• Asian-Australasian Journal of Animal Sciences
• /
• v.29 no.11
• /
• pp.1646-1652
• /
• 2016

Mammalian target of rapamycin complex 1 (mTORC1) is a central regulator of cell growth and metabolism and is sufficient to induce specific metabolic processes, including de novo lipid biosynthesis. Elongation of very-long-chain fatty acids 1 (ELOVL1) is a ubiquitously expressed gene and the product of which was thought to be associated with elongation of carbon (C) chain in fatty acids. In the present study, we examined the effects of rapamycin, a specific inhibitor of mTORC1, on ELOVL1 expression and docosahexaenoic acid (DHA, C22:6 n-3) synthesis in bovine mammary epithelial cells (BMECs). We found that rapamycin decreased the relative abundance of ELOVL1 mRNA, ELOVL1 expression and the level of DHA in a time-dependent manner. These data indicate that ELOVL1 expression and DHA synthesis are regulated by mTORC1 in BMECs.

• The Bulletin of The Korean Astronomical Society
• /
• v.36 no.2
• /
• pp.59.1-59.1
• /
• 2011

I present an analysis of the long-term evolution of the fluxes of six active galactic nuclei (AGN) - 0923+392, 3C 111, 3C 273, 3C 345, 3C 454.3, and 3C 84 - in the frequency range 80 - 267 GHz using archival calibration data of the IRAM Plateau de Bure Interferometer. Our dataset spans a long timeline of ~14 years with 974 - 3027 flux measurements per source. We find strong (factors ~2-8) flux variability on timescales of years for all sources. The flux density distributions of five out of six sources show clear signatures of bi- or even multimodality. Our sources show mostly steep (alpha~0.5-1), variable spectral indices that indicate outflow dominated emission; the variability is most probably due to optical depth variations. The power spectra globally correspond to red-noise spectra with five sources being located between the cases of white and flicker noise and one source (3C 111) being closer to the case of random walk noise. For three sources the low-frequency ends of their power spectra appear to be upscaled in spectral power by factors ~2-3 with respect to the overall powerlaws. We conclude that the source emission cannot be described by uniform stochastic emission processes; instead, a distinction of "quiescent" and (maybe multiple) "flare" states of the source emission appears to be necessary.

• ALGAE
• /
• v.22 no.4
• /
• pp.273-286
• /
• 2007

Records of selected gymnodinioid dinoflagellates from the open waters in the vicinity of the Kuroshio and Oyashio Currents, the Philippine, Celebes, Sulu and South China Seas, western and central equatorial and southeast Pacific Ocean are described and illustrated. The species Gymnodinium fusus Schütt, Gyrodinium falcatum Kofoid et Swezy, G. caudatum Kofoid et Swezy, G. sugashimanii J. Cachon et al. and Pseliodinium vaubanii Sournia are considered to be morphotypes of a single species, that until further studies can establish the correct genus, are named G. falcatum. This study is the first to record individuals of G. falcatum with very long curly extensions. Other gymnodinioid dinoflagellates that showed bifurcated hyposomes may be related to Gyrodinium bifurcatum Kofoid et Swezy or cells of thecate dinoflagellates exuviated from their thecae. Some specimens showed a rigid cover, although no discernible thecal plates. In this group, the most common species was Ptychodiscus noctiluca Stein and, for the first time, a micrograph of a tentative specimen of the genus Berghiella Kofoid et Michener is reported. The validity of the genera Berghiella and Balechina Loeblich Jr. et Loeblich III with thick cell covers is discussed. Several species with apical extensions, other unknown taxa with distinctive shapes, and colonial forms are illustrated. The diversity of gymnodinioid dinoflagellates is underinvestigated in the open ocean.

• Journal of Agricultural Extension & Community Development
• /
• v.8 no.2
• /
• pp.223-234
• /
• 2001

The community consciousness used to be the core of the social capital in rural Korea, and there used to be a long tradition of mutual trust and cooperation in rural village community in Korea. However, recent trends in rapid urbanization or de-ruralization may affected community consciousness and social capital in rural society in Korea. The social capital has been existed in terms of mutual trust, commonly shared norms, and cooperative behavior in farm work and daily life of rural people. Commonly shared norms and networks have accelerated social effectiveness and promoted cooperative work as well as moral and spiritual aspects of rural society. Social capital in terms of community consciousness, participation of village work, visit and invitation of the neighborhood, and participation in various village group and networks were suveyed in JanggogRi, Jori Myun, Paju city, Gyeonggi province. The data collected from 65 persons, and the major findings of the study were as follow; The respondents responded that the community consciousness of de-rural area decreased in general with a few exception in the groups of alumni, family, religion and voluntary society. Social capital in terms of participation of village work, visiting the neighbors and voting increased slightly. Further research on social capital should be conducted to strengthen community consciousness, and various measures to increase the social capital should be adopted for livable community development.

• Clinical and Experimental Pediatrics
• /
• v.58 no.2
• /
• pp.41-46
• /
• 2015

Growth hormone (GH) treatment has been increasingly widely used for children with GH deficiencies as the survival rate of pediatric patients with malignancies has increased. Both GH and insulin-like growth factor-I have mitogenic and antiapoptotic activity, prompting concern that GH treatment may be associated with tumor development. In this review, the authors examined the relationship between GH treatment and cancer risk in terms of de novo malignancy, recurrence, and secondary neoplasm. Although the results from numerous studies were not entirely consistent, this review of various clinical and epidemiological studies demonstrated that there is no clear evidence of a causal relationship between GH treatment and tumor development. Nonetheless, a small number of studies reported that childhood cancer survivors who receive GH treatment have a small increased risk of developing de novo cancer and secondary malignant neoplasm. Therefore, regular follow-ups and careful examination for development of cancer should be required in children who receive GH treatment. Continued surveillance for an extended period is essential for monitoring long-term safety.

