• Clinical and Experimental Pediatrics
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• 제55권6호
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• pp.185-192
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• 2012

The prevalence of allergic diseases has increased worldwide, a phenomenon that can be largely attributed to environmental effects. Among environmental factors, air pollution due to traffic is thought to be a major threat to childhood health. Residing near busy roadways is associated with increased asthma hospitalization, decreased lung function, and increased prevalence and severity of wheezing and allergic rhinitis. Recently, prospective cohort studies using more accurate measurements of individual exposure to air pollution have been conducted and have provided definitive evidence of the impact of air pollution on allergic diseases. Particulate matter and ground-level ozone are the most frequent air pollutants that cause harmful effects, and the mechanisms underlying these effects may be related to oxidative stress. The reactive oxidative species produced in response to air pollutants can overwhelm the redox system and damage the cell wall, lipids, proteins, and DNA, leading to airway inflammation and hyper-reactivity. Pollutants may also cause harmful effects via epigenetic mechanisms, which control the expression of genes without changing the DNA sequence itself. These mechanisms are likely to be a target for the prevention of allergies. Further studies are necessary to identify children at risk and understand how these mechanisms regulate gene-environment interactions. This review provides an update of the current understanding on the impact of air pollution on allergic diseases in children and facilitates the integration of issues regarding air pollution and allergies into pediatric practices, with the goal of improving pediatric health.

• 대한간호학회지
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• 제36권4호
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• pp.612-620
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• 2006

Purpose. Smoking is the leading cause of death and smoking initiation rarely occurs after adolescence. Thus research on adolescent smoking is crucial. A consistent definition of smoking is important because inconsistent definitions make comparisons across studies an arduous task. Thus, the aim of the study was to suggest future research directions for smoking definitions after examining pitfalls in the literature. Methods. In this study the literature on adolescent smoking in the U.S. and South Korea was examined, and three types of smoking definitions were identified. Limitations in the studies are identified and future research directions are suggested. Results. In the U.S. literature, smoking definitions can be categorized into three groups: definitions based on stage models, smoking trajectories, and definitions derived from specific data. In the South Korean literature, various levels of smoking have not been differentiated. Conclusions. While the literature does not provide a definitive answer regarding the definition of smoking, it suggests three issues to consider for future research. First, multiple measures of smoking are more desirable than a one-time measure. Second, theory- or trajectory-based smoking definitions are more desirable than definitions derived from available data. Finally, regularity and amount of cigarette use should be incorporated in defining smoking behavior.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제15권4호
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• pp.317-321
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• 1993

본 교실에서는 이전에 구순 및 구개성형술을 받은 2명의 상악골 발육부전 환자에서 각각 상하악 동시 이동술과 상악 단독 이동술을 시행하여 다음과 같은 결과를 얻었다. 1. 술후 상악골은 상방으로 이동한 후 다시 하방으로 이동하였으며 후방으로의 재발은 비교적 작았다. 2. 두 증례 모두 술후 하악골의 전방 재발이 많았다. 3. 순악구개열환자의 외과적 교정술에 있어서 술후 안정성을 높일 방법들이 강구되어야 할것으로 사료된다.

• Structural Engineering and Mechanics
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• 제75권3호
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• pp.295-309
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• 2020

The construction of Reinforced Concrete (R/C) buildings with unreinforced masonry infills is part of the traditional building practice in many countries with regions of high seismicity throughout the world. When these buildings are subjected to seismic motions the presence of masonry infills and especially their configuration can highly influence the seismic damage state. The capability to avoid configurations of masonry infills prone to seismic damage at the stage of initial architectural concept would be significantly definitive in the context of Performance-Based Earthquake Engineering. Along these lines, the present paper investigates the potential of instant prediction of the damage response of R/C buildings with various configurations of masonry infills utilizing Artificial Neural Networks (ANNs). To this end, Multilayer Feedforward Perceptron networks are utilized and the problem is formulated as pattern recognition problem. The ANNs' training data-set is created by means of Nonlinear Time History Analyses of 5 R/C buildings with a large number of different masonry infills' distributions, which are subjected to 65 earthquakes. The structural damage is expressed in terms of the Maximum Interstorey Drift Ratio. The most significant conclusion which is extracted is that the ANNs can reliably estimate the influence of masonry infills' configurations on the seismic damage level of R/C buildings incorporating their optimum design.

