• Asian Pacific Journal of Cancer Prevention
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• 제15권14호
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• pp.5627-5631
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• 2014

Background: Oral cancer presents with high mortality rates, and the likelihood of survival is remarkably superior when detected early. Dental professionals have an important role and responsibility in prevention and early detection of oral cancer. Purpose: The aim of this study was to assess the knowledge, practices and opinions regarding oral cancer among dentists in Yemen. Materials and Methods: A cross-sectional survey was conducted using a self-administered questionnaire involving private and public dental practitioners, working in different governorates in Yemen. Results: Of the 800 dentists surveyed, a total of 221 questionnaires were completed and returned (response rate 27.6%). A vast majority of dentists (96.38%) identified tobacco as the major risk factor for oral cancer, and 82.8% knew that squamous cell carcinoma is the most common form. While 47.1% of the dentists agreed that they were adequately trained in oral cancer screening, the majority (86%) believed that they need further training in oral cancer screening. Conclusions: These results suggest that additional training and continuing educational programs on prevention and early detection of oral cancer for dentists are to be highly recommended.

• Biomolecules & Therapeutics
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• 제15권4호
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• pp.261-265
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• 2007

Hydroxyproline (HYP) is a post-translational product of proline hydroxylation catalyzed by an enzyme prolyl 4-hydroxylase (P4H) which plays a crucial role in the synthesis of all collagens. Considering the role of collagen and its significance in many clinically important diseases such as liver fibrosis, a great deal of attention has been directed toward the development of an assay at cell-based system. The reason is that cell-based assay system is more efficient than enzyme-based in vitro system and takes much less time than in vivo system. Several assay procedures developed for P4H are laborious, time-consuming and not feasible for the massive-screening. Here, we report the cell-based assay method of prolyl 4-hydroxylase in immortalized rat hepatic stellate HSC-T6 cells. To optimize the cell culture condition to assay for HYP content, various concentrations of reagents were treated for different times in HSC-T6 cells. Our data showed that the treatment with ascorbate in a hypoxic condition for 24 h resulted in the maximal increase of HYP by 1.8 fold. Alternatively, cobalt chloride ($5\;{\mu}M$) and ascorbate ($50\;{\mu}M$) in normoxic states exhibited similar effect on the production of HYP as in a hypoxic condition. Therefore, cobalt chloride can be substituted for a hypoxic condition when an anaerobic chamber is not available. Rosiglitazone and HOE077, known as inhibitors of collagen, synthesis decreased P4H enzyme activity by 32.3% and 15%, respectively, which coincided with previous reports from liver tissues. The level of the smooth muscle ${\alpha}$-actin, a marker of activated stellate cells, was significantly increased under hypoxia, suggesting that our experimental condition could work for screening the anti-fibrotic compounds. The assay procedure took only 3 days after treatment with agents, while assays from the primary stellate cells or liver tissues have taken several weeks. Considering the time and expenses, this assay method could be useful to screen the compounds for the inhibitor of prolyl 4-hydroxylase.

• Imaging Science in Dentistry
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• 제41권1호
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• pp.1-6
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• 2011

Purpose : The purpose of this review is to evaluate the possibility of panoramic radiography as a national oral examination tool. Materials and Methods : This report was carried out by review of the literatures. Results : Panoramic radiography has sufficient diagnostic accuracy in dental caries, periodontal diseases, and other lesions. Also, the effective dose of panoramic radiography is lower than traditional full-mouth periapical radiography. Conclusion : Panoramic radiography will improve the efficacy of dental examination in national oral examination. However, more studies are required to evaluate the benefit, financial cost, and operation time and also to make selection criteria and quality management program.

• 대한장애인치과학회지
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• 제13권2호
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• pp.67-72
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• 2017

The purpose of study was to analyze the types of dental treatment and their frequencies in a charity dental clinic for the disabled people, and to figure out baseline data for developing oral health policies. This study was based on the 141 patient records who visited the charity free dental clinic between 2011 and 2016. Data were evaluated according to gender, types of disability, types of treatment, and the average number of caries. The number of dental treatment according to sex was 70% for men and 30% for women. Patients were classified according to types of disability. The most common type of disability is intellectual disabilities (53.9%). After that, developmental disabilities were 37.5%, and brain lesions were 8.51%. The highest frequency of dental treatment is preventive treatment (45.1%). The mean number of dental caries was higher than the number of initial dental caries in all types of disability. Preventive oral care education and regular oral screening are necessary for the oral health of patients with disabilities.

• 보건의료산업학회지
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• 제10권2호
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• pp.121-131
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• 2016

Objectives : The purpose of this study was to analyze the status of oral health in relation to the acknowledgement of oral health trouble and oral health habits. Methods : This study was conducted after IRB was received, on 273 patients who had received health screenings between October-1, 2014 and January-31, 2015 at a general hospital in Busan. Results : Regarding the status of oral health in relation to the acknowledgement of oral health trouble, the rates of dental caries and periodontal disease were higher when the patients knew the reasons for trouble about the oral hygiene. With regard to oral health habits, our results showed that the more frequently the patients ate sugary snacks per day, the probability of experiencing periodontal disease was higher than for the patients who did not eat sugary snacks. Our results also, showed that the occurrence of dental caries is very much dependent upon whether a patient had experienced education on toothbrushing. Conclusions : Patients need to become more aware of their oral health through education. A program that emphasizes the importance of preventive oral health behaviors and the maintenance of correct oral health behavior should be developed.

