• Proceedings of the Korean Vacuum Society Conference
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• 2016.02a
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• pp.360.1-360.1
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• 2016

Hydroxyapatite (Ca10(PO4)6(OH)2, HAP) particles have attracted a great deal of attention in biomedical fields due to their good biocompatibility, bioactivity and fairly broad applications as drug delivery, dental implant, bone cement, and etc. Thus, many researchers have made an effort to add new functionalities such as luminescence, drug delivery, and bone regeneration properties up to HAP powders by controlling their nanostructure as well as composition. In this research, the mesoporous strontium substituted HAP (Sr-HAP) microspheres were synthesized using a hydrothermal method. In this synthesis, aspartic acid monomers were utilized to form microsphere by controlling surface energy of HAP particles and Sr ions were substituted into Ca ion sites, which induced luminescence property in HAP powders. Moreover, the change in the amount of Sr substitution was found to influence the particle size, morphology, and concurrently surface area, which led to changing drug loading as well as drug release property. The amount of Sr influences the morphology, luminescent properties, particle size, surface area cell viability and drug loading property, which are investigated by SEM, TEM, XRD, FTIR, BET, XPS and in vitro test such as MTT assay and drug release test. In particular, the multifunctional Sr-HAP with molar ratios of 0.25 (Sr/(Ca+Sr)) possessed the strongest luminescent property as well as the superior drug loading and sustained release properties that were correspondent with large surface area and pore size. Our study indicates that the fabricated multifunctional Sr-HAP microspheres are quite useful for bone regeneration and drug delivery.

• Journal of The Korean Society of Agricultural Engineers
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• v.52 no.4
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• pp.19-26
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• 2010

To provide the basic information for the water quality management of the Sumjin River Basin, delivery ratios for flow duration were studied. Using the day-interval data set of discharge and water quality observed from the Chooryeong-cheon watershed, the flow-duration and discharge-load relation curves for the watershed were established, then the load-duration curve was constructed. Delivery ratios for flow duration were also developed. Delivery ratios showed wide variation according to flow conditions. In general, delivery ratio of high flow condition showed higher value reflecting nonpoint source pollution contribution from the forest dominating watershed. To resolve this problem, a regression model explaining the relation between flow rate and delivery ratio was suggested. The delivery ratios for different flow regime could be used for pollutant load estimation and TMDL (Total maximum daily load) development.

• International Journal of Computer Science & Network Security
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• v.21 no.12spc
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• pp.443-450
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• 2021

The study is devoted to the formation of a economic principles cargo delivery management in global supply chains. Mathematical model of delivering special categories of goods by road is a key element of these principles. The article analyzes the existing studies on solving the problem of cargo delivery in various aspects. It was noted that the greatest attention is paid to legal regulation, last mile delivery, optimization of routes and delivery schemes, information support, technological innovations, cluster routing, etc. In the developed mathematical model a minimum of total costs of forming loading units and freight shipments was defined as the criterion of optimality of organizing delivery by motor transport. The authors propose the creation of logistics clusters allowing the integration of urban transport flows and global supply chains.

• Polymer(Korea)
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• v.33 no.5
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• pp.441-445
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• 2009

In order to develop an intelligent delivery system for cosmetic active agents (e.g., arbutin, ascorbic acid, and adenosine), pH-responsive P(MAA-co-PEGMA) hydrogel particles having an average size of approx. $2{\mu}m$ and spherical shape were synthesized via dispersion photopolymerization. There was a drastic change in the swelling ratio of P (MAA-co-PEGMA) hydro gels at a pH 5, which is the $pK_a$ of the hydrogel. To determine the factors that have an effect on the loading of cosmetic active agents into the hydrogel, the loading efficiency of the active agents was investigated at various MAA and EG compositions of the hydrogel and the loading pH conditions. When the MAA contents in the hydrogel decreased, the loading efficiency of the active agents increased. In loading experiments with different pH conditions, the active agents showed higher loading efficiency into the hydrogel at the pH where the hydrogel was at the swollen state than at the pH where the electrostatic repulsion was minimized.

