• Journal of the Korean Data and Information Science Society
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• v.23 no.5
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• pp.961-970
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• 2012

To evaluate companies that participated in the defense R&D project, 27 variables are chosen through literature survey, feature analysis of defense R&D and interviews with military experts. 17 variables are selected after factor analysis which is applied to reduce the number of variables and to detect structure in the relationships among variables, that is to classify variables using Likert-type scales. And then 17 variables are prioritized by AHP (analytic hierarchy process) method. It is shown that communication skill & cooperation strategy, level of technology, possession of needs technology have high priorities. However, protection plan of technology leakage, expertise of subcontractors, software development plan have low priorities.

• Molecular & Cellular Toxicology
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• v.5 no.1
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• pp.51-57
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• 2009

Quantum Dot (QD) nanoparticles are used in various industrial applications, such as diagnostic, drug delivery, and imaging agents of biomedicine. Although QDs are extensively used in many medical science, several studies have been demonstrated the potential toxicity of nanoparticles. The first objective of this study was to investigate the nanotoxicity of QDs in the HaCaT human keratinocyte cell line by focusing on gene expression pattern. In order to evaluate the effect of QDs on gene expression profile in HaCaT cells, we analyzed the differential genes which related to oxidative stress and antioxidant defense mechanisms by using human cDNA microarray and PCR array. A human cDNA microarray was clone set, which was sorted for a list of genes correlated with cell mechanisms. We tried to confirm results of cDNA microarray by using PCR array, which is pathway-focused gene expression profiling technology using Real-Time PCR. Although we could not find the exactly same genes in both methods, we have screened the effects of QDs on global gene expression profiles in human skin cells. In addition, our results show that QD treatment somehow regulates cellular pathways of oxidative stress and antioxidant defense mechanisms. Therefore, we suggest that this study can enlarge our knowledge of the transcriptional profile and identify new candidate biomarker genes to evaluate the toxicity of nanotoxicology.

• Journal of the Korean Society for Railway
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• v.14 no.6
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• pp.501-506
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• 2011

The study and techniques of system engineering have been applied to various fields including space-air, national defense division in advanced countries. Korea is currently in the early stages of introducing system engineering scheme in railway system and national defense division restrictedly. As theory and application of system engineering covers a wide scope, documents management and requirement analysis technology applied to establishment of standard and core unit development of the research target. The techniques which are historical management and trace among standards for establishment of standard are introduced using SE tools and participating agencies shared the information by constructing of database from all documents which are generated from the project. Through the functional analysis of the requirements for the intelligent station monitoring system in basic design stage, established requirements are verified and will be made official announcement as standard of the intelligent station monitoring system.

• Journal of the Korea Society of Computer and Information
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• v.14 no.4
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• pp.161-169
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• 2009

Republic of Korea is actively adopting IT fusion technologies to achieve the goal of 'Advanced National Defense'. This study is aiming to directly contribute to the ongoing DHRMIS project by analyzing its any discovered and substantial problems as well as suggesting improvements. Current difficulties include the efficient estimation on project cost, the lack of statistics for cross-referencing, the inefficient development methodology, compliance with global quality control standard, and the separated command centers. This study suggests the budget appraisal process prior to the actual execution, the introduce of regulatory business registration system, applying an efficient development methodologies as well as ISO9126 standard for quality control, and a centralized command department. We expect this study would contribute to following researches in advancing our national defense.

• Korean Journal of Construction Engineering and Management
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• v.3 no.4 s.12
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• pp.114-122
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• 2002

Earned Value Management System(EVMS) is a management technique that is emerging as a valuable tool in the management of all projects, including and in particular construction projects. It is based on C/SCSC that has been released by the U.S. Department of Defense (DOD) in 1967. In a project that employs the earned value management concept, the project's measurable performance plans will be formed with the creation of CAPs. The formation of CAPs is a planning step necessary to form an earned value baseline. In this paper, a method is proposed to form CAPs using Material Requirement Planning(MRP) that is also known as a useful planning tool in the manufacturing industry. An application to a real project has been carried through workpackaging model.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.22 no.3
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• pp.645-654
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• 2012

The South Korean Defense Ministry is planning and pushing forward to conduct a cloud computing pilot project in 2012. Taking into consideration the high-level security necessary in the military as well as wartime duties, if not designed properly, this project may anticipate severe damage to national security and interest. In particular, despite the fact that vulnerability due to inter-Korean confrontation and regular security-related incidents have been triggered, unconditionally conducting a cloud computing pilot project without reviewing not only violates security regulations but also causes various security-related side effects in and outside South Korea. Therefore, this thesis found conditions for conduct of this project by suggesting duties that can apply cloud computing as well as security technology, administration, post-accident matters and conditions for legally solving cloud computing in the military.

