• 동의신경정신과학회지
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• 제15권2호
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• pp.141-148
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• 2004

Objective : This study is designed to assess the effects of Gongjin-dan on cognitive decline of the patients with mild Dementia of Alzheimer Type(DAT). Method : 33 patients with mild DAT were measured by using K-DRS, and after 100 days again. During 100 days the patients with mild DAT were treated with Gongjin-dan. The scores of K-DRS between before and after treatment were analyzed by paired t-Test. Result : 1. the mean age of patients was $70.3{\pm}4.1$ years (range 65 to 84 years) 2. the mean education of patients was $5.5{\pm}5.3$ years 3. the mean K-DRS score of the patients before treatment was $93.2{\pm}12.1$, and the mean K-DRS score of the patients after treatment was $114.7{\pm}14.5$. K-DRS scores after treatment was significantly different with the K-DRS scores before treatment.(t=9.907, r=.573, p<.00l) Conclusion : Treatment with Gongjin-dan for 100 days increased the cognitive ability in patients with mild DAT

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1995년도 춘계학술대회
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• pp.35-36
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• 1995

To gain insight into the etiological mechanism of dementia and to develop clinically effective congnitive enhancers, it is required to prepare animal models with symptoms and mechanism resemble to that in human. Dementia is mainly classified into two types : senile type of Alzheimer's disease (STAD) and cerebral ischemia-induced one. As animal models of cerebral ischemia, a couple of types in rats have been introduced : one is the occlusion of bilateral carotid arteries-induced forebrain/global ischemia and the other is the occlusion of middle cerebral arteries-induced focal/regional ischemia.

• 한국농촌간호학회지
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• 제12권2호
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• pp.45-54
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• 2017

Purpose: The purpose of this study was to provide a survey of patients with dementia registered and managed by primary health care posts. Method: Computation of 2016 dementia data registered in Health Care Center programs of 14 municipalities in ChoongNam province was analyzed. Data collection was done based on a pretest for dementia prevention and general management of registered dementia patients. Results: Results showed; Screening tests for dementia, 40% of population 60 or over, average number of cases, 174, average number of dementia registrants, 3.1, programs for prevention, approximately 70% special policy measures and 28% cognitive rehabilitation programs, counseling and education operating well overall, average number of dementia registrants/clinic 11.8, with women accounting for 70%, elders with less than 3 years of education, 75%, residence type cohabitation by married couples, 41%, and elders with Alzheimer type dementia, 64%. Conclusion: During early detection of dementia and follow-up examinations, high-risk groups (women, elders) should receive a dementia examination. In management of dementia there is a need to develop various programs including physical, economic, and emotional support not only for patients, but also for families. Health care managers also need systematic education to give them expert knowledge of dementia and management of dementia.

• 대한의생명과학회지
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• 제27권4호
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• pp.208-215
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• 2021

The purpose of this study was to explain the pathology of Alzheimer's disease (AD) and to investigate the correlation between AD and microRNA. AD is the most common type of dementia, accounting for about 80% of all types of dementia, causing dysfunction in various daily activities such as memory loss, cognitive impairment, and behavioral impairment. The typical pathology of AD is explained by the accumulation of beta-amyloid peptide plaques and neurofibrillary tangles containing hyperphosphorylated tau protein. On the other hand, microRNA is small non-coding RNA 22~23 nucleotides in length that binds to the 3' untranslated region of messenger RNA to inhibit gene expression. Many reports explain that microRNAs found in circulating biofluids are abundant in the central nervous system, are involved in the pathogenic mechanism of AD, and act as important factors for early diagnosis and therapeutic agents of AD. Therefore, this paper aims to clarify the correlation between AD and microRNA. In this review, the basic mechanism of miRNAs is described, and the regulation of miRNAs in the pathological processes of AD are highlighted. Furthermore, we suggest that miRNA-based system in development of therapeutic and diagnostic agents of AD can be a promising tool.

• 대한치매학회지
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• 제17권3호
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• pp.90-99
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• 2018

Background and Purpose: To explore anatomic substrate of specific wandering patterns in patients with Alzheimer's disease (AD) by performing positron emission tomography with $^{18}F$ fluorodeoxyglucose positron emission tomography (FDG PET). Methods: Drug-naïve AD patients with wandering (n=80) and without wandering (n=262) were recruited. First, the specific pattern of wandering type was operationally classified according to specific wandering score and clinical assessment. Second, brain FDG PET was performed and fluorodeoxyglucose (FDG) uptake differences of specific brain regions according to wandering patterns were compared to those of non-wanderers. Results: In patients with pacing pattern, FDG PET showed significant lower FDG uptake in both middle cingulum and left putamen cluster compared to non-wanderers. The right precuneus and supplementary motor area in patients with random pattern and left calcarine sulcus, right calcarine sulcus, right middle cingulum, and right post central gyrus in patients with lapping pattern had significantly lower FDG uptake compared to non-wanderers. Conclusions: This study showed that wandering in patients with AD had three distinct patterns. These specific patterns showed significant lower FDG uptake in specific brain areas compared to non-wanderers.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
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• 제6권11호
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• pp.97-106
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• 2000

The purpose of this study is to suggest the architectural planning data on the senile dementia facilities. The elderly with senile dementia can be medically classified into many types. And their activity pattern is so different from each other. And so, the space for them is differently designed according to their activity. The method of space design for the elderly with alzheimer type and the elderly with cerebro vascular type is suggested in this thesis.

