• Nutrition Research and Practice
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• 제9권2호
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• pp.186-191
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• 2015

BACKGROUND/OBJECTIVES: Rheumatoid arthritis (RA) is associated with an excess mortality from cardiovascular disease which is likely attributed to an atherogenic lipid profile. Among nutritional factors vitamin K has been recently focused as a pivotal nutrient in improvement of lipid related markers. Thus, this study was designed to determine the effects of vitamin K on lipid profile in this disease. SUBJECTS/METHODS: Fifty eight patients with definitive RA were participated in the present double blind placebo controlled study. They were randomly allocated into two groups to receive vitamin $K_1$ as phylloquinone [10 mg/day] (n = 30) or placebo pills (n = 28), for eight weeks. In order to control the effects of probable confounders dietary intakes, anthropometric measurements including weight and height, clinical status using disease activity score-28 (DAS-28), physical activity and anxiety status were evaluated at baseline. Moreover, serum levels of lipid related markers including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) were measured at baseline and at the end of intervention. RESULTS: There were no significant differences between the two groups regarding any of the baseline characteristics. After adjusting for some relevant confounders, in comparison between two groups, we observed no significant changes in lipid related markers at the end of intervention. Also, there was no significant difference between before and after intervention values within groups (P > 0.05). CONCLUSIONS: Function of vitamin $K_1$ in lipid profile modification remains still controversial. This study showed that vitamin $K_1$ has no effect on lipid profile in women with rheumatoid arthritis. Further studies with a longer follow-up are required to determine the effects of vitamin K on atherogenic lipid profile.

• 대한수의학회지
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• 제32권4호
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• pp.585-595
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• 1992

We have investigated the characteristics of encephalomyocarditis(EMC) virus isolated in Korea. The CPE, buoyant density, polypeptide profile and the size of RNA of EMC virus were examined. The granulation, pyknosis and necrosis were observed from 30 to 48 hour's post inoculation of the virus into baby hamster kidney and lung cells. The buoyant density was 1.30 and $1.35g/m{\ell}$. Three different polypeptides, 26Kd, 32Kd, and 34Kd in size, were observed and the size of viral RNA was 7.7Kb.

• Journal of Magnetics
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• 제21권3호
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• pp.437-441
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• 2016

Dipole model based analytical expression is proposed to estimate the length and depth of the rectangular defect on ferromagnetic pipe. Among the three leakage profiles of Magnetic Flux Leakage (MFL), radial and axial leakage profiles are considered in this work. Permeability variation of the specimen is ignored by considering the flux density as close to saturation level of the inspected specimen. Comparing the profile of both the components, radial leakage profile furnishes the better estimation of defect parameter. This is evident from the results of error percentage of length and depth of the defect. Normalized pattern of the proposed analytical model radial leakage profile is good agreement with the experimentally obtained profile support the performance of proposed expression.

• 대한통합의학회지
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• 제6권3호
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• pp.1-9
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• 2018

Purpose : We investigated the effects of horseback riding and horseback riding machine exercise on the serum lipid profile in elderly individuals. Methods : Our study included 30 healthy elderly individuals who were randomly assigned to 2 groups: the horseback riding and the horseback riding machine exercise group, with each group comprising 15 individuals. The riding exercise program was performed 25 times a week over 12 weeks. The repeated measures analysis of variance was used to determine changes in serum lipid profiles before and after exercise 6 and 12 weeks after exercise. Results : An intergroup comparison of blood tests showed that triglyceride, total cholesterol and low-density lipoprotein-C levels were decreased in both groups after 12 weeks of the riding exercise program. However, both groups showed an increase in high-density lipoprotein-C levels, although this difference was not statistically significant. Conclusion : Horseback riding and horseback riding machine exercise showed a positive effect on the serum lipid profile in elderly individuals.

• Asian Pacific Journal of Cancer Prevention
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• 제15권22호
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• pp.9841-9846
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• 2014

Objectives: To compare the metabolic indices, lipid profile, androgens, and prostate specific antigen between prostate cancer and BPH and between grades of prostate cancer in a cross-sectional study. Materials and Methods: The study enrolled 95 cases of prostate cancer and 95 cases of benign prostatic hyperplasia (BPH). Prostate gland volume was measured using transrectal ultrasound. We compared insulin, testosterone, dihydrotestosterone, prostate specific antigen levels and lipid profile between prostate cancer of different grades and BPH. Further, prostate cancer patients were classified into low grade and high grade. Unpaired t-test for normally distributed variables and Man-Whitney U test for non-normal variables were used to assess differences. Results: We found that prostate cancer patients had significantly higher levels of insulin, testosterone, PSA, cholesterol, triglycerides, low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) in comparison to their BPH counterparts. Higher levels of these parameters also correlated with a higher grade of the disease. Conclusions: We conclude that higher levels of insulin, testosterone, PSA, and cholesterol correlate with a higher risk of prostate cancer, and also with a higher grade of the disease.

