• 한국환경성돌연변이발암원학회지
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• 제23권4호
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• pp.115-130
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• 2003

Idiopathic Parkinson's disease (IPD) represents a common neurodegenerative disorder. While epidemiological studies have suggested a number of risk factors including age, gender, race, and inherited disorder, the cumulative evidence supports the view that environmental or occupational exposure to certain chemicals may contribute to the initiation and progress of Parkinsonism. More recently, clinical and laboratory investigations have led to the theory that dysregulation of iron, an essential metal to body function, may underlie IPD by initiating free radical reaction, diminishing the mitochondrial energy production, and provoking the oxidative cytotoxicity. The participation of iron in neuronal cell death is especially intriguing in that iron acquisition and regulation in brain are highly conservative and thus vulnerable to interference from other metals that bear the similar chemical reactivity. Manganese neurotoxicity, induced possibly by altering iron homeostasis, is such an example. In fact, the current interest in manganese neurotoxicology stems from two primary concerns: its clinical symptoms that resemble Parkinson's disease and its increased use as an antiknock agent to replace lead in gasoline. This article will commence with addressing the current understanding of iron-associated neurodegenerative damage. The major focus will then be devoted to the mechanism whereby manganese alters iron homeostasis in brain.

• 디지털콘텐츠학회 논문지
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• 제11권1호
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• pp.65-71
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• 2010

태생적으로 디지털 게임은 플레이어의 관심과 흥미를 끌고 몰입을 유도하기 위해 한 개 이상의 재미 요소를 포함하고 있다. 재미의 요소로는 경쟁과 퍼즐, 인터랙션과 역할놀이 등 다양하다. 본 논문에서는 디지털 게임의 재미 요소의 본질을 바흐찐의 카니발리즘 이론으로 해석해보고자 한다. 축제와도 같은 디지털 게임을 즐기는 플레이어들은 장소와 지속성에 의해 일상적인 삶과 게임을 구분한다. 또한 게임을 진행하는 동안 죽음과 부활을 반복하면서 재생되는 생명력을 경험하며, 시시각각 변화하는 캐릭터의 모습이나 인터페이스의 전복으로 인해 일상으로부터의 일탈을 경험하며 웃음을 생산해낸다.

• 한국의사학회지
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• 제27권1호
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• pp.15-31
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• 2014

This study performed to examine the genuineness of Kyung-Jong's poison hypothesis which was the one of the biggest topic in the history of Joseon Dynasty. Kyung-Jong's poison hypothesis is that Kyung-Jong who was the 20th king of the Joseon Dysansty was poisoned by the next king Young-Jo who became the 21st king. This theory was hyphosized by Sim-Yoohyun and was widely known in the 4th year of Young-jo through the revolt. Kyung-Jong suffered with severe diarrhea for 5 days which finally took his life away right after he had have marinated raw crab and persimmon. Some insist the poison must had been in those foods. However, the symptoms that Kyung-jong had were not matched with the poisons which used in those days and also poison was not the reasonable way of murder, so it is hard to say there is little possibility of poison. On the other hand, considering of Kyung-jong's health, marinated raw crab and persimmon could result of severe diarrhea. In the mean time, the possibility of Young-Jo's intention of killing Kyung-Jong is very low. Rather, he blame the royal doctors who scout the outside doctors, because he believed that it led Kyung-jong's death since the treatment was chaotic with all those different doctors. Even after the Kyung-Jong's death, Young-jo was always strict to scout the outside doctors and missed Kyung-jong consistently. On this basis, it is hard to say that king Kyung-Jong was murdered by poisoning.

