• Journal of Periodontal and Implant Science
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• 제40권4호
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• pp.180-187
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• 2010

Purpose: This study evaluated the spontaneous healing capacity of surgically produced cranial defects in rabbits with different healing periods in order to determine the critical size defect (CSD) of the rabbit cranium. Methods: Thirty-two New Zealand white rabbits were used in this study. Defects of three sizes (6, 8, and 11 mm) were created in each of 16 randomly selected rabbits, and 15-mm defects were created individually in another 16 rabbits. The defects were analyzed using radiography, histologic analysis, and histometric analysis after the animal was sacrificed at 2, 4, 8, or 12 weeks postoperatively. Four samples were analyzed for each size of defect and each healing period. Results: The radiographic findings indicated that defect filling gradually increased over time and that smaller defects were covered with a greater amount of radiopaque substance. Bony islands were observed at 8 weeks at the center of the defect in both histologic sections and radiographs. Histometrical values show that it was impossible to determine the precise CSD of the rabbit cranium. However, the innate healing capacity that originates from the defect margin was found to be constant regardless of the defect size. Conclusions: The results obtained for the spontaneous healing capacity of rabbit cranial defects over time and the underlying factors may provide useful guidelines for the development of a rabbit cranial model for in vivo investigations of new bone materials.

• Journal of Ginseng Research
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• 제41권2호
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• pp.144-150
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• 2017

Background: The presence of gross deletions in the human immunodeficiency virus nef gene ($g{\Delta}nef$) is associated with long-term nonprogression of infected patients. Here, we investigated how quickly genetic defects in the nef gene are associated with Korean Red Ginseng (KRG) intakein 10 long-term slow progressors. Methods: This study was divided into three phases over a 20-yr period; baseline, KRG intake alone, and KRG plus highly active antiretroviral therapy (ART). nef gene amplicons were obtained using reverse transcription polymerase chain reaction (PCR) and nested PCR from 10 long-term slow progressors (n = 1,396), and nested PCR from 36 control patients (n = 198), and 28 ART patients (n = 157), and these were then sequenced. The proportion of $g{\Delta}nef$, premature stop codons, and not in-frame insertion or deletion of a nucleotide was compared between three phases, control, and ART patients. Results: The proportion of defective nef genes was significantly higher in on-KRG patients (15.6%) than in baseline (5.7%), control (5.6%), on-KRG plus ART phase (7.8%), and on-ART patients (6.6%; p < 0.01). Small in-frame deletions or insertions were significantly more frequent among patients treated with KRG alone compared with controls (p < 0.01). Significantly fewer instances of genetic defects were detected in samples taken during the KRG plus ART phase (7.8%; p < 0.01). The earliest defects detected were $g{\Delta}nef$ and small in-frame deletions after 7 mo and 67 mo of KRG intake, respectively. Conclusion: KRG treatment might induce genetic defects in the nef gene. This report provides new insight into the importance of genetic defects in the pathogenesis of AIDS.

• 한국철도학회논문집
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• 제14권6호
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• pp.535-544
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• 2011

레일 표면 결함이 발생할 경우 매우 높은 충격하중이 발생하여 레일 피로 진전 또는 레일 파단에 이를 수 있고 레일이 파단될 경우 열차탈선 등 대형 사고가 발생할 수 있으므로 레일 결함부에 대한 관리기준의 정립이 매우 중요하다. 본 연구에서는 차량-궤도 동적 상호작용 해석 프로그램을 이용하여, 실제 고속철도 자갈궤도에서 결함이 발생한 43개 지점에서 측정된 레일요철을 입력값으로 하여, 요철 깊이에 따른 충격 윤중과 레일 휨응력을 산정하였다. 궤도틀림을 감안하여 윤중 및 레일 휨응력의 한계값을 설정하고, 해석결과로부터 얻은 윤중 및 레일 휨응력 최대값과 결함 깊이 및 폭과의 상관관계를 분석함으로써 레일 표면 결함부에 대한 관리기준을 제시하였다. 분석 결과, 허용할 수 있는 요철 깊이는 충격 윤중에 의하여 발생할 수 있는 레일 두부의 소성 변형을 방지하기 위하여 관리되어야 하며, 엄격한 조건을 평가할 경우 그 값은 0.2mm 정도가 적당함을 알 수 있었다.

