• 한국건설관리학회논문집
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• 제24권2호
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• pp.59-69
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• 2023

FIDIC White Book은 클라이언트와 컨설턴트간 모델 서비스 계약조건이다. 본 연구는 델파이 기법을 활용하여 FIDIC White Book 일반조건의 63개 세부조항들 중 핵심 리스크 세부조항 도출을 목표로 하였다. 해외건설 서비스계약 및 FIDIC White Book에 대한 10년 이상의 경험과 전문지식을 보유한 40명의 전문가 패널을 구성하여 총 3회의 델파이 조사 과정을 통해 전문가의 의견 일치성을 높이는 방향으로 신뢰성을 향상시켰다. 델파이 1차 조사에서는 일반조건 63개 세부조항들 중 리스크의 영향력을 리커트 5점 척도로 폐쇄형 설문조사를 수행하였고 26개의 주요 리스크 세부조항들을 도출하였다. 델파이 1차 조사결과의 내용 타당성은 내용타당도 CVR값으로 검증하였다. 델파이 2차 및 3차 조사에서는 26개의 주요 리스크 세부조항들에 대하여 리커트 10점 척도로 폐쇄형 설문조사를 수행하고 각각의 리스크 발생도 및 영향도를 평가하였다. 델파이 3차 조사 결과의 신뢰성은 변이계수 COV값으로 검증하였다. 26개의 주요 리스크 세부조항들 각각의 리스크 발생도와 영향도 평균값을 PI Risk Matrix에 적용하여 총 14개의 핵심 리스크 세부조항들을 도출하였다. 핵심 리스크 세부조항 도출결과는 구체적인 서비스 범위의 합의, 지연관리, 변경관리가 가장 중요한 것으로 나타났다. 본 연구 결과로 실무관점에서는 컨설팅업체의 컨설턴트가 클라이언트와 서비스 계약을 체결할 때 계약적 리스크 최소화를 위해 검토해야 하는 가이드라인을 제공해 주고 있다. 학문적 관점에서는 해외건설에 참여하는 컨설턴트들을 위한 서비스 계약 관련 핵심리스크 도출에 대한 연구의 방향성을 제시하고 있다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권2호
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• pp.759-765
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• 2016

Background: Breast cancer is the most frequent cancer of women in Pakistan with the majority presenting with stage III or IV lesionsat initial diagnosis. Patient and health system related factors are well known determinants of delay in presentation and diagnosis. Additionally, breast cancer being a heterogeneous disease, the various molecular subtypes featuring different aggressiveness also need to be considered. The present study evaluated the association of stage at initial diagnosis of breast cancer with these two factors in local women at a tertiary level health care facility in Lahore, Pakistan. Materials and Methods: Patient and tumor features were recorded separately during diagnostic workup in Breast Clinics at INMOL and at Services Hospital, Lahore. Data were entered in MS Excel and analyzed by descriptive statistics and Chi-Square test. Results: Among the 261 patients, 64% were staged as late breast cancer (LBC), the mean age was 46.8 with standard deviation of 13 years. Some 92% had invasive ductal carcinoma (IDC), 61% had luminal types (LT) of non-aggressive tumor while 39% had the non-luminal types (NLT) of of HER2-enriched or basal aggressive tumors. While 70% of patients presented within one year of symptomatic disease (early report group "ERG"), 30% reported after a mean delay of 4 years with a standard deviation of 3.75 years. The stage distribution among ERG patients was not statistically different from those reporting late (P=0.123). Statistically larger proportion of patients with NLT presented as LBC as compared to the LT (P =0.034). Among the ERG, statistically different stage distribution of disease was observed for the NLT versus LT (P=0.047). Among those presenting late, this difference was insignificant (P=0.416). Conclusions: Breast cancer is a distinct disease in Pakistan with a high frequency of aggressive molecular types affecting younger women, with the majority presenting as LBC. Association of NLT with higher stage at diagnosis is statistically significant whereas time delay in diagnosis is not. Further research is required to define the risk profile and features in local patients. The burden of LBC can be reduced by promoting breast health awareness and by establishing easily accessible dedicated breast care set ups in the hospitals.

• Child Health Nursing Research
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• 제23권3호
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• pp.259-267
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• 2017

Purpose: This study was done to identify contraceptive practices in adolescent girls in South Korea and predictors of contraceptive practices. Methods: The study sample included 743 girls who had experienced sexual activity. Using statistics from the 12th (2016) Korea Youth Risk Behavior Web-based Survey, hierarchical logistic regression analysis was conducted. Results: The contraceptive practice rate for adolescent girls was 34%. Contraceptive practice was associated with 'age at first intercourse' and 'sexual intercourse after drinking'. For adolescent girls who had early sexual initiation and drank alcohol before sexual intercourse there was a tendency to reduce the practice of contraception. Conclusion: It is necessary to provide practical sex education to improve the practice of contraception in these adolescents. In addition, adolescent girls should be encourage to delay their first intercourse. The results of this study can also be used to develop education interventions regarding healthy sexuality behaviour including the practice of contraception.

