• The Korean Journal of Nuclear Medicine
• /
• v.3 no.1
• /
• pp.33-39
• /
• 1969

The conventional triolen absorption test has its defect in that the stool collection was cumbersome, time and energy-wasting. In the present study, the triolen absorption test was carried out using double tracer technique with $^{125}I-triolen\;and\;^{51}Cr_2O_3$ to determine if it can overcome the defect of the conventional method also with satisfactory results. Following were the results: 1. The clinical significance of this double tracer method was essentially the same with that previously done by radioactive. triolen alone. With the fractional fecal samples, the equation, y=0.626x+2.010 was substantiated, hence, this method appears to be clinically valuable if the appropriate correction is applied. With the mixed fecal samples, the equation y=0.642x+1.468 was substantiated (p<0.005) which appears to be also clinically valuable. When these two data were compared, the equation y=0.975x+0.090 (P<0.05) was substantiated, hence, $x{\fallingdotseq}y$. 2. The normal ranges of the fecal triolen excretion rate in this double tracer method were $3.46{\pm}1.69%$, namely, less than 6.9%. 3. The samplings were done from the first to third defecation in cases of clinically normal, and from the first to second defecation in cases of diarrhea or malabsorption. 4. The intestinal malabsorption of triolen was not observed in whom the triolen absorption was supposed to be clinically normal, however. a good number of suspicious malabsorptive cases showed the normal values.

• Korean Journal of Adult Nursing
• /
• v.28 no.6
• /
• pp.637-645
• /
• 2016

Purpose: The purpose of this study was to identify the occurrences and the factors contributing to constipation in the post surgical period following major orthopedic surgery. Methods: The sample included 133 patients who had surgery of the hip, knee, or spine. Patients were excluded from the study if there was a history of bowel surgery or constipation from chart review. Data were collected using questionnaires such as Korean version of Modified Barthel index (K-MBI), Hospital Anxiety and Depression Scale, and Constipation Assessment Scale (CAS) before surgery and on the third postoperative day. Results: Reports of constipation occurred in 77 instances (57.9%). The first reported defecation was within $4.0{\pm}2.2days$ following surgery. Mean days of first defecation of constipation group vs. non-constipation group was $5.5{\pm}1.7days$ vs. $2.1{\pm}1.0days$. There were statistically significant differences between patients who reported than those who did not in terms of age, length of NPO period, postoperative ADL, and the reported incidents of preoperative and postoperative depressive symptoms. Postoperative ADL, age, and NPO period were significant influencing factors of constipation and explained 52.4% of the variance. Conclusion: Constipation is a very common symptom for patients undergoing orthopedic surgery. These results indicate a need for improving patient's ADL after surgery to prevent constipation.

• The Korean Journal of Rehabilitation Nursing
• /
• v.2 no.1
• /
• pp.22-28
• /
• 1999

The development of standards and guidelines of rehabilitation nursing has been the major concerns for providing better nursing to the rehabilitation clients. As the patients with stroke and spinal cord injuries are the most prevalent physical disabilities in Korea, this study focussed on the nursing diagnoses of these two groups of patients. In order to identify the nursing diagnoses frequently used In their practice for the patients with stroke and spinal cord injuries, a survey was done with the questionnaire form developed by the research team. The surveyee were the staff nurses working at rehabilitation wards more than 2 years from 8 general hospitals in Korea, They identified and set the priorities of 13 nursing diagnoses from 79 stroke patients and 10 nursing diagnoses from 35 patients with spinal cord injuries during the periods from March 1 to June 2, 1999. The identified nursing diagnoses for the stroke patients are impaired physical immobility, sensory-perceptual alteration, activity intolerance, self-care deficit, altered defecation, altered urination, risk for injury, unilateral neglect, impaired skin integrity, altered thought processes, pain, altered health maintenance, dysreflexia. The identified nursing diagnoses for spinal cord injuries are altered urination, altered defecation, impaired skin integrity, pain, risk for injury, reflex incontinence, impaired physical immobility, self-care deficit, activity intolerance, knowledge deficit.

