• Proceedings of the Korean Society of Toxicology Conference
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• 2003.10b
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• pp.163-163
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• 2003

Difficulties of long-tenn survival of lung cancer patients treated with conventional therapies require the need for novel approaches and gene therapy holds promise in this area. Several genes are known to have anti-tumor activities and have been used as a gene of delivery, however, a number of problems such as efficiency, specificity of the gene delivery hinder the application of gene therapy.(omitted)

• Clinical and Experimental Vaccine Research
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• v.13 no.2
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• pp.73-82
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• 2024

DNA cancer vaccines as an approach in tumor immunotherapy are still being investigated in preclinical and clinical settings. Nevertheless, only a small number of clinical studies have been published so far and are still active. The investigated vaccines show a relatively stable expression in in-vitro transfected cells and may be favorable for developing an immunologic memory in patients. Therefore, DNA vaccines could be suitable as a prophylactic or therapeutic approach against cancer. Due to the low efficiency of these vaccines, the administration technique plays an important role in the vaccine design and its efficacy. These DNA cancer vaccine delivery systems include physical, biological, and non-biological techniques. Although the pre-clinical studies show promising results in the application of the different delivery systems, further studies in clinical trials have not yet been successfully proven.

• Journal of the Korean Operations Research and Management Science Society
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• v.41 no.3
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• pp.75-96
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• 2016

This paper investigates the usefulness of drones in an urban delivery system. We define the vehicle and drone routing problem with time window (VDRPTW) and present a model that can describe a dual mode delivery system consisting of drones and vehicles in the metropolitan area. Drones are relatively free from traffic congestion but have limited flight range and capacity. Vehicles are not free from traffic congestion, and the complexity of urban road network reduces the efficiency of vehicles. Using drones and vehicles together can reduce inefficiency of the urban delivery system because of their complementary cooperation. In this paper, we assume that drones operate in a point-to-point manner between the depot and customers, and that customers in the need of fast delivery are willing to pay additional charges. For the experiment datasets, we use instances of Solomon (1987), which are well known in the Vehicle Routing Problem society. Moreover, to mirror the urban logistics demand trend, customers who want fast delivery are added to the Solomon's instances. We propose a hybrid evolutionary algorithm for solving VDRPTW. The experiment results provide different useful insights according to the geographical distributions of customers. In the instances where customers are randomly located and in instances where some customers are randomly located while others form some clusters, the dual mode delivery system displays lower total cost and higher customer satisfaction. In instances with clustered customers, the dual mode delivery system exhibits narrow competition for the total cost with the delivery system that uses only vehicles. In this case, using drones and vehicles together can reduce the level of dissatisfaction of customers who take their cargo over the time-window. From the view point of strategic flexibility, the dual mode delivery system appears to be more interesting. In meeting the objective of maximizing customer satisfaction, the use of drones and vehicles incurs less cost and requires fewer resources.

• Korean Journal of Construction Engineering and Management
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• v.18 no.2
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• pp.3-11
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• 2017

Aging buildings over 15 years reaches about 74% of 177 thousand buildings in Domestic public buildings. Due to the aging building, the energy loss is a serious problem. In order to reduce the energy usage through improving the energy efficiency on the existing buildings, the government & the local autonomous entity conduct the energy efficiency projects through the remodeling, repairing & equipment replacement on the existing buildings. The green remodeling is applied to the existing public buildings in recently revised the act on the creation and support of green building. However, the standard is not obvious that the work scope of green remodeling, financing and project delivery method. This paper propose is to suggest project delivery system for vitalizing the green remodeling. Green remodeling is defined on basis of the occurring work under project life cycle based on the existing building process and the financing method for owners and companies and the project delivery system according to work scope of green remodeling are proposed in this paper

• 한국생물공학회:학술대회논문집
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• 2003.10a
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• pp.655-659
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• 2003

Solid lipid nanoparticle (SLN) system has been attracted increasing attention during last few years as a potential drug delivery carrier However, the SLN have disadvantage of low encapsulation efficiency for hydrophilic drug. In this study, for increase it's encapsulation efficiency, we prepared the $Eudragit^{\circledR}$ L100-55 (eudragit) coated SLN(E-SLN) based on solvent evaporation method and melt dispersion technique, and analyzed their physicochemical properties in terms of particle size, morphology, and encapsulation efficiency. As a result, they have a ${\pm}150$ nm particle size, spherical shape, and $10^{\sim}25$ % loading efficiency. SLN consists of coconut oil as core material, ascorbic acid and okyong-san as hydrophilic drug.

• Journal of Korean Institute of Industrial Engineers
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• v.31 no.4
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• pp.277-288
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• 2005

The proliferation of the internet technologies and applications has intensified business activities on the Internet. This study considered the price competition between two shopping channels, one on-line seller and the other traditional off-line retailer. Based on the Hotelling's linear market model, we derive the Nash and Stackelberg equilibria as a function of the cost parameters which represent the characteristics of the online and off-line channels. By analyzing the equilibrium solutions, the following significant findings were obtained. First, pricing by Stackelberg equilibrium always outperformed that of Nash equilibrium. However the value of the cost parameters played a crucial role in determining both channels' preferred position (price leader or follower). Second, the online seller could benefit more in terms of profit by lowering its efficiency when its efficiency belongs to a certain interval. Third, when the online seller's efficiency is low, lowering its delivery cost has no contribution to its profit. To benefit more from lowering its delivery cost, increasing its channel efficiency to a certain level should be preceded.

