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A Study on the Direction of Developing a Simulator for Performance Evaluation of Pulse Wave Detectors Through a Review of the Development Status of Cardiovascular Simulators (심혈관계 시뮬레이터 개발 동향 분석을 통한 맥파검사용기기 성능평가 시뮬레이터 연구개발 방향 모색)

  • Lee, Ju-Yeon;Kim, Jaeyoung;Go, Dong-Hyun;Lee, Ji-Won;Lee, Tae-Hee;Park, Chang-Won;Lee, Su-Kyoung
    • Journal of Biomedical Engineering Research
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    • v.43 no.3
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    • pp.136-146
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    • 2022
  • In this study, it is intended to provide basic data that can help develop a cardiovascular simulator for performance evaluation of pulse wave detectors by identifying the development status of domestic and overseas cardiovascular simulators. A total of 119 papers were selected by excluding duplicate literature, gray literature, and literature not related to a cardiovascular simulator. Based on the selected literature, the research trend of cardiovascular simulators was analyzed. As a result of analyzing the purpose of the study, most of the simulators were developed to evaluate the hemodynamic properties of artificial hearts and valves. In addition, it was used for simulation evaluation or hemodynamic studies such as pulse wave studies. As a result of analyzing configurations of the simulators, a heart most often consisted of only one left ventricle. For blood vessels, the Windkessel model was most often constructed using chambers and valves. In most studies, blood was reproduced by mixing glycerin and water to reproduce both density and viscosity. In addition, as a result of analysis from the perspective of medical device performance evaluation, simulators for evaluating artificial heart and artificial valves have been studied a lot, whereas simulators for blood pressure, pulse wave, and blood flow devices have been relatively insignificant. Based on the review results, we suggested considerations when developing a simulator for performance evaluations of a pulse wave detector.

Non-conductive Film Effect on Ni-Sn Intermetallic Compounds Growth Kinetics of Cu/Ni/Sn-2.5Ag Microbump during Annealing and Current Stressing (열처리 및 전류인가 조건에서 Cu/Ni/Sn-2.5Ag 미세범프의 Ni-Sn 금속간화합물 성장 거동에 미치는 비전도성 필름의 영향 분석)

  • Kim, Gahui;Ryu, Hyodong;Kwon, Woobin;Son, Kirak;Park, Young-Bae
    • Journal of the Microelectronics and Packaging Society
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    • v.29 no.2
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    • pp.81-89
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    • 2022
  • The in-situ electromigration(EM) and annealing test were performed at 110, 130, and 150℃ with a current density of 1.3×105 A/cm2 conditions to investigate the effect of non-conductive film (NCF) on growth kinetics of intermetallic compound (IMC) in Cu/Ni/Sn-2.5Ag microbump. As a result, the activation energy of the Ni3Sn4 IMC growth in the annealing and EM conditions according to the NCF application was about 0.52 eV, and there was no significant difference. This is because the growth rate of Ni-Sn IMC is much slower than that of Cu-Sn IMC, and the growth behavior of Ni-Sn IMC increases linearly with the square root of time, so it has the same reaction mechanism dominated by diffusion. In addition, there is no difference in the activation energy of the Ni3Sn4 IMC growth because the EM resistance effect of the back stress according to the NCF application is not large.

Ginsenoside Rg1 alleviates Aβ deposition by inhibiting NADPH oxidase 2 activation in APP/PS1 mice

