• Science of Emotion and Sensibility
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• v.15 no.4
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• pp.527-540
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• 2012

We examined the effect of delayed and immediate rewards on short- and long-term memory performance depending on the level of stress. It has been demonstrated that delaying feedback during memory tasks could lead to better retention than presenting it immediately (a.k.a., feedback delay benefit or delay-retention effect). In this study, we manipulated stress level(high-stress or low-stress), reward-timing(delayed or immediate reward), reward-existence(500 or 0 won) and retrieval-timing(delayed or immediate memory test). On the high-stress learning condition, one week later, the number of correct answers with delayed-rewards were significantly more than that of delayed-no-rewards but there was not any difference between immediate-rewards and immediate-no-rewards. On the other hand, in the high-stressful immediate memory test, immediate-rewards only had a positive effect on memory performance. The results indicated that delayed rewards improved long-term memory performance by promoting memory consolidation and the sensitivity to rewards was higher under the high-stress condition.

• Archives of Pharmacal Research
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• v.25 no.5
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• pp.718-723
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• 2002

CKD-602 (7-[2-(N-isopropylamino)ethyl]-(20S)-camptothecin) is a recently-developed synthetic camptothecin analogue and currently under clinical development by Chong Kun Dang Pharm (Seoul, Korea). CKD-602 showed potent topoisomerase inhibitory activity in vitro and broad antitumor activity against various human tumor cells in vitro and in vivo in animal models. This study describes the pharmacodynamics of the immediate and delayed cytotoxicity induced by CKD-602 in a human colorectal adenocarcinoma cell line, HT-29, and its intracellular drug accumulation by HPLC. The present study was designed to address whether the higher activity of CKD-602 with prolonged exposure is due to delayed exhibition of cytotoxicity and/or an accumulation of anti proliferative effect on continuous drug exposure. The drug uptake study was performed to determine whether the delayed cytotoxicity is due to a slow drug accumulation in cells. CKD-602 produced a cytotoxicity that was exhibited immediately after treatment (immediate effect) and after treatment had been terminated (delayed effect). Both the immediate and delayed effects of CKD-602 showed a time dependent decrease in 4IC_{50}$ values. Drug uptake was biphasic and the second equilibrium level was obtained as early as at 24hr, indicating that the cumulative and delayed antitumor effects of CKD-602 were not due to slow drug uptake. On the other hand, CKD-602 treatment was sufficient to induce delayed cytotoxicity after 4hr, however, longer treatment (＞24hr) enhanced its cytotoxicity due to the intracellular accumulation of the drug, which requires 24hr to reach maximum equilibrium concentration. In addition, $C^n$$\times$T=h analysis (n=0.481) indicated that increased exposure times may contribute more to the overall antitumor activity of CKD-602 than drug concentration. Additional studies to determine the details of the intracellular uptake kinetics (e.g., concentration dependency and retention studies) are needed in order to identify the optimal treatment schedules for the successful clinical development of CKD-602.

• Current Research on Agriculture and Life Sciences
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• v.16
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• pp.37-44
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• 1998

The estimation of PMP (Probable Maximum Precipitation) and the analysis of characteristics of PMF (Probable Maximum Flood) according to the types of time distribution of rainfall and variations of base flow for the determination of design flood of major hydraulic structures in the watershed area of Wi stream were analysed. The PMP was estimated by the hydro-meteorological method suggested by the guideline of the World Meteorological Organization(WMO). The Blocking method was cited to transpose from PMP to PMS (Probable Maximum Storm) with time distribution. The unit hydrograph, applied for the estimation of PMF was derived by Clark's method. The summaryzed results : (1) The 72 hrs duration PMP in the area is 477.3mm which is 80mm less than the PMP map in Korea and 134 mm lager than the maximum precipitation of 342.9mm in Taegu, near the Wi stream watershed. (2) According to the types of time distribution and variations of base flow, the ranges of PMF for advanced type, central type and delayed type are 3,145.3~3,348.3cms, 3,774.6~3,977.7cms and 3,814.6~4,017.3cms, respectively. Those mean that peak discharge of advanced type is 600cms less than the central type and delayed type. (3) Delayed type among three types by Blocking method has been estimated the largest PMF of 4,017.3cms, and the advanced type has been estimated the smallest PMF of 3,145.3cms. The mean value of the peak PMF of 3,653.6cms may probably be resonable PMF in the Wi stream watershed. The mean PMF could probably be 1.7 times lager than the result of Gajiyama's equation. It is equivalent to the flood of return period 1,000 to 10,000 yrs.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.32 no.5
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• pp.669-673
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• 1999

