• 문화기술의 융합
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• 제9권5호
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• pp.493-499
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• 2023

신용거래(Trade Credit)는 제품 공급자가 중간유통자에게 제품 구입비용에 대하여 일정 기간 동안 지불 유예를 허용하는 거래 행위로 일반적으로 경쟁 기업과의 차별화 수단으로 허용되어 진다. 이와 같은 신용 거래는 고객의 거래량(주문량 크기) 증대를 목적으로 거래량의 크기에 따라 종속적으로 허용되는 것을 흔히 볼 수 있다. 또한 중간유통자 입장에서 보면 신용거래가 허용되면, 제품 구입비용에 대하여 일정 기간 동안의 지불 유예가 가능하여 재고투자비용의 절감 효과를 기대할 수 있고, 이와 같은 재고 투자비용의 절감은 최종 고객의 수요를 늘릴 수단으로 판매가격을 할인하는 요인이 될 수 있다. 본 연구에서는 공급자가 중간유통자의 거래량에 종속적으로 지불 유예 기간을 허용하는 상황 하에서 최종고객의 연간 수요가 중간유통자의 판매가격에 지수적으로 감소하는 가격탄력함수(a price elasticity function)의 경우를 고려하여 중간유통자 관점의 최적 판매가격과 주문량을 결정하는 모형을 분석하고자 한다. 문제 분석을 위하여 제품은 시간이 경과함에 따라 일정율로 퇴화하는 경우에 중간유통자의 재고 모형을 수립하고, 퇴화가 중간유통자의 재고 정책에 미치는 영향에 대해서 분석 해 보고자 한다.

• Smart Structures and Systems
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• 제25권2호
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• pp.155-167
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• 2020

This paper demonstrates a real-time hybrid substructuring (RTHS) shake table test to evaluate the seismic performance of a base isolated building. Since RTHS involves a feedback loop in the test implementation, the frequency dependent magnitude and inherent time delay of the actuator dynamics can introduce inaccuracy and instability. The paper presents a robust stability and performance analysis method for the RTHS test. The robust stability method involves casting the actuator dynamics as a multiplicative uncertainty and applying the small gain theorem to derive the sufficient conditions for robust stability and performance. The attractive feature of this robust stability and performance analysis method is that it accommodates linearized modeled or measured frequency response functions for both the physical substructure and actuator dynamics. Significant experimental research has been conducted on base isolators and dampers toward developing high fidelity numerical models. Shake table testing, where the building superstructure is tested while the isolation layer is numerically modeled, can allow for a range of isolation strategies to be examined for a single shake table experiment. Further, recent concerns in base isolation for long period, long duration earthquakes necessitate adding damping at the isolation layer, which can allow higher frequency energy to be transmitted into the superstructure and can result in damage to structural and nonstructural components that can be difficult to numerically model and accurately predict. As such, physical testing of the superstructure while numerically modeling the isolation layer may be desired. The RTHS approach has been previously proposed for base isolated buildings, however, to date it has not been conducted on a base isolated structure isolated at the ground level and where the isolation layer itself is numerically simulated. This configuration provides multiple challenges in the RTHS stability associated with higher physical substructure frequencies and a low numerical to physical mass ratio. This paper demonstrates a base isolated RTHS test and the robust stability and performance analysis necessary to ensure the stability and accuracy. The tests consist of a scaled idealized 4-story superstructure building model placed directly onto a shake table and the isolation layer simulated in MATLAB/Simulink using a dSpace real-time controller.