• Oncology Letters
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• 제18권6호
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• pp.5889-5896
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• 2019

The elimination of residual microscopic cancer cells is important cancer treatment. The immunoediting theory describes the balance between the immune system and cancer cells. The current study investigated changes in the immune system during the elimination of cancer cells and evaluated the influence of cluster of differentiation (CD)4 or CD8 depletion. A human squamous cell cancer cell line (SNU1041) was injected in the lateral tongue of immunocompetent mice and the changes in the CD4, CD8, CD11b, CD19, CD40 and CD40 ligand (L) populations in the blood, lymph nodes and spleen were evaluated using flow cytometry, and changes in serum cytokine levels were evaluated using a magnetic bead panel. Cancer cell elimination was delayed by CD4 depletion but not by CD8 depletion. The CD8-depleted group indicated increased levels of CD40L, interferon-gamma, interleukin (IL)-10, IL-6, and tumor necrosis factor-α. It was concluded that CD4 served a crucial role in the elimination of human cancer cells. Furthermore, the efficacies of CD40 agonist and programmed cell death protein 1 (PD1) antagonist treatments were assessed in CD4-depleted mice. CD40 agonist treatment resulted in faster cancer cell elimination and increased cytokine excretion. In conclusion, CD4 or CD40L significantly influenced cancer elimination. CD40 agonist antibodies may be potent adjuvant agents that can be used in patients with reduced CD4 or CD40L expression

• 산업진흥연구
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• 제7권4호
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• pp.85-95
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• 2022

본 연구는 전통사회와 현대를 이어주는 제례(祭禮)가 의례(儀禮)의 전승(傳乘)이라는 관점에서 제례진설에 나타난 상징성의 의미를 분석하고자 한다. 전통의례의 삶과 죽음에 대한 유교적 생사관과 사상적 바탕이 되었던 음양오행론, 우주구조의 이해와 사시(四時)의 변화로 나타난다. 제사상의 진설이 조상의 존재를 인정하고 상징체계를 통해 산 자와 죽은 자가 시간과 공간적으로 소통하는 의례적 도구로 이해하였다. 또한 사계절과 하늘·땅·지하의 공간을 제수(祭需)의 선정과 배열을 통해 상징화하고 구체화하였다. 현대 제례진설에서 위치를 결정하는 요인은 대상에 대한 시·공간적 분석을 필요로 한다. 이는 제물이 기능적 역할 뿐만 아니라 제물을 통해 표현하고자 하는 시·공간적 상징성으로 이해되기 때문이다. 본 연구에서는 제례진설에 나타난 사상적 배경과 상징체계에 대한 논의를 통해 제례문화의 계승이라는 관점에서 고찰하는데 의의가 있다.

• 벤처창업연구
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• 제11권2호
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• pp.135-144
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• 2016

중소기업청은 대학 및 연구기관의 인적(교수, 연구원) 물적(설비, 공간) 자원을 활용하기 위하여 1998년부터 최근까지 약 4,000여억원의 예산을 투입하여 창업보육센터(Business Incubator, BI)의 건립 및 운영을 지원하여 왔다. 그 결과 2013년 말 기준으로 5,500여개의 기업이 보육공간에 입주하여 매출 1조 6천억원과 고용인력 1만 6천여명을 성과를 창출하였다. 하지만 이러한 양적인 성장에도 불구하고 하드웨어 중심의 지원, 기관 내 자원의 활용부족, 민간부문과의 협력부족, 스타기업 발굴 부진 등의 여러 문제점이 노출되었다. 본 연구는 이러한 질적 성장의 한계점에 봉착한 창업보육센터의 역량강화 및 혁신방안을 모색하기 위하여 창의성 개념을 도입하여 센터의 개선방향을 제시하고자 한다. 특히 죽음의 계곡을 극복하는 방법으로서 기술사업화의 관점에서 역량, 제품, 시장이라는 CPM(Capability, Product, Market) 조합이 원활히 될 수 있도록 보육센터의 역할을 제시하였다. 또한 대학 내 자원의 유기적 연계를 제안하였다.