• Molecules and Cells
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• v.44 no.5
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• pp.281-291
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• 2021

Tissue-resident macrophages play an important role in maintaining tissue homeostasis and innate immune defense against invading microbial pathogens. Brain-resident macrophages can be classified into microglia in the brain parenchyma and non-parenchymal brain macrophages, also known as central nervous system-associated or border-associated macrophages, in the brain-circulation interface. Microglia and non-parenchymal brain macrophages, including meningeal, perivascular, and choroid plexus macrophages, are mostly produced during embryonic development, and maintained their population by self-renewal. Microglia have gained much attention for their dual roles in the maintenance of brain homeostasis and the induction of neuroinflammation. In particular, diverse phenotypes of microglia have been increasingly identified under pathological conditions. Single-cell phenotypic analysis revealed that microglia are highly heterogenous and plastic, thus it is difficult to define the status of microglia as M1/M2 or resting/activated state due to complex nature of microglia. Meanwhile, physiological function of non-parenchymal brain macrophages remain to be fully demonstrated. In this review, we have summarized the origin and signatures of brain-resident macrophages and discussed the unique features of microglia, particularly, their phenotypic polarization, diversity of subtypes, and inflammasome responses related to neurodegenerative diseases.

• Journal of the Korean Society of Systems Engineering
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• v.15 no.2
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• pp.87-97
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• 2019

This paper focuses on the SE concept based on the weapon system design, which is the lack of systematic research at the stage of military requirements creation prior to acquisition management phase. Influence factors were derived by focusing on the core issues that were at issue in the process of requirements analysis, requirements verification, and business management in recent years. Next, the impact factor was prioritized using the AHP technique and then alternatives were suggested. As a result, through the hierarchical analysis process, 'substantiation of necessity' was found to be the most important factor in the large category, and 'satisfaction of the operating concept' was the most important factor. In addition, as a result of calculating the final weight for each nutritional factor, it was analyzed in order of 'enemy threat response ability', 'response to operational environment change', 'performance considering operational environment', and 'guaranteed power generation'. The results of this analysis suggest which factors should be focused on, firstly, based on the concept of SE by the military and JCS.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.46 no.6
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• pp.513-518
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• 2018

Nitrogen charging trailer applied to KUH-1 is a device to charge Nitrogen in main front wheel buffer, tail bumper buffer, brake accumulator and tire of aircraft. As the name suggests, it is a device that has mobility along with nitrogen charging. Originally supplied by Tronair in the United States, it was imported from Korea, and the locally developed product not only satisfies the performance of the existing product, but also designed to be easier than the product introduced in the operation. It was selected as the joint investment project of the 15th civilian government building, and development needs analysis and test evaluation were carried out under the support of development and management of Korea Aerospace Industries and Defense Agency for Technology and Quality.

• Journal of the Korean Society of Industry Convergence
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• v.23 no.3
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• pp.445-452
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• 2020

The air cleaning unit of K00 IFV(or Infantry Fighting Vehicle) has important roles to make sure the engine of the vehicle works precisely as filtering foreign substances in the air such as dust and sands. The entire components including scavenge fan which is one of the important inner part of the air cleaning unit are developed so that we can produce it domestically and don't need to import it from P^⁎⁎ Co., the original maker in United Kingdom. This paper introduces a few verification processes including cleaning efficiency and reliability. As this core unit has developed successfully the improvement of military strength and logistics support can be expected. And design capability, manufacturing skills, maintenance ability of tracked weapon system will be increased thanks to the accumulated technical knowledge obtained from this developing project. Foreign currency savings and reducing operational cost can be expected as well in military industry.