• 한국근적외분광분석학회:학술대회논문집
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• 한국근적외분광분석학회 2001년도 NIR-2001
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• pp.1627-1627
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• 2001

In this study, a newly constructed optical measurement system, whose main components were a parametric tunable laser and a near infrared photoelectric multiplier, was applied to detection of the information for the inside of Satsuma mandarin using time-of-flight near infrared spectroscopy (TOF-NIRS). The combined effects on the time resolved profile of sample diameter, sugar content, the wavelength of the laser beam, and the detection position of transmitted light were investigated in detail. The samples used were Satsuma mandarin (Citrus unshu $M^{ARC}$.) (location: Wakayama, Japan) having the diameters of 50-84 mm. The sugar content measured by a refractometer varied from 9.9 to 16.3 Brix%. Equator of sample was irradiated vertically with the pulsed laser, and transmitted output power was measured on the restricted position of the equator using the optical fiber cable. The sampling time and the number of averaging the output power were 100 ns and 100 times, respectively. The variation of the attenuance of peak maxima At, the time delay of peak maxima t and the variation of full width at half maximum w were strongly dependent on the detection position and the wavelength of the laser beam. At, t and w increased gradually as the sample diameter increased to be much absorbed and vigorously scattered. On the other hand, each optical parameter had a tendency to increase as the sugar content increased. Such behavior was remarkable when the transmitted light was detected at the side face of a sample. When we apply TOF-NIRS to detection of the information for the inside of fruit with high moisture content like Satsuma mandarin, it is very important to give attention to the difference in the scattered light within tissues and the semi-straightly propagated light. Furthermore, we tried to express the resulting phenomena by using a model samples composed of water, sucrose, and milk. The variation of the time resolved profile is strongly governed by the combination of the light absorption component, scattering medium, and refractive index.

• 한국근적외분광분석학회:학술대회논문집
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• 한국근적외분광분석학회 2001년도 NIR-2001
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• pp.1626-1626
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• 2001

In this study, a newly constructed optical measurement system, whose main components were a parametric tunable laser and a near infrared photoelectric multiplier, was applied to detection of the information for the inside of Satsuma mandarin using time-of-flight near infrared spectroscopy (TOF-NIRS). The combined effects on the time resolved profile of sample diameter, sugar content, the wavelength of the laser beam, and the detection position of transmitted light were investigated in detail. The samples used were Satsuma mandarin (Citrus unshu $M_{ARC}$.) (location: Wakayama, Japan) having the diameters of 50-84 mm. The sugar content measured by a refractometer varied from 9.9 to 16.3 Brix%. Equator of sample was irradiated vertically with the pulsed laser, and transmitted output power was measured on the restricted position of the equator using the optical fiber cable. The sampling time and the number of averaging the output power were 100 ns and 100 times, respectively. The variation of the attenuance of peak maxima At, the time delay of peak maxima $\Delta$t and the variation of full width at half maximum Δw were strongly dependent on the detection position and the wavelength of the laser beam. At, $\Delta$t and $\Delta$w increased gradually as the sample diameter increased to be much absorbed and vigorously scattered. On the other hand, each optical parameter had a tendency to increase as the sugar content increased. Such behavior was remarkable when the transmitted light was detected at the side face of a sample. When we apply TOF-NIRS to detection of the information for the inside of fruit with high moisture content like Satsuma mandarin, it is very important to give attention to the difference in the scattered light within tissues and the semi-straightly propagated light. Furthermore, we tried to express the resulting phenomena by using a model samples composed of water, sucrose, and milk. The variation of the time resolved profile is strongly governed by the combination of the light absorption component, scattering medium, and refractive index.

• Biomolecules & Therapeutics
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• 제19권3호
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• pp.282-287
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• 2011

Sirt1, a nicotinamide adenine dinucleotide ($NAD^+$)-dependent histone deacetylase, is known to deacetylate a number of proteins that are involved in various cellular pathways such as the stress response, apoptosis and cell growth. Modulation of the stress response by Sirtuin 1 (Sirt1) is achieved by the deacetylation of key proteins in a cellular pathway, and leads to a delay in the onset of cancer or aging. In particular, Sirt1 is known to play an important role in maintaining genomic stability, which may be strongly associated with a protective effect during tumorigenesis and during the onset of aging. In these studies, Sirt1 was generated in stably expressing cells and during the stimulation of DNA damage to examine whether it promotes survival. Sirt1 expressing cells facilitated the repair of DNA damage induced by either ionizing radiation (IR) or bleomycin (BLM) treatment. Fastened damaged DNA repair in Sirt1 expressing cells corresponded to prompt activation of Chk2 and ${\gamma}$-H2AX foci formation and promoted survival. Inhibition of Sirt1 enzymatic activity by a chemical inhibitor, nicotinamide (NIC), delayed DNA damage repair, indicating that promoted DNA damage repair by Sirt1 functions to induce survival when DNA damage occurs.