• 동국한의학연구소논문집
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• 제8권2호
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• pp.131-154
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• 2000

<난경(難經)>은 <내경(內經)>의 사상(思想)을 보다 자세(仔細)하고 심도(深度)있게 문답(問答)을 가설(假說)하여 의난(疑難)을 해석하는 방식으로 편찬된 서적(書籍)으로써, 논술(論述)은 기초이론(基礎理論)을 위주로 하고, 또 일부 병설(病說)도 분석(分析)하였는데 그 내용이 간요(簡要)하며, 변석(辨析)이 매우 정미(精微)하게 되어있다. 그 중 1-23난(難)은 맥(脈)을 논(論)하고, 23-29난(難)은 경락(經絡)을 논(論)하고, 30-47난(難)은 장부(臟腑)를 논(論)하고, 48-61난(難)은 병(病)을 논(論)하고, 62-68난(難)은 혈도(穴道)를 논(論)하고, 69-81난(難)은 침법(鍼法)을 논(論)하였다. 특히 <난경(難經)>에는 진법(診法)으로써 오늘날까지 한의학의 맥진방법(脈診方法)으로써, 가장 많이 응용되고 있는 '독취촌구법(獨取寸口法)'을 명확하게 밝히고 있다. 이에 본(本) 저자(著者)는 <난경(難經)>의 맥론(脈論)에 대한 이해를 높이기 위하여 <난경지연구(難經之硏究)>를 중심으로 1-23난(難)에 나오는 맥론(脈論)들을 정리하여 다음과 같이 정리하였다. 팔십일(八十一) 난경중(難經中) 일난(一難)부터 삼십삼난(三十三難)까지의 맥학(脈學)에 관(關)한 조문중(條文中)에는, 백맥(百脈)이 조회(朝會)하고 그 시작(始作)과 끝이 되는 촌구(寸口)를 중심개념(中心槪念)으로 하고 정상적(正常的)인 생리적(生理的) 맥(脈)과 병적(病的)인 맥(脈)이 대비(對比)되면서 제시(提示)되어있다. 1. 십난(十難)에서 오사(五邪)와 강유(剛柔)의 이론(理論)과 각(各) 장부(臟腑)의 고유(固有)한 맥상(脈狀)이 등장(登場)하고 있다. 2. 십삼난(十三難)에서는 색(色)과 맥(脈), 형육(形肉)의 세가지 요소(要素)가 상응(相應) 또는 상승(相勝)하는가에 따라서 병(病)의 난(難) 역치(易治)를 결정(決定)한다고 하였다. 3. 십사난(十四難)에서는 맥(脈)을 손(損)(지맥(遲脈))과 지(至)(수맥(數脈))으로 구분하는데, 맥(脈)의 손(損)에 따른 이경(離經), 탈정(奪精), 사(死), 절명(絶命)의 구분(區分)과, 맥(脈)의 지(至)에 따른 이경(離經), 탈정(奪精), 사(死), 절명(絶命)을 구분(區分)을 설명(說明)하였다. 4. 십오난(十五難)에서는 현(弦), 구(鉤), 모(毛), 석맥(石脈)으로 사시(四時)에 따라서 맥(脈)이 다르다는 것을 말하였다. 이와같이 난경(難經)에서는 "독취촌구(獨取寸口)"의 맥법(脈法)을 명화(明確)하게 확립(確立)하였으며, <내경(內經)>의 이론(理論)을 더욱 다져서 진일보(進一步)시키면서도 <내경(內經)>과는 다른 독창적(獨創的) 이론(理論)을 제시(提示)한 것이 <난경(難經)>의 가치(價値)를 더하게 하였다.

• 지역사회간호학회지
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• 제9권1호
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• pp.143-162
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• 1998