• Archives of Plastic Surgery
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• 제37권4호
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• pp.421-426
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• 2010

Purpose: Patients with serious burns are prone to chondritis due to lack of soft tissue in the auricle, which can cause severe defects in the auricular morphology. In addition, skin damage occurs frequently in the vicinity of post-burn wounds, presenting difficulties in reconstruction surgery. An auricular reconstruction has functional and cosmetic significance. The aim of this study is to develop appropriate reconstruction methods for auricular defects. Methods: Thirty seven patients, who were treated for auricular defects from 2005 to 2009, were enrolled in this study. A local flap, multiple regional flaps and cartilage framework with or without a temporal fascial flap were applied in reconstruction surgery according to the location of the auricular defect. Results: The age of the subjects ranged from 11 to 56. Some subjects had defects that cover more than half of the helical rim with most exhibiting post-burn scars in the vicinity, for whom a multiple regional flap was used. A single use of a tubed flap was sufficient for subjects with defects that covered less than half of the helical rim. A regional flap was also used for reconstruction in subjects with defects covering both the helical rim and antehelix. Conclusion: Achieving satisfactory results from the skin flaps and skin grafts for post-burn auricular defects in both functional and cosmetic aspects is a difficult task. Therefore, selecting an appropriate surgical method through proper diagnosis of the auricular defect and the state of the available skin in the vicinity is essential.

• Childhood Kidney Diseases
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• 제24권2호
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• pp.98-106
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• 2020

Purpose: The aim of this study is to evaluate the clinical utility of late 6-month dimercapto-succinic acid (DMSA) renal scan in predicting vesicoureteral reflux (VUR) and long-lasting renal scars in children with first acute pyelonephritis (APN). Methods: A retrospective case study of children admitted with APN from January 2010 to July 2017 was performed. The study included patients with voiding cystourethrography (VCUG) and acute and late 6-month DMSA scan. We analyzed the clinical, laboratory and imaging findings of patients with and without late cortical defects at 6 months and those with or without VUR. Results: Among 145 children with APN, 50 (34.5%) had cortical defects on the late DMSA renal scan and 60 (41.4%) showed VUR. Thirteen of 38 (34.2%) children undergoing 18-month DMSA renal scan showed a long-lasting renal scars. Compared with children without late cortical defects, patients with late 6-month cortical defects had a higher incidence of VUR and long-lasting renal scars, and relapse of UTI (all P<0.05). In a multivariable analysis, both high-grade VUR and relapse of UTI were independently correlated with the presence of late 6-month cortical defects (P<0.05). Late cortical defects and relapse of UTI were also associated with the presence of VUR (P<0.05). Only the late 6-mo cortical defects was an independent predictor of long-lasting renal scars in children with APN (P<0.05). Conclusion: An abnormal late 6-month DMSA renal scan may be useful in identifying VUR and long-lasting renal scars in children diagnosed with APN.

• 비파괴검사학회지
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• 제18권6호
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• pp.445-454
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• 1998

본 연구는 박판 용접부 결함 검출 기법의 확립을 위해서 실시된 기초 연구로서, 전기강판 소재의 모재에 인위적인 결함을 작성하고, 이론 및 시험적 결과를 이용하여 결함을 검출하기 위한 최적의 조건과 임계 검출 결함 크기를 조사한 것이다. 이를 위해서 소재의 dispersion curve를 구하고, 두께 2.4mm의 박판에 대해서 tone burst방식에 의한 초음파 탐상을 실시하였다. 실험적 검토를 행한 결과 840kHz의 가진 주파수와 30도 그리고 85도의 입사각이 최적의 탐상 조건임을 알았다. 한편, 초음파의 속도와 dispersion커브를 비교 검토하여 본 바, 30도의 입사각에서 발생하여 전파하는 초음파는 symmetic mode이고 85도의 입사각에서는 antisymmetric mode의 파가 전파하고 있었다. 결함의 위치와 형상에 따라 반사파의 특성이 다르게 나타나고 있었으며, 특히 표면 결함의 경우에는 antisymmetric 모드의 초음파가 symmetric 모드 보다 높은 반사파 에너지를 나타내고 있었다. 또한 이러한 초음파 모드의 종류와 결함 검출과의 관계에 대해서는 유도파의 구조에 의해서 설명이 가능했다.

