• Genomics & Informatics
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• 제15권2호
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• pp.56-64
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• 2017

We have previously reported that NS-398, a cyclooxygenase-2 (COX-2)-selective inhibitor, inhibited replicative cellular senescence in human dermal fibroblasts and skin aging in hairless mice. In contrast, celecoxib, another COX-2-selective inhibitor, and aspirin, a non-selective COX inhibitor, accelerated the senescence and aging. To figure out causal factors for the senescence-modulating effect of the inhibitors, we here performed cDNA microarray experiment and subsequent Gene Set Enrichment Analysis. The data showed that several senescence-related gene sets were regulated by the inhibitor treatment. NS-398 up-regulated gene sets involved in the tumor necrosis factor ${\beta}$ receptor pathway and the fructose and mannose metabolism, whereas it down-regulated a gene set involved in protein secretion. Celecoxib up-regulated gene sets involved in G2M checkpoint and E2F targets. Aspirin up-regulated the gene set involved in protein secretion, and down-regulated gene sets involved in RNA transcription. These results suggest that COX inhibitors modulate cellular senescence by different mechanisms and will provide useful information to understand senescence-modulating mechanisms of COX inhibitors.

• Nuclear Engineering and Technology
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• 제36권5호
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• pp.450-459
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• 2004

For the evaluation of emission sources by air sampling, airborne particulate matter for fine (<2.5 ${\mu}m2$ EAD : $PM_{2.5}$) and coarse partical (2.5-10 ${\mu}m2$ EAD : $PM_{2.5-10}$ fractions were collected using a Gent stacked filter unit low volume sampler and two types of polycarbonate filters. Air samples were collected twice monthly at two regions in and around Daejeon city in the Republic of Korea from January to December 2002. Monthly mass concentration of $PM_{2.5}$ and $PM_{2.5-10}$ were measured and the concentrations of 10 marker elements (Al, Sc, Ti ; Na, Cl ; As, V. Sb, Br, Se) were determined by an instrumental neutron activation analysis. Analytical quality control was corried out using certified reference materials. Enrichment factors were also calculated from the monitoring data to classify the anthropogenic and crustal origins.

• The Journal of Asian Finance, Economics and Business
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• 제8권1호
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• pp.519-529
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• 2021

This study aims to investigate the impact of Human Resource Management Practices (HRMP) on improving Employee Performance (EP). The study is accomplished by hypothesizing the impact of HRMP on EP, additionally, this impact is theorized to be mediated through job satisfaction. Employee engagement is also taken into account because of the potential moderating effect it has within the theorized model. Data was collected from 480 questionnaires which were distributed among commercial banks' workers in Jordan and were analyzed using structural equation modeling techniques (SEM), path analysis, and confirmatory factor analysis (CFA). Analysis of a moment structures (AMOS) software version 24 was applied to complete our analysis. The results show that HRMP had a positive impact on EP, as well as job satisfaction and its components (job stability and job enrichment). The mediating role of job satisfaction (enrichment and stability) was discovered. Finally, employee engagement emerged as a moderating variable linking HRMP and EP. The findings of this study show the importance of the role played by job satisfaction and employee engagement in achieving human resources performance goals. Future analysis is recommended to gain deeper insight into the relationship between HRMP, job satisfaction, worker training, and performance appraisal.

• Advances in materials Research
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• 제9권4호
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• pp.251-263
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• 2020

α-mangostin imprinted polymers have been synthesized by a non-covalent imprinting approach with α-mangostin as a template molecule. The α-mangostin molecularly imprinted polymers (MIPs) prepared by radical polymerization using methacrylic acid, ethlylene glycol dimethacrylate, benzoyl peroxide, and acetonitrile, as a monomer, crosslinker, initiator, and porogen, respectively. The template was removed by using methanol:acetic acid 90:10 (v/v). The physical characteristics of the polymers were investigated by Fourier Transform Infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and thermogravimetric analysis (TGA). The rebinding studies were carried out by batch methods. The results exhibited that the MIPs was able to adsorb the α-mangostin at pH 2 and the contact time of 180 min. The kinetic adsorption data of α-mangostin performed the pseudo-second order model and followed the Langmuir isotherm model with the adsorption capacity of 16.19 mg·g-1. MIPs applied as a sorbent material in solid-phase extraction, namely molecularly imprinted solid-phase extraction (MISPE) and it shows the ability for enrichment and clean-up of α-mangostin from the complex matrix in medicinal herbal product and crude extract of mangosteen (Garcinia mangostana L.) pericarp. Both samples, respectively, which were spiked with α-mangostin gives recovery more than 90% after through by MISPE in all concentration ranges.

• Molecules and Cells
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• 제45권5호
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• pp.343-352
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• 2022

The advent of the assay for transposase-accessible chromatin using sequencing (ATAC-seq) has shown great potential as a leading method for analyzing the genome-wide profiling of chromatin accessibility. A comprehensive reference to the ATAC-seq dataset for disease progression is important for understanding the regulatory specificity caused by genetic or epigenetic changes. In this study, we present a genome-wide chromatin accessibility profile of 44 liver samples spanning the full histological spectrum of nonalcoholic fatty liver disease (NAFLD). We analyzed the ATAC-seq signal enrichment, fragment size distribution, and correlation coefficients according to the histological severity of NAFLD (healthy control vs steatosis vs fibrotic nonalcoholic steatohepatitis), demonstrating the high quality of the dataset. Consequently, 112,303 merged regions (genomic regions containing one or multiple overlapping peak regions) were identified. Additionally, we found differentially accessible regions (DARs) and performed transcription factor binding motif enrichment analysis and de novo motif analysis to determine new biomarker candidates. These data revealed the gene-regulatory interactions and noncoding factors that can affect NAFLD progression. In summary, our study provides a valuable resource for the human epigenome by applying an advanced approach to facilitate diagnosis and treatment by understanding the non-coding genome of NAFLD.