• 한국정밀공학회지
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• 제21권10호
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• pp.26-33
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• 2004

Ultra precision grinding technology has been developed from the refinement of the abrasive, the development of high stiffness equipment and grinding skill. The conventional wafering process which consists of lapping, etching, 1 st, 2nd and 3rd polishing has been changed to the new process which consists of precision surface grinding, final polishing and post cleaning. Especially, the ultra precision grinding of wafer improves the flatness of wafer and the efficiency of production. Furthermore, it has been not only used in bare wafer grinding, but also applied to wafer back grinding and SOI wafer grinding. This paper focuses on the flatness of the ground wafer. Generally, the ground wafer has concave pronto because of the difference of wheel path density, grinding temperature and elastic deformation of the equipment. Wafer tilting is applied to avoid non-uniform material removal. Through the geometric analysis of wafer grinding process, the profile of the ground wafer is predicted by the development of profile simulator.

• 한국도로학회논문집
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• 제10권4호
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• pp.9-18
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• 2008

줄눈 콘크리트포장(JCP-Jointed Concrete Pavement)의 경우 포장단면 온 습도차에 의해 슬래브 내의 컬링이 발생하게 된다. 컬링에 의해서 발생하는 슬래브의 휨 형상 및 크기는 포장내 응력 및 평탄성에 영향을 미치기 때문에 포장의 구조적, 기능적 성능에 중요한 영향을 줄 수 있다. 슬래브의 휨 형상을 직접 측정하는 것은 시공초기에 포장내에 다량의 계측기를 매설하여야 하며, 시공초기부터 거동의 정교한 측정이 필요하고 고가의 실험비용 및 기술적 인 어려움을 갖고 있다. 본 연구에서는 현장에서 손쉽게 획득할 수 있는 프로파일 데이터(Profile Data)에 파워 스펙트럼 분석(Power Spectrum Density Analysis) 및 역 푸리에 변환(Inverse Fast Fourier Transform) 기법 등을 적용하여 임의의 시간에서 줄눈 콘크리트포장의 슬래브 휨 형상을 측정하는 방법을 개발하였다. 개발한 기법의 실효성을 검증하기 위하여 국내 중부내륙에 위치한 시험도로 줄눈 콘크리트 포장에서 시간대별 프로파일을 측정하고 이 데이터로부터 슬래브 휨 형상을 도출하여 그 결과를 검토하였다. 또한 동 시간대의 연속철근 콘크리트포장(CRCP- Continuous Reinforced concrete Pavement) 구간에서의 프로파일 데이터를 분석하고 이를 줄눈 콘크리트포장에서의 결과와 비교하여 개발한 슬래브 휨 형상 추출기법의 타당성을 검증하였다.

• 천문학회지
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• 제36권3호
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• pp.89-95
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• 2003

Observations of dark matter dominated dwarf and low surface brightness disk galaxies favor density profiles with a flat-density core, while cold dark matter (CDM) N-body simulations form halos with central cusps, instead. This apparent discrepancy has motivated a re-examination of the microscopic nature of the dark matter in order to explain the observed halo profiles, including the suggestion that CDM has a non-gravitational self-interaction. We study the formation and evolution of self-interacting dark matter (SIDM) halos. We find analytical, fully cosmological similarity solutions for their dynamics, which take proper account of the collisional interaction of SIDM particles, based on a fluid approximation derived from the Boltzmann equation. The SIDM particles scatter each other elastically, which results in an effective thermal conductivity that heats the halo core and flattens its density profile. These similarity solutions are relevant to galactic and cluster halo formation in the CDM model. We assume that the local density maximum which serves as the progenitor of the halo has an initial mass profile ${\delta}M / M {\propto} M^{-{\epsilon}$, as in the familiar secondary infall model. If $\epsilon$ = 1/6, SIDM halos will evolve self-similarly, with a cold, supersonic infall which is terminated by a strong accretion shock. Different solutions arise for different values of the dimensionless collisionality parameter, $Q {\equiv}{\sigma}p_br_s$, where $\sigma$ is the SIDM particle scattering cross section per unit mass, $p_b$ is the cosmic mean density, and $r_s$ is the shock radius. For all these solutions, a flat-density, isothermal core is present which grows in size as a fixed fraction of $r_s$. We find two different regimes for these solutions: 1) for $Q < Q_{th}({\simeq} 7.35{\times} 10^{-4}$), the core density decreases and core size increases as Q increases; 2) for $Q > Q_{th}$, the core density increases and core size decreases as Q increases. Our similarity solutions are in good agreement with previous results of N-body simulation of SIDM halos, which correspond to the low-Q regime, for which SIDM halo profiles match the observed galactic rotation curves if $Q {\~} [8.4 {\times}10^{-4} - 4.9 {\times} 10^{-2}]Q_{th}$, or ${\sigma}{\~} [0.56 - 5.6] cm^2g{-1}$. These similarity solutions also show that, as $Q {\to}{\infty}$, the central density acquires a singular profile, in agreement with some earlier simulation results which approximated the effects of SIDM collisionality by considering an ordinary fluid without conductivity, i.e. the limit of mean free path ${\lambda}_{mfp}{\to} 0$. The intermediate regime where $Q {\~} [18.6 - 231]Q_{th}$ or ${\sigma}{\~} [1.2{\times}10^4 - 2.7{\times}10^4] cm^2g{-1}$, for which we find flat-density cores comparable to those of the low-Q solutions preferred to make SIDM halos match halo observations, has not previously been identified. Further study of this regime is warranted.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2016년도 제50회 동계 정기학술대회 초록집
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• pp.93-93
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• 2016

