 및 예약 부도 관리의 문제점을 식별하여 제시하였다. 본 논문의 결과는 병원의 예약 부도에 대한 해결책을 찾는데 이용될 수 있다고 판단된다.

한국 성인에서 정중접근법과 측면접근법에 의한 요부 척추천자시 전굴 자세에 따른 성공률의 비교 (The Difference of Success Rate between the Midline Approach and the Paramedian Approach of Spinal Anesthesia in each of Flexed Patients and Straightened Patients)

  • 조명현;이종선
    • The Korean Journal of Pain
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    • 제9권1호
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    • pp.126-129
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    • 1996
  • Background: Advantages of paramedian approach over midline approach include less tissue trauma and less dependence on patient's ability to assume a fetal position. When midline approach fails in patients who are difficult to take a position with lumbar spine flexed, paramedian approach to interlaminar space may succeed. Methods: Success rates of spinal anesthesia were measured for 47 flexed patients by midline approach, 48 flexed patients by paramedian approach, 23 straightened patients receiving spinal anesthesia by midline approach, and 23 straightened patients by paramedian approach. Results: Success rates in flexed patients were 100% by midline approach and 100% by paramedian approach. Success rates for straightened patients were 13.0% by midline approach and 78.3% by paramedian approach. For straightened patients there were no correlations between success fate and age, weight, Ponderal Index but there were correlations between height and midline approach of spinal anesthesia. Conclusion: Pertaining to adult Koreans, success rates of spinal anesthesia for strainghtened patients were less than those for flexed patients. Success rate of paramedian approach of spinal anesthesia among strainghtened patients were better than those of midline approach.

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급성 뇌졸중 입원 환자의 연하장애 유병률과 관련요인 (Prevalence and associated factors of dysphagia in patients hospitalized with acute stroke)

  • 장희경;윤숙경;길초롱
    • 문화기술의 융합
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    • 제5권1호
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    • pp.417-428
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    • 2019
  • 본 연구는 급성 뇌졸중 입원 환자의 연하장애 유병률과 그 관련요인을 탐색하기 위한 서술적 조사연구로, 일상급종합병원에 급성 뇌졸중으로 진단받은 입원 환자 131명(연령 범위 34-92세, 58.0% 남성)을 대상으로 수행되었다. 본 연구의 결과 급성 뇌졸중 입원 환자의 유병률은 24.4%였으며, 대상자의 나이, 뇌졸중 중증도, 구강상태, 일상활동 의존도가 연하장애에 영향을 미치는 것으로 나타났다. 이러한 결과를 기반으로 뇌졸중 발병 직후부터 연하장애 조기 발견을 위한 적극적인 간호사정과 예방적 중재 프로그램 개발과 적용이 필요하다.

Anterior Cingulate Cortex and Amygdala Dysfunction Among Patients with Alcohol Dependency During Exposure to Negative Emotional Stimuli

  • Park, Mi-Sook
    • 감성과학
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    • 제21권4호
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    • pp.103-112
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    • 2018
  • This study aimed to identify specific psychological and brain activation responses relating to the processing of negative emotions in patients with alcohol dependency. The authors hypothesized that patients with alcohol dependency would demonstrate the abnormal functioning of brain regions involved in negative emotions. Eleven male patients diagnosed with alcohol dependence in an inpatient alcohol treatment facility and 13 social drinkers with similar demographics were scanned using functional magnetic resonance imaging (fMRI) as they viewed film clips that evoked negative emotions. During exposure to negative emotional stimuli, the control group evinced significantly greater activity in the right anterior cingulate cortex (ACC) in comparison to patients with alcohol dependency. Correlation analyses demonstrated a negative association in the relationship between beta values from the right ACC and amygdala in participants classified in the control group. No statistically significant relationship was observed for blood oxygenation level-dependent (BOLD) changes between the two regions in the patient group during the elicitation of negative emotions. On the other hand, patients exhibited a greater activation of the amygdala as negative emotions were induced. These results suggest that alcoholism presents pathophysiology of brain activation that is distinct from the responses of healthy individuals functioning as controls.