• 가족자원경영과 정책
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• 제21권3호
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• pp.97-119
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• 2017

The purpose of this study was to find out the actor effect and the partner effect in relation to spousal support, job support, work-family spillover, and work-life balance in dual-earner couples. The subjects of this study were 176 dual-earner couple, whose youngest children are under the age of 16 and who work over 15 hours each week. The research tool was a questionnaires. Factor analysis, Cronbach's ${\alpha}$, correlation analysis, and APIM were performed for the data analysis. The main results of this study as follows. First, for both wives and husbands, perceived spousal support had a positive actor effect on work-life balance. However, perceived husband's spouse support for wife's support had positive partner effect on the wife's work-life balance, the wife's perceived spousal support for her husband' did not have a partner actor effect on the husband's work-life balance. Second, for both wives and husbands, job support had a positive actor effect on work-life balance. In addition, the wife's job support had a positive partner effect on the husband's work-life balance, however, the husband's job support did not have a partner actor effect on the wife's work-life balance. Third, for both wives and husbands, work-family conflict had a negative actor effect on work-life balance. In addition, the wife's work-family conflict had a negative partner effect on the husband's work-life balance, however, the husband's work-family conflict did not have a partner actor effect on the wife's work-life balance. Fourth, for both wives and husbands, work-family enrichment had a positive actor effect on work-life balance. In addition, the husband's work-family enrichment had a positive partner effect on the wife's work-life balance, however, the wife's work-family enrichment did not have a partner actor effect on the husband's work-life balance.

• 천문학회지
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• 제21권1호
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• pp.1-36
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• 1988

The temperature calibration of stars by photometric parameters and spectral type is discussed, using the catalogue data of Cayrel de Strobel et al. (1985) and Morel et al. (1976). The H-R diagrams and the mass-luminosity relation of stars in this catalogue are presented in the [log(L/M)-log $T_e$]-and [$M_{bol}$-log(L/M)]-planes, respectively, discussing the age of main sequence (MS) stars and giant stars. The age-metallicity relation of the nearby stars suggests the initial rapid enrichment of metal abundance.

• Bioinformatics and Biosystems
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• 제2권1호
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• pp.24-27
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• 2007

Human cell regulatory mechanism is one of suspicious problems among biologists. Here we tried to uncover the human breast cancer cell regulatory mechanism from gene expression data (Marc J. Van de vijver, et. al., 2002) using a module network algorithm which is suggested by Segal, et. al.(2003) Finally, we derived a module network which consists of 50 modules and 10 tree depths. Moreover, to validate this candidate network, we applied a GO enrichment test and known transcription factor-target relationships from Transfac(R) (V. Matys, et. al, 2006) and HPRD database (Peri, S. et al., 2003).

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제17권8호
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• pp.2292-2313
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• 2023

With improving computing performance, various digital platforms are being developed to enable easily utilization of high-performance computing environments. EDISON 1.0 is an online simulation platform widely used in computational science and engineering education. As the research paradigm changes, the demand for developing the EDISON 1.0 platform centered on simulation into the EDISON 2.0 platform centered on data and artificial intelligence is growing. Herein, a data framework, a core module for data-centric research on EDISON 2.0 digital platform, is proposed. The proposed data framework provides the following three functions. First, it provides a data repository suitable for the data lifecycle to increase research reproducibility. Second, it provides a new data model that can integrate, manage, search, and utilize heterogeneous data to support a data-driven interdisciplinary convergence research environment. Finally, it provides an exploratory data analysis (EDA) service and data enrichment using an AI model, both developed to strengthen data reliability and maximize the efficiency and effectiveness of research endeavors. Using the EDISON 2.0 data framework, researchers can conduct interdisciplinary convergence research using heterogeneous data and easily perform data pre-processing through the web-based UI. Further, it presents the opportunity to leverage the derived data obtained through AI technology to gain insights and create new research topics.

• 한국콘텐츠학회논문지
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• 제15권11호
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• pp.202-214
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• 2015

본 연구는 다문화가정 부부의 특별한 개별적 요구에 기반을 둔 부부 의사소통 및 관계증진 프로그램을 개발하고 적용 효과를 살피는 데 그 목적을 두었다. 본 프로그램은 기존 프로그램 및 선행연구 검토와 참여자의 요구조사, 전문가 면담의 과정을 통해 개발되었고, 4쌍의 다문화가정 부부에게 11주간(주 1회, 회당 120분) 부부 대화기법, 부부 상담을 활용한 부부의사소통 중재 프로그램으로 적용되었다. 프로그램이 실행되는 동안 수집된 녹음파일, 활동지, 연구자의 현장노트 등의 질적자료를 통해 살펴본 프로그램의 효과는 다음과 같다. (1) 다문화가정 부부의 친밀성이 향상되었고, (2) 부부간의 대화가 증가되었으며, (3) 특히 부부간의 의사소통 방식은 "역기능적 의사소통"에서 "협력적인 의사소통"으로 변화되었다. 결론적으로 이러한 변화가 부부관계 증진에 긍정적인 영향을 미치는 것으로 나타났다. 본 연구에서 개발한 부부 의사소통 프로그램은 다문화가정 부부대화의 물꼬를 열었다는 점과 부부갈등을 해결하고 관리하기 위해 의사소통 전략과 전문적인 상담지원을 하였다는 점에서 의의를 가진다.