• 제목/요약/키워드: Data Tree

검색결과 3,320건 처리시간 0.033초

전장유전체수준 메틸레이션 분석을 통한 두경부암 특이 메틸레이션 바이오마커의 발굴 (Genome-wide Methylation Analysis and Validation of Cancer Specific Biomarker of Head and Neck Cancer)

  • 장재원;박기완;홍소혜;정승남;류려화;김진만;오태정;구본석
    • 대한두경부종양학회지
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    • 제33권1호
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    • pp.21-29
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    • 2017
  • Methylation of CpG islands in the promoter region of genes acts as a significant mechanism of epigenetic gene silencing in head and neck squamous cell carcinoma (HNSCC). DNA methylation markers are particularly advantageous because DNA methylation is an early event in tumorigenesis, and the epigenetic modification, 5-methylcytosine, is a stable mark. In the present study, we assessed the genome-wide preliminary screening and were to identify novel methylation biomarker candidate in HNSCC. Genome-wide methylation analysis was performed on 10 HNSCC tumors using the Methylated DNA Isolation Assay (MeDIA) CpG island microarray. Validation was done using immunohistochemistry using tissue microarray of 135 independent HNSCC tumors. In addition, in vitro proliferation, migration/invasion assays, RT-PCR and immunoblotting were performed to elucidate molecular regulating mechanisms. Our preliminary validation using CpG microarray data set, immunohisto-chemistry for HNSCC tumor tissues and in vitro functional assays revealed that methylation of the Homeobox B5 (HOXB5) and H6 Family Homeobox 2 (HMX2) could be possible novel methylation biomarkers in HNSCC.

비신호 횡단보도에서의 어린이 횡단행태 분석 연구 (A Study on Analyzing Children's Crossing Behaviors on Non-signalized Crosswalk)

  • 이덕환;이윤석;김원호;이백진
    • 대한교통학회지
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    • 제31권3호
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    • pp.19-32
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    • 2013
  • 본 연구의 목적은 그간 교통안전 정책에서 간과되어온 어린이 보행자 횡단행태에 대한 분석을 통해 향후 어린이 교통안전 정책을 개선하기 위한 기초자료를 제공함에 있다. 어린이 횡단행태 분석은 물리적 형태와 사고발생빈도가 상이한 어린이 보호구역에서의 횡단행태 및 패턴의 차이를 비교하는 부분에 초점을 두고 이루어졌다. 자료는 경기도 7개 초등학교 비신호 횡단보도를 대상으로 현장관찰과 비디오 녹화를 통해 수집하였으며, 통계분석, CHAID 알고리즘 분석, 통행 패턴비교를 실시하였다. 분석결과, 사고발생 빈도와 유의한 관계가 있는 횡단특성은 대기유무, 주의유무, 특이행동 유무 순으로 나타났다. 구체적으로 사고발생빈도가 낮은 지점에서 대기후 횡단하는 비율이 69.1%인 반면, 사고다발지점에서 대기를 하지 않고 횡단하는 경우가 83.6%로 상이함을 확인하였다. 횡단 전 대기 및 주의 정도는 횡단 시작부 보도폭이 넓고 학교 출구에서 횡단보도까지 거리가 일정규모 이상일 때 높게 나타났다. 한편, 횡단패턴과 사고발생빈도의 관계성은 뚜렷하게 나타나지 않았다. 향후 어린이 보호구역의 안전성 개선을 위해서는 대기 후 통행이 이루어질 수 있도록 각 보호구역에서의 어린이 횡단특성에 기반한 차별화된 맞춤형 접근이 긴요할 것으로 판단된다.

Flail Chest 의 치료와 늑골고정술 (Treatment of Flail Chest and a Fixation Technique of Flail Segments)

