• 대한통합의학회지
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• 제10권2호
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• pp.49-59
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• 2022

Purpose : The purpose of this study is to directly understand the health condition of residents of mental health sanatoriums nationwide, which has been difficult to ascertain in surveys conducted to date. The study presents specific measures for improving the health of these residents. Methods : A "physical examination questionnaire for residents of mental health sanatoriums" was developed to check the basic physical condition of residents, and 20 out of 59 mental health sanatoriums nationwide were randomly selected. Medical personnel visited the sanatoriums, interviewing and examining the residents in person. A total of 396 health surveys were completed. Results : Many of the residents were underweight but had abdominal obesity. It was confirmed that chronic diseases among the residents were not diagnosed early or were not properly managed. Among the subjective symptoms complained of by the residents, musculoskeletal symptoms were the most common. Oral examinations revealed a serious level of oral health problems among the residents, including dental caries and missing teeth. Basic physical examinations found health problems that required additional examination or medical treatment. Blood pressure abnormalities made up the highest percentage of the health problems. Conclusion : Regular health surveys are needed to determine the health condition of residents of mental health sanatoriums. Access to and quality of primary medical services within the sanatoriums need to be dramatically improved. A delivery system for severe diseases and emergency medical care in the sanatoriums should also be specifically presented. The residents should be notified upon admission and during their stay that they have the right to the enjoyment of the highest attainable standard of mental and physical health. The issue of health rights should be addressed within a larger framework of reorganizing management plans for people in the community - not only residents - with chronic mental illness.

• 대한소아치과학회지
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• 제50권2호
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• pp.142-154
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• 2023

상악 견치는 기능과 외모에 있어서 중요한 역할을 하지만, 맹출 장애로 인해 문제를 일으키는 경우가 많다. 상악 견치의 매복은 비교적 흔하며 구조적 장애, 발달 이상, 공간 부족, 유전과 같은 다양한 요인에 의해 발생할 수 있다. 상악 견치의 구개측 매복은 서양인에게서 흔한 것으로 보고되지만 한국인에게는 순측 매복이 더 흔한 것으로 관찰된다. 순측으로 변위된 상악 견치의 경우, 치아 총생 및 골격성 부정교합이 보일 수 있으며, 측절치의 선천적 상실이나 과잉 측절치는 상악 견치의 구개측 매복 가능성을 높일 수 있다. 상악 견치 매복의 조기 발견 및 적절한 처치는 조화로운 치열 발달과 정상적인 치아 기능을 위해 중요하다. 본 종설을 통해 매복 상악 견치의 다양한 처치법을 제안하고 그 원리를 설명하고자 한다.

• 대한수의학회지
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• 제63권4호
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• pp.35.1-35.10
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• 2023

Non-human primate (NHP) research faces challenges due to zoonosis risk and complex veterinary management yet lacks standardized guidelines for animal care. Therefore, we developed an advanced veterinary management protocol for NHP quarantine, anesthesia, and postoperative care. Three female 4 to 5-year-old cynomolgus monkeys were anesthetized and underwent various tests, including body weight, temperature, blood tests, urinalysis, microbiological monitoring, and physical and dental examinations. Ivermectin and medicated baths were administered to eradicate ectoparasites and endoparasites, and testing was repeated 30 days later. Following quarantine, we performed computed tomography and anesthesia maintenance for mastoidectomy. To relieve pain and maintain body weight, we administered tramadol intramuscularly 4 times/day for 3 days and meloxicam subcutaneously twice daily for 14 days. Feed replacements were provided. During the 33-day quarantine period, physical examinations revealed no abnormalities indicative of infectious diseases, and no specific clinical symptoms were observed. Through a preliminary test of anesthesia time, we selected ketamine 4 mg/kg + medetomidine 50 ㎍/kg for short experiments such as computed tomography, and ketamine 8 mg/kg + medetomidine 50 ㎍/kg for intubation. Ten days after mastoidectomy, NHPs consumed 100 kcal/kg and recovered their body weight. This study offers advanced veterinary management guideline for NHP research. Such protocols can lead to more standardized and ethical practices in NHP research, thereby enhancing the quality of studies on NHPs and the translation of findings to human health and disease.