• Journal of Sasang Constitutional Medicine
• /
• v.27 no.4
• /
• pp.436-443
• /
• 2015

Objectives The aim of this study was to report an improvement on the symptoms of Eosinophilic Colitis (EC) by Yeoldahanso-tang.Methods The patient was diagnosed with Taeumin Ganyeol-paeJo Symptomatology and treated with Yeoldahanso-tang. The gastroendoscopy and eosinophilic infitration of mucosa of colitis are investigated. Also patient's subjective symptom of abdominal pain was scored using the Numerical Rating Scale(NRS) during the treatment period. And the number of defecation in a day is also used to decide the degree of colitis.Results and Conclusions The patient had been treated from December 13, 2014 to August 8, 2015. Eosinophilic infiltration of colon was disappeared after the treatment although chronic inflammation still existed. Subjective pain of abdominal pain was measured as NRS 6~8 at the beginning of the remedy, but diminished through the treatment sessions and became NRS 0 in the end. The number of defecation was in average 3, and at the endpoint it became 1. In conclusion, this study suggests that Sasang constitutional Medicine used for treating EC of Taeumin may be effective.

• Journal of Sasang Constitutional Medicine
• /
• v.20 no.2
• /
• pp.43-52
• /
• 2008

1. Objectives This study aims to find out the factors that affect to healthy level according to Sasang Constitutions by comparing THI health state with Sasang Health Index. 2. Methods One hundred twenty one healthy students from Korean oriental medical colleges participated in this study. We used the Questionnaire for Sasang Constitution Classification II(QSCC II) and expert opinion to diagnose Sasang Constitution, and used Sasang Health Index and THI questionnaire to take health information about Sasang Constitution, from 121 people of Sasang Constitution Information Bank. 3. Results 1) The 'Good Sweat' in Taeumin health level was higher than others, especially in case of 'Refreshness after Sweat' and the 'Good Feces' also higher in case of 'Much Volume in Defecation' 'Regularity in Defecation' 'Refreshness after Evacuation'. 2) The 'Good Feces' in Soyangin health level was higher than others, especially in case of 'Thickness'. 3) The 'Good Digestion' in Soeumin health level was not significantly higher than others. 4) The better symptoms in 'Good Sweat', the better health in Taeumin. 4. Conclusions Sasang Constitution Health Level is significantly related with Sasang Health Index.

• Journal of Sasang Constitutional Medicine
• /
• v.24 no.3
• /
• pp.93-103
• /
• 2012

Objectives Rate of gastroesophageal reflux disease accompanied by irritable bowel syndrome is on the increase. This case study reports significant improvement of patients with gastroesophageal reflux disease and irritable bowel syndrome who had suffered from chest pain, globus pharyngis and diarrhea after taking Sasang constitutional treatment. Methods This patient was diagnosed as Large Yin type Esophagus Cold pattern(Taeeumin Wiwanhanjeung). Herb medicine(Jowiseungcheong-tang) was taken by the patient, three or two times per day during treatment periods. We assessed the changes of the main symptoms such as chest pain, globus pharyngis, defecation discomfort, insomnia et al. using visual analogue scale(VAS). Results The symptoms of chest pain, globus pharyngis, defecation discomfort, insomnia decreased from VAS 7~8 to VAS 0~1 for about three months. Conclusions This case shows that Sasang constitutional medicine treatment can be effective treatment method for gastroesophageal reflux disease accompanied by irritable bowel syndrome.

• Clinical and Experimental Pediatrics
• /
• v.50 no.8
• /
• pp.752-756
• /
• 2007

Purpose : The aim of this study was to compare 2 laxatives, namely, polyethylene glycol 4000 without electrolytes and lactulose, evaluating the efficacy and safety for the treatment of constipation in children. Methods : Fifty-six children with chronic functional constipation were randomly assigned to receive polyethylene glycol 4000 (24 patients) or lactulose (32 patients). Patients or their parents reported defecation frequency, stool consistency, abdominal pain, stool incontinence and side effects after 1, 3, 6 and 12 months of treatment. Percentage of recovered patients were compared with each group. Results : Defecation frequency, abdominal pain and stool incontinence were improved in each group. At 12 months of follow up, 60% of patients treated with polyethylene glycol and 57.7% of patients treated with lactulose were considered as recovered. Conclusion : In this study, both polyethylene glycol and lactulose were equally effective and safe in the long-term treatment of constipation in children. There were no significant differences in recovery rates between 2 groups.