  • 김근호
    • Journal of Chest Surgery
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    • 제8권1호
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    • pp.37-44
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    • 1975
  • Authors have reviewed the records of seven patients of multiple rib fractures with severe flail chest who were admitted to Hanyang University Hospital during the 3 years period from 1972 through 1975. Of the seven patients studied, automobile accidents led to the injuries in 4 cases, two patients were injured in fall from a tree and on the ox-heading. All who had a blunt trauma without any open wound on the chest. The numbers of the fractured ribs accounted for 6 to 9 of the ribs including double fractures from 3 to 5 ribs. The left side fractures occurred in the 6 patients and in the right only one patient. Thus the flail segment was more often located in the left antero-lateral position than in the right lateral position [the ratio was 6:1].. All cases had associated injuries. The injuries and multiple fractures were the most common associated injuries occurring in four and five of the patients respectively. The patients were classified as having associated head injuries when they were admitted in comatose or semicomatose state. When a major degree of instability of the thoracic cage exists, adequate respiratory change is not possible. For this reason the tracheostomy was performed in five patients in an acutely injured patient with flail chest only after an endotracheal tube has been inserted or after an endotracheal suction. All patients had secondary complications in the pleural cavity, such as hemothorax or hemopneumothorax with or without intrapulmonary hemorrhage and subcutaneous emphysema. Therefore, closed thoracostomy was performed in five patients in the emergency room. The thoracotomy was required in four patients: immediate operation without closed thoracostomy was performed in two patients and the thoracotomy was indicated in two patients after closed thoracostomy, because of increasing intrathoracic hemorrhage. As to the fixation of the flail segments, authors employed two techniques; one was towel clip traction of the flail segments and the other was intramedullary insertion of Kirschner`s wire in to the double fractured rib fragments for the fixation of the flail segments [Kirschner`s wire fixation]. Because` of an different results in the course of treatment between two techniques, data from patients with towel clip traction was compared with those from patients with thoracotomy and Kirschner`s wire fixation of the flail segments. Of the three patients with towel clip traction, two patients required bronchoscopic toilet due to lung atelectasis which developed because of inadequate motion of thoracic cage and poor expectoration. This was in contrast to the four patients with thoracotomy and Kirschner`s wire fixation, who didn`t these complication because of adequate motion of the thoracic cage and subsequent good expectoration.

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통계모형을 활용한 박새류의 서식지 연결성 평가: 서울시 도시생태현황도 자료를 중심으로 (Habitat Connectivity Assessment of Tits Using a Statistical Modeling: Focused on Biotop Map of Seoul, South Korea)

  • 송원경;김은영;이동근
    • 환경영향평가
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    • 제22권3호
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    • pp.219-230
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    • 2013
  • Species distribution modeling is one of the most effective habitat analysis methods for wildlife conservation. This study was for evaluating the suitability of species distribution to distance between forest patches in Seoul city using tits. We analyzed the distribution of the four species of tits: varied tit (Parus varius), marsh tit (P. palustris), great tit (P. major) and coal tit (P. ater), using the landscape indexes and connectivity indexes, and compared the resulting suitability indexes from 100m to 1,000m. As factors affecting to the distribution of tits, we calculated landscape indices by separating them into intra-patch indices (i.e. logged patch area (PA), area-weighted mean patch shape index (PSI), tree rate (TR)) and inter-patch indices (i.e. patch degree (PD), patch betweenness (PB), difference probability of connectivity (DPC)), to analyze the internal properties of the patches and their connectivity by tits occurrence data using logistic regression modeling. The models were evaluated by AICc (Akaike Information Criteria with a correction for finite sample sizes) and AUC (Area Under Curve of ROC). The results of AICc and AUC showed DPC, PA, PSI, and TR were important factors of the habitat models for great tit and marsh tit at the level of distance 500~800m. In contrast, habitat models for coal tit and varied tit, which are known as forest interior species, reflected PA, PSI, and TR as intra-patch indices rather than connectivity. These mean that coal tit and varied tit are more likely to find a large circular forest patch than a small and long-shaped forest patch, which are higher rate of forest. Therefore, different strategies are required in order to enhance the habitats of the forest birds, tits, in a region that has fragmented forest patches such as Seoul city. It is important to manage forest interior areas for coal tit and varied tit, which are known as forest interior species and to manage not only forest interior areas but also connectivity of the forest patches in the threshold distance for great tit and marsh tit as adapted species to the urban ecosystem for sustainable ecosystem management.