  • Zhang, Han;Su, Yong;Sun, Zhenghao;Chen, Ming;Han, Yuli;Li, Yan;Dong, Xianan;Ding, Shixin;Fang, Zhirui;Li, Weiping;Li, Weizu
    • Journal of Ginseng Research
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    • v.45 no.6
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    • pp.665-675
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    • 2021
  • Background: Ginsenoside Rg1 (Rg1), an active ingredient in ginseng, may be a potential agent for the treatment of Alzheimer's disease (AD). However, the protective effect of Rg1 on neurodegeneration in AD and its mechanism of action are still incompletely understood. Methods: Wild type (WT) and APP/PS1 AD mice, from 6 to 9 months old, were used in the experiment. The open field test (OFT) and Morris water maze (MWM) were used to detect behavioral changes. Neuronal damage was assessed by hematoxylin and eosin (H&E) and Nissl staining. Immunofluorescence, western blotting, and quantitative real-time polymerase chain reaction (q-PCR) were used to examine postsynaptic density 95 (PSD95) expression, amyloid beta (Aβ) deposition, Tau and phosphorylated Tau (p-Tau) expression, reactive oxygen species (ROS) production, and NAPDH oxidase 2 (NOX2) expression. Results: Rg1 treatment for 12 weeks significantly ameliorated cognitive impairments and neuronal damage and decreased the p-Tau level, amyloid precursor protein (APP) expression, and Aβ generation in APP/PS1 mice. Meanwhile, Rg1 treatment significantly decreased the ROS level and NOX2 expression in the hippocampus and cortex of APP/PS1 mice. Conclusions: Rg1 alleviates cognitive impairments, neuronal damage, and reduce Aβ deposition by inhibiting NOX2 activation in APP/PS1 mice.

Determining Correlation between Experiences of a Sensory Courtyard and DAS (Depression, Anxiety and Stress)

  • Nam, Jinvo;Kim, Keunho
    • Journal of People, Plants, and Environment
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    • v.24 no.4
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    • pp.403-413
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    • 2021
  • Background and objective: There is growing concern about the effects of modern society on mental health, coming with Covid-19-related caveats on depression, anxiety, and stress (DAS). This can be a subject to provide alternative methods which alleviate DAS. In line with this context, sensory gardens are widely acknowledged to stimulate the five major senses (sight, sound, taste, touch, and smell) and can have a significant (positive) impact on mental health. However, there is limited empirical evidence on the effect of these gardens with regard to alleviating DAS - particularly with respect to urban society This is a gab in knowledge how such limits can be addressed. Accordingly, this present study is clearly needed in order to verify if there are any correlations between sensory gardens and (positive) effects on DAS. The aim of this study was therefore to understand current levels of DAS in a high density building with a sensory garden in a courtyard and determine correlations between experiences in the sensory courtyard and levels of DAS. Methods: The Depression Anxiety and Stress Scale (DASS-21) was employed to test the level of DAS. Results: Additionally, 13 different factors associated with experiences in the building, including the stimulation of the five major senses in the sensory courtyard, were measured to reveal their contribution to mitigating depression, anxiety, and stress. It is noted that the average levels of DAS were 7.91, 7.77 and 9.01 respectively indicating that the mental health of participants requires mental health management. However, results show that factors associated with the sensory courtyard could improve mental health. For example, new social relationships, walking with colleagues, and the stimulation of each of the five major senses in the sensory garden could improve DAS. Conclusion: This illustrates that external experiences are more effective at mitigating depression, anxiety, and stress than internal ones. Factor analysis revealed four components: stimulating the five senses; internal and external facilities; internet-based device use; and new social relationships. There was a strong positive correlation between new social relationships and walking with colleagues. There were also strong positive correlations among the stimulation of each of the five senses. In conclusion, there are strong indications that sensory courtyards can help alleviate DAS and should therefore be promoted, particularly in the current Covid-19 situation wherein the physical and mental health of the public at large are threatened. Accordingly, courtyard design should be rethought in light of the relationship between the positive impact of sensory gardens and mental health.

A Basic Study on the Generation of Tire & Road Wear Particles by Differences in Tire Wear Performance (타이어 마모성능 차이에 의한 타이어 마모입자 생성에 관한 기초 연구)

  • Kang, Tae-Woo;Kim, Hyeok-Jung
    • Journal of the Korean Recycled Construction Resources Institute
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    • v.9 no.4
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    • pp.561-568
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    • 2021
  • In this study, in order to observe the change in the amount of Tire and Road Wear Particles and the ratio of tire components in it according to the tire wear resistance performance, carried out the evaluation by varying the vulcanization reaction design of the tire tread rubber. In addition, in order to improve the reliability of the evaluation of Tire and Road Wear Particles, the evaluation was performed indoor laboratory test equipment that simulates the condition on real driving to exclude various environmental influences including minerals, driver's habits, road surface, weather, tire structure and pattern designs. After the evaluation in closed space, it is estimated that the amount of collected Tire and Road Wear Particles is 84% compared to 100% of the tire and road wear loss weight, of which 96.4~97.7% was around the road and 2.3~3.6% was in the air. As a result of analy sis of the collected Tire and Road Wear particles, the tire component existed 63~75% in the Tire and Road Wear Particles depending on the wear resistance performance of the tire.