• Clinical and Experimental Reproductive Medicine
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• 제44권2호
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• pp.57-62
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• 2017

The purpose of this paper is to assimilate all data pertaining to the use of gonadotropin-releasing hormone (GnRH) antagonists in in vitro fertilization cycles after ovulation trigger to reduce the symptoms of ovarian hyperstimulation syndrome (OHSS). A systematic review of the literature was performed to identify all studies performed on the use of a GnRH antagonist in IVF cycle post-ovulation trigger with patients at high risk for OHSS. Ten studies were identified and reviewed. Descriptions of the studies and their individual results are presented in the following manuscript. Due to significant heterogeneity among the studies, it was not possible to perform a group analysis. The use of GnRH antagonists post-ovulation trigger for treatment of OHSS has been considered for almost 20 years, though research into its use is sparse. Definitive conclusions and recommendations cannot be made at this time, though preliminary data from these trials demonstrate the potential for GnRH antagonists to play a role in the treatment of OHSS in certain patient populations.

• Asian Pacific Journal of Cancer Prevention
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• 제16권5호
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• pp.1965-1969
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• 2015

Cancer prevalance and incidence is increasing with aging of populations and age is a critical factor in decision-making for anti-cancer treatment. However it is believed that chronological age is not enough to guide management in elderly cancer patients. Multidisciplinary evaluation and comprehensive geriatric assessment has gained importance regarding the treatment selection especially for definitive anti-cancer therapy recently. We here aimed to analyse the effect of the comprehensive geriatric assessment parameters on radiotherapy toxicity and tolerability in a series of geriatric cancer patients in Turkey.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제11권1호
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• pp.255-260
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• 1989

Unfavorable healing of maxillary fractures may impose functional and esthetic burdens upon the trauma victim. Malunited maxillary fractures are generally a result of treatment delay, incomplete or inaccurate immobilization of the fracture fragments, or infection. Dysfunctions of mastication, distortions in speech, gross defects in facial contour, and related psychic changes are problems which may require secondary correction. When it is necessary to delay definitive treatment or when inadequate maxillary fracture reduction is recognized within the first week following injury, the maxilla can be mobilized by heavy handed dental manipulation under anesthesia or by elastic traction to an external fixation appliance attached to the maxilla by arch bars or an acrylic splint. But malunited maxillary fracture that have progressed to bony malunion require osteotomy procedure in order to establish normal anatomic relationships. This report parents two cases of malunited unilateral maxillary fracture surgically corrected by unilateral Le Fort I osteotomy.

• 한국지능시스템학회논문지
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• 제12권6호
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• pp.543-548
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• 2002

퍼지 클러스트링은 전통적인 FCM을 이용하여 수행될 수 있다 그러나 FCM을 사용하는데 있어서 고려해야 할 문제점은 크게 두가지이다. 첫째는 FCM은 초기 멤버쉽 함수의 지정에 민감하고, 둘째는 FCM 알고리듬의 수행에는 클러스터의 개수를 미리 지정 해 주어야 한다는 것이다. 따라서 FCM과 동시에 수행하여야 할 과제는 클러스터의 개수를 찾기 위하여 타당성 척도를 이용한 시뮬레이션을 수행하여야 한다. 본 논문에서는 위의 두 가지 문제점을 동시에 해결 할 수 있는 FCM 알고리듬을 제시하고, 그 적용성을 시뮬레이션을 통하여 검증한다. 본 논문의 기여도는 MV-FCM 알고리듬의 제시와 이 알고리듬의 타당성 척도로써의 효율성이다.

• 한국어병학회지
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• 제23권1호
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• pp.113-118
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• 2010

The present work describes myxozoan parasite found in the skin of cultured snakehead, Channa argus fingerings (total length, 5.5~7.2 cm) from Busan, Korea. Nature spores and plasmodia were found in the skin mucus of infected fishes. In fresh state, the total length of the spore was $27.96{\pm}2.50{\mu}m$. The size of spore body was $14.16{\pm}1.78{\mu}m{\times}4.88{\pm}0.61{\mu}m$. The polar capsules were pyriform and the size was $5.57{\pm}0.66{\mu}m{\times}1.36{\pm}0.33{\mu}m$. This is the first report of Henneguya sp. from cultured fish species in Korea, and further studies are necessary for definitive identification.

• Parasites, Hosts and Diseases
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• 제54권3호
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• pp.323-327
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• 2016

A man with only yellowing of the skin and eye sclera was diagnosed with clonorchiasis, which rarely manifested jaundice as the initial symptom. However, because of a lack of evidence for a diagnostic gold standard, the time until definitive diagnosis was more than a week. The diagnostic process relied on inquiring about the patient's history, including the place of residence, dietary habits, and symptoms, as well as on serological findings, an imaging examination, and pathological findings. MRCP and CT results showed mild dilatation of intrahepatic ducts and increased periductal echogenicity. The eggs were ultimately found in stool by water sedimentation method after the negative report through direct smear. DNA sequencing of PCR production of the eggs demonstrated 98-100% homology with ITS2 of Clonorchis sinensis. After anti-parasite medical treatment, the patient's symptoms were gradually relieved. Throughout the diagnostic procedure, besides routine examinations, the sedimentation method or concentration method could be used as a sensitive way for both light and heavy C. sinensis infection in the definite diagnosis.