• 한국임상약학회지
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• 제21권2호
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• pp.57-65
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• 2011

Incretin hormones such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide delay gastric emptying, increasing satiety, and enhance insulin secretion. Two new classes of treatments related to incretin hormones for the management of type 2 diabetes mellitus have emerged: GLP-1 receptor agonists (e.g., exenatide, liraglutide) and the dipeptidyl peptidase-4 (DPP-4) inhibitors (e.g., sitagliptin, saxagliptin, vildagliptin, alogliptin), which prevent the degradation of GLP-1. A MEDLINE search was conducted in order to evaluate the efficacy and safety of incretin-based therapies and publications were reviewed. Data from clinical trials indicated incretin-based treatment showed clinically significant reductions in hemoglobin A1c with low risk of hypoglycemia. Weight reductions were observed with GLP-1 receptor agonists where as DPP-4 inhibitors are weight neutral.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제21권1호
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• pp.68-71
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• 2018

Androgen therapy has proven efficacy in treating patients with bone marrow failure who are not candidates for bone marrow transplantation. Herein, we report on a case of colonic angioectasia secondary to oxymetholone use in an adolescent patient with Hoyeraal-Hreidarsson syndrome (HHS). A 13-year-old Caucasian male with HHS characterized by cerebellar hypoplasia, developmental delay, microcephaly, esophageal strictures and myelodysplasia presented with severe hematochezia from colonic angioectasia secondary to long-term oxymetholone therapy. These vascular lesions resolved spontaneously once this anabolic steroid was discontinued. While androgen therapy is often recommended for certain anemias and myelodysplastic syndromes, clinicians should be aware of the potential complication in developing these perceived uncommon colonic angioectasias. Moreover, pediatric gastroenterologists should familiarize themselves in identifying these vascular lesions by colonoscopy, especially among the high risk groups on long-term anabolic steroid therapy.

• Clinical and Experimental Pediatrics
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• 제52권9호
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• pp.976-983
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• 2009

Urinary tract infection (UTI), the most common bacterial disease in childhood, is frequently associated with urinary tract anomalies (15-50%) and can induce renal scarring, which is a cause of hypertension and chronic kidney disease. Despite the high risk of renal scarring in infancy, the diagnosis may be delayed due to its nonspecific presenting symptoms; moreover, over-diagnosis is frequent due to the contamination of urine samples. The delay in diagnosis and treatment may induce sepsis or renal scar, while over-diagnosis is responsible for unnecessary antibiotic treatment and costly urinary imaging studies. UTI guidelines have been ever-changing for the past three decades, but some controversial issues remain. This article is a revision of the previous KSPN (Korean Society of Pediatric Nephrology) guideline and addresses the recent controversies concerning childhood UTI.

• 한국안전학회지
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• 제24권5호
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• pp.28-33
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• 2009

The thermochemical parameters for safe handling, storage, transport, operation and process design of flammable substances are explosion limit, flash point, autoignition temperatures(AITs), minimum oxygen concentration(MOC), heat of combustion etc.. Also it is necessary to know explosion limit at high temperature and pressure. For the safe handling of benzene, lower explosion limit(LEL) at $25^{\circ}C$, the temperature dependence of the explosion limits and flash point were investigated. And the AITs for benzene were experimented. By using the literatures data, the lower and upper explosion limits of benzene recommended 1.3 vol% and 8.0 vol%, respectively. This study measured relationship between the AITs and the ignition delay times by using ASTM E659-78 apparatus for benzene, and the experimental AIT of benzene was $583^{\circ}C$. The new equations for predicting the temperature dependence of the explosion limits of benzene is proposed. The values calculated by the proposed equations were a good agreement with the literature data.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2004년도 춘계학술대회 논문집
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• pp.224-228
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• 2004

In these days, as it frequently happens that water level in the river exceeds the design floods due to irregular heavy rainfall, so it is required, first of an, to manage with railroad bridge safely. Because train control criterion under heavy rainfall is still not prepared and automatic flood monitoring system for railroad bridges is not used, worry over invisible economic loss due to train passage delay is in existence. Therefore, it is important to secure the safety and detect the risk like turnover or failure of railroad bridges through systematic disaster prevention system. And the transition from conventional monitoring method to real time monitoring method supported by sensors and communication system with high technology is rapidly needed. This research is on developing the real time flood monitoring system which prevents railroad disasters in advance by detecting continuously the water level of railroad bridge through CCD camera and water level gauge.

• International journal of advanced smart convergence
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• 제5권3호
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• pp.27-31
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• 2016

High-tech industries in a state well enough to troubleshoot hacking information introduction a big barrier to delay the growth of the market related to IoT(Internet of Things) as is likely to be on the rise. This early on, security issues introduced in the solution, a comprehensive solution, including the institutional laws/precautions needed. Recent examples of frequent security threats while IoT is the biggest issue of introducing state-of-the-art industry information due to the vulnerable security hacking. This high-tech industries in order to bridge the information responsible for the target attribute, target range, and the protection of security and how to protect the subject, IoT environment (domestic industrial environment) considering the approach is needed. IoTs with health care and a wide variety of services, such as wearable devices emerge. This ensures that RFID/USN-based P2P/P2M/M2M connection is the implementation of the community. In this study, the issue on the high-tech industrial information and the vulnerable security issues of IoT are described.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제20권1호
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• pp.65-70
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• 2017

Bannayan-Riley-Ruvalcaba syndrome (BRRS) is one of the phosphatase and tensin homolog hamartoma tumor syndrome with a PTEN gene mutation. It is a rare dominant autosomal disorder characterized by cutaneous lipomas, macrocephaly, intestinal polyps, and developmental delay. Diagnosing this syndrome is important, because it may represent the pediatric phenotype of Cowden syndrome, in which there is an increased risk for malignant tumors in children. Until now, the prevalence of BRRS is unknown. Several dozen cases have been reported in the medical literature, but no case has been reported in Korea. Here we report a case of a 19-year-old girl who was diagnosed with BRRS because of macrocephaly, intellectual disability, and intestinal polyps. Her mother had similar findings and a PTEN mutation. Neither patient had mutations detected by conventional mutation-detection techniques, but a PTEN gene deletion was demonstrated by chromosomal microarray analysis.