• 구강회복응용과학지
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• 제40권2호
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• pp.46-54
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• 2024

목적: 투석을 받고 있으며 신장 이식 수술 전 구내 평가를 위해 의뢰된 말기 신장 질환자의 치주 상태를 신장 기능이 정상인 대상자들과 비교 평가하고자 함이다. 연구 재료 및 방법: 말기 신장 질환으로 투석을 받고 있으면서 신장 이식 수술 전 구강내 평가를 위해 대학병원 신장 내과에서 치과진료센터로 의뢰된 환자들을 대상으로 하였다. 치주 상태의 비교를 위해 신장 기능에 이상이 없으면서, 나이와 성별이 부합하는 대상자를 추출하여 건강한 대조군으로 선정하였다. 신장내과 진료 기록을 통해 환자의 연령, 성별, 동반질병, 받고 있는 투석의 종류, 투석 기간을 조사하였으며, 치주과 진료 기록을 통해 치주 상태에 대한 자료를 분석하였다. 결과: 투석을 받는 환자 51명 및 건강한 대조군에 속한 51명을 합하여 모두 102명이 본 연구에 포함되었다. 신장 이식 수술을 받기 전까지 투석을 받은 말기 신장 질환자들에서 건강한 대상자들에 비해 치주낭 깊이, 임상적 부착수준, 치주낭 깊이가 5 mm 이상 되는 부위의 백분율, 임상적 부착수준이 4 mm 이상 되는 부위의 백분율, 탐침시 출혈이 일어나는 치아의 백분율, 상실치 수 등이 유의하게 크게 나타났다. 또한 투석을 받는 환자 그룹에서 중등도에서 중도 치주염을 지닌 비율이 건강한 대조군에 비해 더 높은 것으로 나타났다. 결론: 본 연구에서 투석을 받고 있으며 신장 이식 수술 전 구강내 평가를 위해 의뢰된 말기 신장 질환자의 치주 상태는 연령과 성별이 유사한 건강한 대조군에 속한 대상자들에 비해 악화된 상태였다.

• 대한소아치과학회지
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• 제31권3호
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• pp.372-380
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• 2004

쇄골두개 이형성증은 골격과 치아 이상을 동반하는 선천성 질환으로서 다수의 조직과 장기에 직접적인 영향을 주는 중배엽성 기능장애이다. 쇄골두개 이형성증에서 일반적인 골격 결함은 두개 봉합과 천문의 지연 폐쇄, wormian bone, clavicle aplasia가 나타날 수 있다. 또한 장골, 지골, 척추, 골반 등의 전체 골격 뿐 아니라 근육, 중앙 신경계 등에 영향을 줄 수 있다. 구강내 특징으로 유치의 만기잔존, 다수의 과잉치, 미맹출된 영구치, 낭 형성 등이 나타난다. 그러나 쇄골두개 이형성증 환아의 경우 정신적 및 신체적으로 특별한 이상을 나타내지 않아 스스로 질환을 인식하지 못하는 경우가 많으며 이의 결과유치 탈락 후 영구치의 미맹출로 인하여 저작 및 심리적인 문제가 초래되는 경우가 많다. 따라서 쇄골두개 이형성증은 조기진단이 필요하며, 적절한 시기에 과잉치 제거 및 영구치 맹출을 유도하는 치료를 시행하여 저작기능의 회복 뿐 아니라 환자의 안모도 개선시킬 수 있어야 한다.

• 대한소아치과학회지
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• 제36권3호
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• pp.456-463
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• 2009