지구단위 차원에서의 비오톱 보전가치평가 연구 - 대구광역시 신서동 택지개발 사업지구를 사례로 - (A Study on the Evaluation of Biotope Preservation Value in District Unit - Case Study in Sinseo-Dong, Daegu -)

  • 조현주;나정화;박인환;김수봉;류연수;장갑수
    • 한국환경복원기술학회지
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    • 제11권5호
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    • pp.38-59
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    • 2008
  • This research has a meaning to provide basic data for eco-friendly way of district unit plans and ecological landscape planning by evaluation of biotope preservation value at the level of district unit and designating land development of the site, the whole area of Sinseo-dong (Dong-gu, Daegu metropolitan city) for research site. The summary of analysis result is as follows. As a result of classification of biotope types on the research site, it is divided into 11 biotope groups such as a residential biotope group and 51 specific biotope types which is subordinate to the groups. As a result of the first value assessment on classified biotope types, there are 16 types of natural rivers which is full of vegetation as a I class. Also it is analysed as 9 types of IIclass, 14 of IIIclass, 8 of IVclass, and 4 of Vclass. In particular, in light of a wildlife habitat, EB, in case of broad-leaved tree of mixed forest assessed as a II class, was classified into Iclass which is one-step upgraded as a final class with the analysis as there is a structural characteristic (more than 71% of low density, 50 years of age-class). As a result of second assessment, it is analysed that there are 17 special sites (1a,1b) and 33 special sites (2a, 2b, 2c) respectively for preservation of species and biotope. Particularly, in case of the No. 27 space, it was assessed that it has the value of about medium (IIIclass) level, but its value was upgraded with the on-spot detailed investigation that most of Aristolochia contorta, designated as a rare plant by Ministry of Environment, is growing. It is regarded that the above-mentioned research result on evaluation of biotope preservation value is expected to provide very important basic materials for future district unit plans and smooth integration with landscape ecology plans and eco-friendly space development.

배과원에서 꼬마배나무이 월동성충의 수상 이동시기 예측 모형 (An Empirical Model for the Prediction of the Onset of Upward-Movement of Overwintered Caccopsylla pyricola (Homoptera: Psyllidae) in Pear Orchards)

  • 김동순;양창열;전흥용
    • 한국농림기상학회지
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    • 제9권4호
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    • pp.228-233
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    • 2007
  • 꼬마배나무이(Caccopsylla pyricola)는 배나무의 주요한 해충으로 배나무의 거친 껍질 밑에서 성충상태로 월동하는 해충이다. 봄철 날씨가 따뜻해지면 월동성충은 활동을 시작하여 나무 가지로 이동하고 단과지에 알을 낳는다. 본 연구는 기계유유제를 이용한 꼬마배나무이 월동성충 적기 방제를 위하여 월동해충이 나무위로 이동하는 시기를 예측하는 모형을 개발하고자 수행하였다. 봄철 배나무 거친 껍질 밑 및 수상 단과지에서 꼬마배나무이 월동성충 밀도를 조사하여, 성충의 상대적인 이동비율(단과지에서 상대적 발생비율)을 계산하였다. 임의로 $5\sim9^{\circ}C$까지 $1^{\circ}C$ 간격으로 꼬마배나무이 월동성충 활동에 필요한 하한온도를 선정하고 2월 1일부터 일별 최고온도 자료를 이용하여 상대적 이동비율이 0.8 이상 되는 날까지 각 하한온도를 초과하는 누적일수를 계산하고 비교하였다. 또한 같은 방법으로 꼬마배나무이 월동성충이 낳은 알 초발생일까지 누적일수를 계산하였다. 그 결과 하한온도를 6으로 했을 때 각 예측일까지 누적일수의 평균에 대한 변이 계수가 가장 낮았으며, 평균 누적일수가 12에 도달할때 월동성충의 이동이 일어났고, 25일 때 산란이 관측되었다. 이 조건의 모형 매개변수를 이용하여 수원 및 천안 지역에서 포장적합결과 모형 예측결과는 실측 이동시기를 잘 표현하였다. 기타 실제 농가포장에서 꼬마배나무이 월동성충 이동시기 예측모형의 활용방안에 대하여 고찰하였다.