• 생약학회지
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• 제40권4호
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• pp.339-344
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• 2009

Diabetic cataract is a major complication of diabetes mellitus. Excess accumulation of sorbitol plays an important role in the pathogenesis of diabetic complications such as cataract formation. In this study, we investigated the inhibitory effect of the extract of the aerial parts of Aster koraiensis (AK) on diabetic cataractogenesis. To examine this further, we evaluated sorbitol accumulation during cataract development using streptozotocin-induced diabetic rat, an animal model of type 1 diabetes. Diabetic rats were treated orally with AK (100 mg/kg and 200 mg/kg body weight) once a day orally for 9 weeks. In vehicle-treated diabetic rats, lens opacity was increased, and lens fiber swelling and membrane rupture were observed. In addition, sorbitol accumulation in diabetic lens was markedly enhanced. However, AK treatment delayed the progression of diabetic cataract through the inhibition of sorbitol accumulation, and prevented lens fiber degeneration in a dose-dependent manner. These observations suggest that AK treatment can delay the progression of lens opacification in the diabetic rats during the early diabetic cataractogenesis.

• 대한교통학회지
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• 제17권5호
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• pp.137-149
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• 1999

기존 엇갈림 구간의 속도 및 서비스수준 분석에 관한 연구들은 현장조사를 통하여 엇갈림 구간 주행속도에 영향을 미치는 여러 요소 즉, 구간길이, 차로수, 교통량 등을 독립변수로 하는 회귀식을 도출하였다. 그러나 우리나라의 경우는 엇갈림 구간이 많이 존재하지 않으므로 기존 연구들처럼 현장조사를 통해 회귀식에 필요한 매개변수 값들을 추정하는데 어려움이 있다. 따라서, 엇갈림 구간의 속도추정 및 용량분석을 수행하기 위해 새로운 분석 방법론 개발의 필요성이 대두하게 되었다. 이를 위해 본 연구에서는 엇갈림 구간의 기본적인 특성을 규명하고 이를 수학적 확률식에 의거 엇갈림 구간 주행속도 예측모형을 개발함으로써, 분석대상 엇갈림 구간 수의 부족을 극복하고 범용적으로 적용될 수 있는 방법론을 모색하고자 하였다. 연구는 첫째, 엇갈림 영향권 파악, 둘째, 엇갈림 영향권에서의 차두간격 분포 파악, 셋째, 엇갈림 구간의 최대 가능 엇갈림 교통량 산정, 넷째, 이상적 엇갈림 구간 길이의 산정, 다섯째, 엇갈림 영향권의 속도 예측, 여섯째, 모형의 검증의 여섯 가지 범주로 구분되어 수행되었다. 특히 엇갈림 영향권의 속도 예측은 고속도로 기본구간의 속도와 엇갈림 영향권에서 발생하는 지체시간을 비교하여 결정하였다.

• 한국정보과학회논문지:정보통신
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• 제27권1호
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• pp.98-107
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• 2000