• 대한예방한의학회지
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• 제24권1호
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• pp.37-48
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• 2020

Objective : In this article, we overviewed clinical Korean Medicine studies on dementia by analyzing papers published in Korea from 2010 to 2019. Methods : We explored research articles on dementia from 5 Korean research databases using the keyword 'dementia' and 'Korean Medicine'. We included original articles and reviews of clinical Korean Medicine and excluded single case study and experiment article of animal model. Then we analyzed them according to the published year, journal type, and research topics. Results & Conclusions : Research topics were classified into 'research trend', 'treatment', 'prevention', 'evaluation', 'medical expenses', 'collaborative practice' and 'others'. The largest number of articles were published in 2011(24.4%). 'Journal of Oriental Neuropsychiatry' was the journal with the most published articles(46.3%). In research topics, the analyses of research trend accounted for the largest portion(39.0%) and the articles about treatment for dementia or evaluation index in Korean medicine had the second largest proportion(14.6%). We hope that various researches for therapeutic effects, mechanisms and preventive effects of Korean Medicine in dementia would be conducted for future study.

• 동의신경정신과학회지
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• 제18권3호
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• pp.135-145
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• 2007

Objective: The purpose of this study is to indicate further research direction in dementia by examining recent Korean-medicine journals. Method: We have reviewed eleven different journals that have been published from 1997 to 2006. Result 1.In philological study paper, cerebrovascular dementia is most common type of dementia and age, sex, past history have influence on the attack of disease. Introduced medical treatment to dementia of Korean medicine are Removing wind(祛風), Be in the peace(安神), Refreshing lung and raising blood(淸肺養血) etc. 2.According to the research paper, a prognosis of dementia which Is mixed(Alzheimer type and cerebrovascular type) is bad. Sinmac(申脈)-BL.62), Jeohae(照海)-Kl.06), waegwan(外關)-TE.05), naegwan(內關)-PC.6) among the palmacgyohoeheol(八脈交會穴) have good effect in medical treatment. Medical treatment which is based on chaejil(體質)) shows up to be more effective. Also many medicines have good effect, especially chongmyung-tang(聰明湯)) and chongmyung-tang-gamibang(聰明湯加味方)) have good effect on decreasing memory caused by nerve cell degeneration. Conclusion: The Korean medical treatments have many advantage in taking the dementia so the researches about this are more needed.

• 한국산학기술학회논문지
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• 제16권9호
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• pp.6201-6213
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• 2015

본 연구의 목적은 경증 알츠하이머 환자를 대상으로 현실감각과 시간차 회상 훈련을 적용한 CERAD-K형 인지재활 프로그램의 효과를 밝히는 것이다. 연구에 사용된 도구는 CERAD-K 신경심리 검사로, 하위 영역으로 보스턴 이름 대기, 간이 정신 상태, 단어 목록 회상, 구성 행동으로 구성되어 있다. 연구 설계는 비동등성 대조군 전 후 실험 설계이다. 연구는 경기도의 G 보건소에 등록된 경증 알츠하이머 치매 환자를 편의 표집 하여 실험군 32명과 대조군 53명을 대상으로 하였다. 실험군은 2014년 9월 1일 부터 9월 30일까지 매주 화요일과 금요일에 두 팀으로 나누어 오전 10시부터 11시, 오후 2시부터 3시까지 한 팀당 16명씩 주 2회씩 8회의 인지재활 프로그램을 실시하였다. 대조군은 해당 보건소의 일상 프로그램에 참여하였다. 자료는 SPSS WIN 21.0 program을 이용하여 분석하였다. 연구 결과 단어 목록 회상(F=.75 p>.05)을 제외한 보스턴 이름 대기(F=3.22, p<.001), 간이 정신 상태(F=5.92, p<.001), 구성 행동(F=4.67, p<.001)이 유의하게 향상되어 현실감각과 시간차 회상훈련을 적용한 CERAD-K형 인지재활 프로그램은 경증 알츠하이머 치매 환자의 인지 기능을 향상 시키는 것으로 나타났다.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1995년도 춘계학술대회
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• pp.38-40
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• 1995

There have reports suggested that cerebral blood flow (CBF) has decreased in patients with both senile dementia of the Alzheimer's type and multi-infarct dementia, which are characterized by marked cognitive impairments. In addition, recent studies have demonstrated that decrease of CBF precedes the onset of multi-infarct dementia. These findings further suggest that chronic reduction of CBF may play an important role in the formation and progression of cerebral vascular dementia. Although transient cerebral ischemia, based upon vascular “reperfusion”, is apparently not paralleling the clinical condition, the transient cerebral ischemia model is one of the major methods investigated and the other is the cerebral embolism operation. Cognitive impairment and neuronal damages have been fully studied using these transient and/or embolic ischemia models. There are, however, few investigations focused the attention on the influence of chronic decrease of CBF on cognitive processes. In the present study, we have chosen a chronic ischemic model which is produced by permanent occlusion of bilateral common carotid arteries (2VO) in rats to investigate the neuronal damage and cognitive deficits through radial maze performance. We investigated furtherly the effects of tetramethylpyrazine (TMP), a constituent isolated from Ligusticum Chuanxiong on such a model.