This is a study for the construction of nursing care based upon the Korean attitude toward medicine. Factors which were investigated include the source of nursing care, the reason for choosing care, the type of heath care chosen, the accessability of caregivers, and the desired location of death. The population examined in this study consisted of 517 adults distributed in six large cities and 191 adults from five rural communities. Data was analyzed using frequency, percent, Cronbach alpha, $X^2$ - test, t - test, F - test and scheffe post hoc contrast with an SAS program. The results of this study are summarized as follows: 1. Among sources of nursing care used, first rank rated-pharmacy(54.4), private hospital(18.2), general hospital(8.4), folk remedies in house (5.0), chinese hospital(2.8), prayer(2.8) and others(8.4), and the reasons for choosing nursing care rated 'the easiest method' (63.6), 'the best method'(15.7), 'reliable'(10.8) and 'lower cost burden'(4.6) in order of preference. 2. The type of nursing care chosen rated western medicine(6.80), chinese medicine(6.15), folk remedies(5.46), faith remedies(3.51) and divination remedies (1.41). There were significant differences in the effect recognition degree to various kinds of medicine. 3. The difference of the type of nursing care chosen according to general characteristics showed that urban residents were higher than rural community residents(t=2.15, p=0.0320) in western medicine, and urban residents, women, and singles were higher than rural community residents(t=2.04, p=0.0414), men (t= -2.89, p=0.0039), and married(t=2.50, p= 0.0126) on folk remedies. With repect to age and education those 21-30, under 20 and 31-40, graduated from college and graduate school were higher than above 51, above 61 (F = 7.76, p = 0.0001), graduated from elementary school(F=4.39, p=0.0006) on folk remedies. In other categories, rural community residents, women, younger people. Christians were higher than urban residents ( t = -2.73, p=0.0305), men(t= -4.15, p=0.0001), older people (F=2.48, p=0.0307), Catholic, Buddhist, or atheist (F= 70.18, p=0.0001) on faith remedies. Those graduated from high school and Buddhist were higher than unschooled, graduated from middle school(F=3.18, p= 0.0075), atheist, Catholic or Christian(F=18.32, p=0.0001) on divination redemies. There were significant differences concerning age and education level. 4. The accessibility of caregivers rated 'caregivers should be nearby if the patients need them' (50.0), 'caregivers must be there all day (24 hours)' (39.6), 'caregivers must be there at night only'(5.0), 'caregivers must be there during the day only'(2.6), 'caregivers always should visit during visiting hours' 0.4), 'caregivers don't need to be there at all' (1.2). The frist rank of suitable caregivers were rated as spouse(66.6), mother(24.2), daughter (3.6), daughter-in-law(1.9), and the reasons of thinking thus were rated as 'the most comfortable' (81.5), 'people should correctly with regards to family they'(7.1), 'the easiest' (5.4), 'take good care of the patient' (5.1) and 'lower cost burden' (0.4). 5. The desired location of death rated as the following: his/her house (91. 6) to the hospital(8. 4). A person going to encounter death in the hospital wanted his house(78.5) over the hospital(21.5), and a person dieing in the hospital prefered his house(52.9) over the hospital(47.1) as a funeral ceremony place. The following suggestions are made based on the above results. 1. A sampling method that enhances the re presentativeness should be used in regional and/or national related research and replicated to confirm the result of this study. 2. This study should be used to understand the Korean view of medical centers and to meet the expectations of patients in Korean nursing. 3. Research on the Korean traditional view of humans and expectations of the sick, health and illness, and health behavior, the perception of dying, the decision to heal, and the view of general medicine should continue to be conducted continuosly so that Korean nursing theory can be advanced on these concepts.

• 동의생리병리학회지
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• 제20권4호
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• pp.766-783
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• 2006