돼지 Duroc 품종에서 미토콘드리아 유전체 서열의 특성과 집단의 유전적 다양성 (Complete Mitochondrial Genome Sequence and Genetic Diversity of Duroc Breed)

  • 조인철;한상현;최유림;고문석;이정규;이준헌;전진태
    • Journal of Animal Science and Technology
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    • 제46권6호
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    • pp.937-946
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    • 2004
  • Duroc 품종은 돼지 사육에 있어 산육성과 육질 향상을 위해 이용되고 있다. 본 연구는 육종에 많이 이용되는 Duroc 품종의 모계 특이적인 서열의 검색과 계통유전학적 유연관계의 정립을 위하여 미토콘드리아 유전체의 전체 염기서열을 결정하고 집단 내 다형성을 조사하였다. mtDNA 전체 서열의 길이는 16,584-bp 이고, D-loop과 tRNA, rRNA 유전자 영역에서는 삽입/결실이 확인되었다. 4개의 coding gene (COⅡ, COⅢ, ND3, ND4)에서 불완전한 종결코돈을, ND4L과 ND2 유전자는 선택적 개시코돈 양상을 보였다. Duroc 집단에 대한 분석 결과 조절영역에서의 특이적인 11-bp 중복 단위가 일부 개체(15.2%)에서 발견되었고, ND2의 개시코돈과 CYTB 유전자에서도 다형현상을 보였다. 각각의 유전자 영역에서의 다형성은 서로 연관되어 있었고, 그 결과 Duroc 집단은 크게 두 가지 haplotype으로 구분되었다. 계통수에서 Duroc mtDNA 서열은 유럽계열 cluster에 위치하였으나, haplotype 분석과 기존에 연구결과들을 종합해 보면 Duroc 품종은 여러 모계선조 집단에서 기원한 것으로 보이며, 유럽과 아시아 계열 모두가 품종 형성에 이용된 것으로 사료된다된 것으로 사료된다.

흰눈섭황금새(Muscica narcissina zanthopygia HAY)의 생태-특히 번식경과와 육령기의 식습성 (Ecological Notes on Narcissus Flycatcher, Musciapa narcissina zanthopygia HAY - With special reference to the breeding process and feeding habits of nestlings during their nesting period-)

  • 원병오;이경조
    • 한국동물학회지
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    • 제8권2호
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    • pp.89-127
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    • 1965
  • 1. This report is on the outcome of observation made up the breeding process of Narcissus flycatcher, Muscicapa narcissina zanthopygia, using 15 ness-boxes at Seoul and Kwang Nung Experimental forest in 1964, and the relevant feeding habit was studied by the collar method of wrapping the necks of thenestlings for 50-60 minutes or more in some cases from 1963 to 1964. 2. The Narcissus flycatcheris a common summer resident throughout Korea arriving at the end of April. The earliest data of arrival of this species in Seoul, is April 26, 1964. They migrate southward from the later part of September to early part of October. 3. In a week after their arrival , they start to build nest after a brief courtship. Male and female prepare their nest ina nestboxes in 4 or 5 days. Nests are usually found in the moss, which provide definite frame-work. The inner side of the nest is usually composed of roots of Gramineae or leaves of pine, oak or other broad leave tree. 4. The laying period is generally from the later part of April to the middle of June : and the number of eggs laid is from 3 to 8 , therefore 5 in average : eggs are pink with traces of milky yellow blending of light auburn and orange red spots and chicken-egg-like in shape. 5.The incubation takes place for 7-12 days from the middle part of May to the middle of June, in the order of male and female . The hatching rate tends to increase in proportion to clutch size. 6. The feeding period usually lasts 15 days in average from the early part of June to the middle of July and the feeding urge tends to increase in proportion to brood size. 7. The animals invading into their nest-boxes are red ants, chipmunks, bees , barkbeetles and philippine red-tailed shirkes, etc. 8. On the basis of analysis covering 714 birds in 31 nests, the food they consumed during the nesting period of nestlings were mostly of animal matters composing of : insect larvae form-39. 88% insect adult form 36.26%, insect pupae-0.19%, spider-17.75% and other animal matters 5.92% , Besides a small amount of plant pieces were found . As to the insect larvae, Lepidoptera was the largest in the content followed by Hymenoptera , Orthoptera and Coleoptera. As to the insect adult, Diptera was the largest in the content followed by Coleoptera, and Hymenoptera. In view of forest protection, noxious insect was of 69.38%, useful insect 4.39%, and spider 17.75%. 9. The rich assortment of its food, the ability of acquiring various insect (adults as well as larvae), its destruction of great numbers of harmful insects , and its quick assimilation artificial nesting with the nest-boxes of 2.5-3cm entrance hole employed, allow us to conclude that the flycatcher may be successfully employed in the elimination of fores pests. The above results are only that part obtained near Seoul in the middle of Korea, however, if we would extend the scheme to other broad areas using similar techniques, the nest-boxes could not only be well used by the birds, but also it would help to prevent the increase of harmful. insects.

