한국생물공학회:학술대회논문집

The Korean Society for Biotechnology and Bioengineering (한국생물공학회)
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Preparation of Eudragit coated solid lipid nanoparticles (SLN) for hydrophilic drug delivery

  • Han, Sung-Chul (Department of Material & Biochemical Engineering Chonnam National University) ;
  • Yoon, Hee-Sun (Department of Material & Biochemical Engineering Chonnam National University) ;
  • Lee, Ki-Young (Faculty of Applied Chemical Engineering, Chonnam National University) ;
  • Kim, Yeon-Zu (Department of Skin and Beauty, Kwangju Health College & Polymer Engineering, Chonnam National University) ;
  • Kim, Dong-Woon (Department of Environmental Science, kwangyang Health college, Nanobiomed Inc.)
  • Published : 2003.10.22
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Abstract

Solid lipid nanoparticle (SLN) system has been attracted increasing attention during last few years as a potential drug delivery carrier However, the SLN have disadvantage of low encapsulation efficiency for hydrophilic drug. In this study, for increase it's encapsulation efficiency, we prepared the $Eudragit^{\circledR}$ L100-55 (eudragit) coated SLN(E-SLN) based on solvent evaporation method and melt dispersion technique, and analyzed their physicochemical properties in terms of particle size, morphology, and encapsulation efficiency. As a result, they have a ${\pm}150$ nm particle size, spherical shape, and $10^{\sim}25$ % loading efficiency. SLN consists of coconut oil as core material, ascorbic acid and okyong-san as hydrophilic drug.

수용성 약물의 캡슐화 효율을 높이기 위하여 eudragit이 코팅된 SLN을 제조하였고 TEM을 이용하여 그 형태가 양호하게 형성된 것을 확인하였다. DLS를 이용하여 형성된 입자의 분포와 크기를 확인하였으며 옥용산을 포함하는 E-SLN은 ${\pm}180$ nm, ascorbic acid는 ${\pm}150$ nm의 크기를 가지는 것으로 확인되었다. 캡슐화 효율은 옥용산을 경우 41%, ascorbic acid는 33%로 나타났으며, 이는 E-SLN이 수용성 약물을 캡슐화하는 데 유용함을 보여준다.

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