• 한국건축시공학회지
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• 제20권6호
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• pp.567-576
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• 2020

본 연구는 공동주택의 하자소송의 사례분석을 통해 하자소송단계에서 추가적으로 하자로 인정되는 하자 항목을 제안한다. 이 하자 항목은 하자소송에서 추가적인 비용의 증가, 일정 지연, 재감정 혹은 추가소송을 방지할 수 있을 것이다. 하자소송에서는 입주자 및 건설사에서 사전에 인지하지 못한 새로운 하자항목이 발생되며, 이를 새로운 하자인정항목으로 정의하였다. 이를 위해 본 연구에서는 국내의 15개의 하자소송의 사례분석을 실시하였다. 이를 통해 77개의 소송하자를 1차 선별하고 전문가 자문을 통해 최종적으로 23개의 소송하자를 도출하였다. 이후 하자의 요인을 분석하여 최종적으로 23개의 소송항목을 총 10개의 요인항목으로 정립하였으며, 사례연구를 통해 효용성을 분석하였다. 본 연구의 결과는 하자의 발생을 저감하고 분쟁을 최소화하는 데 기여할 수 있을 것이다.

• Corrosion Science and Technology
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• 제20권3호
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• pp.158-168
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• 2021

Austenitic 316 stainless steel was irradiated with protons accelerated by an energy of 2 MeV at 360 ℃, the various defects induced by this proton irradiation were characterized with microscopic equipment. In our observations irradiation defects such as dislocations and micro-voids were clearly revealed. The typical irradiation defects observed differed according to depth, indicating the evolution of irradiation defects follows the characteristics of radiation damage profiles that depend on depth. Surface oxidation tests were conducted under the simulated primary water conditions of a pressurized water reactor (PWR) to understand the role irradiation defects play in surface oxidation behavior and also to investigate the resultant irradiation assisted stress corrosion cracking (IASCC) susceptibility that occurs after exposure to PWR primary water. We found that Cr and Fe became depleted while Ni was enriched at the grain boundary beneath the surface oxidation layer both in the non-irradiated and proton-irradiated specimens. However, the degree of Cr/Fe depletion and Ni enrichment was much higher in the proton-irradiated sample than in the non-irradiated one owing to radiation-induced segregation and the irradiation defects. The microstructural and microchemical changes induced by proton irradiation all appear to significantly increase the susceptibility of austenitic 316 stainless steel to IASCC.

• Advances in nano research
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• 제14권1호
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• pp.1-15
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• 2023

Driven by the scaling down of transistor node technology, graphene became of interest to many researchers following the success of its fabrication as graphene nanoribbons (GNRs). However, during the fabrication of GNRs, it is not uncommon to have defects within the GNR structures. Scaling down node technology also changes the modelling approach from the classical Boltzmann transport equation to the quantum transport theory because the quantum confinement effects become significant at sub-10 nanometer dimensions. The aim of this study is to examine the effect of Stone-Wales defects on the electronic properties of GNRs using a tight-binding model, based on Non-Equilibrium Green's Function (NEGF) via numeric computation methods using MATLAB. Armchair and zigzag edge defects are also implemented in the GNR structures to mimic the practical fabrication process. Electronic properties of pristine and defected GNRs of various lengths and widths were computed, including their band structure and density of states (DOS). The results show that Stone-Wales defects cause fluctuation in the band structure and increase the bandgap values for both armchair GNRs (AGNRs) and zigzag GNRs (ZGNRs) at every simulated width. In addition, Stone-Wales defects reduce the numerical computation DOS for both AGNRs and ZGNRs. However, when the lengths of the structures increase with fixed widths, the effect of the Stone-Wales defects become less significant.

• 한국초전도학회:학술대회논문집
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• 한국초전도학회 2006년도 High Temperature Superconductivity Vol.XVI
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• pp.5-5
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• 2006