• Korean Journal of Construction Engineering and Management
• /
• v.1 no.2 s.2
• /
• pp.71-80
• /
• 2000

Project delivery systems determine the relationship, responsibility, authority and the scope of works of those involved in project, hence, optimum project delivery system should be selected to so that construction project would be executed successfully, Until now, the traditional design-bid-build mainly has been used for public projects, but the government is making efforts actively to introduce other methods such as design-build, alternative bidding by its policy. However, delivery systems should be determined through considering physical projects characteristics, owner's goals, external factors, etc, rather than government' policy. Therefore, the purpose of this research is to propose objective delivery system selection criteria and delivery system selection model, which help owners to select the suitable delivery system through quantitative and reasonable manner.

• Proceedings of the Korean Institute Of Construction Engineering and Management
• /
• 2008.11a
• /
• pp.591-596
• /
• 2008

Success or failure highly depends on delivery method in construction projects. This paper mainly focused on operation model for technical proposal in Large construction projects. This operational model uses Technical Proposal-Based Tender. This project studied order and delivery method in large construction projects. And delivery systems of international and domestic market are researched, and then condition of delivery system and problems are derived from them. Especially, it researched that it is hard to reflect special feature in large construction projects. As a result of having referenced idea as describe above, this paper will be studied by this process. First, definition of delivery method and large construction projects is researched. Second, delivery systems of international and domestic market are checked. Third, problems and condition of delivery system in large construction projects are investigated. Fourth, application of operation model for technical proposal-based tender are presented in large construction projects.

• Journal of Environmental Science International
• /
• v.21 no.1
• /
• pp.31-39
• /
• 2012

The objective of this study is to provide pollutant loads delivery ratio for flow duration in Oenam-cheon watershed, which is upstream watershed of Juam Lake. To calculate the delivery ratio by flow duration, rating curves and discharge-loads curves using measured data were established, then Flow Duration Curve(FDC) and pollutant loads delivery ratio curves were constructed. The results show that the delivery ratios for $BOD_5$ for abundant flow($Q_{95}$), ordinary flow($Q_{185}$), low flow($Q_{275}$), and drought flow($Q_{355}$) were 23.9, 12.7, 7.1, and 2.9%, respectively. The delivery ratios of same flow regime for T-N were 58.4, 31.2, 17.2 and 7.1%, respectively. While, the delivery ratios T-P were 17.3, 7.5, 3.4, and 1.1% respectively. In general, delivery ratio of high flow condition showed higher value due to the influence of nonpoint source pollution. Based on the study results, generalized equations were developed for delivery ratio and discharge per unit area, which could be used for ungaged watershed with similar pollution sources.

• Health Policy and Management
• /
• v.26 no.4
• /
• pp.246-255
• /
• 2016

The study of public health systems is an important, but very difficult task. The concept and functions of public health systems are influenced by the views, interests, and influence of the various stakeholders belonging to public health systems and broader social, economic, political, and environmental sectors. To define public health system with conceptual clarification, we must take into account the dynamic and complex aspect of the public health system. This paper reviews health systems and public health systems literature to suggest the concept, goals, and functions of public health systems. In addition, this paper recognizes some challenges, such as leadership and management, resource development, economic support, and service delivery to strengthen public health systems for improving health and well-being of population.

• Journal of Pharmaceutical Investigation
• /
• v.40 no.spc
• /
• pp.113-118
• /
• 2010

Pharmaceutical technology has primarily focused on the development of the best dosage forms depending on the route of administration. The design of dosage forms is greatly influenced by the route of administration. Due to a variety of advantages such as avoidance of first-pass effect, abundant blood supply and easy access to the absorption site, the oral cavity has frequently been selected as a site for drug delivery. Since the oral cavity is relatively unique from the anatomical and physiological viewpoint, one should always consider these conditions when designing the drug delivery systems for the oral cavity. In this regard, the current review paper was prepared to summarize the essential features of the drug delivery systems utilized in the oral cavity, along with the introduction of various dosage forms developed to date.

• Journal of Pharmaceutical Investigation
• /
• v.30 no.1
• /
• pp.1-12
• /
• 2000

Gene therapy is a method for the treatment of diseases with introducing the gene-engineered materials into a patient with gene-deficiency disease (e.g. cystic fibrosis) or cancer to produce a therapeutic protein in a patient's cells. Successful gene therapy requires establishing both gene expression systems and delivery systems. Viral and non-viral vectors have been used for gene delivery. Viral vectors have a high transfection efficiency, but are limited in relations to issues of safety, toxicity and immunogenecity. Non-viral vectors are easy to prepare and relatively safe. However, non-viral vectors have a low transfection efficiency. Cationic liposomes are the most available among non-viral vectors. Cationic liposomes have been used to transfect cells both in vitro and in vivo experiments. Besides, several formulations containing cationic lipid are being used in clinical trials in cases of cystic fibrosis or cancer. A crucial subject to the further development of gene delivery vectors will be a long-term gene expression with following characteristics; protecting and deliverying DNA efficiently, non-toxic and non-immunogenic, and easy to produce in large scale.