• Macromolecular Research
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• v.15 no.6
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• pp.547-552
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• 2007

Water soluble polymer, poly(vinyl pyrrolidone) was chosen to conjugate with 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(succinyl) (N-succinyl DPPE) to make a new drug delivery system. PVP with an amine group (amino-PVP) was polymerized by free radical polymerization. The amine group of amino-PVP was conjugated with the carboxylic group of N-succinyl DPPE. The resultant conjugate could form nanoparticles in the aqueous solution; these nanoparticles were termed a lipid-polymer system. The critical aggregation concentration was measured with pyrene to give a value of $1{\times}10^{-3}g/L$. The particle size of the lipid-polymer system, as measured by DLS, AFM and TEM, was about 70 nm. Lipophilic component in the inner part of the lipid-polymer system could derive the physical interaction with hydrophobic drugs. Griseofulvin was used as a model drug in this study. The loading efficiency and release profile of the drug were measured by HPLC. The loading efficiency was about 54%. The release behavior was sustained for a prolonged time of 12 days. The proposed lipid-polymer system with biodegradable and biocompatible properties has promising potential as a passive-targeting drug delivery carrier because of its small particle size.

• International Journal of Internet, Broadcasting and Communication
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• v.14 no.1
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• pp.85-94
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• 2022

Recently, consumers who prefer contactless consumption are increasing due to pandemic trends such as Corona 19. This is the driving force for developing the last mile-based logistics ecosystem centered on the online e-commerce market. Lastmile led to the continued development of the logistics industry, but increased the amount of cargo in urban area, and caused social problems such as overcrowding of logistics. The courier service in the logistics base area utilizes the process of visiting the delivery site directly because the courier must precede the loading work of the cargo in the truck for the delivery of the ordered product. Currently, it's carried out as automated logistics equipment such as conveyor belt in unloading or classification stage, but the automation system isn't applied, so the work efficiency is decreasing and the intensity of the courier worker's labor is increased. In particular, small-scale courier workers belonging to the sub-terminal unload at night at underdeveloped facilities outside the city center. Therefore, the productivity of the work is lowered and the risk of safety accidents is exposed, so robot-based loading technology is needed. In this paper, we have derived the top-level concept and requirements of robot-based loading system to increase the flexibility of logistics processing and to ensure the safety of courier drivers. We defined algorithms and motion concepts to increase the cargo loading efficiency of logistics sub-terminals through the requirements of end effector technology, which is important among concepts. Finally, the control technique was proposed to determine and position the load for design input development of the automatic conveyor system.

• The Journal of Korean Academy of Prosthodontics
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• v.34 no.1
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• pp.70-84
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• 1996

This paper reports marginal bone loss around osseointegrated implants after loading in partially edentulous patients in dental hospital, Yonsei University. Two types of implants($Br{\aa}nemark^{TM},\;IMZ^{TM}$) were used. Through the digital measurement on periapical radiograph around 37 implants in human subjects, marginal bone loss was observed for 24 months after delivery of prostheses. The results were as follows; 1. According to experimental periods marginal bone loss in total implants was 1.775 mm at 12 months, 1.921 mm at 24 months after delivery of prostheses(p<0.05). 2. Marginal bone loss in the $Br{\aa}nemark$ implants was 1.831 mm at 12 months, 1.833 mm at 24 months after delivery of prostheses(p<0.05). 3. Marginal bone loss in the IMZ implants was 1.578 mm at 12 months, 2.907 mm at 23 months after delivery of prostheses(p<0.05). 4. During the first year after loading, the IMZ implants showed less marginal bone loss than the $Br{\aa}nemark$ implants but, during the next the $Br{\aa}nemark$ implants showed less than the IMZ implants(p>0.05). These results indicate that marginal bone loss around osseointegrated implants occurs within the first 12 months after delivery of prostheses and stabilizes thereafter, so it is necessary to be careful of using dental implants for the first year after delivery of prostheses.