쇄골두개 이형성증(Cleidocranial Dysplasia)은 안면, 두개골, 쇄골의 비정상적인 성장을 보이는 증후군으로 상염색체 우성으로 유전되거나 유전적 요인 없이 돌연변이에 의해 야기된다. 쇄골두개 이형성증의 일반적 소견은 두개 봉합과 천문의 지연 폐쇄, 편측이나 양측성으로 쇄골의 형성 장애, 상대적으로 커진 이마에 의해 상악골이 함몰된 것처럼 보이는 안면 형태가 특징적이다. 구강내 소견으로는 유치의 만기 잔존, 그로 인한 영구치의 맹출 지연을 보이며 방사선 사진 상에서 매복된 다수의 과잉치가 존재한다. 쇄골두개 이형성증은 정신적 및 신체적으로 특별한 이상을 나타내지 않아 진단이 늦어지는 경우가 많아 영구치의 미맹출로 인하여 저작 및 심리적인 문제가 초래되는 경우가 많다. 따라서 조기 진단을 통해 적절한 시기에 유치 발치 및 과잉치 제거 후 교정적 처치로 영구치의 맹출을 유도하여 저작 기능의 회복뿐 아니라 환자의 안모도 개선시켜야 한다. 본 증례는 영구치 맹출 장애와 전치부 반대교합을 주소로 내원하여 쇄골두개 이형성증으로 진단받은 환아들의 구강내 증상과 치아 맹출 유도법을 통하여 치아를 맹출시킬 수 있었기에 보고하는 바이다.

• 대한구순구개열학회지
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• 제4권1호
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• pp.13-26
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• 2001

Cleft lip and/or palate is the congenital orofacial malformation most commonly occurred in humans, The disease is multifactorial and is probably caused by genetic and/or environmental factors, So, there are many problems in research concerning etiology and in treatment of the disease, Even the most practiced and sophisticated methods of surgical repair are necessarily followed by scar contraction and fibrosis, which result in skeletal defects, dental abnormalities, cosmetic disfigurement, and speech impairment, As a result, Fetal surgery can be considered but practiced rarely when the deformity is not fatal to life, And treatment of cleft palate is performed in the form of medicine projection into uterus in animal experiments, Many studies show that growth factor and its receptor emerge from the developing palate; and the epidermal growth factor receptors have a important role in craniofacial development and in palatal fusion, The palatal morphogenesis of the avine is different from the mammal's; it takes the form of physiologic cleft palate, Recently, cleft palate fusion experiment was performed when the avine were in the period of palate formation through the exogenous TGF-β3 addition, and it showed that the exogenous TGF-β3 makes fusion of divided palate through certain process when cleft palate is occurred in palatal formation, In this study, I had the conformation of the fusion of cleft palate through the addition of TGF-β in case of chicken embryo, and observed the effect of TGF-β in EGF receptor distribution, And the following is the results of this study, 1. In case of the TGF-βl and β3 addition group, there was the decrease of EGFR(Epidermal Growth Factor Receptor) immunoreactivity in mesenchymal cells beneath the medial edge epithelium and also in epithelial mesenchymal interface which is between medial edge epithelium and nasal septum in 72 hours, 2, The immunoreactivity of the control group resembles that of normal chicken embryo palate in development, 3. In the view through fluorescence confocal microscopy, there was confluence in TGF-β3 addition group, This shows that the confluence induced by exogenous TGF-β3 is related to EGFR expression in palate of chicken embryo, which is a physiologic cleft palate model.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제22권2호
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• pp.191-205
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• 2000