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우리나라 서어나무 임분의 군집구조와 식생천이 (Community Structure and Vegetation Succession of Carpinus laxiflora Forest Stands in South Korea)

  • 변성엽;윤충원
    • 한국환경생태학회지
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    • 제32권2호
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    • pp.185-202
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    • 2018
  • 산림천이는 몇 단계의 산림생태계 변화과정을 거쳐 최종단계인 극상림에 도달하는 것으로 우리나라 온대림의 극상림을 이루는 대표 수종이 서어나무라고 하는 많은 연구결과가 제시되어 왔다. 특정지역 또는 국지적으로 나타나는 서어나무의 상관 군락을 대상으로 식생구조와 천이과정의 연구가 주를 이루고 있고 우리나라 온대림의 극상림으로서 서어나무림을 제시한다는 것은 논란이 있을 수 있다. 따라서 본 연구는 2014년부터 2017년까지 17개산 75개소의 서어나무림을 대상으로 식생유형과 층위구조를 파악하고 이에 따른 생태적 천이경향을 구명하고자 수행되었다. 유형분류는 식물 사회학적 방법에 따라 수행하였으며 층위구조는 중요치를 분석하여 파악하였다. 종조성에 따른 유형분류결과, 총 6개의 식생단위와 9개의 종군 유형으로 분류되었다. 서어나무군락군은 난티나무군락, 개암나무군락(갈참나무군, 개암나무전형군), 철쭉군락(물들메나무군, 개서어나무군, 철쭉전형군)으로 분류되었다. 각 층위별로 중요치를 분석하여 서어나무림의 천이경향을 예측해 본 결과, 서어나무림은 (1) 당분간 서어나무림으로 유지되는 유형(식생단위 2, 3, 6), (2) 까치박달림으로 천이가 진행되는 유형(식생단위 1, 4), (3) 붉가시나무림으로 천이가 진행되는 유형(식생단위 5)의 총 3가지 천이유형으로 나타났다.

택지개발지구 조경공사의 주민관여 분석 - 경기도 광교지구를 중심으로 - (Resident Involvement Analysis of New Town Landscape Architecture Construction - Focused on the Gyeonggi GwangGyo District -)

  • 오정학
    • 한국조경학회지
    • /
    • 제44권6호
    • /
    • pp.51-59
    • /
    • 2016
  • 본 연구는 조경공사의 주민관여방식과 내용을 분석하여 공사 주체와의 상호작용 향상을 목적으로 하였다. 이를 위해 경기도 수원의 광교택지개발지구 공공조경공사를 연구대상으로 삼았다. 준공 전후 약 4년간 입주자들의 조경 관련 의견이 연구자료로 활용되었다. 사업시행처와 지자체로 접수된 412건의 민원에 대한 질적분석과 양적분석을 하였다. 그 결과, 첫째, 의견제기의 주목적은 '불만표출 및 개선요구'에 있었고, 그 대상은 '공원'과 '하천'이 많았다. 내용적으로는 '품질'을 가장 많이 지적하였는데, 공종별로는 수목식재공사, 생태하천공사, 포장공사가 많이 언급되었다. 둘째, 내용분석으로 핵심어를 추출한 결과, '고사목 처리'가 가장 많았다. 그 다음은 '추가 식재', '화장실 관리동 이전'의 순이었다. 고사목에 대한 많은 지적은 이식가능시기에 한꺼번에 처리하기 위해 기다리는 과정에서 계속 눈에 띈 탓이 컸다. 셋째, 민원내용의 타당성을 5점 척도로 평가한 결과, 중간값 이상으로 나타났다. 따라서 제기된 의견들은 무리한 요구도 있었지만, 전체적으로는 일정한 객관성을 가진 민원이 더 많은 것으로 분석되었다.