• Journal of Pharmaceutical Investigation
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• v.31 no.4
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• pp.241-256
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• 2001

Alginate microspheres, containing fluorescein isothiocyanate-bovine serum albumin (FITC-BSA) or green fluorescent protein (GFP) were prepared and used as a model drug to develop the oral vaccine delivery system. The alginate microspheres were coated with poly-L-lysine or chitosan. Two methods, w/o-emulsion and spray, were used to prepare alginate microspheres. To optimize preparation conditions, effects of several factors on the particle size and particle morphology of microsphere, and loading efficiency of model antigen were investigated. In both preparation methods, the particle size and the loading efficiency were enhanced when the concentration of sodium alginate increased. In the w/o-emulsion preparation method, as the concentration of Span 80 was increased from 0.5% to 2%, the particle size was decreased, but the loading efficiency was increased. The higher the emulsification speed was, the smaller the particle size and loading efficiency were. The concentration of calcium chloride did not show any effect on the particle size and loading efficiency. In the spray preparation method, the particle size was increased as the nozzle pressure $(from\;1\;kgf/m^2\;to\;3\;kgf/m^2)$ and spray rate was raised. Increasing calcium chloride concentration (<7%) decreased the particle size, in contrast to no effect of calcium chloride concentration on the w/o-emulsion preparation method. Alginate microspheres prepared by two methods were different in the particle size and loading efficiency, the particle size of microspheres prepared by the spray method was about $2-6\;{\mu}m$, larger than that prepared by the w/o emulsion method $(about\;2{\mu}m)$, and the loading efficiency was also higher with spray method. Furthermore, drying process for the microspheres prepared by the spray was simpler and easier, compared with the w/o emulsion preparation. Therefore, the spray method was chosen to prepare alginate microspheres for further experiments. Release pattern of FITC-BSA in alginate microspheres was evaluated in simulated intestinal fluid and PBS (phosphate buffered saline). Dissolution rate of FITC-BSA from alginate/chitosan microsphere was lower than that from alginate microsphere and alginate/poly-L-lysine microsphere. By confocal laser scanning microscope, it was revealed that alginate/FITC-poly-L-lysine microspheres were present in close apposition epithelium of the Peyer's patches of rabbits following inoculation into lumen of intestine, which proved that microspheres could be taken up by Peyer's patch. In conclusion, it is suggested that alginate microsphere prepared by spray method, showing a particle size of & $10\;{\mu}m$ and a high loading efficiency, can be used as a model drug for the development of oral vaccine delivery system.

• Journal of Forest and Environmental Science
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• v.35 no.3
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• pp.141-149
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• 2019

Nanocellulose, which can exist as either cellulose nanocrystals or cellulose nanofibrils, has been used as a biomaterial for drug delivery owing to its non-immunogenicity, biocompatibility, high specific area, good mechanical properties, and variability for chemical modification. Various water-soluble drugs can be bound to and released from nanocelluloses through electrostatic interactions. The high specific surface area of nanocellulose allows for high specific drug loading. Additionally, a broad spectrum of drugs can bind to nanocellulose after facile chemical modifications of its surface. Controlled release can be achieved for various pharmaceuticals when the nanocellulose surface is chemically modified or physically formulated in an adequate manner. This review summarizes the potential applications of nanocelluloses in drug delivery according to published studies on drug delivery systems.

• KOREAN JOURNAL OF PACKAGING SCIENCE & TECHNOLOGY
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• v.21 no.2
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• pp.61-65
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• 2015

Agricultural products packaged for transportation are put in the various dangerous environments owing to the damage factors like vibration, shock, compression, climate etc. under the distribution process. On fruits packaging for transportation, especially, the shock and vibration is considered as the most important damage factors. A major cause of shock damage to fruits is drops during manual handling. Especially, the damages of fruits during the parcel delivery service are very serious. The parcel delivery services of fruits are increasing and contribute to increasing of farm house earning. Also, the freight vehicle is mostly used to transport the fruits. Shock and impact generated by the freight vehicle may give serious damage to fruits. The optimum packaging design of parcel delivery service of fruits during transportation is required to reduce the fruits damages. In order to design the packaging system for parcel delivery service of fruits considering the transportation environment, the comprehension of characteristics for vibration and shock generated by manual handling and acting on transportation vehicles under various road conditions and loading methods is required. This research was performed to analyze the shock characteristics, acceleration level and power spectral density (PSD) during the parcel delivery service of fruits. The overall level of recommended PSD profile in a specific transportation of parcel delivery service for fruits was $0.63G_{rms}$.