The purpose of this study was undertaken to determine the effects of orthognathic surgery on speech. The hyposis stated herein is that functional behaviors of the dentofacial complex, such as speech production, may be adversely affected by deviations of a structural nature(especially, Class III malocclusion). Twenty adults with Class III malocclusion(13 female and 7 male) were studied preoperative, immediate postoperative and either 6 or 12 months postoperative lateral cephalograms. They had mandibular prognathism and had undergone mandible setback operation. The position of tongue, soft palate(Uvula), hyoid bone, respiratory track width, and pharyngeal depth were assessed on lateral cephalograms with 23 cephalometric variables, ANOVA, Paired t-tests and Pearson's product-moment correlation coefficient tests were used to evalute the operative changes in all cephalometric parameters. A experienced speech and language pathologists performed narrow phonetic transcriptions of tape-recorded words and sentences produced by each of the ninth patients and the recording tapes were analyzed by phonetic computer program(Computerized Speech Lab(CSL) Model 4300BI(U.S.A.)) These judges also recorded their ratings of each patient's overall consonants, hypernasality, hyponasality, and articulation proficiency. The results obtained are as follows; 1. There were significant changes in distance of posterior pharyngeal wall to tongue (TI-TW2, TS-TW3) after the surgery at 6 months postoperatively(each p<0.01 p<0.05). 2. The posterior tongue point(TI, TS, PPT) moved posteriorly after surgery and remained to its changed position at 6 months postoperatively(p<0.05). The displacement of tongue was correlated with the movement of mandibular setback amount(p<0.05). The hyoid bone moved posteriorly superiorly after immediate postoperative period. There was significant changes in hyoid bone movement after immediated postoperative period(p<0.05), but returned to its original position during the follow-up period(p>0.05) 3. The soft palate was displaced posteriorly superiorly after immediated operative period and remained to its changed position at 6 months postoperatively(p<0.05). ANS-PNS-SPT angle increasing, PPU-PPPo distance narrowing was showed after surgery, and remained its appearance 6 months postoperatively(p<0.05). 4. There were significant changes in formant value and squre diagram of vowel sound after the orthognathic surgery and the follow-up period. There were significant changes in /ㅅ/sound and posterior tongue sound. 5. The posterior movement of tongue and the posteriosuperior movement of soft palate was correlated with mandibular setback amount after orthognathic surgery. On the vowel squre diagram, the author found that the place of articulation after operation moved downward, backward, upward. 6. In assessing speech abnormalities, dental occlusion should be considered as a contributing factor. The vast majority of subjects with preoperative misarticulations eliminated or reduced their errors following orthognathic surgery. There was significant difference in speech impovement between pre- and postoperation.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제37권5호
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• pp.415-420
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• 2011

Purpose: Calcium phosphate cement (CPC) is one of many useful materials for restoring tooth defects, periodontium and maxillofacial area. Chitosan is a biodegradable material that has been shown to promote the growth and differentiation of osteoblasts in culture. This study examined the interaction between odontoblasts and bio-calcium phosphate cement reinforced with chitosan. Materials and Methods: $5{\times}10^3$ odontoblastic cells were seeded into each well. Various concentrations of bio-calcium phosphate cement reinforced with chitosan (10, 20, 50, 100, 200, 500 ${\mu}g$/ml, 1, 2, 4 mg/ml) were diluted and added to the wells. The well was incubated for 24 h, 48 h and 72 h. After incubation, the number of cells was assessed to determine the cell viability. A cytokinesis-block micronucleus assay and chromosomal aberration test were carried out to estimate the extent of chromosomal abnormalities. Microscopic photographs and RT-PCR were performed to examine the adhesion potential of bio-calcium phosphate cement reinforced with chitosan. Results: Bio-CPC-reinforced chitosan did not show significant cytotoxicity. The number of damaged chromosomes in the cells treated with Bio-CPC-reinforced chitosan was similar to that in the control cells. There was no significant increase in the number of chromosomal aberrations in the Bio-CPC reinforced chitosan exposed cells. Microscopic photographs and RT-PCR confirmed the adhesive potential of bio-CPC reinforced chitosan to odontoblasts. Conclusion: Bio-CPC-reinforced chitosan did not affect the odontoblastic cell viability, and had no significant cytotoxic effect. Bio-CPC-reinforced chitosan showed adhesive potential to odontoblasts. These results are expected form the basis of future studies on the effectiveness of dental restorative materials in Bio-CPC reinforced with chitosan.

• 한국방사선학회논문지
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• 제12권2호
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• pp.261-269
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• 2018

흡연 유무의 남성을 대상으로 뇌 회백질의 손상 유무를 파악 할 수 있는 확산텐서영상을 검사하여 영상을 획득 한 후 Tract-Based Spatial Statics(TBSS)방법으로 뇌 회백질 부위의 기저핵 신경섬유로의 비등방도 FA(fractional anisotropy)값을 측정 분석한 결과 모든 영역에서 흡연자가 비흡연자보다 비등방성 측정값이 낮게 관찰되었으며 FA값은 통계적으로 유의하였다. 본 연구의 측정한 FA결과 값으로 추측하자면 즉, 흡연이 뇌 회백질 기저핵의 모든 해부학적 미세 구조성 변화에 크게 영향을 미치며 신경 섬유로를 손상시키고 이와 관련된 기능적 이상에 영향을 준다고 할 수 있다.