The effect of delayed initial feeding (1, 3, 5, 7 days) and starvation on morphological change, mortality and cannibalism on larvae of Siniperca scherzeri was examined by laboratory rearing. The larvae of S. scherzeri began to feed on Artemia nauplii at 4 days after hatching. In case of unfed and 7-days delayed groups, all of the larvae died at 12 days after hatching. The larvae of 1 day delayed feeding survived and grew as almost same as the control group, and 3-days delayed groups showed $33\%$ survival rate at the end of experiment (12 days after hatching). In case of the unfed group, total length of the starved larvae showed lower growth rate than the control group, and they did not reached at the same size of the larvae of the control group. Cannibalism were more common in the unfed group and the delayed fed group than the control group. The highest rate of daily mortality caused by cannibalism in the delayed fed group was $23\%$ at 8 days after hatching.

• Korean Journal of Radiology
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• v.25 no.4
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• pp.384-394
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• 2024

Objective: To evaluate the image quality of novel dark-blood computed tomography angiography (CTA) imaging combined with deep learning reconstruction (DLR) compared to delayed-phase CTA images with hybrid iterative reconstruction (HIR), to visualize the cervical artery wall in patients with Takayasu arteritis (TAK). Materials and Methods: This prospective study continuously recruited 53 patients with TAK (mean age: 33.8 ± 10.2 years; 49 females) between January and July 2022 who underwent head-neck CTA scans. The arterial- and delayed-phase images were reconstructed using HIR and DLR. Subtracted images of the arterial-phase from the delayed-phase were then added to the original delayed-phase using a denoising filter to generate the final-dark-blood images. Qualitative image quality scores and quantitative parameters were obtained and compared among the three groups of images: Delayed-HIR, Dark-blood-HIR, and Dark-blood-DLR. Results: Compared to Delayed-HIR, Dark-blood-HIR images demonstrated higher qualitative scores in terms of vascular wall visualization and diagnostic confidence index (all P < 0.001). These qualitative scores further improved after applying DLR (Dark-blood-DLR compared to Dark-blood-HIR, all P < 0.001). Dark-blood DLR also showed higher scores for overall image noise than Dark-blood-HIR (P < 0.001). In the quantitative analysis, the contrast-to-noise ratio (CNR) values between the vessel wall and lumen for the bilateral common carotid arteries and brachiocephalic trunk were significantly higher on Dark-blood-HIR images than on Delayed-HIR images (all P < 0.05). The CNR values were significantly higher for Dark-blood-DLR than for Dark-blood-HIR in all cervical arteries (all P < 0.001). Conclusion: Compared with Delayed-HIR CTA, the dark-blood method combined with DLR improved CTA image quality and enhanced visualization of the cervical artery wall in patients with TAK.

• Proceedings of the KSME Conference
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• 2005.11a
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• pp.111.2-111.2
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• 2005

• Proceedings of the Korean Nuclear Society Conference
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• 2001.05a
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• pp.341-341
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• 2001

• 전기의세계
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• v.30 no.9
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• pp.579-581
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• 1981

A rendezvous method via delayed state feedback is presented for a class of linear systems with time-delays. The property of pointwise degeneracy of delay differential system is utilized and it is shown that the controller is a minimun-time suboptimal controller.

• 제어로봇시스템학회:학술대회논문집
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• 2002.10a
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• pp.59.4-59
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• 2002

$\textbullet$ Introduction-Previous results and motivation of this paper $\textbullet$ Problem Statements-The system considered and the objective of this paper $\textbullet$ Main Results-The Sufficient Condition for 8 delayed feedback non-fragile H_inf control $\textbullet$ Numerical Example-The effectiveness of the proposed method $\textbullet$ Conclusion

• Bulletin of the Korean Chemical Society
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• v.34 no.1
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• pp.275-278
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• 2013