Performance on Flame-Retardant Polyurethane Coatings for Wood and Wood-based Materials (목재 및 목질재료용 난연성 폴리우레탄수지 도막의 난연성능)

  • Kim, Jong-In;Park, Jong-Young;Kong, Young-To;Lee, Byoung-Hoo;Kim, Hyun-Joong;Roh, Jeang-Kwan
    • Journal of the Korean Wood Science and Technology
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    • v.30 no.2
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    • pp.172-179
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    • 2002
  • In this study, two materials treated with a flame retardant were examined for their fire resistance. The first, MDF (medium density fiberboard) was overlaid by an oak sliced veneer, which was either treated by soaking in a 6wt.% solution of flame retardant chemicals (pentabromine-chlorinated paraffin) or non-treated and then was coated with either a flame retardant polyurethane coating or with a common polyurethane coating. The second material, Pinus koraiensis penal was either treated by a spray treatment using a flame retardant solution or non-treated and then was coated with either a flame retardant polyurethane coating or with a common polyurethane coating. Pentabromine-chorinated paraffin chemicals were added (6 part of urethane resin) as the flame retardant chemicals in the polyurethane coatings. In the fire resistance test, the th𝜃(℃·min) decreased with the flame retardant treatment or/and the flame retardant coatings, compared to the untreated sample Weight loss (%) decreased with the flame retardant treatment or/and the flame retardant coatings. The ignition time (sec.) increased and the residual flame time (sec.) decreased with the flame retardant treatment or/and flame retardant coatings. Therefore, the flame retardant treatment or/and flame retardant polyurethane coatings have excellent incombustibility.

Design and Development of the SNIPE Bus System (초소형위성 SNIPE 본체 설계 및 개발)

  • Kim, Hae-Dong;Choi, Won-Sub;Kim, Min-Ki;Kim, Jin-Hyung;Kim, KiDuck;Kim, Ji-Seok;Cho, Dong-Hyun;Lee, Jaejin
    • Journal of Space Technology and Applications
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    • v.2 no.2
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    • pp.81-103
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    • 2022
  • In this paper, the contents of the design and development process of the 6U micro-satellite Snipe (SNIPE, national name Toyosat; small scale magnetospheric and Ionospheric plasma experiment ), which was developed to observe the near-global space environment through polarization flight for the first time in Korea, were described. Snipe performs transversal flight to observe the Earth's surrounding space environment in three dimensions, and aims to simultaneously observe the space plasma density and temperature in the ionosphere, as well as temporal changes in the solar magnetic field and electromagnetic waves. In this way, it was developed by dividing it into a test certification model (EQM) and a flight model (FM) to perform the actual mission for at least six months, away from developing a cube satellite for short-term space technology verification or manpower training. Currently, Snipe, which has completed the development of a total of four FM and completed all space environment tests, is scheduled to launch 2023. In this paper, we introduce the design contents and development process of the Snipe satellite body ahead of launch, and hope that it will be a useful reference for the development of 6U-class micro-satellite for full-scale mission in Korea.