금연동기단계에 따른 코칭프로그램이 환자 금연에 미치는 영향 (The Effects of Smoking Cessation Coaching Program based on Motivation Stage to Stop Smoking of Patients at a Public Hospital)

  • 곽미영;황은정
    • 한국산학기술학회논문지
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    • 제17권4호
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    • pp.188-198
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    • 2016
  • 본 연구의 목적은 N시에 소재한 공공병원의 금연클리닉 프로그램을 이용한 흡연 환자(입원 및 외래 포함)를 대상으로 Prochaska와 Diclemente의 변화단계모형(Transtheoretical Model, TTM)을 적용한 금연동기단계에 따른 코칭프로그램 참여 전과 후 대상자의 흡연량, 니코틴의존도, 호기 일산화탄소 농도, 소변 코티닌의 차이를 확인하기 위함이다. 연구설계는 금연동기에 따른 코칭프로그램이 환자들의 금연에 미치는 효과를 확인하기 위해 대상자의 흡연량, 니코틴의존도, 호기 일산화탄소 농도, 소변 코티닌을 프로그램 전, 2주, 6주 후간의 차이를 비교하는 다중반복 간헐적 시계열 설계연구이다. 본 연구에서 활용된 자료는 2011년 공공보건의료프로그램 중 금연프로그램을 통해 수집된 2차 자료를 활용하였다. 코칭프로그램은 6주동안 중재가 진행되며, 첫방문, 2주째 방문, 6주째 방문에 제공되며, 12주째 금연 유지 상태를 점검한다. 연구대상자의 교육 전과 교육 후 흡연량, 니코틴 의존도, 호기 일산화탄소 농도, 소변 코티닌 차이는 카이제곱 검정과 t-test로 비교하였다. 이 연구대상자는 총 47명이며, 남자는 44명(93.62%), 여자는 3명(6.38%)으로 대부분 남자였다. 금연동기단계별 대상자 수는 실천단계가 4명(8.51%), 준비단계는 43명(91.49%)이었다. 금연동기단계에 따른 코칭프로그램 전과 후를 비교한 결과, 실천단계 집단은 대부분 프로그램 전과 후 흡연량, 니코틴의존도, '0'상태를 유지하였다. 준비단계 집단은 흡연량, 니코틴의존도, 호기 일산화탄소가 프로그램 전과 6주후 유의한 차이를 보이면 감소한 것으로 나타났다(p<.001). 환자들을 대상으로 한 병원 현장에서의 금연코칭 프로그램은 매우 효과적임을 확인할 수 있었다. 하지만, 환자들을 대상으로 한 금연프로그램은 건강한 사람들에 비해 인적 재정적 부담이 더 높다. 따라서 환자들의 금연을 위해 적극적인 인적, 재정적 지원이 있어야 할 것이다.

뇌졸중환자의 희망 (The Hope of the Stroke Patients)