• 치위생과학회지
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• 제17권5호
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• pp.398-404
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• 2017

The present study aimed to examine the influence of mental health factors on oral health factors using data from the Korean National Health and Nutrition Examination Survey (KNHANES). A total of 1,548 elderly individuals aged over 65 years who completed the screening and health questionnaire were selected as the final study participants. The psychological health factors related to perceived oral health status were depression and stress when the gender was controlled, and in terms of gender, both elderly male and female individuals were stressed and depressed. These results suggested that the psychological health of elderly individuals negatively affects not only perceived oral health but also the quality of life. In addition, the psychological health of the elderly individuals should be systematically managed along with oral health care and overall health care and lifestyle. If a comprehensive health management system is available for low-income groups or an elderly person living alone, it should positively affect and improve the quality of life of elderly individuals.

• 한국치위생학회지
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• 제20권3호
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• pp.257-268
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• 2020

Objectives: This purpose of this study was to examine the trends in interventional research and analyze the contents and results of intervention through a systematic literature review of the domestic research literature, suggesting the effect of an oral care program on elementary school students. Methods: A total of 262 articles were retrieved initially, and the duplicate articles were then removed, excluded after screening titles, abstracts, and full-text articles. Finally, a total of 16 papers were used in the review. Results: The study included 9 articles with the nonequivalent control group pretest-posttest design and 7 with the one-group pretest-posttest design. All articles were of non-randomized studies. The most common index of the interventional effect was dental plaque. Further, oral health behaviors and knowledge, perception, self-efficacy, and DMFT index were common indices. In the quality assessment, in the "blinding of outcome assessment" among six items of ROBANS, 12 studies showed a high risk of bias. Conclusions: In order to develop an interventional oral health care program for elementary school students and evaluate the effectiveness, a strict research design and qualitative improvement of research reports are required, and continuous research should be conducted to develop a systematic protocol.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제48권1호
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• pp.3-12
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• 2022

Selection of potential disease-specific biomarkers from saliva or epithelial tissues through next generation sequencing (NGS)-based protein studies has recently become possible. The early diagnosis of oral squamous cell carcinoma (OSCC) has been difficult, if not impossible, until now due to the lack of an effective OSCC biomarker and efficient molecular validation method. The aim of this study was to summarize the advances in the application of NGS in cancer research and to propose potential proteomic and genomic saliva biomarkers for NGS-based study in OSCC screening and diagnosis programs. We have reviewed four categories including definitions and use of NGS, salivary biomarkers and OSCC, current biomarkers using the NGS-based technique, and potential salivary biomarker candidates in OSCC using NGS.

• Journal of Dental Anesthesia and Pain Medicine
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• 제22권2호
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• pp.75-86
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• 2022

This review aims to identify the influence of the vehicle and its concentration used to carry calcium hydroxide (Ca(OH)₂) medicament on postoperative pain. The protocol for this review was registered in the open science framework (Registration DOI-10.17605/OSF.IO/4Y8A9) and followed the guidelines provided by the Joanna Briggs Institute. Reporting was based on the preferred reporting items for systematic reviews and meta-analyses extension for scoping reviews (PRISMA-ScR). Literature screening and searches were performed on PubMed/Medline, Scopus, and EBSCO hosts. Furthermore, additional records were manually analyzed using various sources. The selected studies were published in English and included the use of any vehicle adjunct to Ca(OH)₂ to evaluate postoperative pain using qualitative and quantitative pain assessment tools. Descriptive analysis was conducted to review the study design, vehicle elements, and their effects. A preliminary search yielded 7584 studies, of which 10 were included. According to the data collected, the most commonly used Ca(OH)₂ vehicles were chlorhexidine (CHX), normal saline, and camphorated paramonochlorophenol/glycerine (CPMC/glycerine), which had a significant effect on postoperative pain. Among the included studies, six evaluated the effect of CHX as a vehicle. It was observed that a higher concentration of the vehicle (2%) showed a favorable response in reducing postoperative pain. A majority of studies have validated a positive consequence of using a vehicle on postoperative pain. Although higher vehicle concentrations were found to alter postoperative pain levels, the data were insufficient to draw a firm conclusion. Our scoping review indicates that further clinical studies should focus on using different vehicles at various concentrations and application times to check for feasible and safe exposure in addition to providing pain relief.

• Journal of Oral Medicine and Pain
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• 제37권3호
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• pp.135-139
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• 2012

유전성출혈모세혈관확장증은 피부 및 점막에 있는 말단 혈관이 비정상적으로 확장된 모세혈관 확장증과 내부 장기, 특히 폐, 뇌, 간 부위의 동정맥기형 발생을 특징으로 하는 상염색체 우성 유전질환이다. 이 질병을 가진 환자들은 종종 오랜 시간 동안 진단이 되지 않은 채로 지내다가 생명을 위협할 수 있는 심각한 출혈, 뇌졸중, 뇌농양과 같은 합병증이 발생하기도 한다. 따라서 이 질환의 조기 진단 및 적절한 선별검사가 매우 중요하다. 유전성출혈모세혈관확장증의 조기 진단을 통해 증상 없이 존재하다 합병증을 유발할 수 있는 폐, 간, 뇌 부위의 동정맥기형에 대한 선별 검사를 시행함으로써 이 질병에 이환된 환자와 가족에 대한 예방적 관리가 가능하다. 피부 및 점막에 발생하는 모세혈관확장증은 특징적인 소견을 보이며 치과의사에 의해 쉽게 발견되므로 치과의사는 유전성출혈모세혈관확장증에 대해 잘 알고 조기 진단에 기여할 필요가 있다. 최근 이 질환으로 진단된 증례가 있어 문헌 고찰과 함께 보고하고자 한다.