A Review on the Deposition/Dissolution of Lithium Metal Anodes through Analyzing Overpotential Behaviors (과전압 거동 분석을 통한 리튬 금속 음극의 전착/탈리 현상 이해)

  • Han, Jiwon;Jin, Dahee;Kim, Suhwan;Lee, Yong Min
    • Journal of the Korean Electrochemical Society
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    • v.25 no.1
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    • pp.1-12
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    • 2022
  • Lithium metal is the most promising anode for next-generation lithium-ion batteries due to its lowest reduction potential (-3.04 V vs. SHE) and high specific capacity (3860 mAh/g). However, the dendritic formation under high charging current density remains one of main technical barriers to be used for commercial rechargeable batteries. To address these issues, tremendous research to suppress lithium dendrite formation have been conducted through new electrolyte formulation, robust protection layer, shape-controlled lithium metal, separator modification, etc. However, Li/Li symmetric cell test is always a starting or essential step to demonstrate better lithium dendrite formation behavior with lower overpotential and longer cycle life without careful analysis. Thus, this review summarizes overpotential behaviors of Li/Li symmetric cells along with theoretical explanations like initial peaking or later arcing. Also, we categorize various overpotential data depending on research approaches and discuss them based on peaking and arcing behaviors. Thus, this review will be very helpful for researchers in lithium metal to analyze their overpotential behaviors.

A Study on the Possibility of Using Fire-Retardant Working Cloth Made from Silicon Carbide (SiC) Composite Spun Yarns (Silicon Carbide (SiC) 복합방적사로부터 제조된 원단의 방화복 활용 가능성에 관한 연구)

  • Kang, Hyun-Ju;Kang, Gun-Woong;Kwon, Oh-Hoon;Kwon, Hyeon-Myoung;Hwang, Ye-Eun;Jeon, Hye-Ji;Joo, Jong-Hyun;Park, Yong-Wan
    • Science of Emotion and Sensibility
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    • v.24 no.4
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    • pp.149-156
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    • 2021
  • The mechanical properties of a woven fabric made of SiC (silicon carbide) fibers were determined in this study using the KES-FB system. The woven fabric is used in high heat settings above 1500℃. Composite spun yarns were used to create SiC fibers. By analyzing the wearing properties, we studied the prospect of using the textiles as fire-retardant work clothes. Mechanical properties determine the wearing attributes. Therefore, the tensile linearity (LT), tensile resilience (RT), and shear stiffness (G) values of the fabric varied according to the yarn type (filament or spun yarn). The thickness, weight per square meter, and density of the fabric were found to have an effect on the shear hysteresis (2HG) and compression resilience (RC) values. In terms of wearable clothing qualities, the fabric qualities of the SiC composite yarn demonstrated the highest ratio of compressive energy to thickness (WC/T), which indicates bulkiness. The fabric manufactured from SiC composite yarns passed the KFI criteria for carbonation length and cumulative flame time in the flame-retardant test. Therefore, we discovered that the material can be used as a fire-resistant work cloth.

Rating of Fire Risk of Combustible Materials by the New Chung's Equation-IX (새로운 Chung's equation-IX에 의한 연소성 물질의 화재 위험성 등급 평가)

  • Yeong-Jin Chung;Eui Jin
    • Applied Chemistry for Engineering
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    • v.34 no.2
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    • pp.144-152
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    • 2023
  • To evaluate the fire risk of combustible materials, Chung's equations VII, VIII, and IX were newly established. The fire risk index-IX (FRI-IX) and fire risk rating (FRR) were calculated. Ginkgo, dawn redwood, toona, lime, walnut, and polymethylmethacrylate (PMMA) were selected as test specimens. The combustion characteristics were evaluated using a cone calorimeter according to ISO 5660-1. After combustion, the fire performance index-VII (FPI-VII) of the specimens, varied between 15.15 and 182.53 s2/kW, as determined by Chung's equations, and the fire growth index-VII (FGI-VII) varied between 0.0023 and 0.0165 kW/s2. The fire performance index-VIII (FPI-VIII) based on PMMA varied between 0.29 and 3.45, and the fire growth index-VIII (FGI-VIII) varied between 2.88 and 20.63. The FRI-IX, which is the fire risk rating, showed dawn redwood has a very high fire risk, with FRI-IX values of 71.14 (fire risk rating: G). Therefore, wood with a large amount of volatile organic compounds and a low bulk density showed a high value of FRI-IX by lowering FPI-VII and FPI-VIII and increasing FGI-VII and FGI-VIII.