• Food Science of Animal Resources
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• v.43 no.2
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• pp.220-231
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• 2023

Although omega-3 fatty acids including docosahexaenoic acid (DHA) contain various health-promoting effects, their poor aqueous solubility and stability make them difficult to be induced in dairy foods. The aims of this research were to manufacture casein derivative-based delivery system using acid-induced gelation method with glucono-σ-lactone and to investigate the effects of production variables, such as pH and charged amount of linoleic acid, on the physicochemical properties of delivery systems and oxidative stability of DHA during storage in model milk. Covalent modification with linoleic acid resulted in the production of casein derivatives with varying degrees of modification. As pH was reduced from 5.0 to 4.8 and the charged amount of linoleic acid was increased from 0% to 30%, an increase in particle size of casein derivative-based delivery systems was observed. The encapsulation efficiency of DHA was increased with decreased pH and increased charged amount of linoleic acid. The use of delivery system for DHA resulted in a decrease in the development of primary and secondary oxidation products. An increase in the degree of modification of casein derivatives with linoleic acid resulted in a decrease in the formation of primary and secondary oxidation products than of free DHA indicating that delivery systems could enhance the oxidative stability of DHA during storage in model milk. In conclusions, casein derivatives can be an effective delivery system for DHA and charged amount of linoleic acid played a key role determining the physicochemical characteristics of delivery system and oxidative stability of DHA.

• BMB Reports
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• v.49 no.11
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• pp.585-586
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• 2016

Extracellular vesicles (EVs) are natural carriers of biomolecules that play central roles in cell-to-cell communications. Based on this, there have been various attempts to use EVs as therapeutic drug carriers. From chemical reagents to nucleic acids, various macromolecules were successfully loaded into EVs; however, loading of proteins with high molecular weight has been huddled with several problems. Purification of recombinant proteins is expensive and time consuming, and easily results in modification of proteins due to physical or chemical forces. Also, the loading efficiency of conventional methods is too low for most proteins. We have recently proposed a new method, the so-called exosomes for protein loading via optically reversible protein-protein interaction (EXPLORs), to overcome the limitations. Since EXPLORs are produced by actively loading of intracellular proteins into EVs using blue light without protein purification steps, we demonstrated that the EXPLOR technique significantly improves the loading and delivery efficiency of therapeutic proteins. In further in vitro and in vivo experiments, we demonstrate the potential of EXPLOR technology as a novel platform for biopharmaceuticals, by successful delivery of several functional proteins such as Cre recombinase, into the target cells.

• Journal of The Korean Society of Agricultural Engineers
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• v.55 no.4
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• pp.45-53
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• 2013

Efficient water operation and management of an irrigation system plays an important element in the sustainability of irrigated agriculture. An agricultural water is delivered in many open canals of irrigation delivery system by reservoirs. The poor water distribution and management in an irrigation system is a major factor leading to low water efficiency. It is necessary to compare the estimated irrigation demands with the actual water supplies for decision making to maintain the water supply according to demand strategy. Smarter water management, new technologies and improvement of water management system, is essential to solve the problem of water efficiency and availability. In this paper, the irrigation efficiencies according to water delivery performance indicator were measured with automatic water gauge at irrigation canals, and calculated from spatial and temporal distribution of water supply for the lack of planning in water delivery. The analysis of results are obtain an insight into possible improvement methods to develop canal water management policies that enable irrigation planners to optimally manage scarce available water resources.

• Archives of Pharmacal Research
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• v.29 no.7
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• pp.598-604
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• 2006

In many conventional drug delivery systems in vogue, failure to deliver efficient drug delivery at the target site/organs; is evident as a result, less efficacious pharmacological response is elicited. Microspheres can be derived a remedial measure which can improve site-specific drug delivery to a considerable extent. As an application, Lung-targeting Ofloxacin-loaded gelatin microspheres (GLOME) were prepared by water in oil emulsion method. The Central Composite Design (CCD) was used to optimize the process of preparation, the appearance and size distribution were examined by scanning electron microscopy, the aspects such as in vitro release characteristics, stability, drug loading, loading efficiency, pharmacokinetics and tissue distribution in albino mice were studied. The experimental results showed that the microspheres in the range of $0.32-22\;{\mu}m$. The drug loading and loading efficiency were 61.05 and 91.55% respectively. The in vitro release profile of the microspheres matched the korsmeyer’s peppas release pattern, and release at 1h was 42%, while for the original drug, ofloxacin under the same conditions 90.02% released in the first half an hour. After i.v. administration (15 min), the drug concentration of microspheres group in lung in albino mice was $1048\;{\mu}g/g$, while that of controlled group was $6.77\;{\mu}g/g$. GLOME found to release the drug to a maximum extent in the target tissue, lungs.