본 논문에서는 멀티캐스트 가용비트율 (Available Bit Rate: ABR) 서비스를 위해 현재 ATM 포럼 등을 통해 제안되고 있는 신속한 폭주 통지 (fast overload indication) 기능을 기존 피드백통합 알고리즘들에 적용하여 이들의 성능을 시뮬레이션을 통해 비교 분석하였다. 성능 분석의 지표로 송신원의 허용된 셀률 (Allowed Cell Rate: ACR), 스위치에서의 큐 길이, 링크 이용 효율, 공평성, 역방향 자원관리 셀 (Backward Resource Management: BRM) 셀의 오버헤드 등을 사용하였다. 분석 결과, 신속한 폭주 통지 기능이 추가된 피드백 통합 알고리즘들은 망에 심각한 폭주가 발생한 경우에 매우 효과적임을 알 수 있었다. 신속한 폭주 통지 기능은 기본적인 피드백 통합 알고리즘에 관계없이 쉽게 추가될 수 있는 반면에, 이러한 기능이 추가된 알고리즘들의 성능은 기본적인 피드백 통합 알고리즘들의 성능에 매우 의존적임을 알 수 있었다.

• 약학회지
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• 제48권4호
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• pp.247-253
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• 2004

We investigated the hypoglycemic effect of formula containing Euonymus alatus (EA) and Mori Folium (MF) in multiple low dose (MLD) streptozotocin (STZ)-induced diabetic rats. In order to iduce hyperglycemic state 25 mg/kg of STZ was injected intraperitoneally for 5 consecutive days. SD rats were randomly divided into diabetic control and treatment groups. Treatment groups were administered with either 250 mg/kg of EA and 250 mg/kg of MF (E1Ml), or 500 mg/kg of EA mixed with same dose of MF (E2M2) for 3 weeks. Blood glucose levels and body weights were measured every 5th or 6th day. E1Ml and E2M2 both significantly reduced food intake, water intake, and fasting blood and urine glucose levels as compared to those in diabetic control group in a dose dependent manner. Body weight in diabetic control group was increased slightly after 3 weeks. Treatment group, however, showed gradual increase in body weights during 3 week-period. While plasma insulin levels of the diabetic control group were decreased to the level of 387$\pm$14 pg/ml from 534$\pm$36 pg/ml, those levels in E1Ml and E2M2-treated groups were both markedly increased by 13% and 26%, respectively. Urine glucose levels in E1Ml and E2M2-treated groups were also remarkably reduced by 17 and 26% compared to the levels of diabetic control group. While expression of membrane-bound glucose transporter-4 (GLUT-4) protein in skeletal muscle was reduced by 45% in diabetic control compared to the normal control, GLUT-4 protein expressions in E1Ml and E2M2-treated groups were augmented by 2 and 3.5 times compared to the diabetic control, respectively. Pancreatic HE staining experiments showed that E2M2-treated group revealed much less infiltrated mononuclear cells, indicating that E2M2 efficiently blocked insulitis induced by multiple low dose streptozotocin. Taken together, we conclude that formula containing EA and MF may prevent or delay the development of hyperglycemia through overexpression of GLUT-4 protein in skeletal muscle and prevention of insulitis.

• 한국통신학회논문지
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• 제42권2호
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• pp.393-402
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• 2017

육상의 셀룰러 네트워크와 같이 수중에서도 기지국을 통해 유입되는 트래픽 양에 따라 적응적으로 기지국의 백홀 자원을 할당하여 전체 네트워크 자원을 효율적으로 관리할 수 있는 수중 셀룰러 통신 네트워크가 필요하다. 본 논문에서는 수중 셀룰러 통신 네트워크에서 기지국에 유입되는 트래픽에 비례하여 기지국의 백홀 자원을 할당하는 자원분배 프로토콜을 제안한다. 자원분배 프로토콜은 자원을 할당하는 주기에 따라 고정주기 방식과 적응주기 방식으로 분류된다. 더 효율적인 자원분배 프로토콜을 결정하기 위해 모의시험을 이용하여 고정주기 방식과 적응주기 방식의 수신율, 메시지 오버헤드, 전송지연 성능을 비교하고 분석하였다. 그 결과, 고정주기 방식이 적응주기 방식에 비해 최대 수백 배 이상의 전송지연이 증가하였으며, 수백 배 이상의 메시지 오버헤드가 더 발생하여 모든 성능 지표에서 적응주기 방식이 고정주기 방식보다 성능이 우수함을 확인하였다.