• Journal of Korea Society of Industrial Information Systems
• /
• v.23 no.5
• /
• pp.33-41
• /
• 2018

Most important thing when designing and implementing a supply chain network is to consider various problems which may occur in real world situation. In this paper, we propose a supply chain network considering two problems (environmental factor and transportation types) under real world situation. CO2 emission amount as environmental factor is considered since it is usually generated from production and transportation processes. Normal delivery, direct delivery and direct shipment as transportation types are also considered since many customers ask various transportation types for delivery or shipment of their products under on-line or off-line purchase environment. The proposed supply chain network considering environmental factor and transportation types is represented in a mathematical formulation and implemented using hybrid genetic algorithm (HGA) approach. In numerical experiments, several scales of supply chain networks are presented and implemented using HGA approach. The performance of the HGA approach is compared with those of some conventional approaches under various measures of performance. Finally, it is proved that the performance of the HGA approach is superior to those of the others.

• International conference on construction engineering and project management
• /
• 2007.03a
• /
• pp.662-671
• /
• 2007

Since variety of construction projects with their individual specifications could be handled through different procurement systems, selection of the most appropriate project delivery system is a vital step towards more efficient project execution. The appropriate selection of project delivery system may also ensure more competent management of the project. Its impacts are not only limited to the first stages of the project, as it could also influence pre-construction, construction and operational phases of the project. Among different approaches exerted for this purpose, none has taken uncertainty into account, despite the fact that during first stages of the project most of the selection factors are still uncertain and not clearly defined. This paper, hence, aims to provide a fuzzy insight into the project delivery system selection. Through this approach more tangible model of the evaluation process may be presented. Proposed fuzzy method is indeed a multi criteria decision making model, based on the group of criteria, assigned for the evaluation procedure. A case study is also conducted, based on the opinion of an invented group of the experts.

• Biomedical Science Letters
• /
• v.30 no.2
• /
• pp.37-48
• /
• 2024

Liposomes are one of the most actively studied and promising drug delivery systems for the treatment of various diseases. In this study, an aptamer-conjugated liposome called "aptamosome" was used, in which an anti-PD-L1 aptamer targeting cancer cells was conjugated to the liposome. These aptamosomes showed remarkable cellular uptake and efficient delivery to Lewis lung carcinoma 2 (LL/2) cancer cells. In addition, suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor (HDACi), was delivered through this aptamer to induce a strong anticancer immunotherapeutic effect. The results of this study showed that when LL/2 cells were treated with SAHA-entrapped aptamosome [SAHA] and liposome [SAHA] and free SAHA, aptamosome [SAHA] improved cell death compared with that of liposomes [SAHA] or free SAHA, and it has demonstrated anticancer efficacy. Moreover, aptamosome [SAHA] induce the secretion of chemokines that promote the migration of activated T cells into tumor tissues. Finally, in vivo experiments showed that aptamosome [SAHA] significantly inhibited the growth rate of LL/2 tumors. Therefore, liposomes combined with an anti-PD-L1 aptamer for efficient SAHA delivery are suggested as an excellent model for drug delivery systems suitable for targeting cancer cells.

• Information Systems Review
• /
• v.20 no.1
• /
• pp.1-16
• /
• 2018

The development and generalization of the Internet increased the popularity of food delivery service applications in Korea. The food delivery market based on online-to-offline service is growing rapidly. This study compares the usability of Korean food delivery service application between that of Chinese food delivery service application. This study suggests improvement points for Korean food delivery service applications. To conduct this study, we explore the status of various food delivery service applications and conduct interviews and surveys based on the honeycomb model developed by Peter Morville. This study obtained the following results. First, all restaurants participating in the Korean food delivery service must be able to accept order through the application. Second, the shopping cart function must be able to accept order of all restaurants simultaneously. Third, when users look for menu recommendation, their purchase history and shopping cart functions should appear at the first page of the website. Users should be able to perceive the improved usability of the website using those functions. Fourth, when the search window is fixed on the top of each page, users should be able to find the information they need. Fifth, the application must allow users to find the exact location of the delivery person and the estimated delivery time. Finally, the restaurants'address should be disclosed and fast delivery time should be confirmed to enhance users'trust on the application. This study contributes to academia and industry by suggesting useful insight into food delivery service applications and improving the point of food delivery service application in Korea.