This study describes philosophical background regarding '虛' in oriental medicine in an effort to understand the relationships among some of the Eastern philosophy in accordance with differentiated meanings in several resources by analyzing examples of '虛' in Huang Di Nei Jing. The various usages of '虛' used in Huang Di Nei Jing are as follows: naming; condition of pulse; emptiness; '太虛' which was referred universal space by Chinese ; insufficiency, lack or scarcity, deficiency ; and the description of vitality, mental faculties. 外丹修煉(training by external substances) had the attitude do that withdraw the death by taking external materials. The meaning of '虛'in 外丹修煉 is similar to that in oriental medicine in terms of deficiency. That is, both 外丹修煉 and the oriental medicine consider that the death and disease are caused by the deficiency of something. However, there also exists difference between 外丹修煉 and the oriental medicine. 外丹修煉 supplements through withdrawal prohibition due to the characteristic of unchangeability and stern or immortal while oriental medicine provides concrete object of deficiency. 精(essence of life), 氣(ki, functional activity), and fe(vitality) not only have been considered as basic component of human body, but they also have been an important subject of health preservation for longevity with health in Taoism and oriental medicine. In oriental medicine, 精 and 氣 have been perceived as physical basis of human body and 神 as controller. 內丹修煉(Training of internal active substances) 掠nds to return to '虛', the early state of life through individual training, and attempts to withdraw death through continuous recurrence. The oriental medicine and 內丹修煉 held great value of 神 among health preservation of 精, 氣, and 神. They seek theoretical basis from philosophical Taoism. However, '虛' in Taoism is different from that in training by internal substances and oriental medicine: '虛' in philosophical Taoism has metaphysical concept which refers overcome of life and death, but '虛' in 內丹修煉 and oriental medicine have empirical concept. '太虛' is considered as formless space where it is emp Dut filled with 氣. It is conceptualized with the premise of the relevant adaptation of human body to natural environment theory referring that the interaction between the heaven and the earth makes changes; all creation is originated , and human is affected by the interaction of the heaven and the earth. Furthermore, in $\ulcorner$運氣七篇$\lrcorner$ (Seven chapters described about the five circuit phases and the six atmospheric influences), the expression that the earth is in the center of '太虛' and huge amount of 氣 supports it proves that $\ulcorner$運氣七篇$\lrcorner$ adapts '渾天設'(Chaotic universe thee). In Taoism, '虛' is the grounds where all creation is generated in the optimal condition of Tao. As regards the aspect of mentality, it is the condition in which one can free from the dualistic concepts such as right and wrong, beauty and ugliness, life and death, and so on. Although the ultimate goal of oriental medicine, the achievement of longevity without sickness, might contrast with the Taoist belief that perceives life and death as the natural phenomena or the flowing of the 氣, and eliminates all international, the idea of Taoism that one should live substantial life with naivety, and make Harmony with the nature might be influential to the oriental medicine.

• 미술이론과 현장
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• 제2호
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• pp.7-26
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• 2004

Since the 20th century, it was often announced that a painting was dead, but it is still alive. Even in the epoch of recently increasing virtuality, painting is still appealing, consistently pursed by many with a thirst. Thus, it is said that the mission of a picture is to maintain its reality without being trapped in virtuality. In the history of Western painting spanning over several hundreds of years the myriad of techniques and styles have emerged, going though a huge variety of changes: namely, its not possible any longer to find the new ways of expression in painting. Hence, painters today feel that it becomes more gradually difficult for them to execute something. In the midst of swiftly changing, diversely evolving trends of contemporary art, the painters incessantly pose a question why they go on working on painting, and seek to find its answer. Why the painters still try to say something about painting? Is that because they consider it the quintessence of fine arts or think that it is in no way possible or meaningful to comment on fine arts without relying on painting? If then, is there any avenue of escape for the painting? The question of the 'crisis of painting' is still raised, when reviewing the rapidly changing conditions of inventing artworks. That is also why the recent works failed to offer a conceptually unified, universally shared perspective of painting. Moreover, painting is left to shrink comparatively with the pervasive existence of videos and installations briskly employing digital images and technologies in their creations. Whats more problematic is the fact that there is a growing sense of crisis not only in the sphere of painting hut also in the entire realm of art. As the organizers and curators of big-scale exhibitions and art projects tend to exploit their space spectacularly, focusing primarily on their abilities to control the space, there is a pervasive notion amongst them that painting is a medium that is not properly to suit such purposes and requests. Today, the death of painting is, in fact, the death of modernist painting, which assumed a central role in the history of art for a considerable amount of time, rather than the death of painting itself. Employing a new paradigm of invention, a picture is now entering a new domain which is perhaps unknown to us. Moving beyond the stereotypical concepts of painting, physical property and flatness, pictures today reveal the introduction of time and space and the penetration of new media such as installation, photography, video and the Internet. Despite such trends, the dexterity and tactile capability of painters is still to be considered significant in the future. The renewal of painting is made in an entirely unexpected manner and place.