• 한국축산식품학회지
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• 제43권2호
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• pp.220-231
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• 2023

Although omega-3 fatty acids including docosahexaenoic acid (DHA) contain various health-promoting effects, their poor aqueous solubility and stability make them difficult to be induced in dairy foods. The aims of this research were to manufacture casein derivative-based delivery system using acid-induced gelation method with glucono-σ-lactone and to investigate the effects of production variables, such as pH and charged amount of linoleic acid, on the physicochemical properties of delivery systems and oxidative stability of DHA during storage in model milk. Covalent modification with linoleic acid resulted in the production of casein derivatives with varying degrees of modification. As pH was reduced from 5.0 to 4.8 and the charged amount of linoleic acid was increased from 0% to 30%, an increase in particle size of casein derivative-based delivery systems was observed. The encapsulation efficiency of DHA was increased with decreased pH and increased charged amount of linoleic acid. The use of delivery system for DHA resulted in a decrease in the development of primary and secondary oxidation products. An increase in the degree of modification of casein derivatives with linoleic acid resulted in a decrease in the formation of primary and secondary oxidation products than of free DHA indicating that delivery systems could enhance the oxidative stability of DHA during storage in model milk. In conclusions, casein derivatives can be an effective delivery system for DHA and charged amount of linoleic acid played a key role determining the physicochemical characteristics of delivery system and oxidative stability of DHA.

• 산업경영시스템학회지
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• 제36권4호
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• pp.138-145
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• 2013

A sweep-based heuristic using common area is developed for multi-vehicle VRPs under time various and unsymmetric forward and backward vehicle moving speed. One depot and 2 delivery vehicle are assumed in this research to make the problem solving strategy simple. A common area is held to make adjustment of possible unbalance of between two vehicle delivery completion times. The 4 time zone heuristic is used to solve for efficient delivery route for each vehicle. The current size of common area needs to be studied for better results, but the suggested problem solving procedures can be expanded for any number of vehicles.

• Journal of Pharmaceutical Investigation
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• 제40권spc호
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• pp.119-129
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• 2010

The emergence of new biological drugs based on RNA interference (RNAi) technology has been one of the most attractive issues in the field of gene therapy for years. However, the use of siRNA therapeutics in clinical settings is still limited due to lack of appropriate delivery systems for the highly charged macromolecular drug. In this review, recent development of major non-viral siRNA delivery systems, including lipid, liposome, polymer, and peptide-based carriers, is to be summarized.

• Journal of Pharmaceutical Investigation
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• 제38권6호
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• pp.429-432
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• 2008

Drug delivery systems (DDS) have entered mainstream in the pharmaceutical industry in the recent years. Major pharmaceutical companies as well as small or medium-sized biotechnology companies are developing various DDS-based products. We have established Drug Delivery System Company Database, which is an online searchable database of companies that develop DDS-based products and technologies or supply formulations and/or materials. Company summary, products and key technologies are listed in the database. DDS technology fields also include administration routes and indications of drugs. DDS terminologies, Statistical analysis, Useful Links, Glossary and Comments pages are also provided.

• 산업경영시스템학회지
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• 제37권1호
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• pp.133-140
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• 2014

An efficient heuristic for two-vehicle-one-depot problems is developed in this research. Vehicle moving speeds are various along hour based time intervals due to traffic jams of rush hours. Two different heuristics are examined. One is that the delivery area assignment is made using Sweep algorithm for two vehicles by splitting the whole area in half to equally divide all delivery points. The other is using common area by leaving unassigned area between the assigned for two vehicles. The common area is reassigned by two stages to balance the completion time of two vehicle's delivery. The heuristic with common area performed better than the other due to various vehicle moving speeds and traffic jams.

• Clinical and Experimental Vaccine Research
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• 제13권2호
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• pp.73-82
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• 2024

DNA cancer vaccines as an approach in tumor immunotherapy are still being investigated in preclinical and clinical settings. Nevertheless, only a small number of clinical studies have been published so far and are still active. The investigated vaccines show a relatively stable expression in in-vitro transfected cells and may be favorable for developing an immunologic memory in patients. Therefore, DNA vaccines could be suitable as a prophylactic or therapeutic approach against cancer. Due to the low efficiency of these vaccines, the administration technique plays an important role in the vaccine design and its efficacy. These DNA cancer vaccine delivery systems include physical, biological, and non-biological techniques. Although the pre-clinical studies show promising results in the application of the different delivery systems, further studies in clinical trials have not yet been successfully proven.

• International Journal of Internet, Broadcasting and Communication
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• 제14권3호
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• pp.258-269
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• 2022

In these days, innovative functions are required to unmanned parcel delivery lockers. As non-face-to-face transactions become the center due to the recent COVID-19 pandemic, many problem occurs in society such as theft crimes and lack of loading space. Therefore, New concept storage device is developed in korea. It has the functions that minimizes empty spaces by using the internal transport device to enable efficient space loading and refrigerate goods such as foods. In order to systematically approach the system design of the unmanned parcel delivery lockers which is the new function is applied, We applied model-based system engineering to improve the development efficiency and use a system modeling language to express the system. We conducted interworking research of CAD data including system modeling and design data. it is expected that this method will increase the effective development efficiency such as maintenance traceability and reduction of development period and cost.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.292.2-293
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• 2003

In the gene therapy. viral gene delivery systems are limited in use because of several drawbacks like host immune reactions. Hence, non-viral gene delivery systems such as cationic polymers or synthetic gene carriers are being widely investigated to overcome the problems in the use of viral vectors. We synthesized a new conjugate of polyethyleniminet carrying galactose moieties as a targeting ligand for asialoglycoprotein (ASGP) receptors of hepatocytes. (omitted)

• 한국조리학회지
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• 제4권
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• pp.189-209
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• 1998

This study attempts to approach to the Peter Jones' and Marian C. Spears' foodservice delivery system with a focus on their theory. First, ten stages and ten dedicated foodservice delivery systems were introduced. And the author made an attempt to analyze the Peter Jones' ten stages and ten dedicated foodservice delivery systems and then the author's suggestions about them were presented. Second, the author explain the Marian C. Spears' four types of foodservice operations enabling us to establish the type of foodservice operation newly.

• 산업융합연구
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• 제5권2호
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• pp.21-32
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• 2007

This paper deals with the sequencing problem in the operation of the manufacturing systems with the constraint of buffer capacity. Some of studies for this theme have been progressed for several years. And then most of them considered only one objective, such as maximum lateness, machine utilization, makespan, mean flowtime and so on. This study deal with two objectives of the delivery for customers and the idle time of machines for producers. For the decision of sequence, the utility function is used. The developed heuristic algorithm presents a good solution. Through a numerical example, the procedures of the job sequencing is explained.