Large scale integrated circuits (LSIs) has been improved by the shrinkage of the circuit dimensions. The smaller chip sizes and increase in circuit density require the miniaturization of the line-width and space between metal interconnections. Therefore, an extreme precise control of the critical dimension and pattern profile is necessary to fabricate next generation nano-electronics devices. The pattern profile control of plasma etching with an accuracy of sub-nanometer must be achieved. To realize the etching process which achieves the problem, understanding of the etching mechanism and precise control of the process based on the real-time monitoring of internal plasma parameters such as etching species density, surface temperature of substrate, etc. are very important. For instance, it is known that the etched profiles of organic low dielectric (low-k) films are sensitive to the substrate temperature and density ratio of H and N atoms in the H2/N2 plasma [1]. In this study, we introduced a feedback control of actual substrate temperature and radical density ratio monitored in real time. And then the dependence of etch rates and profiles of organic films have been evaluated based on the substrate temperatures. In this study, organic low-k films were etched by a dual frequency capacitively coupled plasma employing the mixture of H2/N2 gases. A 100-MHz power was supplied to an upper electrode for plasma generation. The Si substrate was electrostatically chucked to a lower electrode biased by supplying a 2-MHz power. To investigate the effects of H and N radical on the etching profile of organic low-k films, absolute H and N atom densities were measured by vacuum ultraviolet absorption spectroscopy [2]. Moreover, using the optical fiber-type low-coherence interferometer [3], substrate temperature has been measured in real time during etching process. From the measurement results, the temperature raised rapidly just after plasma ignition and was gradually saturated. The temporal change of substrate temperature is a crucial issue to control of surface reactions of reactive species. Therefore, by the intervals of on-off of the plasma discharge, the substrate temperature was maintained within ${\pm}1.5^{\circ}C$ from the set value. As a result, the temperatures were kept within $3^{\circ}C$ during the etching process. Then, we etched organic films with line-and-space pattern using this system. The cross-sections of the organic films etched for 50 s with the substrate temperatures at $20^{\circ}C$ and $100^{\circ}C$ were observed by SEM. From the results, they were different in the sidewall profile. It suggests that the reactions on the sidewalls changed according to the substrate temperature. The precise substrate temperature control method with real-time temperature monitoring and intermittent plasma generation was suggested to contribute on realization of fine pattern etching.

• 한국항만학회지
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• 제11권2호
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• pp.215-230
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• 1997

미국에서는 오래 전부터 보다 효율적인 폐수 처리를 위해 1차 처리된 폐수를 연안의 폐수처리장으로부터 긴 관을 통해 심해저로 흘러 보내고 있고 큰 효과를 보는 것으로 알려져 있다. 그러나, 십해저 확산배출구률 통해 흘러 나와 형성된 플룸이 근접한 연안에 간접적으로는 인간의 건강에 해를 줄 수가 있기 때문에 바다의 물리적인 조건과 지형적인 조건을 고려한 심해저 확산배출구의 적절한 수심에서의 배치가 필수적이라 하겠다. 미국의 세계적인 관광 도시 호놀룰루시가 위치해 있는 오하우섬 남쪽에서는 위치의 중요성과 다량의 배출 폐수 때문에 중요시되는 샌드 아일랜드 배출구와 호노울리우리 배출구가 관심의 대상이 되었으며 현재까지 화산배출구의 배치에 적합한 수십선정에 대한 타당성 연구가 진행되어져 왔다. 최근에는 9백만 불의 지원을 받아 행한 마말라 만에 대한 이전의 연구(프로젝트MB-4)에서는 샌드아일랜드의 확산 배출구 주위예서 플룸의 표면수도달 빈도가 실질적인 값보다 훨씬 높은 값으로 계산되었는데 본 논문에서는 마말라 만에 대한 연구의 단점을 보완하고 마말라 만 연구에서와 같은 모델을 이용하여 플룸의 표면수 도달 빈도와 초기 회석도를 실질적인 값에 거의 근접시키는데 성공했다. 본 논문에서 중요시한 것은 마말라 만 연구에서 선택된 특정 모델의 입력 변수 중에서 배출구 주위의 해수 컬럼에서 상층과 전체적인 밀도분포를 고려하지 않은 데서 오는 단점을 보완하여 1미터 간격으로 측정된 상충을 포함한 현실적인 밀도분포를 이용하고 플룸의 상승과 초기 희석도를 계산할 때 상층의 밀도 분포를 고려하였다. 앞으로의 연구에서 상층파 전체적인 밀도 분포를 고려함으로써 예측 수치를 더욱 현실 값에 접근시킬 수 있음을 입증하였다.