• Ocean and Polar Research
• /
• v.37 no.3
• /
• pp.179-188
• /
• 2015

This study was carried out to determine the optimal number of ARGO floats in the East Sea in order to maximize their applications. The dominant spatio-temporal scale, size of the domain, and the typical float lifetimes in the East Sea were taken into consideration. The mean spatial de-correlation scale of temperature on isobaric surfaces reaches about 60 km. The minimum necessary number of floats is about 82 on average in order to secure independent ARGO profiles with the de-correlation scale. Considering the float lifetimes, about 27 floats per year should be deployed to maintain the 82 ARGO float array every year. To obtain spatially uniform distribution of ARGO float data, mean residence time and dispersion rate (basin area/residence time) of ARGO floats were evaluated in each basin of the East Sea. A faster (slower) dispersion rate requires more (less) ARGO floats to maintain the spatially uniform number of floats. According to the analysis, it is likely that the optimal ratio of the number of floats for each basin is 1:2:4 corresponding to Ulleung Basin:Yamato Basin:Japan Basin. In order to maintain relatively uniform ARGO observing networks, it is necessary to establish a long-term plan for deployment strategy based on float pathways and the dispersion rate parameters estimated by using currently active ARGO float trajectory data as well as reanalysis data.

• Journal of Powder Materials
• /
• v.20 no.6
• /
• pp.479-486
• /
• 2013

In the present work, physicochemical treatments were introduced for de-aggregation and stable dispersion of detonation nanodiamonds (DND) in polar solvents. The DNDs in water exhibited a particle size of 138 nm and high dispersion stability without particular treatment. However, the DNDs in ethanol were severely aggregated to several micrometers in size and showed poor dispersion stability with time. To break down aggregates of DNDs and enhance the dispersion stability of them in ethanol, mechanical force and chemical surfactant were introduced as functions of zirconia ball size, kind of surfactant and amount of surfactant added. From the analyses of average particle size and Turbiscan results, it was suggested that the size of DNDs in ethanol can be reduced by only mechanical force; however, the DNDs were re-aggregated due to high surface activity. The long-term dispersion stability can be achieved by applying mechanical force to break down the aggregates of DNDs and by preventing re-aggregation of them using proper surfactant.

• Smart Structures and Systems
• /
• v.12 no.5
• /
• pp.483-499
• /
• 2013

A new piezoceramic $d_{15}$ shear-induced torsion actuation mechanism representative benchmark is proposed and its experimentations and corresponding 3D finite element (FE) simulations are conducted. For this purpose, a long and thin smart sandwich cantilever beam is dimensioned and built so that it can be used later for either validating analytical Saint Venant-type solutions or for analyzing arm or blade-based smart structures and systems applications. The sandwich beam core is formed by two adjacent rows of 8 oppositely axially polarized d15 shear piezoceramic patches, and its faces are dimensionally identical and made of the same glass fiber reinforced polymer composite material. Quasi-static and static experimentations were made using a point laser sensor and a scanning laser vibrometer, while the 3D FE simulations were conducted using the commercial software $ABAQUS^{(R)}$. The measured transverse deflection by both sensors showed strong nonlinear and hysteretic (static only) variation with the actuation voltage, which cannot be caught by the linear 3D FE simulations.

• Advances in concrete construction
• /
• v.5 no.5
• /
• pp.539-561
• /
• 2017

In this study, the effects of initial damage of concrete columns on the post-repair performance of reinforced concrete (RC) columns strengthened with carbon-fiber-reinforced polymer (CFRP) composite are investigated experimentally. Four kinds of compression-damaged RC cylinders were reinforced using external CFRP composite wraps, and the stress-strain behavior of the composite/concrete system was investigated. These concrete cylinders were compressed to four pre-damaged states including low -level, medium -level, high -level and total damage states. The percentages of the stress levels of pre-damage were, respectively, 40, 60, 80, and 100% of that of the control RC cylinder. These damaged concrete cylinders simulate bridge piers or building columns subjected to different magnitudes of stress, or at various stages in long-term behavior. Experimental data, as well as a stress-strain model proposed for the behavior of damaged and undamaged concrete strengthened by external CFRP composite sheets are presented. The experimental data shows that external confinement of concrete by CFRP composite wrap significantly improves both compressive strength and ductility of concrete, though the improvement is inversely proportional to the initial degree of damage to the concrete. The failure modes of the composite/damaged concrete systems were examined to evaluate the benefit of this reinforcing methodology. Results predicted by the model showed very good agreement with those of the current experimental program.

• Nuclear Engineering and Technology
• /
• v.53 no.11
• /
• pp.3465-3473
• /
• 2021

For a long time, research into integrated deterministic-probabilistic safety assessment has been continuously conducted to point out and overcome the limitations of classical ET (event tree)/FT (fault tree) based PSA (probabilistic safety assessment). The current paper also attempts to assert the reason why a technical transformation from classical PSA is necessary with a re-interpretation of the categories of risk. In this study, residual risk was classified into interpolating- and extrapolating-censored categories, which represent risks that are difficult to identify through an interpolation or extrapolation of representative scenarios due to potential nonlinearity between hardware and human behaviors intertwined in time and space. The authors hypothesize that such risk can be dealt with only if the classical ETs/FTs are freely relocated, entailing large-scale computation associated with physical models. The functional elements that are favorable to find residual risk were inferred from previous studies. The authors then introduce their under-development enabling techniques, namely DICE (Dynamic Integrated Consequence Evaluation) and DeBATE (Deep learning-Based Accident Trend Estimation). This work can be considered as a preliminary initiative to find the bridging points between deterministic and probabilistic assessments on the pillars of big data technology.