  • 김이순
    • 대한간호학회지
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    • 제27권1호
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    • pp.212-227
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    • 1997
  • Cerebrovascular diseases in Korea is an important health problem since mortality and mobidity have been increased rapidly. It marked the 2nd cause of specific death rates in 1993. The stroke causes physical function disorder due to hemiparalysis and emotional disorder, and stroke patients experience helplessness, powerlessness. sense of alienation and loss of hope. These feelings make the rehabilitation difficult because they lose the will of life. The subjects of the study were seven citizens who live in Pusan, are over 50 years old and belong to low income-level. The data were collected from Jan. to Sep. 1995. The researcher as a caregiver and volunteer made confidence of them and asked for their agreement on the purpose of the study. The subjects expressed their experience as openheartedly as possible. The analysis of the data was made through the phenomenological analytic method suggested by Giorgi, which is as follows ; as an unit of description which include the subject' expressions and the researcher's observation, it is examined the theme that express the hope experience with the subject's language(underlining), and the focal meanings are identified. The focal meaning is the crystalization of the theme, which is written in the language of the researcher. After intergrating the focal meaning and make the situated structural description as the meaning of the hope experience identified on each subject's point. After intergrating the situated structural description and make the general structural description as the meaning of the hope experience identified on total subject's point then the systemizing of the structure of the hope experienced phenomena and the flowing of the conciousness was researched. The conclusions of this study was as follows : The ten sources of hope which the subjects experienced were sorted as under 〈mutual relations to others : spouse, children, relatives, fellow believer. health professioner. associate patient group〉, 〈spiritual dependence〉. 〈recovery of physical function〉. 〈rumination of the past life〉, 〈expectation of the future〉. 〈economic power〉, 〈belief〉, 〈ability〉. 〈spontaneous participation〉 and 〈recovery of roles〉. Their hope was spoken out by the following two kinds of linguistics. First. the hope was expressed in the affirmative expression as follows : 〈 to be dependable〉, 〈to make efforts〉, 〈to keep under control〉, 〈to desire〉, 〈to be pleasant〉, 〈to be peaceful〉, 〈to be grateful〉, 〈to give help〉, 〈self-confidence. Courage〉, 〈to be happy〉, 〈to satisfy oneself〉, 〈to share with others〉, 〈to understand〉 and 〈to be affected, be impressed〉 Second, the hope was expressed in the negative on pression as under : 〈to be distressed〉, 〈to be uneasy〉, 〈to be sorry, be unsatisfied〉 〈despair〉, 〈to abandon〉, 〈to be fearful〉, 〈to suffer〉, 〈to bear a burden〉 〈to be confused〉, 〈to be solitary〉, 〈chest trouble〉, 〈to feel heavy〉 〈grief〉, 〈to be daunted〉, 〈to get angry〉, 〈to be uncomfortable〉, 〈to have something regretable〉 and 〈to feel guilty〉. And their hope was expressed by the following four behavioral expressions : 〈physical sphere〉, 〈psychological sphere〉, 〈social support sphere〉 and 〈spiritual sphere〉. The reaction patterns of their hope experience appeared in the following 4 coping method : 〈conquest type〉, 〈dependence type〉, 〈adaptation type〉 and 〈fate type〉. Finally, in the hope structure the sense of certainty don't always coexict with the sense of uncertainty, When the stroke patients try to search for the best quality of life, the senses of certainty and uncertainty make a continual cyclic system in the hope structure.

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3차원 모델링을 이용한 대퇴 전염각의 측정 (A NEW MEASUREMENT METHOD OF FEMORAL ANTEVERSION BASED ON THREE DIMENSIONAL MODELING)

  • 김준식;박희정;최광수;최귀원;김선일
    • 대한의용생체공학회:학술대회논문집
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    • 대한의용생체공학회 1997년도 춘계학술대회
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    • pp.141-144
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    • 1997
  • Femoral neck anteversion is the angle between the neck and the knee axis projected on a plane perpendicular to the longitudinal axis. Conventional methods that use cross-sectional Computed Tomography(CT) images to estimate femoral anteversion have several problems because of the complex 3D structure of the femur. These are the ambiguity of defining the longitudinal axis, the femoral neck axis and condylar line, and the dependence on patient positioning. Especially the femoral neck axis that is known as a major source of error is hard to determine from a single or multiple 2D transverse images. So we developed a new method for measuring femoral anteversion by 3D modeling method. In this method, femoral head is modeled as a sphere. The center of femoral neck is the mid-point of the 2D reconstructed oblique image in the femoral neck part. Then neck axis is a line connecting foregoing two centers. We model the longitude of femur as a cylinder, and the long axis is defined from the fitted cylinder. The knee axis which is tangent to the back of the femoral condyles is easily determined by table-top method. By the definition of femoral anteversion, the femoral anteversion is easily calculated from this model.

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