• Journal of Sasang Constitutional Medicine
• /
• v.25 no.1
• /
• pp.62-70
• /
• 2013

Objectives This study reports a case of rectal cancer patient treated with Dokhwaljihwang-tang. Methods The patient's subjective symptoms such as pain, sleeping difficulty, frequent defecation and dysuria were observed and the change of the quality of life(QOL) was evaluated using Functional Assessment of Cancer-Colon (FACT-C). Results After the treatment, symptoms such as pain, sleep disorder, defecation, and urination difficulty ameliorated and the score of the FACT-C improved. Conclusions A rectal cancer patient suffering from adverse consequences from the low anterior resection and the pain induced by the metastases showed the improvement of general condition and the quality of life after treated with Dokhwaljihwang-tang.

• Journal of Acupuncture Research
• /
• v.25 no.5
• /
• pp.127-137
• /
• 2008

Objectives : These days, herbal acupuncture therapy is widely applied to many diseases and symptoms by Korean medical doctors in Korea. The aim of this study was to demonstrate the effect of Carthami-Semen herbal acupuncture(CSHA) on chronic constipation. Methods : This single-blind placebo-controlled randomized parellel study enrolled 24 adults with chronic constipation. After one week's run-in period, they were randomly assigned to receive CSHA therapy, or placebo therapy for 4 weeks by 2 times per week. After completing 4 week's therapy, 2 week's follow-up period was continued. During study, defecation frequency, consistency and ease of evacuation were checked before study, every week and follow-up periods. Also, the VAS of constipation, quality of life(QoL) and heart rate variability(HRV : low frequency, high frequency) were checked 3 times totally. Finally, 21 subjects completed the protocol and 20 subjects were analyzed.(1 subject is excluded for analysis because of not following the protocol.) Results : In CSHA group, defecation frequency(continued after 1 week), consistency and ease of evacuation(at 1 week after and follow-up) were increased significantly. The VAS of constipation in CSHA group was significantly decreased. There was no significant change at QoL and HRV. Conclusions : CSHA therapy was effective in treating adults with chronic constipation. Study that have larger case number and longer follow up will be needed in the future.

• Animal cells and systems
• /
• v.16 no.4
• /
• pp.280-288
• /
• 2012

Targeted degradation of proteins through ubiquitin-mediated proteolysis is an important control mechanism in various cellular processes. The process of ubiquitin conjugation is achieved by three enzyme complexes, among which the ubiquitin ligase complex (E3) is in charge of substrate specificity. The SCF (SKP1-CUL1-F-box) family portrays the largest and the most characterized member of the E3 ligases. For each SCF complex, the ubiquitination target is recognized by the F-box protein subunit, which interacts with the substrate through a unique C-terminal domain. We have characterized a novel F-box protein CFL-1 that represents a single LRR-type F-box (FBXL) in the Caenorhabditis elegans genome. CFL-1 is highly homologous to FBXL20 and FBXL2 of mammals, which are known to regulate synaptic vesicle release and cell cycle, respectively. A green fluorescence protein (GFP)-reporter gene fused to the cfl-1 promoter showed restricted expression around the amphid and the anus. Modulation of CFL-1 activity by RNAi affected the time interval between defecations. RNAi-treated worms also exhibited reduced tendency to form dauer when exposed to daumone. The potential involvement of CFL-1 in the control of defecation and pheromone response adds to the ever expanding list of cellular processes controlled by ubiquitin-mediated proteolysis in C. elegans. We suggest that CFL-1, as a single LRR-type F-box protein in C. elegans, may portray a prototype gene exerting diverse functions that are allocated among multiple FBXLs in higher organisms.